Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Ssenoga Badru
ID: UNCST-2026-R026364
Development of Gritap AI, an Explainable Machine Learning Clinical Decision Support Tool for Predicting Viral Rebound and Virologic Failure in HIV-Positive Patients on Antiretroviral Therapy in Uganda: A Two-Phase Mixed-Methods Translational Health Informatics Study.
REFNo: SIR771ES

(1) To build, train, test and validate the ML model, using collected de-identified patient data. (2) To assess the explainability of the best-performing ML model, translating model internal feature attributions into clinician-readable explanations, using explainable AI techniques. (3) To assess the ML model`s usability, acceptability, and clinical-workflow fit of the tool among ART clinicians at a pilot site, using a usability and feedback questionnaire.
Uganda 2026-08-27 19:47:43 2029-08-27 Engineering and Technology Non-Clinical Trial Non-degree Award
Molly Nantongo
ID: UNCST-2026-R025337
Exploring the Role of Intimate Partner Violence (IPV) Shelters in Supporting Women’s Mental Health in Uganda. Phenomenological Qualitative.
REFNo: SS5804ES

To explore how women survivors of intimate partner violence living in IPV shelters in Uganda interpret and describe their experiences of the shelter environment and how these experiences influence their mental health and emotional well-being. To examine women survivors’ perceptions of the factors within the shelter environment that facilitate or hinder their mental health and emotional well-being. To explore key informants’ perceptions of the effectiveness of shelter-based services in supporting the mental health and emotional well-being of women survivors of IPV, and the factors that facilitate or hinder service provision.
Uganda 2026-08-27 19:43:42 2029-08-27 Social Science and Humanities Non-Clinical Trial Degree Award
Godfrey  Siu
ID: UNCST-2021-R005439
Unpacking Constraints and Enablers of Disability Inclusion in Universal Parenting Interventions to Address Violence Against Children in Uganda (DIUPI)
REFNo: HS7344ES

Objectives
Overall goal
The research aims to generate an empirically grounded framework for mainstreaming disability inclusion in universal parenting programmes and produce actionable recommendations for implementation actors, by addressing the research question: What systemic factors hinder or enable disability inclusion within Uganda’s universal parenting programmes?
Objectives
1- In planning phase, how are disability-inclusive adaptations planned, and what shapes these decisions?
2- In implementation phase, how are inclusive practices operationalised during delivery?
3- What barriers and enablers influence participation and outcomes?
4- What are the barriers and enablers that affect equitable reach and safe participation of caregivers of children with disabilities across difficulties in parenting programmes?

Uganda 2026-08-27 19:41:24 2029-08-27 Medical and Health Sciences Non-Clinical Trial Degree Award
Pontiano Kaleebu
ID: UNCST-2021-R013577
Usability Study for the Label Comprehension and Results Interpretation Study of Biolineâ„¢ Malaria Ag P.f/P.v Antigen Rapid Test & Results Interpretation Study of NxTekâ„¢ Malaria Pf Antigen Rapid Test
REFNo: HS8392ES

Primary Objectives
To assess whether intended users can locate, understand, and correctly apply critical
IFU and labelling information
• To assess whether intended users can accurately interpret test results (positive,
negative, invalid, faint/weak positive

Secondary Objective
• To evaluate effectiveness of IFU and labelling as risk control measures for identified
critical tasks
Uganda 2026-08-27 19:38:11 2029-08-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
ExperitoMuyanja Kabuga Muyanja
ID: UNCST-2025-R023148
INTEGRATING INDIGENOUS AND SCIENTIFIC KNOWLEDGE FOR PARTICIPATORY DEVELOPMENT AND EVALUATION OF CONTEXT-SPECIFIC SOIL FERTILITY MANAGEMENT INNOVATIONS IN SMALLHOLDER TOMATO PRODUCTION SYSTEMS IN YUMBE DISTRICT-UGANDA
REFNo: A808ES

