Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Simon Peter Kibira Peter Sebina
ID: UNCST-2019-R000492
Evaluation of feasibility, acceptability and cost of implementing a Multiple First-line Therapies strategy for treatment of uncomplicated malaria in Uganda
REFNo: HS6995ES

1. To evaluate the process of co-design (stakeholder participation, inclusiveness, decision-making mechanisms, and alignment with policy processes). 2. To evaluate the outputs of co-design, including whether the resulting MFT models are feasible, contextually appropriate, and aligned with national policies and system capacities. 3. To implement, document and iteratively adapt MFT strategies, assessing feasibility, fidelity, acceptability and contextual adaptation across delivery settings. 4. To identify and assess the policy, supply chain, and health system factors – including stakeholder engagement – that influence implementation and decisions on scale-up across sectors. 5. To evaluate the cost, cost drivers, and overall cost impact of implementing and sustaining MFT models implemented across the four countries in diverse health system contexts.
Uganda 2026-02-20 15:16:41 2029-02-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ruth Kigozi Nassali
ID: UNCST-2021-R013025
Optimizing Malaria Surveillance: National-level Review of approaches, tools and interventions to inform innovative strategies for Uganda
REFNo: SS4862ES

2.1 Study Aim: • To assess the impact, experiences and outcomes of malaria surveillance interventions, approaches and tools in Uganda. 2.2 Study Objectives: • To investigate the effects of interventions, approaches and tools aimed at improving malaria surveillance system performance, data quality, and data use. • To systematically identify surveillance strengthening challenges and existing evidence-informed solutions critical for impact and provision of value for money.
Uganda 2026-02-20 15:12:21 2029-02-20 Social Science and Humanities Non-Clinical Trial Non-degree Award
Balaamsikina Mwasa
ID: UNCST-2025-R022991
FINANCIAL MANAGEMENT REFORMS AND FINANCIAL ACCOUNTABILITY AMONG SELECTED PUBLIC SECTOR ORGANIZATIONS IN UGANDA
REFNo: SS4822ES

I. Evaluate the effect of structural financial management reforms on financial accountability in selected public sector organizations in Uganda.
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II. Assess the effect of policy-related financial management reforms on financial accountability in selected public sector organizations in Uganda.
III. Examine the effect of technological financial management reforms on financial accountability in selected public sector organizations in Uganda.
IV. Analyse the influence of audit and internal control reforms on financial accountability in selected public sector organizations in Uganda.
V. Determine the effect of revenue management reforms on financial accountability in selected public sector organizations in Uganda.
VI. Examine the moderating effect of institutional culture on the relationship between financial management reforms and financial accountability in selected public sector organizations in Uganda.
Uganda 2026-02-20 15:11:19 2029-02-20 Social Science and Humanities Non-Clinical Trial Degree Award
GEOFFREY OCEN
ID: UNCST-2025-R022953
Tuberculosis Treatment Outcomes and associated factors among patients receiving treatment at Dokolo HCIV, Northern Uganda
REFNo: HS7060ES

General Objective To measure Tuberculosis (TB) treatment outcomes and associated factors among patients receiving treatment at Dokolo HCIV in Northern Uganda. Specific Objectives 1.To describe the TB treatment outcomes among patient’s receiving treatment at Dokolo HCIV 2.To determine the proportion of patients achieving successful TB treatment outcomes 3.To identify Socio-demographic factors associated with TB treatment outcomes 4.To investigate the clinical factors associated with TB treatment outcomes
Uganda 2026-02-20 15:09:10 2029-02-20 Medical and Health Sciences Non-Clinical Trial Degree Award
Joan Kekimuri
ID: UNCST-2025-R021625
MUJAGUZO ROYAL DRUM OF BUGANDA KINGDOM: CHRONICLES OF ITS ORIGIN, MEANING-MAKING, AND CONTINUITY
REFNo: SS4868ES

