Wilber Sabiiti
ID: UNCST-2024-R016293
|
Field clinical evaluation of the point of care diagnostic algorithm combining BBIOxford lateral flow device and Dragonfly molecular diagnostic device for improved Mpox diagnosis in Uganda
REFNo: HS8035ES
Overall Objective
To evaluate the diagnostic performance, operational feasibility, and cost implications of a decentralized two-step mpox point-of-care diagnostic algorithm combining the BBIOxford lateral flow antigen test with the Dragonfly molecular diagnostic platform among clinically suspected mpox patients in Uganda.
Specific Objectives
1. To validate the mpox community testing model at the study sites with key stakeholders.
2. To determine the diagnostic sensitivity, specificity, and predictive values of the BBIOxford rapid diagnostic test alone, the Dragonfly molecular platform alone, and the combined two-step diagnostic algorithm, using PCR as the reference standard.
3. To document and compare the implementation costs of the different diagnostic testing strategies at both per-test and national scale.
4. To identify circulating MPXV clades, detect recombinant strains, and map their prevalence and spatial distribution using PCR and genomic sequencing.
5. To quantify selected MPXV antigens and assess the relationship between antigen load and diagnostic test performance.
6. To assess the operational feasibility, usability, and acceptability of the Dragonfly molecular platform and the two-step diagnostic algorithm among healthcare workers and patients.
|
Uganda |
2026-07-17 19:22:15 |
2029-07-17 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Nazarius Tumwesigye Mbona
ID: UNCST-2019-R000664
|
KOFIH/OPM BUSOGA WASH PROJECT ON WATERBORNE DISEASE REDUCTION AND PREVENTION -AN ENDLINE SURVEY
REFNo: HS8079ES
3.1 General Objective
Assess changes in WASH indicators and waterborne disease outcomes following implementation of project interventions
3.2 Specific objectives
i. Measure project outcomes against baseline data and defined performance indicators;
ii. Evaluate the effectiveness of interventions in improving access to clean water, sanitation, and hygiene practices;
iii. Identify successes, challenges, and gaps in project implementation;
iv. Provide evidence-based recommendations for sustainability, replication, and scaling of interventions;
|
Uganda |
2026-07-17 17:12:16 |
2029-07-17 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Mohammed Hamid Osman Ali
ID: UNCST-2026-R024137
|
Harnessing Borassus Fruits as a Sustainable Source of Biofuels: A Techno-Economic Feasibility Study at Soroti University
REFNo: SIR726ES
Overall Objective
To evaluate and demonstrate the potential of Borassus tress as a sustainable source of renewable energy for Soroti University and its surrounding community by 2026.
Smart Specific Objectives
1. To analyze the chemical composition (sugar content, metals, calorific value and moisture) of Borassus fruits and sap, and quantify their potential yield for biofuels production.
2. To conduct bench scale, high precision sap to biofuel conversion through fractional distillation and refining.
3. To conduct a techno-economic feasibility assessment comparing Borassus-derived energy with current energy sources (national electricity grid, firewood and charcoal) used in Soroti University.
|
Sudan |
2026-07-17 17:09:06 |
2029-07-17 |
Engineering and Technology |
Non-Clinical Trial |
Non-degree Award |
|
Sam Ononge
ID: UNCST-2020-R000328
|
Evaluation of a self-monitoring tool to detect early obstetric complications in the immediate postpartum period: A validation study of the ImPoWa tool
REFNo: HS7770ES
Main Objective
1. To evaluate the validity of the ImPoWA tool in facilitate self-monitoring for early warning signs of an obstetric complication during the immediate postpartum period by women and their birth companions
Specific Objectives
1. To explore the accuracy of the mothers’ and companions’ assessments when using the tool
2. To ?Explore the reliability of mothers’ and companions’ assessments when using the tool in different clinical contexts and time periods
|
Uganda |
2026-07-17 17:05:51 |
2029-07-17 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Miriam Nakalembe
ID: UNCST-2021-R014040
|
A PHASE 3, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLINDED TRIAL TO EVALUATE THE SAFETY, TOLERABILITY, AND IMMUNOGENICITY OF A MULTIVALENT GROUP B STREPTOCOCCUS VACCINE IN HEALTHY PREGNANT WOMEN AND THEIR INFANTS (BEATRIX)
REFNo: HS8109ES
To describe GBS serotype-specific IgG concentrations measured from dried blood spots in a subset of infant participants at birth;
To describe anti-GBS antibodies present in breast milk in a subset of maternal participants vaccinated with GBS6
To describe serum IgG responses to active immunization with diphtheria toxoid�containing vaccine and PCV in infant participants born to maternal participants vaccinated with GBS6 versus placebo.
