Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Abel  Kakuru
ID: UNCST-2022-R009193
Dihydroartemisinin-piperaquine plus sulfadoxine-pyrimethamine versus sulfadoxine-pyrimethamine alone for the prevention of febrile illnesses in children with sickle cell anemia: a double-blind randomized controlled trial
REFNo: HS6294ES

1.
To compare the incidence of all-cause febrile illness among children with sickle cell anemia randomized to receive monthly SP vs. monthly DP+SP.
2.
To compare the incidence of adverse events among children with sickle cell anemia randomised to receive monthly SP vs. monthly DP+SP.
3.
To compare the prevalence of markers of antimalarial resistance, including those associated with SP and DP resistance, among parasitemic children with sickle cell anemia randomized to receive monthly SP vs. monthly DP+SP.
Uganda 2025-10-29 15:55:44 2028-10-29 Medical and Health Sciences Clinical Trial Non-degree Award
Jane  Kabami
ID: UNCST-2021-R012588
Peerled Dynamic Choice HIV Prevention for Women. The Peer-led DCP Study
REFNo: HS6556ES

To refine and pilot test a Peer-led Dynamic Choice HIV Prevention intervention for women at elevated HIV risk in southwestern Uganda
Uganda 2025-10-29 12:53:43 2028-10-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Hannah Tusabe Not Applicable
ID: UNCST-2025-R022045
EXPLORING THE IMPLEMENTATION OF EARLY GRADE READING METHODOLOGY IN UGANDA PRIMARY SCHOOLS
REFNo: SS4540ES

1.3.1 Main Objective

To explore the implementation of Early-Grade Reading Methodology in primary schools in Uganda.

1.3.2 Specific Objectives

To establish the current practices of Early-Grade Reading methodologies by teachers in primary schools in Uganda.

To identify the challenges teachers face in implementing Early-Grade Reading methodologies in their classrooms.

To determine strategies that can be adopted to improve the implementation of Early-Grade Reading methodologies in Ugandan primary schools.
Uganda 2025-10-29 12:51:10 2028-10-29 Social Science and Humanities Non-Clinical Trial Degree Award
richard kasirye
ID: UNCST-2025-R018157
Instructional Technologies for Teacher Education at Busitema University: Application of Skills to Practice
REFNo: SS4450ES

The study aims to answer: How do Busitema University’s teacher education alumni apply ICT knowledge and skills in the secondary schools where they teach? What are their experiences in using ICT in their classrooms? How can the university improve the teacher education program to better prepare graduates for technology-enhanced teaching?
Uganda 2025-10-29 12:48:06 2028-10-29 Social Science and Humanities Non-Clinical Trial Degree Award
ALEX KAYONGO
ID: UNCST-2019-R001641
Clonotyping Airway T-cells to Uncover Microbiome-Specific Inflammotypes in HIV-Associated COPD
REFNo: HS6625ES

Study Aim:
To investigate the airway microbiome-specific inflammotypes in COPD among HIV-infected individuals in a rural Uganda.

Specific objectives
1.To determine, in vitro, the CD4+T-cell clonotypic library specific to airway bacterial species associated with COPD among HIV-infected individuals in rural Uganda.

2.To determine, ex vivo, the microbiome-specific clonotypic landscape of BAL-derived CD4+T cells from a cohort of individuals stratified by HIV and COPD in rural Uganda.

3.To validate airway microbiome-specific inflammotypes among individuals with COPD transitioning from stable disease to exacerbation and back to stable disease.

Uganda 2025-10-29 12:47:04 2028-10-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
AGNESS NATABA
ID: UNCST-2024-R002018
Reclaiming Rights:Bunyoro Kitara Kingdom Women and their Quest for Reparative Justice from British Colonialism
REFNo: SS4501ES

1. To examine how historical injustices faced by women in the Bunyoro Kitara Kingdom during British colonial rule affected their cultural setting. 2. To evaluate existing reparative justice efforts for women in the Bunyoro Kitara Kingdom. 3. To assess how gender-responsiveness the existing reparative efforts are in fostering inclusive justice, healing, and environmental justice for women in the Bunyoro Kitara Kingdom.
Uganda 2025-10-29 12:44:59 2028-10-29 Social Science and Humanities Non-Clinical Trial Degree Award
JACOB BIBOHERE
ID: UNCST-2025-R021298
Assessment of CDC Data Triangulation Activities to Enhance Immunization and Vaccine-Preventable Disease Surveillance Programs in Selected African Countries
REFNo: HS6596ES

