Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Crispus Natwijuka
ID: UNCST-2024-R016280
TESTING NRIMS VERSION 2
REFNo: SIR729ES

testing testing testing
Uganda 2026-05-06 10:30:12 2029-05-06 Engineering and Technology Clinical Trial Non-degree Award
Joseph Babigumira
ID: UNCST-2026-R023369
Behavioral Research for Informed Government Decision-Making Using Evidence (BRIDGE Trial)
REFNo: SS5072ES

Primary Objectives 1. To determine the relative effect of narrative framing (with citizen voice) versus technical framing of research evidence on senior policymakers' use of evidence, measured through citations in policy documents, requests for new analyses, and evidence-informed budget allocations. 2. To determine the relative effect of peer civil servant messengers versus external academic expert messengers on senior policymakers' use of research evidence, measured through the same behavioural outcomes. 3. To assess whether framing and messenger mechanisms interact, and which combination produces the greatest improvement across the four evidence-informed policymaking (EIPM) outcome domains: conceptual, attitudinal, procedural, and content. Secondary Objectives 4. To identify through which cognitive, social, and procedural pathways framing and messenger interventions influence evidence use (e.g., comprehension, trust, integration into decision routines). 5. To assess how treatment effects vary by ministry (Finance, Trade, Energy, NPA), seniority (U1–U2 vs. U3–U4), gender, and baseline orientation to evidence. 6. To estimate the cost-effectiveness of each intervention variant per unit increase in evidence uptake, expressed as cost per 0.1 standard deviation increase in the Evidence Use Index (EUI). 7. To examine how electoral cycles, bureaucratic turnover, and patronage networks moderate the effectiveness of behavioural interventions during Uganda's 2025–2027 reform window. Exploratory Objective 8. To assess what early signals suggest that increased evidence use contributes to improved economic policy outcomes (e.g., trade facilitation, domestic revenue mobilisation), recognising that attribution is limited within the 24-month trial horizon.
Uganda 2026-04-30 18:43:15 2029-04-30 Social Science and Humanities Non-Clinical Trial Non-degree Award
PROSSY SENYANGE
ID: UNCST-2025-R020541
PREVALENCE AND FACTORS ASSOCIATED WITH HIGH-RISK HPV POSITIVITY FOLLOWING TREATMENT FOR PRECANCEROUS CERVICAL LESIONS AMONG WOMEN LIVING WITH HIV AT MBARARA REGIONAL REFERRAL HOSPITAL.
REFNo: HS7368ES

General objective
To determine the prevalence and factors associated with high risk HPV positivity after treatment for precancerous lesions among women living with HIV at Mbarara Regional Referral Hospital
Specific Objectives
1. To determine the prevalence of high-risk HPV positivity after treatment for precancerous lesions among women living with HIV at Mbarara Regional Referral Hospital.
2. To determine the factors associated with high risk HPV positivity after treatment for precancerous lesions among women living with HIV at MRRH

Uganda 2026-04-30 18:41:23 2029-04-30 Medical and Health Sciences Non-Clinical Trial Degree Award
Mercy chelangat
ID: UNCST-2025-R017873
PREVALENCE OF HIGH ACUTE GLYCEMIC VARIABILITY, ITS ASSOCIATED FACTORS, AND 14 DAY MORTALITY AMONG PATIENTS ADMITTED WITH SEPSIS AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS7303ES

General Objective
To determine the prevalence of high acute glycemic variability, its associated factors and 14-day mortality among patients admitted with sepsis at MRRH.
Specific Objectives
1. Determine the prevalence of high acute glycemic variability among patients admitted with sepsis at MRRH
2. To determine the factors associated with high acute glycemic variability among patients admitted with sepsis
3. To compare the 14-day mortality rates between sepsis patients with high versus normal acute glycemic variability

