Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Kimuli NamyaloAngella
ID: UNCST-2025-R022072
 PREVALENCE OF HELICOBACTER PYLORI, ASSOCIATED FACTORS AND MAGNITUDE OF RESISTANCE AGAINST FIRST LINE ANTIBIOTICS AMONG CHILDREN PRESENTING WITH GASTRO-INTESTINAL SYMPTOMS AT HOLY INNOCENTS CHILDREN’S HOSPITAL, SOUTHWESTERN UGANDA
REFNo: HS6980ES

1. To determine the prevalence of H. pylori infection among children aged 1-16 years at Holy Innocents Children’s Hospital, southwestern Uganda 2. To assess the factors associated with the presence of H. pylori among children presenting with gastrointestinal symptoms at Holy Innocents Children’s Hospital, Southwestern Uganda 3. To determine the proportion of H. pylori strains that possess resistance genes to Amoxicillin, metronidazole and clarithromycin among the children population at Holy Innocents Children’s Hospital, Southwestern Uganda
 Uganda 2026-04-10 18:12:39 2029-04-10 Medical and Health Sciences Non-Clinical Trial Degree Award
ASIPHAS OWARAGANISE
ID: UNCST-2026-R023544
 Licensing Foreign Trained Doctors and Dentists in Uganda: Performance and Stakeholder Perspectives, 2015-2025.
REFNo: HS7299ES

Our overarching goal is to generate robust, mixed-methods evidence detailing trends, grades, and the perspectives of FTDs and their examiners to inform the professional council’s policies on licensure and workforce integration. Specifically, we will i) characterize the structural attributes and outcome performance of FTDs seeking licensure in Uganda, and ii) explore stakeholder experiences and perceptions of the medical licensure process for FTDs, situating findings within the context of evolving regional health workforce policies
 Uganda 2026-04-10 18:11:34 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sally Hargreaves
ID: UNCST-2025-R022294
 Designing for Immunization: A Co-design Thinking Approach to Improving Catch-up Vaccination among South Sudanese Refugees in Uganda (TUKU-VAC Study)
REFNo: HS7289ES

This project aims to explore the drivers of catch-up vaccination uptake among South Sudanese refugees in Uganda and to co-design community-led solutions using a participatory, design thinking research approach. Refugees often face significant challenges in accessing vaccinations, including limited healthcare access, vaccine hesitancy, misinformation, and systemic barriers. This study seeks to gain a deeper understanding of these issues and develop culturally appropriate, sustainable strategies to improve uptake of essential catch-up vaccines. The study will utilise an adapted version of the World Health Organization’s Behavioural and Social Drivers (BeSD) of vaccination framework to examine the key social behavioural factors influencing vaccine uptake among migrants and refugees’ population. This framework considers four key domains: individuals’ cognitive and emotional responses to vaccine-preventable diseases and vaccines, the influence of social norms and recommendations, the level of motivation and willingness to be vaccinated, and the practical barriers individuals encounter when attempting to access vaccination services. In parallel, a complementary healthcare provider survey adapted from a CDC-developed knowledge, attitudes, and practices (KAP) survey on catch-up vaccination, previously implemented in a national study in the United States will be used to assess the knowledge, practices, and system-level barriers affecting the delivery of catch-up vaccination services to refugees. This tool covers four core domains: demographic and professional characteristics; knowledge and awareness of catch-up vaccination; service delivery practices; and perceived enablers and barriers to vaccine provision. The research will be conducted in collaboration with refugee communities and healthcare providers to ensure that interventions are locally relevant, practical, and effective. Through qualitative interviews and participatory co-design workshops, refugees and healthcare providers will collectively identify challenges and develop solutions that align with their needs and lived experiences.
 UK 2026-04-10 18:09:36 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Richard Idro
ID: UNCST-2021-R013599
 Dihydroartemisinin-piperaquine for the post-discharge management of children with severe acute malnutrition in Malawi and Uganda; A multicentre, parallel-group, two-arm, randomised, double-blind superiority trial [Short Title: Post-discharge Malaria Chemoprevention - SAM (PDMC-SAM)]
REFNo: HS7291ES