1.To assess the extent to which data triangulation has been integrated into the existing immunization and/or VPD surveillance staff workload, program processes, and practices at national and sub- national levels. 2.To identify programmatic successes, challenges, enabling factors, and innovations reported by immunization and/or VPD program staff through the application of triangulation analytic tools. 3.To examine the immunization programmatic decisions, actions, and outcomes that have been informed by the use of data triangulation concepts. 4.To explore and identify sustainability strategies and recommendations for ensuring that data triangulation and existing tools remain integrated into routine program activities.
Uganda 2025-10-29 12:42:52 2028-10-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Shivan Kamugisha Kaitesi
ID: UNCST-2025-R019815
Socio-Ecological Systems Assessment of Factors Influencing the Lion population in the Greater Virunga Landscape
REFNo: NS989ES

1. Develop a population dynamics model for lions in the Greater Virunga Landscape 2. Assess the functionality of lion movement corridors within GVL 3. Examine the impacts of land use and climate change on the suitable habitat for lions 4. Evaluate factors of human-lion conflict and develop strategies for conflict mitigation and coexistence.
Uganda 2025-10-29 12:41:40 2028-10-29 Natural Sciences Non-Clinical Trial Degree Award
Michael Harvey
ID: UNCST-2025-R022115
HERPETOFAUNAL DIVERSITY AND BASELINE ECOLOGICAL ASSESSMENT IN SELECT SITES OF NORTHERN AND WESTERN UGANDA
REFNo: NS1049ES

• Generate a list of reptiles and amphibians inhabiting Mount Kadam and surrounding areas
• Compare the distributions of reptiles and amphibians across different habitats within the boundaries of the research site.
• Establish a reference collection of vouchered specimens from the reserve in a local international research collection/museum.
• Tabulate baseline ecological data for each species (see data collection for details)
• Involve local community, students, and other stakeholders in survey methods and data recording
• Publish results of survey in peer-reviewed scientific journals

USA 2025-10-24 17:36:31 2028-10-24 Natural Sciences Non-Clinical Trial Non-degree Award
DENISH  ONGOL OGWANG
ID: UNCST-2025-R022077
THE IMPLEMENTATION OF THE PRISONERS’ RIGHT TO VOTE IN UGANDA. A CASE STUDY OF LUZIRA PRISONS, 1995-2021
REFNo: SS4502ES

1. To assess the adequacy of the legal framework for the implementation of prisoners’ right to vote in Uganda.
2. To identify the challenges that Luzira Prisons face in the implementation of the prisoners’ right to vote
3. To develop a framework for the implementation of the prisoners’ right to vote in Uganda.

Uganda 2025-10-24 17:35:10 2028-10-24 Social Science and Humanities Non-Clinical Trial Degree Award
Mudarshiru Bbuye
ID: UNCST-2025-R019080
EXPLORING THE ASSOCIATION BETWEEN AIR QUALITY AND THE BURDEN OF RESPIRATORY TRACT INFECTIONS IN KAMPALA, UGANDA
REFNo: HS6603ES

General objective To explore the impact of ambient air pollution on the incidence, prevalence, and severity of respiratory tract infections, and the extent of enforcement of air quality control policies and regulations in Kampala, Uganda, a low-resourced urban setting Specific Objectives 1.To conduct a systematic review and meta-analysis to quantify the association between ambient air pollution and respiratory tract infections in low- and middle-income countries (LMICs). 2. To characterise the spatial variation in ambient PM2.5 exposure and its correlation with respiratory tract infection health effect among sub-populations in Kampala, Uganda 3.To determine the effect of air quality policies and regulations on the long-term ambient PM2.5 levels and the respiratory tract infections health effects in Kampala, Uganda. 4. To explore the limitations of adaptation and enforcement of air pollution control policies and regulations to reduce the ambient air pollution health effects in Kampala, Uganda.
Uganda 2025-10-24 17:34:12 2028-10-24 Medical and Health Sciences Non-Clinical Trial Degree Award
Dr. James Wasike Mangeni Byanasaye
ID: UNCST-2020-R008019
DENTAL ANTIMICROBIAL STEWARDSHIP IN UGANDA - DEVELOPING AN EVIDENCE BASED INTERVENTION
REFNo: HS6561ES

Aim: To develop evidence-based, behaviour science informed antimicrobial stewardship intervention aimed at reducing antibiotic prescribing to adult patients for dental issues.
Objectives:
1. To understand the factors that influence antibiotic prescribing by health care practitioners to adult patients for dental issues.
2. To explore the perspectives of patients seeking dental care on the use of antibiotics for dental issues.
3. To explore community stakeholders' perspectives on the use of antibiotics for dental issues
4. To co-produce an evidence-based, behaviour science informed dental antibiotic stewardship intervention for Uganda.


