Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Annet Sumba
ID: UNCST-2026-R023884
A City as a Peace Project
REFNo: SS5095ES

1. To examine how cityness is lived and expressed by different actors in a post-conflict city context; 2.To investigate how informal and marginal actors contribute to the remaking of urban space and social relations; and 3. To analyse how public spaces and infrastructures function as affective and symbolic sites of peace-building.
Uganda 2026-04-24 14:34:33 2029-04-24 Social Science and Humanities Non-Clinical Trial Degree Award
Allen Kabagenyi
ID: UNCST-2019-R000665
A Gendered Analysis of Preparedness and Response to Natural Disasters in Kasese District
REFNo: SS4854ES

To examine household-level flood and landslide response strategies in Kasese District, with a focus on the extent of response mechanisms, the socio-economic and cultural factors influencing their effectiveness, and gender-based differences in disaster response approaches.
Uganda 2026-04-24 14:28:53 2029-04-24 Social Science and Humanities Non-Clinical Trial Non-degree Award
Francis Ssali
ID: UNCST-2021-R012134
A5424 Menopausal Hormone Therapy for Women Living with HIV (HoT)
REFNo: HS7391ES


1.2 Primary Objective

1.2.1 Determine the effects of HT on VMS in WLWH in the late menopausal transition or early postmenopause.

1.3 Secondary Objectives

1.3.1 Evaluate the safety and tolerability of HT as compared to placebo.

1.3.2 Determine the effect of HT on neurocognition.

1.3.3 Determine the effect of HT on mood.

1.3.4 Determine the effect of HT on sleep.

1.3.5 Determine the effect of HT on quality of life.

1.3.6 Determine the effect of HT on sexual function.

1.3.7 Determine the effect of HT on weight, waist circumference, and waist-to-hip ratio.

1.4 Exploratory Objectives

1.4.1 Determine the effect of HT on markers of bone turnover.

1.4.2 Determine the effect of HT on markers of cardiometabolic health.

1.4.3 Determine the effect of HT on systemic markers of inflammation and immune activation.

1.4.4 Determine the effect of HT on HIV reservoir size, clonality, and activity.

1.4.5 Determine the effect of HT on measures of physical function.

1.4.6 Determine the effect of HT on the rectal and vaginal microbiome.

1.4.7 Explore the effect of HT on all primary and secondary outcomes by antiretroviral regimen.

1.4.8 Explore exposure-response relationships between estradiol pharmacokinetics (PK) and study outcomes in those treated with estradiol.

1.4.9 Evaluate acceptability and feasibility of ambulatory monitors for VMS and sleep on a subset of participants.

1.4.10 Explore agreement between subjective VMS frequency with objective VMS frequency in a subset of participants.


Uganda 2026-04-24 13:20:15 2029-04-24 Medical and Health Sciences Clinical Trial Non-degree Award
Peter Olupot Simon
ID: UNCST-2025-R022744
Implementation of Sustainable Public Procurement in the Procurement of Works in Uganda’s Central Government Entities
REFNo: SS5085ES

i. To examine the relationship between external pressures and implementation of SPP.
ii. To examine the relationship between resource heterogeneity and implementation of SPP.
iii. To examine the relationship between stakeholder engagement and implementation of SPP.
iv. To examine the mediating role of resource heterogeneity in the relationship between external pressures and implementation of SPP.
v. To examine the mediating role of resource heterogeneity in the relationship between stakeholder engagement and implementation of SPP.
vi. To examine the moderating effect of procurement officers’ attitude in the relationship between resource heterogeneity and implementation of SPP.
vii. To examine how procurement officers’ attitude will moderate the relationship between external pressures and implementation of SPP through resource heterogeneity.
viii. To examine how procurement officers’ attitude moderates the relationship between stakeholder engagement and implementation of SPP through resource heterogeneity.

Uganda 2026-04-20 9:42:42 2029-04-20 Social Science and Humanities Non-Clinical Trial Degree Award
Robert Mboizi Baldwin
ID: UNCST-2020-R014356
Optimising Eligibility Criteria for Participant Selection in Maternal Vaccine Trials in Low-Resource Settings (ACCESS).
REFNo: HS7404ES

1. To conduct a systematic review and analyse existing eligibility criteria used in maternal vaccine trials globally, with a focus on their applicability and limitations in low-resource settings.