To determine if 4 months of PDMC with dihydroartemisinin piperaquine (DP) compared to placebo is superior in reducing hospital readmissions and death by 6 months in children aged <5 years admitted with ‘SAM’ who are clinically stable and ready to be discharged to OTC.,
 Uganda 2026-04-10 18:06:21 2029-04-10 Medical and Health Sciences Clinical Trial Non-degree Award
alfred andama andama
ID: UNCST-2022-R011051
 Evaluation of a novel molecular platform for MTB detection using contrived oral swab samples
REFNo: HS6821ES

To compare the performance of the BLINK X shaker with the reference lysis method,To optimize the lysis protocol for MTB detection from contrived oral samples using the BLINK X Shaker,To estimate the analytical sensitivity of the BLINK dPCR laboratory detection platform for MTB detection using contrived oral swab samples.,
 Uganda 2026-04-10 18:02:52 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Geofrey Emesu
ID: UNCST-2025-R021670
 UTILIZATION OF CERVICAL CANCER SCREENING SERVICES AMONG WOMEN LIVING WITH HIV IN RURAL NORTH EASTERN UGANDA; A CASE OF SOROTI AND KATAKWI DISTRICTS
REFNo: HS7217ES

1. To estimate the level of uptake of cervical cancer screening among women living with HIV attending ART clinics at Tiriri health center IV and Katakwi General hospital 2. To identify Individual and health facility factors associated with utilization of cervical cancer screening among women living with HIV attending ART clinics at Tiriri health center IV and Katakwi General hospital 3. To explore multi-level barriers and facilitators of cervical cancer screening among women living with HIV attending ART clinics at Tiriri health center IV and Katakwi General hospital
Uganda 2026-04-10 18:01:11 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Patience Atyang Eunice
ID: UNCST-2025-R021360
 FACTORS INFLUENCING INITIATION OF KANGAROO MOTHER CARE AMONG MOTHERS OF PRE-TERM BABIES IN HEALTH FACILITIES OF YUMBE DISTRICT
REFNo: HS7228ES

i. To assess the initiation practices to KMC among mothers of Pre-term babies in the health facilities of Yumbe district, Uganda. ii. To determine the maternal factors associated with initiation to KMC among mothers of Pre-term babies in the health facilities of Yumbe district, Uganda. iii. To determine the healthcare provider factors associated with initiation to KMC among mothers of Pre-term babies in the health facilities of Yumbe district, Uganda.
Uganda 2026-04-10 17:51:06 2029-04-10 Medical and Health Sciences Non-Clinical Trial Degree Award
Kaleab Moges Tesfaye
ID: UNCST-2025-R019103
 Congenital Central Nervous System(CNS) and non CNS Anomalies in Children at Cure Children’s Hospital of Uganda
REFNo: HS7204ES

1.2.1 Primary Objective To describe the congenital CNS and non-CNS anomalies in children treated at CCHU from July 2025 to July 2027 1.2.2 Specific Objectives 1. To determine the burden of congenital CNS anomalies in children treated at CCHU. 2. To describe the epidemiology of congenital CNS anomalies in children treated at CCHU. 3. To describe the common congenital non-CNS anomalies in children with congenital CNS anomalies treated at CCHU. 4. To create a pictorial-clinical illustrative album of the congenital anomalies in children treated at CCHU.
 Ethiopia 2026-04-10 17:49:46 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Simon Peter Okiror
ID: UNCST-2025-R022830
 Building Artificial Intelligence Models for predicting TB risk among HIV/AIDS patients using routine clinical data at the Joint Clinical Research Centre, Kampala-Uganda
REFNo: HS7054ES

