Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
Search By Approval Date:
Clear Filter Total: 6,449
Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
James Kakande
ID:
Endline Evaluation of the National Cancer Management and Capacity Building Project in Uganda (CANCAP-UG)
REFNo: SS5864ES

1. To assess coverage in cervical cancer screening services following project implementation.
2. To evaluate improvements in healthcare worker knowledge, competencies, and clinical capacity for cervical cancer prevention, screening, diagnosis, treatment, and referral.
3. To examine the effectiveness and efficiency of training, supportive supervision, referral systems, cancer information systems, and community engagement activities in strengthening cancer service delivery.
4. To assess changes in community awareness and utilization of cervical cancer screening services.
5. To assess the increase in level of Knowledge, Awareness and Practices (KAP) toward cervical cancer of the community and health professionals.
6. To evaluate improvements in healthcare facility readiness, referral systems, and cancer data management.
7. To assess the sustainability of the project's achievements and identify recommendations for future cancer control programs in Uganda.

Uganda 2026-08-24 15:10:45 2029-08-24 Social Science and Humanities Non-Clinical Trial Non-degree Award
Shallon Ahimbisibwe
ID: UNCST-2025-R022235
An Interpretable Kernel Hybrid Approach for Early Detection of Postpartum Depression
REFNo: SIR768ES

Main Objective
The main objective of this study is to develop, evaluate, and clinically validate an interpretable kernel hybrid machine learning–based screening tool, together with a prototype mobile application, for early identification and risk stratification of postpartum depression among postpartum women in Uganda using routinely collected health data.

Specific Objectives
i.To conduct a scoping review of machine learning approaches for postpartum depression detection in low- and middle-income countries, with emphasis on Sub-Saharan Africa, in order to map existing evidence, identify methodological gaps, and inform the design of the proposed kernel hybrid model.
ii.To design and develop a hybrid predictive model that integrates Kernelized Support Vector Machines and Gaussian Process models for accurate early detection of postpartum depression.
iii.To evaluate the performance of the proposed hybrid model using appropriate predictive metrics to assess its accuracy, robustness, and generalization to unseen data.
iv.To clinically validate the proposed kernel hybrid machine learning model and prototype mobile screening application by comparing model predictions against a reference standard defined by the Edinburgh Postnatal Depression Scale (EPDS) scores and, where available, clinician-documented postpartum depression assessments at the selected health facilities.
Uganda 2026-08-24 13:48:08 2029-08-24 Engineering and Technology Non-Clinical Trial Degree Award
Huzaifah Mutyaba
ID: UNCST-2026-R027389
Urban Waste Governance in Fort Portal City: A Rapid Evaluation of Disposal Practices and Management Structures
REFNo: HS8446ES

General Objective:

To evaluate the effectiveness of urban waste governance in Fort Portal City by examining the roles and responsibilities of institutions, prevailing waste disposal practices, identifying systemic gaps, and assessing community awareness, participation, and compliance with waste
management policies and practices.

Specific Objectives:
1.To explore the roles,responsibilities, and effectiveness of institutions and stakeholders involved in urban waste management.

2. To evaluate the prevailing waste disposal practices among households, businesses, institutions, and informal waste actors in Fort Portal City.

3. To identify governance, regulatory, infrastructural, and behavioural gaps that hinder effective waste management.

4. To explore level of community
awareness, participation, and compliance with existing waste management policies and practices.
Uganda 2026-08-24 13:46:12 2029-08-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joseph Magoola
ID: UNCST-2025-R017394
Evaluation of outcomes of targeted defaulter tracking on uptake of Malaria and Measles Rubella Vaccine in Uganda from September 2025 to May 2026
REFNo: HS8335ES