Uganda 2025-10-24 17:32:56 2028-10-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Deogratius Ssemwanga
ID: UNCST-2025-R021563
Performance Evaluation for Diagnostic Tests
REFNo: HS6649ES

Primary Objective

The overall objectives of this performance evaluation are:

• To verify the performance characteristics of new on-the-market NAATs and antigen RDTs.
• To establish well-characterized viral pathogen sera/plasma reference panels to support evaluation efforts and quality assurance.

• To evaluate the performance characteristics of new, on-the-market, EIAs and RDTs (IgA, IgG and IgM).
• To train laboratory and POC staff in biosecurity and the required technical skills to perform diagnostic testing.

Specific Objectives:

• To confirm whether or not a new NAAT complies with the manufacturer’s specifications,
• To determine the performance equivalence of new on-the-market NAATs, including POC devices, using available gold standards (or any other comparatively/equally as good WHO/FDA approved NAAT),
• To determine the performance equivalence of new on-the-market antigen tests against the gold-standard NAAT,
• To determine the sensitivity and specificity of new on-the-market diagnostic EIAs and RDTs against a gold-standard method,
• To evaluate the operational characteristics of new on-the-market immunoassays. Operational utility characteristics that may be considered include;
o ease of performance
o specimen type utility
o inter-reader variability
o reaction endpoint stability
o suitability for use in facilities with limited infrastructure (no/limited electricity, no/limited clean water)
• To document SOPs and train laboratory staff in performing testing using recommended diagnostic tests,
• To establish a repository of well-characterized natural infection and vaccination sera/plasma as well as swabs/extracted RNA to support future evaluation and verification of immunoassays.
• To establish a cohort of natural infection and vaccinated cases in the country whose samples and demographic characteristics will be used to help understand the dynamics of human immunity development to viral infection in order to inform the clinical interpretation of the various diagnostic assays.

Uganda 2025-10-24 17:31:36 2028-10-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Grace Muzanyi
ID: UNCST-2021-R013731
Exploration Of the Correlation Between Active TB Immunological Markers and Sputum Culture: A Cytokine TB (CYTO-TB) Study
REFNo: HS6426ES

Main Objective
1. To explore the correlation of TB immunological markers (IL-2, IL-2Ra, I-P10, MIP-β, MCP-1) and TB sputum cultures at five-time points: before the start of treatment (Month 0), then Months 1, 2, 5, and 6.
Specific Objectives
1. 1. To assess the level of each or a combination of cytokines at the time points of active TB diagnosis, months 1, 2, 5, and 6, and how they relate to sputum culture on liquid (days to positivity) and solid (quantitative colony counts) media
2. 2. 2. To assess the baseline level of each cytokine or a combination and how it correlates with (a) the clinical response to TB treatment at months 1, 2, 5, and 6; (b) the clinical severity, and radiographic extent (severity) of TB disease at diagnosis and end of treatment.
3. 3. To evaluate the differences in the TB cytokine levels between active and latent TB during treatment with ERHZ (for active TB), and 6H (for latent TB), stratified by HIV status
4. 4. To evaluate the TB cytokine levels across three populations of active TB, Latent TB, and TB-exposed healthy volunteers who are TST/IGRA negative
5. 5. To compare the cost-effectiveness of TB immunological markers against sputum culture (standard of care).
Uganda 2025-10-24 17:30:54 2028-10-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Wilber Sabiiti
ID: UNCST-2024-R016293
UNDERSTANDING INFECTIOUS AND NON-INFECTIOUS DISEASE TRENDS IN KANUNGU DISTRICT TO INFORM PUBLIC HEALTH PLANNING AND INTERVENTIONS
REFNo: HS6462ES

1. Determine types and trends of diseases in Kanungu from 2015–2025.
2. Compare quality and quantity of HCF records with MoH’s DHSI data.