1. To assess the feasibility of applying AI-driven TB risk prediction tools at the Joint Clinical Research Centre. 2. To develop an AI-based predictive model for predicting TB risk among HIV/AIDS patients using routinely collected patient data. 3. To evaluate the performance of the developed models in predicting TB risk among HIV/AIDS patients.
Uganda 2026-04-10 17:48:29 2029-04-10 Medical and Health Sciences Non-Clinical Trial Degree Award
Sanya Donald
ID: UNCST-2025-R016737
 FAMILY PLANNING SERVICES UTILIZATION AND HEALTH RELATED QUALITY OF LIFE IN UGANDA: A CASE OF SELF-SETTLED URBAN REFUGEE AND MIGRANT WOMEN IN WEST NILE SUB-REGION.
REFNo: SS4707ES

i. To examine the impact of access to FPS on HRQoL among self-settled urban refugee and migrant women in Uganda, West Nile Sub-Region.
ii. To analyze the influence of availability of FPS on HRQoL among self-settled urban refugee and migrant women in Uganda, West Nile Sub-Region.
iii. To assess the casual association between FPS education (knowledge, information & awareness) and HRQoL among self-settled urban refugee and migrant women in Uganda, West Nile Sub-Region;
iv. To evaluate the moderating effect of patient factors on FPS and HRQoL among self-settled urban refugee and migrant women in Uganda, West Nile Sub-Region.

Uganda 2026-04-10 17:47:19 2029-04-10 Social Science and Humanities Non-Clinical Trial Degree Award
Onesmus Kamacooko
ID: UNCST-2023-R005897
 Caregiver Mental Health, Family Structure, and Positive Parenting:Evidence from the Uganda Parenting for Respectability Program
REFNo: HS6902ES

i. To synthesize evidence on the effectiveness of parenting interventions in enhancing positive parenting practices among multiple caregivers of children aged 0–17 years in Sub-Saharan Africa through a systematic review. ii. To determine the factors associated with depression and anxiety among parents and caregivers of children aged 0-17 years in Uganda. iii. To investigate the longitudinal relationship between caregiver mental health and positive parenting practices over a 12-month follow-up period. iv. To examine the moderating role of family structure in the mediation relationship between intervention effects, caregiver mental health, and positive parenting practices.
Uganda 2026-04-10 17:39:00 2029-04-10 Medical and Health Sciences Non-Clinical Trial Degree Award
GRACE KANSIIME
ID: UNCST-2019-R000380
 REDUCING TB MORTALITY DURING AND AFTER TREATMENT THROUGH SCREENING FOR KIDNEY DYSFUNCTION AND IMPLEMENTATION OF A MORTALITY RISK PREDICTION SCORE IN UGANDA
REFNo: HS7321ES

TO REDUCE TB MORTALITY DURING AND AFTER TREATMENT THROUGH SCREENING FOR KIDNEY DYSFUNCTION AND IMPLEMENTATION OF A MORTALITY RISK PREDICTION SCORE IN UGANDA,2. To explore patients’ views on the provision of nutritional support (meals) during TB care and its influence on adherence and recovery.(secondary),1. To explore healthcare workers’ perspectives on the ease of use and acceptability of point-of-care (POC) creatinine testing in TB care (Secondary),4. To determine one-year outcomes among patients admitted with TB and kidney disease. ,3. To introduce bedside point-of-care (POC) creatinine testing and assess the agreement between POC and laboratory-based creatinine tests in evaluating kidney function among adults admitted with TB,2. To revise the PROS score to include the optimal serum creatinine cut-off as a component and determine the accuracy of the revised score to predict TB mortality. ,To determine the optimal serum creatinine cut-off that predicts mortality among patients admitted with TB in Uganda. ,
 Uganda 2026-04-10 17:37:08 2029-04-10 Medical and Health Sciences Non-degree Award
KIZZA GERALD
ID: UNCST-2021-R012792
 An mHealth-Enabled Social Support Framework to Improve Anti-Diabetes Medication Adherence among Type 2 Diabetes Patients with HIV in Uganda
REFNo: SIR624ES

1. To develop an initial context specific implementation framework for utilizing a mobile phone–enabled social support intervention to enhance anti-diabetes medication adherence among type 2 diabetes patients living with HIV/AIDS in Uganda.

2. To co-design and co-develop an mHealth-enabled social support intervention for medication adherence among Type 2 diabetes patients living with HIV, drawing from the developed implementation framework.

3. To implement the developed intervention and assess its implementation outcomes guided by Proctor framework.

4. To explore the preliminary impact of the intervention on anti-diabetes medication adherence and glycaemic control among participants.