2. Determine the proportion of women ineligible to participate in maternal vaccine clinical trials at Kawempe National Referral Hospital using an eligibility assessment tool.

3. Determine the pregnancy outcomes in women ineligible for maternal vaccine trials at Kawempe National Referral Hospital using an eligibility assessment tool.

4. Identify factors associated with pregnancy outcomes among pregnant women excluded from trial participation.

Uganda 2026-04-20 16:50:32 2029-04-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Yudaya Nakyeyune
ID: UNCST-2026-R024597
Using Play in Culturally Responsive Ways to Enhance Children’s Numeracy Skills Achievement in Refugee-Hosting ECD Centers in Kampala
REFNo: SS5116ES

1. To analyze children's voices of learning through play in refugee hosting ECD centers in Kampala.
2. To identify the challenges teachers encounter when using play in the teaching of numeracy in refugee hosting ECD centers in Kampala
3 To establish the impact of engagement in Continuing Professional Development (CPD) on teachers' knowledge regarding the use of play-based methods in culturally responsive ways in refugee hosting ECD centers in Kampala
4. To assess the impact of engagement in culturally responsive learning through play activities on children's numeracy achievement in refugee hosting ECD venters in Kampala
Uganda 2026-04-20 16:47:28 2029-04-20 Social Science and Humanities Clinical Trial Degree Award
PIUS OKELLO ROBERT
ID: UNCST-2026-R024675
School Management Functions and Academic Performance of Students in Government-Aided Secondary Schools A Case of Dokolo District, Uganda
REFNo: SS5162ES

Purpose of Study
To investigate the contribution of School Management Functions and its relationship with academic Performance of Students in Government-aided Secondary Schools in Dokolo District.


Specific Objectives
1. To evaluate the effect of management planning function on academic performance of students in Government-aided Secondary Schools in Dokolo District.

2. To analyze the effect of management organizing function on academic
performance students in Government-aided Secondary Schools in Dokolo District.

3. To assess the role of management controlling function on academic performance of students in Government-aided Secondary Schools in Dokolo District.

4. To investigate the mediating effects of perceived on relationship between school management functions and academic performance of students in government-aided Secondary Schools in Dokolo District.
Uganda 2026-04-20 16:25:31 2029-04-20 Social Science and Humanities Non-Clinical Trial Degree Award
Clifton IRAHUKA
ID: UNCST-2025-R018482
Evaluating the Feasibility and Acceptability of an Offline-First AI Health Companion for Frontline Health Workers in Uganda: A Mixed-Methods Concurrent Triangulation Study
REFNo: HS7408ES

General objective To evaluate the feasibility and acceptability of an offline-first AI Health Companion for clinical decision-making among Frontline Health Workers in health facilities in Luweero District, Uganda. Specific objectives To assess the feasibility of the offline-first AI Health Companion application among FHWs in public health facilities in Luweero district. To evaluate the acceptability of the offline-first AI Health Companion among FHW in public health facilities in Luweero district. To determine the individual, technological and organisational factors that influence the adoption and sustained use of AI clinical decision support tools among FHWs in public health facilities in Luweero district. To explore the facilitators of and barriers to scaling offline AI decision support tools among FHWs in Luweero district
Uganda 2026-04-20 16:19:00 2029-04-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Madrine Nabukenya Mkisa
ID: UNCST-2026-R024084
Psychological Resilience among Teachers in Private Secondary Schools in Wakiso District, Uganda.
REFNo: SS5118ES

i) To document factors that influence the psychological resilience of teachers in private secondary schools in Wakiso district ii) To explore the perception of teachers on self-efficacy, affective flexibility, and spiritual well-being in private secondary schools in Wakiso district. iii) To assess the influence of self-efficacy, flexibility, and spiritual well-being on teachers’ ability to adapt to employment terms (remuneration, job security, career growth, workload management, resource management) in a private secondary school in Wakiso district. iv) Examine the relationships that may exist between self-efficacy, flexibility, spiritual well-being, and psychological resilience among teachers in private secondary schools in Wakiso district.
Uganda 2026-04-20 16:16:00 2029-04-20 Social Science and Humanities Non-Clinical Trial Degree Award
David Mafigiri Kaawa
ID: UNCST-2019-R001276
Testing on the frontline: empowering health engagement through ‘rational use’ of diagnostics for infectious and non-communicable disease (TIYENI Dx)
REFNo: SS5125ES

1. To define ‘rational use’ from the perspective of users, families, communities and frontline health workers and document social and structural drivers of self-testing for self-care under specific external conditions of stigma, emergency disease outbreaks and lifestyle and risk management for chronic disease across mainstream and marginalised groups.