Purpose To assess the effectiveness of defaulter tracking support on malaria vaccine coverage and uptake in Busia, Butambala, Iganga, and Luweero districts in Uganda from September 2025 to May 2026. Specific Objectives: 1. To determine the change in coverage for malaria, oral polio, pentavalent, and measles vaccines before and after the interventions. 2. To determine changes in malaria, polio, pentavalent, and measles vaccine dropout rates before and after the interventions. 3. To determine the effectiveness of the community-led defaulter tracking system in returning identified children to immunization services. 4. To explore the perspectives of HCWs, and VHTs on factors affecting identification, follow-up, and return of children who default from routine immunization services. 5. To assess how defaulter tracking practices impact the health personnel that provide vaccination service delivery.
Uganda 2026-08-24 13:41:51 2029-08-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eugene Ruzagira
ID: UNCST-2023-R008282
A phase 1b randomised double-blinded placebo-controlled study of a Bundibugyo virus disease vaccine, ChAdOx1 Ebola BDBV Vaccine (Recombinant), in healthy participants aged 18 – 55 years in Uganda.
REFNo: HS8453ES

To assess the safety and tolerability profile of a single dose of ChAdOx1 Ebola BDBV Vaccine (Recombinant) in healthy participants To assess the immunogenicity of a single dose of ChAdOx1 Ebola BDBV Vaccine (Recombinant) in healthy participants To assess the safety and tolerability profile of a booster dose of ChAdOx1 Ebola BDBV Vaccine (Recombinant) 6 months following prime vaccination in healthy participants To assess the immunogenicity of a booster dose of ChAdOx1 Ebola BDBV Vaccine (Recombinant) 6 months following prime vaccination in healthy participants To assess the impact of prior rVSV-ZEBOV-GP or rVSV-SEBOV GP vaccination on the immunogenicity of ChAdOx1 Ebola BDBV Vaccine (Recombinant) in healthy adults
Uganda 2026-08-24 13:40:22 2029-08-24 Medical and Health Sciences Clinical Trial Non-degree Award
Maria Dieci
ID: UNCST-2024-R015211
Evaluating The effectiveness of Reducing Price Barriers to Pediatric Fever Care on Caregiver Decision-making and Illness Outcomes
REFNo: SS5757ES

The primary objective of this study is to determine the effectiveness and cost-effectiveness of pharmacy-based discounts for azithromycin and incentives for facilitated referrals, well-established practices for managing childhood fevers, on caregiver decision-making and management of childhood febrile illness among children under 5 years of age in Uganda. The unit of analysis will be at the patient level for this objective, and the primary outcome will be illness duration. The secondary objectives of this study are: To characterize the effect on care-seeking trajectories among caregivers of children under 5 following an index pharmacy visit for febrile illness. The unit of analysis will be at the patient level. To characterize the effect on provider behavior and counseling in study sites. The unit of analysis will be at the site level. To quantify out-of-pocket expenditures on diagnostic testing and medications across study arms. The unit of analysis will be at the patient level. To compare symptom severity and illness progression over the course of a pediatric fever episode between clients that accessed subsidized care compared to the status quo. The unit of analysis will be at the patient level. To assess potential indirect effects of the azithromycin and referral price reductions on prescribing practices at pharmacies that are not directly enrolled in the trial. The unit of analysis will be at the site level (surrounding pharmacies and clinics).
USA 2026-08-24 13:33:45 2029-08-24 Social Science and Humanities Non-Clinical Trial Non-degree Award
Richard Ezinga
ID: UNCST-2025-R019501
Gene Fusion-Associated Splicing Alterations, and Transcript Isoform Diversity in Acute Lymphoblastic Leukemia Patients
REFNo: HS7887ES

I. To map existing evidence on gene fusion-associated alternative splicing events, transcript isoform alterations, and analytical approaches in Acute Lymphoblastic Leukemia.
II. To identify and characterize recurrent gene fusion-associated splicing alterations and transcript isoform diversity in public ALL RNA-Seq datasets and selected eligible ALL sequences from the Uganda Cancer Institute.
III. To determine the predicted functional consequences of recurrent gene fusion-associated transcript isoforms on protein-domain architecture, molecular interaction networks, and oncogenic pathway dysregulation in Acute Lymphoblastic Leukemia Patients.
IV. To develop and validate a Nextflow-based hybrid computational pipeline for cross-platform confirmation of gene fusion-associated splicing and transcript alterations in Acute lymphoblastic leukemia.