1. To characterize farmers’ soil fertility diagnostic framework and determine how it influences their management decision-making amid socioeconomic contextual factors. 2. To analyze farmers’ perceptions of soil fertility technology attributes, including relative advantage, compatibility, complexity, trialability, and observability, and determine how these attributes influence decision-making. 3. To evaluate and compare the technical performance of soil fertility management strategies co-created through integrated diagnostic approaches with those developed using conventional scientific methods. 4. To assess the level of agreement between farmer-based evaluations and scientific measurements of co-created soil fertility management strategies across soil fertility gradients.
Uganda 2026-08-27 19:29:26 2029-08-27 Agricultural Sciences Non-Clinical Trial Degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
CLINICAL PERFORMANCE EVALUATION OF ALINITY m HIV-1 QUALITATIVE ASSAY FOR DBS EID
REFNo: HS8134ES

- To describe and assess the operational characteristics and ease of use of the Alinity m HIV-1 Qualitative assay for DBS EID and its suitability for use in countries with limited infrastructure.,- To evaluate the sensitivity and specificity of Alinity m HIV-1 Qualitative assay for DBS EID assay in comparison with Cobas HIV-1/HIV-2 Qualitative Nucleic Acid Test for use on 5800/6800/8800 Systems as a reference assay on remnant DBS specimens.,The overall objective of this performance evaluation is to assess the clinical performance of the Alinity m HIV-1 Qualitative assay for DBS EID. ,
Uganda 2026-08-27 19:27:29 2029-08-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
SUSAN NAMARA
ID: UNCST-2025-R022916
CHILDCARE AND INFORMAL WORKERS’ PRODUCTIVE WORK: EXPERIENCES OF MOBILE MARKET VENDING MOTHERS IN UGANDA
REFNo: SS5676ES

1. To understand what characterises mobile market vending mothers as a category of informal workers in Kampala.
2. To explore how the mobile market vending mothers in Kampala manage childcare while at work.
3. To examine the reasons behind the way mobile market vending mothers of Kampala manage childcare at work as they do.

Uganda 2026-08-27 19:19:24 2029-08-27 Social Science and Humanities Non-Clinical Trial Degree Award
Nazarius Tumwesigye Mbona
ID: UNCST-2019-R000664
Community-Based Screening, Brief Intervention and Referral for Treatment for Alcohol Use in Rural Gulu District, Northern Uganda (CoSBIRT Study)
REFNo: HS8385ES

The Community-Based Screening, Brief Intervention and Referral for Treatment (CoSBIRT) study aims to assess the feasibility, acceptability, and preliminary effectiveness of a community-based Screening, Brief Intervention and Referral for Treatment model for alcohol use in rural communities in Gulu District, Northern Uganda,
Uganda 2026-08-27 19:13:21 2029-08-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
CharlesDenis Jjuuko
ID: UNCST-2026-R027227
Impact of Mmwanyi Terimba Economic Empowerment Program on Productivity and Welfare of Coffee Farmers in Buganda Region
REFNo: SS5762ES

1. To assess the effect of the level of exposure to Emmwanyi Terimba agronomic extension interventions on coffee productivity among smallholder farmers.
2. To determine the impact of exposure to Emmwanyi Terimba agronomic extension interventions on household income from coffee and other sources.
3. To evaluate the effect of exposure to Emmwanyi Terimba agronomic extension interventions on household food security and poverty status.
4. To examine the effect of exposure to Emmwanyi Terimba agronomic extension interventions on farm diversification, including integration of coffee with crops and livestock.