1. To document the history of the Mujaguzo royal drum. 2. To identify qualities of Mujaguzo Royal Drum as a mystical art form. 3. To disinter the rituals that encompass interregnum meaning of oral continuity from one rule to another 4. To visually interpret the mystical meaning attached to Mujaguzo royal drum through visual art.
Uganda 2026-02-20 15:08:03 2029-02-20 Social Science and Humanities Non-Clinical Trial Non-degree Award
Anacret Byamukama
ID: UNCST-2023-R007193
Prevalence and predictors of structural lung abnormalities among people with and without latent TB infection in rural Uganda
REFNo: HS3537ES

To identify potential predictive factors associated with structural lung abnormalities among people with LTBI compared to those without, exploring demographic, clinical, and environmental variables,To examine the patterns and distribution of structural lung abnormalities in adults with LTBI compared to those without, within southwestern Uganda. ,To assess the prevalence of structural lung abnormalities among people with and without LTBI in a population-based cohort within southwestern Uganda.,To examine the prevalence, patterns, distribution and predictors of structural lung abnormalities among adult people with and without latent TB infection (LTBI) within south-Western Uganda,
Uganda 2026-02-20 14:15:05 2029-02-20 Medical and Health Sciences Non-Clinical Trial Degree Award
Ibrahim Wanyama
ID: UNCST-2025-R017076
CIRcularity of Nutrients in AgroecoSystems and co-benefits on animal and human health (CIRNA)
REFNo: A670ES

The main objective of CIRNA is the development, assessment, and promotion of farmerapproved, lab- and field-tested manure management practices for smallholders that ensure better organic fertilizer quality, health and safety for humans, animals, and the environment, are socially inclusive and improve peoples’ livelihoods. The following are the objectives under this study Research objectives: Objective 1: To characterize manure management practices and feed basket composition in smallholder mixed crop-pig production systems in Uganda and their relationships to manure chemical and zoonotic pathogen/parasite composition. Objective 2: To determine the chemical and zoonotic pathogen/parasite composition of manure in smallholder crop-pig production systems in Uganda, and establish the relationship between manure composition and manure management practices. Objective 3: To quantify nutrient losses from selected manure management interventions in smallholder mixed crop-pig production systems through a mass balance approach and evaluate the fertilizer value of the produced manure. Objective 4: To access the performance of agricultural production, market integration, nutrition and food security, poverty, and gender across the different dimensions of sustainability using the Objective 5: To evaluate effects of selected manure management interventions on occurrence of microbial indicator species in smallholder mixed crop-pig production systems
Uganda 2026-02-20 14:11:36 2029-02-20 Agricultural Sciences Non-Clinical Trial Non-degree Award
Brenda Ogutu
ID: UNCST-2025-R021834
Understanding Community Communication and Pro-Social Engagement in Uganda: A Behavioral System Mapping Approach
REFNo: SS4873ES

This study aims to identify structural and behavioral factors (drivers, barriers, and levers) that
influence either increasing or decreasing prosocial engagement across different population
segments in Uganda, using a systems perspective. The goal is to use these insights to design
and test contextually grounded behavioral interventions that enable and empower civil
society organizations (CSOs) to influence and enhance prosocial engagement in the country.
This study will also apply the COM-B model as follows:
● Capability: Evaluating citizens' knowledge and skills to participate.
● Opportunity: Examining how access to information and spaces for engagement
either promote or hinder prosocial engagement.
● Motivation: Analyzing how beliefs, norms, and trust shape the willingness to
participate in prosocial activities.
Each research question will be aligned with the COM-B dimensions
Kenya 2026-02-18 12:56:59 2029-02-18 Social Science and Humanities Non-Clinical Trial Non-degree Award
Bastien Dieppois Patrice Laurent
ID: UNCST-2025-R022798
Royal Society APEX Award - Foreseeing Management of Emerging Unprecedented Hydroclimatic Extremes to Embrace Resilience in Sub-Saharan African Communities
REFNo: NS1150ES