Uganda 2026-08-24 13:30:18 2029-08-24 Medical and Health Sciences Non-Clinical Trial Degree Award
NICHOLAS MWEKWASE
ID: UNCST-2026-R023825
BARRIERS AND FACILITATORS TO COMPLIANCE WITH BASIC INFECTION PREVENTION AND CONTROL MEASURES AMONG CAREGIVERS OF NEONATES ADMITTED IN NICU AT KAWEMPE NATIONAL REFERRAL HOSPITAL
REFNo: HS8304ES

To explore the barriers to compliance with basic IPC measures among Caregivers of Neonates admitted to the NICU at Kawempe National Referral Hospital. To explore the facilitators to compliance with basic IPC measures among caregivers of Neonates admitted to the NICU at Kawempe National Referral Hospital.
Uganda 2026-08-19 19:01:52 2029-08-19 Medical and Health Sciences Non-Clinical Trial Degree Award
Florian MedetognonBenisan
ID: UNCST-2026-R026238
Social behaviour among adult mountain gorillas in Bwindi Impenetrable National Park, Uganda
REFNo: NS1383ES

In this study we aim to investigate the non-mutually exclusive hypotheses to explain male female bonds in Bwindi mountain gorillas: (1) interest convergence hypothesis: social bonds arise because of a convergence in interest of each sex in providing parental care, resulting in a joint parental investment and (2) interest divergence hypothesis: social bonds arise as a consequence of a power play between the two sex because of a divergence in interest and coveted resource: females are leveraging the protection by males and males are leveraging group membership and mating access (in multi male groups only), each through affiliation. We will investigate these through the perspective of both males and females as well as in the short and long-term. To test our hypotheses, we will collect specific behavioral data for the Bwindi Gorilla Project: 5m distance proximity and grooming data from focal animal sampling and also data on approaching/avoidance behaviour.
France 2026-08-19 18:52:18 2029-08-19 Natural Sciences Non-Clinical Trial Degree Award
Joannah Nalwoga
ID: UNCST-2024-R002651
Awareness and Factors Associated with Postpartum Hemorrhage Among Caretakers of Pregnant and Postpartum Mothers at Kayunga Regional Referral Hospital
REFNo: HS8085ES

To assess the knowledge, attitudes, and practices of caretakers regarding postpartum hemorrhage at Kayunga Regional Referral Hospital.,To assess practices and preparedness of caretakers in recognizing and responding to PPH,To identify factors associated with awareness of PPH among caretakers.,To determine the level of awareness of postpartum hemorrhage among caretakers of pregnant and postpartum mothers at KRRH.,
Uganda 2026-08-19 18:48:34 2029-08-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jasper Nidoi
ID: UNCST-2021-R012079
Costs and cost-effectiveness of a sustainable national integrated interoperable digital health data capture and sharing platform for national scaling in Uganda�s health system (NIHDP-Costing)
REFNo: HS8230ES

2. To determine the cost-effectiveness of a national integrated interoperable digital health data capture and sharing platform compared to traditional data management systems in Uganda.,1. To determine the costs associated with the design, implementation, and operation of a sustainable national integrated interoperable digital health data capture and sharing platform in Uganda.,To assess the cost-effectiveness of a national integrated interoperable digital health data capturing and sharing platform compared to traditional data management to guide resource allocation by policymakers by determining whether an investment in the digital platform yields sufficient health benefits to justify its expense,
Uganda 2026-08-19 18:45:21 2029-08-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Benjamin Geoffrey Tugume
ID:
Fetal cardiac ultrasound training and clinical practice in improving congenital heart disease screening in Uganda
REFNo: HS8430ES