2. To unpack the dynamic between empowerment through self-testing and engagement with public and private health services including the role of frontline health providers influencing self-testing in different contexts and potential for linkage to health and data systems.

3. To explore discourses of uncertainty, trust and risk influencing individual, family, community and frontline health worker decisions, embedded within complex socio-ecological environments and the impact of these on intended and unintended, beneficial and potentially harmful health and social consequences of self-testing.

4. To co-production of toolkits for ‘rational use’ of frontline diagnostics including community review of the UNICEF ‘Lets Test Toolkit’ and co-adaptation of self-testing generic and self-testing specific implementation guidelines and instructions for use.

5. To promote health equity across mainstream and marginalised groups in access to and ‘rational use’ of self-testing and monitoring that appropriately reflects future direct to consumer markets through a) informing country level strategies on frontline diagnostics as part of national health plans and b) developing a theoretical framework for people-centred ‘rational use’.

Uganda 2026-04-20 16:06:19 2029-04-20 Social Science and Humanities Non-Clinical Trial Non-degree Award
John Mary Kanyamurwa
ID: UNCST-2025-R019398
Climate Change Threats to Livelihood Resilience and Adaptive Governance in Uganda's Bulambuli District
REFNo: SS5070ES

Major Objective To critically examine the impacts of climate change on livelihood resilience and adaptive governance in Uganda’s Bulambuli District, focusing on identifying targeted strategies to enhance rural communities' adaptive capacity and resilience to climate-induced shocks. Specific Objectives 1. To analyze the impacts of climate change on rural farm livelihoods and socio-economic stability in Bulambuli District. 2. To investigate the mechanisms by which governance system interventions address climate change challenges and enhance livelihood resilience. 3. To evaluate local communities' coping mechanisms in response to climate-induced challenges in Bulambuli District. 4. To identify gaps in governance mechanisms that hinder effective adaptation of rural communities' resilience to climate change impacts in the district.
Uganda 2026-04-20 16:02:15 2029-04-20 Social Science and Humanities Non-Clinical Trial Non-degree Award
ROGERS NAMWIYIRI
ID: UNCST-2025-R018056
Lived Experiences of Out-of-School Adolescents in Kampala: A Qualitative Exploration of Drivers of Risky Sexual Behaviours, and Mitigation Counselling Strategies
REFNo: SS5119ES

1.To identify the lived experiences of out-of-school adolescents in relation to risky sexual behaviours
2.To describe the underlying drivers of risky sexual behaviours among out-of-school adolescents

3.To identify mitigation strategies for reducing risky sexual behaviours among out-of-school adolescents in Kampala
4.To analyse the effectiveness of counselling strategies tailored to reducing risky sexual behaviours among out-of-school adolescents.

Uganda 2026-04-20 15:57:51 2029-04-20 Social Science and Humanities Non-Clinical Trial Degree Award
Daphine Asiimwe
ID: UNCST-2025-R021246
MANAGEMENT INFORMATION SYSTEMS AND PERFORMANCE OF TOURISM INDUSTRY IN KAMPALA, UGANDA
REFNo: SS5120ES

Purpose
The purpose of this study is to examine the effect of management information systems on performance of the tourism industry in Kampala, Uganda.

Objectives
This study will be based on the following objectives;
1. To examine the effect of information management on performance of the tourism industry in Kampala, Uganda.
2. To examine the effect of customer relationship management on performance of the tourism industry in Kampala, Uganda.
3. To evaluate the effect of destination management on performance of the tourism industry in Kampala, Uganda.
4. To assess the moderating effect of operational efficiency in the relationship between management information systems and performance of the tourism industry in Kampala, Uganda.