To describe PCV serotype-specific OPA titers after a toddler vaccination in infant participants born to maternal participants vaccinated with GBS6 or placebo.
To additionally describe the immune responses to CPS elicited by GBS6 when administered to healthy pregnant women.
To describe serum IgG responses to active immunization with diphtheria toxoid� containing vaccine and/or PCV in infant participants born to maternal participants vaccinated with GBS6 versus placebo.,To further describe the immunogenicity of GBS6 in maternal participants when administered to healthy pregnant women.
To describe anti-CPS IgG antibody levels predicted to provide protection from invasive GBS EOD and LOD, separately, caused by the 6 individual vaccine serotypes (Ia, Ib, II, III, IV, and V) in infants when GBS6 is administered to healthy pregnant women,To assess the ability of GBS6 to induce opsonophagocytic activity (OPA) titers at birth in infant participants born to maternal participants vaccinated with GBS6,To describe anti-CPS IgG antibody levels in infant participants born to maternal participants vaccinated with GBS6.
To describe anti-CPS IgG antibody levels predicted to provide protection from invasive GBS disease (all disease) caused by the 6 individual vaccine serotypes in infants when GBS6 is administered to healthy pregnant women,To evaluate the aggregate predicted VE combining all 6 serotypes in GBS6 to provide protection from invasive GBS EOD based on serotype-specific anti-CPS IgG concentrations measured in infants at birth,To evaluate the aggregate predicted VE combining all 6 serotypes in GBS6 to provide protection from invasive GBS LOD based on serotype-specific anti-CPS IgG concentrations measured in infants at birth.
To assess the ability of GBS6 to induce anti-CPS IgG antibody levels predicted to provide protection from invasive GBS early-onset disease (EOD) caused by the 6 individual vaccine serotypes (Ia, Ib, II III, IV, and V) in infants when GBS6 is administered to healthy pregnant women,To assess the ability of GBS6 to induce anti-CPS IgG antibody levels predicted to provide protection from invasive GBS late-onset disease (LOD) caused by the 6 individual vaccine serotypes (Ia, Ib, II III, IV, and V) in infants when GBS6 is administered to healthy pregnant women,To assess the safety of maternal immunization in infant participants born to pregnant women who were vaccinated with GBS6 during pregnancy. To describe the safety and tolerability of GBS6 in maternal participants
|
Uganda |
2026-07-17 17:00:50 |
2029-07-17 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Esther Nanfuka Kalule
ID:
|
EXPLORING ACCELERATING IMPACT FOR YOUNG WOMEN (AIM) PROGRAM COHORT # 2 AND # 3 LIVELIHOOD EXPERIENCES: A QUALITATIVE STUDY IN UGANDA
REFNo: SS5437ES
Main objective
This study seeks to explore the AIM financial inclusion journey for cohort #2 participants and progress thus far in the livelihoods pathway for those in cohort #3.
Specific objectives
1.To examine opportunities and challenges experienced by cohort #2 project participants and staff in transitioning participants to microfinance.
2.To identify opportunities and challenges experienced by cohort #3 project participants and staff during implementation of cost sharing and coaching elements of AIM 2.0.
3.To document cohort #2 and #3 participants’ perspectives on the impact of AIM on their lives.
|
Uganda |
2026-07-17 16:20:28 |
2029-07-17 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
|
Isaac Ssewanyana
ID: UNCST-2020-R014336
|
ConfiSign HCV Self-Test: Evaluation of Clinical Performance and Usability in the hands of untrained users.