a) To assess deficiencies in knowledge and skills of the obstetric ultrasound professionals in Uganda regarding systematic fetal cardiac ultrasound screening for CHD.
b) To review the global fetal cardiac ultrasound training programs and clinical practice guidelines regarding screening for CHD: identifying opportunities for clinical training in a low-income country.
c) To explore the positive views, experiences and attitudes of obstetric ultrasound professionals in Uganda regarding prenatal ultrasound screening for CHD.
d) To determine the key features to be included in a locally customised fetal cardiac ultrasound clinical training program for CHD screening in Uganda.
e) To assess the impact of a locally customised fetal cardiac ultrasound clinical training program on knowledge and skills of obstetric ultrasound professionals in screening for CHD in Uganda.

Uganda 2026-08-19 18:44:03 2029-08-19 Medical and Health Sciences Non-Clinical Trial Degree Award
GRACE KANSIIME
ID: UNCST-2019-R000380
POINT-OF-CARE PROTEINURIA SCREENING AMONG HIGH-RISK POPULATIONS IN UGANDA
REFNo: HS8148ES

3. To explore the stake holders� perspectives on implementation of POC UACR testing for high risk populations in Uganda ,2. To determine the diagnostic accuracy of point-of-care urine albumin creatinine ratio (UACR) compared to standard laboratory-based UACR for high-risk patients in Uganda.,1. To determine the prevalence and factors associated with proteinuria among adults at high-risk of kidney disease (with diabetes and/or hypertension) in Uganda ,
Uganda 2026-08-19 17:15:08 2029-08-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Christabellah Namugenyi
ID: UNCST-2025-R019265
Service delivery and dual control of HIV and hypertension in Sub-Saharan Africa: A mixed methods study among Persons Living with HIV and hypertension in South-central Uganda
REFNo: HS8005ES

1. To estimate the pooled dual control of HIV and hypertension among PLHIV enrolled in horizontal Integrated Care Models in Sub-Saharan Africa 2. To assess the attitude and care practices among healthcare providers regarding horizontal integrated care for PLHIV and hypertension in South-Central Uganda 3. To explore the barriers and enablers of providing horizontal integrated care among PLHIV and hypertension in South-central Uganda 4. To evaluate the association between horizonal Integrated care models and dual control outcomes of HIV and hypertension among PLHIV and hypertension in South-central Uganda
Uganda 2026-08-18 7:40:28 2029-08-18 Medical and Health Sciences Non-Clinical Trial Degree Award
Paul Masereka
ID: UNCST-2026-R025193
Reading Glasses for Adults - Uganda Endline Survey: Assessment of Implementation Quality and Recipient Experiences Across Two Distribution Models in Budaka and Mbale districts, Eastern Uganda.
REFNo: SS5434ES

To address the rationale above, this study is designed to answer three central research questions that guide the entire evaluation: a) What is the quality and consistency of presbyopia screening and glasses dispensation services delivered by Village Health Teams at the conclusion of the pilot period? b) What are the patterns of glasses usage, satisfaction levels, and perceived benefits among program recipients, and how do these outcomes vary between the two distribution models? c) What proportion of individuals requiring referral for complex eye conditions successfully access facility-based eye care, and what barriers prevent them from seeking care?
Uganda 2026-08-18 7:34:56 2029-08-18 Social Science and Humanities Non-Clinical Trial Non-degree Award
Bukenya Moses
ID: UNCST-2025-R019143
Developing a Model for Evaluating Learner's Experience of the Learning Management Systems in Higher Learning Institutions: A Case of Selected Universities in East Africa.
REFNo: SIR684ES

i. To explore key factors influencing learners’ experiences with LMSs in East African universities. ii. To develop a learners’ experience evaluation model for LMSs for East African Universities using the explored factors in (i) above iii. To validate the learners’ experience evaluation model of LMSs using input from lecturers as experts from the case study universities.
Uganda 2026-08-18 7:31:36 2029-08-18 Engineering and Technology Non-Clinical Trial Degree Award
Gloria  Muhoza Bebwa
ID: UNCST-2025-R021149
A Collaborative Framework for Improving Information sharing Among Cancer Care Groups
REFNo: SIR617ES