Uganda 2026-04-30 18:40:37 2029-04-30 Medical and Health Sciences Non-Clinical Trial Degree Award
Henry Ochola
ID:
MATERNAL EARLY WARNING SCORES AT MBARARA REGIONAL REFERRAL HOSPITAL: SCREENING PERFORMANCE VERSUS SHOCK INDEX, RISK FACTORS, AND EARLY OUTCOME INDICATORS
REFNo: HS7372ES

Main Objective
To evaluate the screening performance of Maternal Early Warning Scores compared with the Shock Index, and to identify associated risk factors and early maternal outcome indicators among women receiving obstetric care at Mbarara Regional Referral Hospital
Specific Objectives
1. To compare the proportion of women flagged high-risk by Maternal Early Warning Signs versus the Shock Index among women admitted at the maternity and gynaecology units at Mbarara Regional Referral Hospital.
2. To determine factors associated with being flagged high-risk at the index observation among women admitted at the maternity and gynaecology units at Mbarara Regional Referral Hospital, monitored with the Maternal Early Warning Signs chart.
3. To describe key process indicators (documentation completeness; guideline-timely escalation) and early outcomes (ICU admission; maternal near-miss; in-hospital mortality) among women admitted at the maternity and gynaecology units at Mbarara Regional Referral Hospital, monitored with the Maternal Early Warning Signs chart.
Uganda 2026-04-30 18:39:12 2029-04-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Winnie  Muyindike R
ID: UNCST-2021-R013558
Exploring low-level HIV viremia among individuals on dolutegravir in sub-Saharan Africa (Low-V Africa Study).
REFNo: HS7580ES

Aim 2: To elucidate pharmacologic, viral, and host factor determinants of the progression to VF among participants in the Low-V Africa Cohort. In doing so, we will also characterize the prevalence of these factors in the setting of pLLV in the Low-V Africa cohort. We will evaluate viral suppression and long-term persistence of LLV as secondary outcomes. Analyses will employ longitudinal modeling with repeated measures, as well as machine learning techniques. Aim 2a will assess adherence, as measured by TFV-DP levels from DBS, as a predictor of VF after pLLV. Aim 2b will assess HIV drug resistance, defined by GSS, as a predictor of VF after pLLV. Aim 2c will evaluate the impact of a hyperactive HIV-1 viral reservoir, identified with long-range plasma SGS and MIP-Seq, on the risk of VF after pLLV. Aim 2d will estimate the relative contributions of adherence, resistance, and the reservoir to VF after pLLV. ,Aim 1: To determine longitudinal outcomes of individuals with pLLV while on tenofovir/lamivudine/dolutegravir (TLD). We will enroll a cohort of 200 adults in Uganda with pLLV (Low-V Africa Cohort), defined as at least two consecutive VLs ranging 50-1,000 copies/mL while on TLD for at least 12 months. We will follow participants for 96 weeks and will collect plasma, dried blood spots (DBS), and peripheral blood mononuclear cells (PBMCs) at enrollment, as well as 24-, 48-, and 96-week study visits. Aim 1a will estimate the 96-week cumulative incidence of VF and poor clinical outcomes after pLLV. We will perform VL quantification at each study visit to determine whether participants progress to virologic failure (>1,000 copies/mL), achieve viral suppression (<50 copies/mL), or have persistence of LLV. As secondary outcomes, we will also estimate the cumulative incidence of opportunistic infections, hospitalization, and death. Aim 1b will determine the 96-week cumulative incidence of emergent HIV drug resistance and a hyperactive reservoir in PWH with pLLV. We will perform Sager sequencing of plasma specimens with VLs >500 copies/mL and long-range plasma single-genome HIV RNA sequencing (SGS) of plasma specimens with VLs ?500 copies/mL at each time point, with genotyping of the protease/reverse transcriptase and integrase. We will perform matched integration site and proviral sequencing (MIP-Seq) on follow-up specimens with ongoing viremia, evidence of high-level ART adherence (by tenofovir diphosphate [TFV-DP] levels), and an active ART regimen (genotypic susceptibility score [GSS]?2). Results will identify individuals with resistance versus a hyperactive reservoir in the setting of pLLV. ,
Uganda 2026-04-30 18:38:20 2029-04-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
CHARLES TIONDI
ID: UNCST-2025-R022907
This research investigates the impact of the outreach programs on TVET training in Uganda
REFNo: SIR655ES