REFNo: HS8059ES
The product design, instructions for use and usability of the ConfiSign HCV Self-Test for self-testing will be assessed by investigation of the following secondary objectives: - Clarity and usability of instructions and packaging � participant-reported ease of understanding and following instructions, collected via a structured questionnaire. - Occurrence of user errors � frequency and type of errors and/or deviations from the test procedure observed during the study - Invalid test results � proportion of tests yielding invalid results due to user errors.,The primary and overall objective of this study is to evaluate the performance and the usability of the ConfiSign HCV Self-Test in the hands of untrained users, recruited in a high prevalence HCV region (> 2%), who have no or limited experience in self-testing. ,
|
Uganda |
2026-07-17 16:17:16 |
2029-07-17 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Herbert Muyinda
ID: UNCST-2019-R000373
|
Digital Humanitarianism:
Governing Vulnerable Populations in an Age of Technological Innovation in Uganda
REFNo: SS5510ES
The general objective of this study is to provide an in-depth understanding of the role of digital innovations in (re)shaping the way humanitarian action is understood, conceived and practiced - how DTs are changing the face of Humanitarian Response in Uganda. The specific objectives are:
1. To analyze how DTs are tested on populations and how they influence conceptions of vulnerability and needs as well as solutions to address them
2. To examine how DTs are transforming humanitarian action among those displaced, the host communities, and the humanitarian workers tasked with safeguarding their rights of the refugees.
3. To identify the barriers in uptake and adaptation of DTs among refugees and the humanitarian workers
|
Uganda |
2026-07-17 16:11:54 |
2029-07-17 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
|
Isaac Ssewanyana
ID: UNCST-2020-R014336
|
Simplified Antenatal Integrated Testing,Partner inclusion and same day Hepatitis B prophylaxis to scale Prevention in Uganda
REFNo: HS8027ES
To determine the acceptability, feasibility, and patient-level costs of the chronic care model for HBV management at intervention sites. ,To determine the optimal linkage to chronic care pathways under the expanded WHO treatment criteria at intervention sites. ,To determine the acceptability, feasibility, and patient-level costs of family-based testing.,To ascertain the yield of family- and partner-based testing of index cases (number positive / number tested) at intervention sites. ,To evaluate the acceptability, feasibility, and patient-level costs of the test-and-prophylaxis approach for both patients and healthcare providers at the intervention sites.,To assess the effectiveness of the test-and-prophylaxis approach, measured through the PMTCT cascade (prophylaxis initiation, adherence, birth dose coverage, and infant HBV status at 9 months) at the intervention sites. ,To measure the change in uptake and completion rate of antiviral prophylaxis (AVP) among HBsAg-positive women in ANC in the intervention as compared to the comparison sites.,
|
Uganda |
2026-07-17 16:09:55 |
2029-07-17 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Benson Nasasira
ID: UNCST-2025-R023111
|
Evaluating the Impact of Integrating Tuberculosis Screening into Routine Community-Based Child Health Services on Childhood Tuberculosis treatment coverage in Kalangala District, Uganda � A quasi-experimental study
REFNo: HS8056ES
Primary Objective
To compare monthly childhood TB treatment coverage—defined as the proportion of National TB and Leprosy Program (NTLP) paediatric TB treatment targets achieved among children aged 0–14 years, before and after integration of TB screening into routine community-based child health outreach activities in Kalangala District.
Secondary Objectives
• To compare the monthly absolute number of presumptive paediatric TB cases identified before and after integration.
• To compare the monthly proportion of presumptive paediatric TB cases completing diagnostic evaluation before and after integration.
• To compare the monthly proportion of all TB cases that are children aged 0–14 years before and after integration.