Uganda 2026-08-27 19:07:14 2029-08-27 Social Science and Humanities Non-Clinical Trial Non-degree Award
Timothy Kintu Mwanje
ID: UNCST-2021-R013684
A Mixed-Methods Needs Assessment to Optimize High-Performance Computing (HPC) Utilization for HIV and Infectious Diseases Research in Uganda
REFNo: HS8300ES

To explore the perceived barriers, facilitators, and opportunities for adoption and sustained use of the HPC cluster among HIV researchers in Uganda.,To determine the current research domains, computational skill levels, self-perceived competencies, and preferred learning modalities of researchers in Uganda.,To describe current and anticipated computational, algorithmic, storage, and software requirements for the analysis of HIV-related data among researchers in Uganda., To explore and characterize the computational, software, training, and operational needs of HIV researchers in Uganda.,
Uganda 2026-08-27 19:04:50 2029-08-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Cyril Kansiime
ID: UNCST-2026-R023995
Experiences of emerging adults regarding School Related Stress and Psychological Wellbeing at Uganda Institute of Allied Health and Management Sciences-Mulago.
REFNo: SS5763ES

1. To assess the experiences of emerging adults regarding school-related stress at UIAHMS-Mulago.
2. To assess the challenges of emerging adults regarding school related stress at UIAHMS-Mulago.
3. To explore the copying strategies of emerging adults regarding school related stress at UIAHMS-Mulago

Uganda 2026-08-27 19:03:03 2029-08-27 Social Science and Humanities Non-Clinical Trial Degree Award
ALEX ARIO RIOLEXUS
ID: UNCST-2024-R002455
Implementation of an Integrated Digital Health System for Infectious Diseases in Maternal and Child Health in East Africa
REFNo: HS7774ES

ensure impact through effective dissemination, exploitation and communication actions (WP7). Measurable Criteria: Implementation of the dissemination, exploitation and communication strategy.,To ensure effective Project Coordination and Scientific Project Leadership, in the consortium cooperation, development of the consortium agreement and other legal agreements among the beneficiaries, development of agreements with the Ministry of Health in each country, communication with the EDCTP3 JU regarding all project management and scientific governance issues, and project monitoring. (WP6, WP8) Measurable Criteria: Consortium agreement, Memorandum of Understanding (MOU) with each Ministry of Health, excellence in research and innovation, and high quality and timely reports submitted to EDCTP3.,To implement a comprehensive capacity building program in the form of training for users in each setting; research and leadership training programmes for individual researchers, including early and mid-career researchers; and capacity building to strengthen the institutions to run the system and utilise data for quality improvement. (WP2, WP4, WP5)Measurable Criteria: Training materials and events, training evaluations, career development plans and career- development workshops.,To demonstrate the scientific value of population-based real-life routinely collected longitudinal individual-level data from eRegistries, harmonised across countries, through multi-country research advancing the state-of-the-art methods and understanding of the epidemiology of infectious diseases in maternity and perinatal life in the partner countries. (WP4) Measurable Criteria: Scientific reports of comparative multi-country epidemiology of poverty-related diseases in support of informed health policies, and multi-country RCT of DHI functionalities to inform regional digital health strategies.,To evaluate the implementation of the eRegistries system including usability and accessibility, economic cost for users, sustainability in terms of ability of the Ministry of Health to run, maintain and support the system, and equity using the RE-AIM framework (Reach, Effectiveness, Adoption, Implementation and Maintenance). (WP3) Measurable Criteria: Country-specific and comprehensive evaluation report of the LINDA-FAMILIA eRegistries system.,To scale up eRegistries in primary maternal healthcare settings in Ethiopia and Rwanda, integrate with the existing digital systems at the hospital level, and fully implement the integrated system in primary maternal care settings and hospital maternity units in Tanzania and Uganda. (WP2) Measurable Criteria: eRegistries operating in the four selected regions; local authorities running the system independently.,To co-design and adapt the eRegistries in Ethiopia, Rwanda, Tanzania and Uganda with the involvement of end users, health services and Ministries of Health to tackle context-specific needs and prepare it for scale-up in the healthcare facilities that provide maternal, postnatal and newborn healthcare and child vaccinations. (WP2) Measurable Criteria: Adapted eRegistry, context specific and ready for scale up.,To understand the current state and progress of maternal and child health information systems in Ethiopia, Rwanda, Tanzania and Uganda, map the local context, current healthcare pathways and digital readiness in each targeted region, and reviewing the current data dictionaries used in maternal healthcare settings and facilitating harmonization within and across the four countries including established infectious disease core outcome sets. (WP1) Measurable Criteria: Landscape review report of the healthcare system levels and services, current data questionnaires, available data on infectious disease in pregnancy, harmonized data dictionaries and digital readiness.,To scale up an innovative, interoperable and adaptable open-source digital health information management system, within the DHIS2 platform replacing paper-based systems in the RMNCH units in the following four regions in East Africa: Addis Ababa Region, Ethiopia; Eastern Province, Rwanda; Kilimanjaro Region, Tanzania; and Lango and North Buganda sub-Region, Uganda.,
Uganda 2026-08-27 19:00:26 2029-08-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
EFRANCE KITOLWA AKANDWANAHO
ID: UNCST-2026-R026617
DIGITAL ORGANISATIONAL CULTURE AND HEALTH SERVICE QUALITY IN PRIVATE HOSPITALS IN UGANDA: A CASE OF MENGO HOSPITAL
REFNo: SS5850ES