Uganda 2025-10-24 17:28:54 2028-10-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Agatha Nakibuule Martha
ID: UNCST-2024-R016574
EXPLORING HIV SELF-TESTING: PERCEPTIONS AND EXPERIENCES OF SEX WORKERS AND MALE CLIENTS ON KOOME ISLAND, UGANDA
REFNo: HS6306ES

1.3 Objectives
1.3.1 General objective
The overall objective of this study is to increase the adoption and use of HIVST kits among sex workers and their clients on Koome Island, by qualitatively exploring their perceptions, preferences and experiences of using HIVST kits for HIV prevention, and assessing how HIVST may influence status disclosure, behaviour change and linkage to care.
1.3.2 Specific objectives
1. To explore the perceptions, preferences and experiences of HIV self-testing among sex workers on Koome Island.
2. To explore the perceptions, preferences and experiences of HIV self-testing among male clients of sex workers on Koome Island.
3. To assess perceptions, practices, and norms of sex worker peers and healthcare providers that may influence HIVST scale-up and implementation for sex workers and their clients in island fishing communities.


Uganda 2025-10-24 17:27:53 2028-10-24 Medical and Health Sciences Non-Clinical Trial Degree Award
MUGISHA BRIAN
ID: UNCST-2025-R017969
Evaluating Health Workers' Competence in Utilizing Electronic Health Records Systems for Quality Service Delivery in Hospitals: Greater Bushenyi, Uganda
REFNo: SIR541ES

Major Objective
-The purpose of this study is to Evaluate Health Workers' Competence in Utilizing Electronic Health Records Systems for Quality Service Delivery in Selected Hospitals in Greater Bushenyi, Uganda.

Specific Objective
1.To establish the current state of Electronic Health Records within hospitals in the Greater Bushenyi region, Uganda.
2.To establish essential requirements for the development of a comprehensive framework model, focusing on the evaluation of effective usage of EHRs.
3.To develop a competence-based framework tailored for evaluating the usage of EHRs in hospitals in the Greater Bushenyi region, Uganda.
4.To Evaluate and validate the effectiveness of the developed framework for assessing EHRs within hospitals in the Greater Bushenyi region, Uganda.

Uganda 2025-10-24 17:15:31 2028-10-24 Engineering and Technology Non-Clinical Trial Degree Award
AISHA NAJJUMA
ID: UNCST-2025-R017830
CONFLICT RESOLUTION STRATEGIES AND ACADEMIC STAFF PERFORMANCE OF PRIVATE CHARTERED UNIVERSITIES IN KAMPALA, UGANDA
REFNo: SS4149ES

i) To evaluate the effect of competitive strategy on academic staff performance of private chartered universities in Kampala, Uganda ii) To examine the effect of collaborative strategy on academic staff performance of private chartered universities in Kampala, Uganda iii) To assess the effect of accommodating strategy on academic staff performance of private chartered universities in Kampala, Uganda iv) To examine the effect of negotiation strategy on academic staff performance of private chartered universities in Kampala, Uganda v) To evaluate the effect of confrontation strategy on academic staff performance of private chartered universities in Kampala, Uganda. vi) To assess the moderating effect of leadership styles in the relationship between conflict resolution and academic staff performance of private chartered universities in Kampala,
Uganda 2025-10-24 17:10:26 2028-10-24 Social Science and Humanities Non-Clinical Trial Degree Award
Peter  Babyenda
ID: UNCST-2023-R007975
Energy Demand and Efficiency among Households and Small and Medium Scale Industries in Uganda
REFNo: SS4418ES

To understand the interlinkages in energy demand, efficiency, and productivity of households and small and medium-scale industries in Uganda.,Determine the impact of energy efficiency on Productivity of Households and Small and Medium Scale Industries. ,Identify the determinants of energy efficiency among small and medium scale industries in Uganda. ,Establish factors influencing energy demand and efficiency among households in Uganda ,
Uganda 2025-10-21 9:27:02 2028-10-21 Social Science and Humanities Non-degree Award
Alen Musisi
ID: UNCST-2022-R009338
Exploring the Frequency and Perceived Scope of Radiation Protection Information in Continuous Medical Education Among Radiation Workers in Uganda
REFNo: HS6455ES

To explore the frequency and perceived scope of radiation protection information provided through continuous medical education programs for radiation workers in Uganda
Uganda 2025-10-21 9:22:28 2028-10-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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