Main Objective To develop a collaborative framework for improving information sharing among care groups in cancer case management. Specific objectives To review existing literature to identify the strengths and weakness of current collaborative processes, frameworks, and systems used for information sharing in cancer case management To design and develop a collaborative framework for improving information sharing in cancer case management. To validate the developed collaborative framework for improving information sharing in cancer case management.
Uganda 2026-08-18 7:28:56 2029-08-18 Engineering and Technology Non-Clinical Trial Degree Award
Patrice Mawa Akusa
ID: UNCST-2024-R015843
Establishing Model Biobanks of Patient Leftover Samples from Routine Healthcare Provision in Kenya and Uganda: a pilot implementation in real-world environment (SAMPLE Study)
REFNo: HS7318ES

(1) To adapt, optimise and co-create effective implementation strategies for biobanking of leftover samples from routine care, using a federated model in Kenya and a centralized model in Uganda.
(2) To implement the optimized models of biobanking by selected healthcare facilities with the goal of enhancing quality sample collection, storage, and implementation of data systems to manage the biobanks, while creating stakeholder awareness and undertaking training of laboratory personnel and continuous monitoring of processes through evidence-based practices for a follow up period of 12 months.
(3) To determine whether the implementation strategies for the model biobanks influence implementation-level outcomes (e.g., acceptability, adoption, appropriateness, feasibility, fidelity, and sustainability).
(4) To determine whether the model biobanks are effective in achieving (i) sufficient sample quantities and ii) sample quality by type of sample.
(5) To estimate the cost and cost-effectiveness of operating the model biobanks for one year.
(6) To strengthen the capacity of researchers and promote the use of biobanks through pilot research projects based on the samples collected in the biobanks.

Uganda 2026-08-17 0:02:19 2029-08-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
WILSON ETOLU JOHN
ID: UNCST-2025-R023102
Teso Community Outreach for Awareness and Control of Hypertension and Diabetes (T-COACH)
REFNo: HS7713ES

1. To train and equip VHTs in the Teso sub region to conduct community-level health education and screening for elevated blood pressure and random blood sugar among adults
2. To implement a community-based screening and referral system using VHTs for timely identification of individuals with suspected or confirmed hypertension or diabetes and facilitate linkage to health facilities.
3. To support VHTs to monitor BP and blood glucose levels among patients diagnosed with hypertension or diabetes and facilitate medication refills in coordination with health facilities.
4. To evaluate the change in community screening rates, detection rates, knowledge and awareness level and control levels of hypertension and diabetes after 6 months of implementation through pre- and post-intervention surveys.
5. To document the feasibility, acceptability, and challenges of integrating hypertension and diabetes care into the VHT mandate to inform future scale-up and policy adoption.

Uganda 2026-08-14 19:31:10 2029-08-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Josephine Nabukenya
ID: UNCST-2026-R024846
NIAMR: Developing and Evaluating a National Interoperable Integrated Digital Data Capture and Sharing Platform for Enhanced Detection and Monitoring of Antimicrobial Resistance to Improve One Health AMR Surveillance and Management in Uganda
REFNo: HS7964ES

1. Assess existing AMR surveillance and data systems in Uganda. 2. Co-design and develop an integrated interoperable digital AMR surveillance platform. 3. Pilot and evaluate the platform across One Health sectors. 4. Strengthen AMR data sharing, analysis and use for decision-making. 5. Generate evidence to support national scale-up and sustainability of integrated AMR surveillance systems.
Uganda 2026-08-14 19:29:34 2029-08-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
View Sort By:

"A prosperous Science and Technology Led Ugandan Society."