General Objective To evaluate the influence of Digital Organisational Culture on Health Service Quality in private sector healthcare organizations in Uganda, using Mengo Hospital as a case study. Specific Objectives To achieve the above purpose, the study investigated the following specific objectives: i. To establish the influence of Technological Adaptability on Health Service Quality at Mengo Hospital, Uganda. ii. To assess the effect of Innovation Orientation on Health Service Quality at Mengo Hospital, Uganda. iii. To determine the contribution of Digital Collaboration to Health Service Quality at Mengo Hospital, Uganda. iv. To examine the moderating influence of Health Information Management on the relationship between Digital Organisational Culture and Health Service Quality at Mengo Hospital, Uganda.
Uganda 2026-08-25 19:23:16 2029-08-25 Social Science and Humanities Non-Clinical Trial Degree Award
Rogers Kajabwangu
ID: UNCST-2022-R010077
Feasibility, acceptability and preliminary diagnostic performance of the OncoE6 Cervical Test for community-based cervical cancer screening in rural Southwestern Uganda
REFNo: HS8502ES

To evaluate the feasibility of using the OncoE6 Cervical Test in community-based cervical cancer screening. To determine the acceptability of OncoE6 testing among women and health workers participating in community screening outreaches. To assess the preliminary diagnostic performance of the OncoE6 Cervical Test compared with HPV DNA testing and visual inspection with acetic acid (VIA)
Uganda 2026-08-25 19:21:29 2029-08-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
BALUKU WATSEMA
ID: UNCST-2026-R024686
Finanacial literacy financial self-efficacy and financial inclusion among households in rwenzori sub region, Uganda
REFNo: SS5772ES

i. To establish the relationship between financial literacy and financial inclusion among households in Rwenzori Sub-Region.
ii. To establish the relationship between Financial Literacy and Financial Self-Efficacy among households in Rwenzori Sub-Region.
iii. The find out the relationship between Financial Self-Efficacy and Financial Inclusion among households in Rwenzori Sub-Region.
iv. To ascertain the relationship between Socio-Cultural Factors and Financial Inclusion among households in Rwenzori Sub-Region.
v. To establish the moderating effect of Socio-Cultural Factors on the relationship between Financial Self- Efficacy and Financial Inclusion among households in Rwenzori Sub-Region.
vi. To ascertain the mediating effect of Financial Self-Efficacy in the relationship between Financial Literacy and Financial Inclusion among households in Rwenzori Sub-Region.