5. To develop an evidence based implementation framework (based on above findings) for utilizing a mobile phone–enabled social support intervention to enhance anti-diabetes medication adherence.

 Uganda 2026-04-10 17:29:34 2029-04-10 Engineering and Technology Non-Clinical Trial Degree Award
ANDREW ACOBI
ID:
KNOWLEDGE, SKILLS, SELF-EFFICACY ON ADOPTION OF RESEARCH EVIDENCE IN PRACTICE AMONG NURSES AT LIRA REGIONAL REFERRAL HOSPITAL, LIRA, UGANDA.
REFNo: HS6844ES

Main Objective
To explore knowledge, skills, and self-efficacy on adopting research evidence in practice among nurses at Lira Regional Referral Hospital (LRRH), Lira City, Northern Uganda.
Specific Objectives or Core Objectives
1. To evaluate level of knowledge on the adoption of research evidence in practice among nurses at LRRH, Lira, Uganda.
2. To assess level of skills on the adoption of research evidence in practice among nurses at LRRH, Lira, Uganda.
3. To evaluate self-efficacy-related adoption of research evidence in practice among nurses at LRRH, Lira, Uganda.

4. To analyze the relationship between knowledge and adoption of research evidence in practice among nurses at LRRH, Lira, Uganda


 Uganda 2026-04-10 17:28:22 2029-04-10 Medical and Health Sciences Non-Clinical Trial Degree Award
Richard Katuramu
ID: UNCST-2022-R011266
 Investigating the Consequences of USAID's suspension of HIV/AIDS Assistance in Tanzania and Uganda: A Multi-Stakeholder Qualitative Study in Uganda and Tanzania
REFNo: HS6630ES

1. To identify list of organizations/institutions previously funded by the USAID to implement different HIV/AIDS services
2. To explore the perception of the different stakeholders on the suspension of USAID funds for HIV/AIDS activities
3. To examine the short term strategies employed by the stakeholders to mitigate the impact of the suspension of USAID funds for HIV/AIDS activities
4. To explore the projected long-term consequences of this funding loss on the HIV/AIDS workforce, program delivery, research and sustainability
5. To assess the different reprioritization strategies and resource allocation in response to the reduced external assistance
6. To explore the different lessons from past funding disruptions and how they can be applied to improve future health system resilience
7. To examine the different roles, if any, do the stakeholders expect from alternative external donors like China

 Uganda 2026-04-10 17:03:11 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
CAROLINE KYOSIIMA MWEBESA
ID: UNCST-2026-R023538
 Baseline and Endline Evaluation of Women's Economic Empowerment and Female Financial Health in Eastern Uganda (Kaliro and Namutumba Districts)
REFNo: SS5052ES

Objective 1 – Baseline documentation: To establish comprehensive baseline conditions (pre-intervention) regarding women's demographic characteristics, livelihood structures, economic activities and income sources, financial service access and financial behaviors, financial knowledge and digital literacy, household economic decision-making participation, gender relations and intra-household dynamics, and experiences of economic empowerment and disempowerment across both intervention and comparison groups in Kaliro and Namutumba districts. Objective 2 – Impact quantification: To measure the impact of WomenSave programming on women's financial inclusion outcomes (financial service access and productive usage), savings behaviors, economic income and diversification, and household economic decision-making participation over six-month and twelve-month periods when compared to similarly-situated a non-beneficiary comparison group. Objective 3: Mechanism exploration: To qualitatively examine the mechanisms through which WomenSave programming generates economic empowerment outcomes, including individual-level pathways, household-level pathways, and community-level pathways. Objective 4: Implementation and context factors: To document implementation realities, institutional coordination mechanisms, contextual enablers and barriers, and sustainability factors associated with WomenSave programming integration within PDM structures for program improvement, replication, and scaling.
Uganda 2026-04-10 16:52:20 2029-04-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Sandra Asizu
ID: UNCST-2026-R024434
 BASELINE SURVEY FOR THE COLLECTIVE ACTION FOR DISABILITY RIGHTS PROGRAMME
REFNo: SS5049ES