The study looks at the effect of outreach programme strategies and how they influence practical and soft skills development, industry partnerships, and equity-based interventions.
2026-04-30 18:35:17 2029-04-30 Engineering and Technology Non-Clinical Trial Degree Award
steven kavuma
ID: UNCST-2025-R020895
Prevalence, severity of, and factors associated with stress urinary incontinence among postpartum women at Mbarara Regional Referral Hospital
REFNo: HS7415ES

to determine the prevalence of stress urinary incontinence among postpartum women at mbarara regional referral hospital
to describe the severity of stress urinary incontinence among postpartum women at mbarara regional referral hospital
to determine the factors associated with stress urinary incontinence among postpartum women at mbarara regional referral hospital
Uganda 2026-04-30 18:33:20 2029-04-30 Medical and Health Sciences Non-Clinical Trial Degree Award
Robinah Walube Nabirye
ID:
WORK ENVIRONMENT, STRENGTHS DEVELOPMENT AND PSYCHOLOGICAL CAPITAL. A CASE OF TEACHERS IN SELECTED SECONDARY SCHOOLS IN WAKISO
REFNo: SS2621ES

iv. To establish the mediating effect of strengths development on the relationship between work environment and psychological capital of secondary school teachers in public secondary schools in Wakiso District.,iii. To establish the relationship between strength development and psychological capital of secondary school teachers in selected schools in Wakiso District,ii. To establish the relationship between work environment and strength development among teachers in selected secondary schools in Wakiso district.,i. To establish the relationship between work environment and psychological capital of teachers in selected secondary schools in Wakiso District,The purpose of this study is to empirically establish the relationship between work environment, strengths development and psychological capital of teachers in public institutions,
Uganda 2026-04-30 18:32:23 2029-04-30 Social Science and Humanities Non-Clinical Trial Degree Award
Barbara Nansamba
ID: UNCST-2025-R020897
Explainable Multimodal Deep Learning for Tuberculosis Diagnosis among Patients with Diabetes Mellitus in Low Resource Settings
REFNo: SIR647ES

Main Objective: To develop an interpretable hybrid multimodal deep learning model for classification of Tuberculosis infection in DM population using a combination of chest x-ray images, demographics, clinical and laboratory data. Specific Objectives 1.To perform exploratory data analysis for both chest x-ray images and clinical data. 2.To build and evaluate deep learning models capable of integrating chest x-ray images and clinical data for classification of latent Tuberculosis in diabetic population. 3.To design a hybrid approach that combines convolutional neural networks and transformers to improve on the diagnosis of latent Tuberculosis based on multimodal learning. 4.To derive interpretable explanations of the model processes to provide transparent insights into diagnostic decisions.
Uganda 2026-04-30 16:35:13 2029-04-30 Engineering and Technology Non-Clinical Trial Degree Award
ISMAEL BARUGAHARE
ID: UNCST-2026-R023318
SUSTAINABLE SUPPLY CHAIN MANAGEMENT PRACTICES, GOVERNANCE MECHANISMS AND SUSTAINABILITY PERFORMANCE OF NATIONAL OIL AND GAS SECTOR PROJECTS IN UGANDA
REFNo: SS4974ES

1.3.1 The General Objective
To establish the relationship between sustainable supply chain management practices, governance mechanisms and sustainability performance of National Oil and Gas Sector Projects in Uganda
1.3.2 Specific Objectives
i. To determine the effect of sustainable supply chain management practices on sustainability performance of National Oil and Gas Sector Projects in Uganda.
ii. To analyze the effect of governance mechanisms on sustainability performance of National Oil and Gas sector Projects in Uganda.
iii. To establish the moderating effect of governance mechanisms on the relationship between sustainable supply chain management practices and sustainability performance of National Oil and Gas sector Projects in Uganda.