• To assess the feasibility and acceptability of integrating TB screening into routine child health outreaches from the perspectives of health workers and Village Health Team (VHT) members.
|
Uganda |
2026-07-17 15:59:12 |
2029-07-17 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Laura LaBarge Rose
ID: UNCST-2025-R017293
|
Next-generation animal tracking for research and conservation the Mweya ATLAS project
REFNo: NS951ES
1. To obtain proof-of-principle for reverse-GPS tracking of wild mammals, using banded mongooses as a model system.
2. To test how group ranging behaviour is influenced by ecology and intergroup interactions.
3. To test the consequences of variation in group movement patterns for reproductive success and population dynamics.
4. To use ATLAS data to anticipate and record intergroup encounters and investigate the causes of intergroup aggression.
|
USA |
2026-07-17 15:44:11 |
2029-07-17 |
Natural Sciences |
Non-Clinical Trial |
Non-degree Award |
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Christine Wiltshire Sekaggya
ID: UNCST-2019-R000578
|
PRIVATE HEALTH PROVIDERS POINT OF CARE TESTING FOR TUBERCULOSIS IN SELECTED URBAN
PRIVATE FACILITIES IN UGANDA.
REFNo: HS7989ES
1. To evaluate whether use of near - point of care (NPOC) for tuberculosis
(TB) testing using the oral and sputum-based swabs is feasible and acceptable in private health provider settings in Wakiso and Kampala districts.
2. To determine the effect of use of NPOC testing on time to TB diagnosis and time to treatment initiation following TB screening and testing at private health facilities in Wakiso and Kampala districts.
|
Uganda |
2026-07-17 15:42:29 |
2029-07-17 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Abel Kakuru
ID: UNCST-2022-R009193
|
Perennial Malaria Chemoprevention With Dihydroartemisinin-Piperaquine Versus Sulfadoxine-Pyrimethamine Plus Amodiaquine Versus No Chemoprevention: A Double Blind Randomised Controlled Trial
REFNo: HS7437ES
1. To compare the protective efficacy of combining R21 vaccination with PMC-DP or PMC-SPAQ vs R21 alone up to 5 years of age.
2. To compare the safety and tolerability of combining R21 vaccination with PMC-DP vs. PMC-SPAQ.
3. To determine the impact of PMC on the drug resistance landscape and R21-specific immunogenicity and durability.
|
Uganda |
2026-07-16 20:29:47 |
2029-07-16 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Andrew Muhumuza
ID: UNCST-2022-R009010
|
CAN TOUCH HELP IDENTIFY PATIENTS WHO NEED AN IMMEDIATE FULL CLINICAL ASSESSMENT BY A PHYSICIAN?
REFNo: HS7768ES
To find out if touch can help identify patients who need an immediate full clinical assessment by a physician.,To compare the ability to predict 24-hour mortality by temperature and moisture subjectively assessed by touch in different parts of the body ,To compare the ability of temperature and moisture subjectively assessed by touch to predict 24-hour mortality with standard thermometry and the National Early Warning Score,
|
Uganda |
2026-07-16 20:26:26 |
2029-07-16 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
MOREEN ASASIRA
ID: UNCST-2026-R023307
|
Climate Resilient Tea Innovations In Uganda: A Case of Nature-Based Strategies in The Tea Value Chain
REFNo: A775ES
1.To evaluate farmer awareness, perceptions, and attitudes about the use of nature-based innovations in tea production
2.Establish the probability of use of nature-based innovations in tea production
3.To map the Uganda tea value chain
4.Establish perceived actor preference of the resilient tea varieties among tea chain actors
|
Ugandan |
2026-07-16 20:13:13 |
2029-07-16 |
Agricultural Sciences |
Non-Clinical Trial |
Degree Award |
|
Faizo Mugerwa
ID: UNCST-2025-R021837
|
EVALUATION OF THE FEASIBILITY AND ACCEPTABILITY OF AN EXHALED BREATH CONDENSATE SAMPLING DEVICE TO COLLECT A RESPIRATORY SAMPLE FOR LIPOARABINOMANNAN TESTING AMONG SUSPECTED TUBERCULOSIS PATIENTS AT MBARARA REGIONAL REFERRAL HOSPITAL (EXHALE STUDY)
REFNo: HS7963ES
To determine the sensitivity, specificity, of the Alere LAM test if used to test the sample collected by the EBC device among suspected tuberculosis patients.