I.Provide quantitative and qualitative baseline values for the programme’s outcome and impact indicators.
II.Assess the inclusivity and accessibility of education, health, economic, and social systems for persons with disabilities (PWDs).
III.Evaluate the institutional capacity and operational effectiveness of Organizations of Persons with Disabilities (OPDs).
IV.Inform programme implementation strategies, adaptive management, and subsequent endline evaluations.
 Uganda 2026-04-10 16:26:42 2029-04-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Lydia Nakiyingi
ID: UNCST-2022-R010102
 Investigating the Mycobacterium tuberculosis-respiratory viruses pathogenesis markers that can be explored for prognosis, diagnosis and disease progression during coinfections.
REFNo: HS7209ES

Primary Objective

-To investigate the pathogenesis markers associated with MTB-respiratory virus co-infection and explore their applications in prognostics, diagnostics, and disease management.

Secondary objectives:

-To identify respiratory viruses that are associated with TB-infected individuals in Makerere University clinical facility.

-To identify and characterize molecular and immunological markers associated with the interaction between MTB and respiratory viruses through immunological assays.

-To elucidate the mechanistic insights underlying the dysregulation of host immune responses in MTB-respiratory virus co-infection through transcriptomics tools.

-To design a statistical algorithm that can be a predictive model of TB-respiratory virus coinfections using immunological and transcriptomics data.

 Uganda 2026-04-10 15:53:46 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Agaba Winston David
ID: UNCST-2026-R023332
 TRANSFORMATION LEADERSHIP, ORGANIZATIONAL CULTURE AND ORGANIZATIONAL PERFORMANCE IN UGANDA’S PUBLIC AND COMMERCIAL BROADCASTING SECTOR
REFNo: SS4916ES

Aligned with the main objective, this study seeks to achieve the following: i. To examine the association between Idealized Influence and Organizational Performance in Uganda’s public and commercial broadcasting sectors. ii. To assess the relationship between Inspirational Motivation and Organizational Performance in Uganda’s public and commercial broadcasting sectors. iii. To analyze the influence of Intellectual Stimulation on Organizational Performance in Uganda’s public and commercial broadcasting sectors. iv. To evaluate the effect of Individualized Consideration on Organizational Performance in Uganda’s public and commercial broadcasting sectors. v. To investigate the moderating role of Organizational Culture on the relationship between Transformational Leadership and Organizational Performance in Uganda’s public and commercial broadcasting sectors. vi. To empirically develop and validate a conceptual model that integrates transformational leadership practices with supportive organizational culture to enhance organizational performance in Uganda’s public and commercial broadcasting sectors.
Uganda 2026-04-10 15:46:36 2029-04-10 Social Science and Humanities Non-Clinical Trial Degree Award
HARRIET NAMBUYA NIL
ID: UNCST-2021-R013414
 Implementation of WHO minimum Maternal and Newborn Health data set in standardized Intrapartum care register and case notes at Jinja Regional Referral and Kamuli General Hospitals in Uganda
REFNo: HS7185ES

1.4 General objective
The aim of the study is to test improvement in the quality of routinely collected data elements necessary to monitor intrapartum maternal and immediate newborn health in hospitals from settings with high burden of maternal and newborn mortality and morbidities, upon implementation of a designed IPC register and obstetric CN.
1.5 Specific objectives of the study

1. To Design a globally standardized IPC register and selected obstetric CN for interprofessional teams involved in RHIS data collection and use in healthcare facilities
2. Test the feasibility and acceptability of implementing the designed IPC register and selected designed obstetric CN in selected healthcare facilities
a) Measure the completeness of intrapartum and immediate postnatal care data elements (including mMNHDS), documented before and after implementation of the designed register and CN.
b) Assess user-experience of the designed IPC register and CN.
c) Assess completeness and quality of the data elements required to inform the mMNHDS during intrapartum care depending on the level of care (lower level versus referral hospital).
3. Identify barriers and challenges encountered by health staff in implementing the standardized IPC register and obstetric case notes.

 Uganda 2026-04-10 15:40:35 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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