Uganda 2026-04-30 16:34:27 2029-04-30 Social Science and Humanities Non-Clinical Trial Degree Award
munduni samuel
ID: UNCST-2025-R019116
ASSOCIATION BETWEEN DECISION TO DELIVERY INTERVAL AND IMMEDIATE ADVERSE PERINATAL OUTCOMES AMONG EMERGENCY CAESAREAN SECTION DELIVERIES AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS7562ES

1.To compare the proportion of immediate adverse perinatal outcomes among women with delayed decision to delivery interval and those with optimal decision to delivery interval among women delivered by emergency caesarean section at Mbarara Regional Referral Hospital.
2.To determine the association between delayed decision to delivery interval and immediate adverse perinatal outcomes among women delivered by emergency caesarean section at Mbarara Regional Referral Hospital.

Uganda 2026-04-30 16:33:13 2029-04-30 Medical and Health Sciences Non-Clinical Trial Degree Award
ESTHER TWINOMUGISHA
ID: UNCST-2026-R024218
ASSESSMENT OF HEALTH FACILITY PREPAREDNESS FOR MARBURG VIRUS DISEASE IN THE SEBEI SUB REGION, EASTERN UGANDA
REFNo: HS7307ES

General Objective

To assess health facility preparedness for Marburg virus disease in the Sebei Sub-region, Eastern Uganda.

Specific Objectives
1. To assess the availability of triage and screening systems for Marburg virus disease in health facilities in Sebei Sub region.
2. To determine the availability of isolation spaces and infection prevention and control capacity in the health facilities.
3. To assess the availability and adequacy of personal protective equipment in the health facilities.
4. To assess the effectiveness of surveillance and reporting systems for Marburg virus disease at the health facility level in Sebei Sub region.

Uganda 2026-04-30 16:31:40 2029-04-30 Medical and Health Sciences Non-Clinical Trial Degree Award
INNOCENT MUHWEZI .
ID:
Education for Sustainable Development: Competence-Based Curriculum Implementation Approaches in Entrepreneurship Education that Contribute to Climate Change Mitigation in Uganda
REFNo: SS5217ES

General Objective To examine the contribution of CBC implementation approaches in Entrepreneurship Education to climate change mitigation for sustainable development in Uganda. The Specific Objectives of the Study 1. To assess the effectiveness of CBC implementation approaches in Entrepreneurship Education in contributing to climate change mitigation for sustainable development. 2. To explore practitioners’ and learners’ perceptions of CBC implementation approaches in Entrepreneurship Education that contribute to climate change mitigation for sustainable development. 3. To identify the challenges and opportunities in implementing the CBC in Entrepreneurship Education to enhance climate change mitigation for sustainable development.
Uganda 2026-04-30 16:30:30 2029-04-30 Social Science and Humanities Non-Clinical Trial Degree Award
David Lubogo
ID: UNCST-2020-R014473
Enhancing metabolic syndrome prevention in Central Uganda: assessing healthcare provider and reproductive-age female knowledge, attitudes, perceptions and practices
REFNo: HS7440ES

1) To determine the level of knowledge regarding metabolic syndrome and its prevention among healthcare providers and females of reproductive age in Wakiso district, central Uganda. 2) To explore the attitudes towards metabolic syndrome and prevention interventions among healthcare providers and females of reproductive age in Wakiso district, central Uganda. 3) To determine practices towards the prevention of metabolic syndrome by healthcare providers and females of reproductive age in Wakiso district, central Uganda. 4) To determine the perceptions of healthcare providers and females of reproductive age regarding metabolic syndrome and its prevention interventions in Wakiso district, central Uganda.
Uganda 2026-04-29 16:04:56 2029-04-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
ELIZABETH EKIRAPA-KIRACHO
ID: UNCST-2021-R013443
An Assessment of Health Financing Landscape and Healthcare Service Impact of the Health Funding Oscillations in Uganda
REFNo: HS7429ES