Uganda 2026-04-20 15:55:56 2029-04-20 Social Science and Humanities Non-Clinical Trial Degree Award
John Othieno
ID: UNCST-2025-R020125
EXPANDING BRAIN TUMOR SEGMENTATION DATA TO CAPTURE AFRICAN POPULATIONS (BRATS-AFRICA)
REFNo: HS6328ES

1. To avail high-quality real-world imaging and clinical data carefully curated to preserve the heterogeneity in real world acquisition of clinical data and the inherent clinical presentation of brain tumors - a heterogenous disease with pathological features overlapping other noncancerous lesions in the brains.
3. To further expand BraTS-Africa project imaging datasets to include other brain tumor types (other than gliomas only), metastasis, and lesions such as stroke, multiple sclerosis, and epilepsy lesions from Uganda.

Uganda 2026-04-20 11:07:38 2029-04-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Shango Patience  Jakheng Emmanuel
ID: UNCST-2025-R020526
WHOLE-GENOME CHARACTERIZATION AND PHYLOGENETIC ANALYSIS OF HUMAN PAPILLOMAVIRUS AMONG PREGNANT WOMEN ATTENDING ANTENATAL CARE AT ISHAKA ADVENTIST HOSPITAL, WESTERN UGANDA.
REFNo: HS7175ES

1. To determine the prevalence of HPV infection among pregnant women attending antenatal care at Ishaka Adventist Hospital. 2. To characterize the genotype distribution and genomic diversity of HPV strains circulating among pregnant women in this population. 3. To identify risk factors associated with HPV infection among pregnant women attending antenatal care at Ishaka Adventist Hospital. 4. To characterize HPV genomic integration patterns using whole-genome sequencing, stratified by HIV status and HPV phylogenetic clade. 5. To quantify E6/E7 oncogene expression using transcriptomic analysis and assess its relationship with HPV genomic status (integrated versus episomal). 6. To determine the phylogenetic relationships of HPV strains detected among pregnant women attending antenatal care at Ishaka Adventist Hospital.
Nigeria 2026-04-20 11:04:16 2029-04-20 Medical and Health Sciences Non-Clinical Trial Degree Award
Gladys Angee
ID: UNCST-2025-R021927
Cost Management Practices, Operational Efficiency and Financial Performance of Agro-processing Firms in Acholi Sub-region
REFNo: SS5093ES

i. To establish the relationship between cost management practices and financial performance of agro-processing firms in Acholi sub-region. ii. To determine the correlation between cost management practices and operational efficiency of agro-processing firms in Acholi sub-region. iii. To establish the association between operational efficiency and financial performance of agro-processing firms in Acholi sub-region. iv. To find out the mediating role of operational efficiency on the influence of cost management practices on financial performance of agro-processing firms in Acholi sub-region v. To document the moderating role of firm characteristics on the relationship between cost management practices and financial performance of agro-processing firms in Acholi sub-region
Uganda 2026-04-20 11:00:51 2029-04-20 Social Science and Humanities Non-Clinical Trial Degree Award
Rupankar Dey
ID: UNCST-2026-R023803
People with Disabilities & Sexual Reproductive Health Citizenship in the Kalangala Islands of Lake Victoria, Uganda
REFNo: SS5105ES

This study aims to understand how the spatial context of the island shapes sexual reproductive citizenship surrounding sexuality norms, disability stigma, and social and environmental conditions in the Sese Islands of the Kalangala archipelago. Specific Objectives: This overarching aim is not explored through a single method. Instead, it is addressed through a set of interrelated objectives, each exploring a specific aspect of sexual and reproductive citizenship within island settings. The objectives focus on different groups and processes, allowing methods to be carefully matched to the sensitivities and experiences aimed to be explored. Objective 1 How does islandness shape experiences of gender-based violence (GBV) among people with diverse disabilities on the Kalangala Islands? Objective 2 How does islandness shape fishermen’s perspectives on gender-based violence (GBV)? Objective 3 What shapes access to SRH services for women with diverse disabilities? Objective 4 How does islandness shape the sexual reproductive citizenship of men with diverse disabilities?
India 2026-04-20 10:56:06 2029-04-20 Social Science and Humanities Non-Clinical Trial Degree Award
Fred Kigozi
ID: UNCST-2025-R021423
Postprandial effect of isocaloric challenge meals enriched with indigenous fruits and vegetables on glucose metabolism in individuals with type 2 diabetes in Wakiso District, Uganda.
REFNo: HS7347ES