To assess the feasibility and acceptability of the EBC sampling device by patients, and healthcare workers.
To determine the positive and negative predictive values of the Alere LAM test if used to test the sample collected by the EBC device among suspected tuberculosis patients.
|
Uganda |
2026-07-16 20:11:09 |
2029-07-16 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
|
Catriona Waitt John
ID: UNCST-2019-R001068
|
PHASE IV HUMAN LACTATION STUDY TO DESCRIBE THE
PHARMACOKINETICS OF SEMAGLUTIDE IN LACTATING
MOTHER-INFANT PAIRS IN UGANDA
REFNo: HS7927ES
Primary Objective
To define the transfer of semaglutide from mother to
breastfed infant during the postpartum period.
Secondary Objectives
? To determine the effect of maternal semaglutide on
breastmilk composition
? To determine the effect of maternal semaglutide on
breastmilk volume and breastfeeding practice
(frequency, duration)
? To determine the effect of maternal semaglutide on
infant growth
? To determine the effect of maternal semaglutide on
maternal HbA1c
? To measure the effect of maternal semaglutide on
body composition (BMI, lipid profile, hip/waist
circ)
? To evaluate participant perceptions of semaglutide
use and the paradigm of postpartum initiation of
medication
? To calibrate semaglutide PBPK model to predict
untested clinical scenarios (infant oral bioavailability,
maternal dose, dose ranges, milk
characteristics/composition)
|
UK |
2026-07-16 20:06:07 |
2029-07-16 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Bridgious Walusimbi
ID: UNCST-2026-R026054
|
Genetic causes and epigenetic consequences of infection in childhood (GECo)
REFNo: HS8006ES
The project will use human genetic tools to understand why some children are at increased risk of infection and how childhood infection shapes immune cell function and long-term health. To deliver this, the project has 3 linked work packages:
1. Work Package 1: Genome-wide association studies of common infection in Ugandan children, addressing:
� What are the human genetic drivers of common childhood infections in Ugandan children?
2. Work Package 2: eQTL and epigenetic studies in immune cells across variable burdens of childhood infection, addressing:
� Whether the epigenetic and transcriptional landscape of monocytes is shaped by childhood infection.
3. Work Package 3: Define clonal haematopoeisis (CH) in genomic data from Ugandan adults, addressing:
� What is the frequency of CH in Ugandan adults?
� Is risk of CH influenced by lifetime infection burden?
|
Uganda |
2026-07-16 20:04:22 |
2029-07-16 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Annet Kahunde
ID: UNCST-2025-R021768
|
Subject Inversion Constructions in Rutooro: A Morphosyntactic, Semantic and Information Structural Account
REFNo: SS5204ES
i. To describe the agreement patterns in Rutooro SICs.
ii. To examine the thematic restrictions on arguments and predicates in Rutooro SICs.
iii. To analyse the role of information structure in Rutooro SICs.
|
Uganda |
2026-07-16 20:01:01 |
2029-07-16 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
|
Grace Nalukwago Kakoola
ID: UNCST-2025-R022885
|
IMPLEMENTATION OF THE NON-MOTORIZED TRANSPORT PILOT CORRIDOR AND ITS EFFECTS ON ACTIVE MOBILITY IN KAMPALA UGANDA.
REFNo: HS7552ES
I. To explore the acceptability, inclusivity, and perceived barriers influencing the intended use of Kampala’s NMT pilot corridor.
II. To examine the effect of the NMT pilot corridor on overall walking and cycling experiences in comparison to a motorized road.
III. To compare walking-related physical activity levels between adults working along the NMT pilot corridor and those working along a motorized road in Kampala.
IV. To examine the implementation of the NMT pilot corridor by examining the strategies adopted, and their outcomes over time during the post-construction phase (2021-2026).
|
Uganda |
2026-07-16 19:58:26 |
2029-07-16 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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