The main objective of this study is to analyze Uganda’s health financing system to identify vulnerabilities and support strategic, short-and medium-term interventions to strengthen fiscal resilience, sustain health services, advance universal health coverage amid economic challenges. Specific objective: 1) To analyze historical trends in health system financial flows and model future funding projections to inform policy and resource allocation in Uganda. 2) To analyze and document the effects of reductions in external assistance on health service delivery. 3) To assess the macro-fiscal capacity of Uganda and subsequently propose transitional funding options and sustainability frameworks to ensure long-term health financing resilience in Uganda. 4) To conduct a political economy analysis to examine decision-making processes as well as barriers and facilitators influencing the implementation of health financing reforms aimed at increasing domestic resources for health and enhancing allocative and technical efficiency. 5) To integrate findings into national financing strategies and global reform dialogues through technical support and multi-stakeholder co-ordination.
Uganda 2026-04-29 15:56:07 2029-04-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Mark Jordans
ID: UNCST-2020-R014861
CORE: A cluster Randomised Control Trial to test the effectiveness of a teacher wellbeing intervention.
REFNo: SS5114ES

1. To assess the impact of CORE on primary and secondary teacher-level outcomes as
outlined in the theory of change,
2. To understand if there is a sustained impact on teacher’s wellbeing two terms following
the end of the teachers’ engagement in CORE.
3. To assess the impact of CORE on child level outcomes,
4. To understand teachers’ experiences of CORE, specifically their perceptions of
changes that occurred and the impact of these.
Netherlands 2026-04-29 15:54:43 2029-04-29 Social Science and Humanities Non-Clinical Trial Non-degree Award
Harriet Angwech
ID: UNCST-2025-R019205
Improved worm management for improved goat production, sustainable livelihood and food security in vulnerable populations in northern Uganda
REFNo: NS1249ES

Aim of the study: To improve the management of worm infections in livestock contributing to the livelihood and food security of vulnerable households in northern Uganda through validating the efficacy of ethnobotanical plants used as dewormers. Specific objectives: 1. To document the plants used as dewormers in goats in Acholi and Lango sub regions. 2. To determine the efficacy of the most mentioned plants (ten) in vitro and in vivo. 3. To establish the optimal dose for two of the most effective plants from 2 above for use in goat production in the region.
Uganda 2026-04-29 15:44:29 2029-04-29 Natural Sciences Non-degree Award
DerrickBukenya Kato
ID: UNCST-2025-R022430
THE SPATIAL VARIATIONS IN WATER QUALITY AND BIOLOGICAL COMMUNITIES OF SELECTED TRIBUTARIES IN THE UGANDAN PART OF THE LAKE ALBERT BASIN
REFNo: NS1240ES

ii. To determine the spatial variation in the water quality parameters of selected streams and nearshore zones of Lake Albertiii. To determine the in-stream and riparian zone habitat integrity scores at the selected sites along the selected streams
Uganda 2026-04-29 15:36:31 2029-04-29 Natural Sciences Non-Clinical Trial Degree Award
Judith Akello
ID: UNCST-2022-R009134
Negotiating Motherhood in Gendered Cultural Spaces: Breastfeeding Student-Mothers and Staff at Lira University Through Performing Arts and Culture
REFNo: SS5146ES

• To document the institutional challenges faced by breastfeeding student-mothers and staff at Lira University within six months.
• To analyse how cultural beliefs and gender norms influence breastfeeding practices
among these mothers within eight months.
• To develop context-specific recommendations for institutional policies and programs that
support breastfeeding mothers in higher education by the end of twelve months.
Uganda 2026-04-29 15:33:41 2029-04-29 Social Science and Humanities Non-Clinical Trial Non-degree Award
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