General Objective To evaluate the postprandial effect of isocaloric challenge meals enriched with indigenous fruits and vegetables on glucose metabolism among people living with type 2 diabetes in Wakiso district, Uganda. Specific Objectives 1.To assess the acute postprandial effects of isocaloric challenge meals enriched with indigenous fruits and vegetables on incremental area under the curve (iAUC) blood glucose levels. 2.To assess the acute postprandial effects of isocaloric challenge meals enriched with indigenous fruits and vegetables on iAUC blood triglyceride levels.
Uganda 2026-04-20 10:47:24 2029-04-20 Medical and Health Sciences Clinical Trial Degree Award
Milton Ayoki
ID: UNCST-2026-R024563
From job displacement to economic resilience: Mapping the net impact of AI on formal and informal employment across three African economies
REFNo: SS5147ES

The overall objective of this study is to generate rigorous, gender-disaggregated, intersectional evidence on the net socio-economic impacts of AI on formal and informal employment in Uganda, Kenya, and South Africa, and translate this evidence into rights-based, African-led policy frameworks that ensure AI transitions are inclusive, safe, and aligned with sustainable development. Specific objectives (i) To measure the causal effect of firm-level AI adoption on net employment task recomposition, earnings volatility, and household poverty risk, disaggregated by gender, age, disability, geography, and formality status. Using a sequentially integrated design—linking 1,200 firms’ AI Intensity Index to 4,500 workers’ diary panel and administrative tax records—we will identify which demographic groups face displacement versus augmentation, and trace micro-to-macro transmission channels affecting social-protection demand. (ii) To identify, test, and refine policy levers—portable social protection benefits, mandatory algorithmic fairness audits, and gender-responsive re-skilling subsidies—that enhance economic resilience for vulnerable workers, particularly women, youth, and persons with disabilities. Through a participatory GEDI Lab (co-chaired with trade unions, women’s networks, and PWD advocates) with veto power over sampling, instruments, and recommendations, we will validate rights-based policy scenarios via a regulatory sandbox covering 20 digital-labour platforms. This ensures policies are not technocratic but reflect lived realities and African priorities, directly minimizing AI’s potential to exacerbate gender inequalities and human rights violations. (iii) To strengthen Africa’s AI-labour research ecosystem by mentoring eight African PhD students (≥60% women, ≥20% PWDs) through a triadic supervision model, and creating an open-source Continental Methodology Toolkit (AI Intensity Index calculator, AfroXLMR models, intersectional DiD estimators) for continent-wide replication. Outputs will be embedded in national AI strategies, ESG disclosure rules, and a COMESA Model Law on Algorithmic Labour Practices, ensuring sustainability beyond the project’s 36-month timeline and transforming global AI-labour debates from models that ignore Africa into African-led evidence that guides the continent’s digital future.
Uganda 2026-04-20 10:43:58 2029-04-20 Social Science and Humanities Non-Clinical Trial Non-degree Award
Emmanuel Wegoye
ID: UNCST-2024-R003214
Neurocognitive Outcomes and Changes in Brain and Cerebral Spinal Fluid (CSF) Volume after Treatment of Post-Infectious Hydrocephalus (PIH) in Ugandan Infants by Shunting versus Endoscopic Third Ventriculostomy/Choroid Plexus Cauterization (ETV/CPC)
REFNo: HS7254ES

We propose to: 1) Develop and empower CURE Children’s Hospital of Uganda as a unique hydrocephalus research center in the developing world 2) Test the hypothesis that ETV/CPC is superior to shunt-dependence in regard to treatment failure at 10 years; 3) Determine whether our initial finding of neurodevelopmental non-inferiority for ETV/CPC at 12 months is durable to the critical time of 10-years follow up; 4) Determine whether our initial finding of non-inferiority in brain growth for ETV/CPC at 12 months holds true at 10-years of follow up
Uganda 2026-04-15 22:23:51 2029-04-15 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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