2026-08-25 19:20:03 2029-08-25 Social Science and Humanities Non-Clinical Trial Degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
Clinical Performance Evaluation of Alinity m HIV-1 Assay Using Dried Plasma Spot Specimens
REFNo: HS8450ES

� To describe the operational characteristics and ease of use of the Alinity m HIV-1 assay using dried plasma spot specimens and its suitability for use in countries with limited infrastructure,� To assess the Alinity m HIV-1 dried plasma spot assay�s agreement with a cobas HIV-1 quantitative nucleic acid test for use on the cobas 6800/8800 Systems (Roche Diagnostics GmbH) on clinical specimens, including: o Quantitative assessment of bias, limits of agreement and correlation o Misclassification above or below the clinical threshold (1000 copies/mL),
Uganda 2026-08-25 19:18:31 2029-08-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Francis Mutebi
ID: UNCST-2023-R007422
TUNGIASIS CONTROL USING A ONE HEALTH APPROACH IN NAPAK DISTRICT AND BUGIRI DISTRICTS, UGANDA
REFNo: HS8362ES

3. To asess the knowledge, attitudes and practices of focal pupils, teachers, and household caretakers regarding tungiasis to guide health education initiatives in the target area, 2. To reduce the average intensity of tungiasis infection to zero in school age children, 1. To lower the prevalence of tungiasis in school-age children to less than one percent in the dry season,To eliminate tungiasis as a public health hazard in highly endemic areas of Napak and Bugiri Districts,
Uganda 2026-08-25 19:16:30 2029-08-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
MEDARD NABAASA
ID: UNCST-2026-R023498
Collaborative Dynamics, Graduate Mindset and Employability of Technical Vocational Education Training (TVET) Graduates in Uganda�s Buganda Region
REFNo: SS5626ES

Main Objective To examine the relationships among collaborative dynamics, graduate mindset, and employability of TVET graduates in Uganda’s Buganda Region and to explore stakeholder perceptions of these constructs. 1.To examine the relationship between collaborative dynamics and employability. 2. To examine the relationship between collaborative dynamics and graduate mindset. 3. To examine the relationship between graduate mindset and employability. 4. To test the mediating role of graduate mindset in the relationship between collaborative dynamics and employability 5. To explore the perceptions of TVET tutors and government officials regarding collaborative dynamics and graduate mindset.
Uganda 2026-08-25 19:14:11 2029-08-25 Social Science and Humanities Non-Clinical Trial Degree Award
ANGEL NANSUBUGA LISA
ID: UNCST-2026-R026770
UNDERSTANDING KNOWLEDGE OF SICKLE CELL DISEASE PRESENTATION, MANAGEMENT AND MYTHS AMONG SCD PATIENTS AT MULAGO NATIONAL REFERRAL HOSPITAL, UGANDA
REFNo: HS8403ES

1. To explore myths and misconceptions related to SCD among patients with SCD in Mulago national referral hospital, Uganda, 2. To assess knowledge of sickle cell disease presentation and management among patients with SCD in Mulago national referral hospital, Uganda,To understand the knowledge of Sickle Cell Disease (SCD) presentation, management and myths among SCD patients at Mulago National Referral Hospital, Uganda.,
Uganda 2026-08-25 19:12:10 2029-08-25 Medical and Health Sciences Non-Clinical Trial Degree Award
Pauline Amuge Mary
ID: UNCST-2023-R005532
HIV treatment outcomes and predictors of virological failure among HIV infected children aged <18years starting second-line and third-line ART in Africa, Europe and Thailand
REFNo: HS8519ES

The study has four main objectives
To evaluate medium-term virologic, immunologic and safety outcomes among HIV-infected children starting dolutegravir (DTG)-based second-line ART compared with boosted protease inhibitor (bPI)-based ART at 96 and 144 weeks.
To identify predictors and incidence of virologic failure among HIV-infected children on DTG-based versus bPI-based second-line ART
To determine the effectiveness of third-line ART regimens and describe immunological response, clinical outcomes and survival among HIV-infected children switched to third-line ART in Uganda.
To explore the lived experiences and support needs of children/adolescents on second- and third-line ART, their caregivers, and healthcare providers.

Uganda 2026-08-25 19:07:34 2029-08-25 Medical and Health Sciences Non-Clinical Trial Degree Award
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