To develop a comprehensive and transferable framework for the robust assessment and management of future hydroclimatic risks across SSA, integrating regional climate science, socio-ecological equity considerations, and long-term decision-making, using Uganda as a demonstrative case study. The research has three specific objectives (SO): [SO1] To model regional climate changes across Sub-Saharan Africa and identify plausible but unprecedented hydroclimatic extremes likely to emerge during the 21st century, with focused high-resolution climate risk assessment analysis for Uganda. [SO2] To co-identify socio-ecologically equitable adaptation priorities with Ugandan stakeholders, and to compare these insights with SSA-wide patterns captured through an online survey, thereby informing broader NbS planning frameworks. [SO3] To co-develop and evaluate long-term decision-making approaches that evaluate whether NbS benefits can be sustained in Uganda in the face of emerging unprecedented floods and droughts, with scalable implications for SSA
France 2026-02-18 12:50:40 2029-02-18 Natural Sciences Non-Clinical Trial Non-degree Award
Rik Lubbers
ID: UNCST-2025-R021634
Exploring Vulnerability and Resilience in Accessing and Providing Nutrition-Sensitive Maternal and Child Health Services During Floods, Droughts, and Compound Events in Katakwi, Uganda: A Multi-Hazard Qualitative Study.
REFNo: HS7019ES

To characterise how floods, droughts, and compound climate events shape vulnerability and resilience in accessing and providing nutrition-sensitive maternal and child health services in Katakwi District, Uganda. Specific objectives: To describe caregivers’ perceived access barriers and decision-making during and after floods, droughts, and compound events. To assess perceived facility-level constraints affecting continuity of maternal and child health services across referral tiers. To document household, provider, and facility-level adaptation strategies that sustain or restore services. To generate actionable, tier-specific recommendations for district preparedness and response.
Netherlands 2026-02-18 12:49:03 2029-02-18 Medical and Health Sciences Non-Clinical Trial Degree Award
raymond Kihumuro bernard
ID: UNCST-2021-R013303
Assessing the Readiness and Contextual Feasibility for Leveraging Interactive Voice Response (IVR) for Depression. Screening Among Adolescents and Young People Living with HIV in Uganda: A Formative Mixed- Methods Study
REFNo: HS7109ES

To examine stakeholder perspectives on how Interactive Voice Response (IVR) for depression screening could be integrated into the HIV care continuum.,To explore the factors influencing depression screening among adolescents and young people living with HIV (AYPLHIV).,Understand factors influencing depression screening of AYPLHIV, explore how IVR for depression screening could be integrated into the HIV care continuum.,Determine accessibility to IVR-capable phones and IVR user preferences among AYPLHIV.,
Uganda 2026-02-18 12:46:14 2029-02-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Deborah Kirabo
ID: UNCST-2025-R022547
Documentation of RAHU Peer Education Model
REFNo: SS4727ES

Objective 1: To comprehensively document RAHU\'s Peer Education Model design, implementation mechanisms, and operational approaches across five regions (Kampala, Kasese, Adjumani, Busoga, and Sebei) from 2014 to present

Objective 2: To assess the peer education model\'s performance against its three core program objectives: (a) improving young people\'s access to SRHR information for informed decision-making, (b) reducing risks and promoting individual and collective empowerment about sexual and reproductive health, and (c) strengthening interpersonal communication skills for peer-to-peer SRHR communication

Objective 3: To analyze implementation challenges, success factors, regional adaptations, and lessons learned to generate evidence-based recommendations for model replication, scaling, and policy advocacy.
Uganda 2026-02-18 12:43:08 2029-02-18 Social Science and Humanities Non-Clinical Trial Non-degree Award
Martin Okello
ID: UNCST-2025-R020344
INVESTIGATION OF PLANT-BASED MOSQUITO REPELLENTS FOR VECTOR-BORNE DISEASE CONTROL, ESPECIALLY MALARIA IN RURAL UGANDA: A MIXED METHODS APPROACH
REFNo: HS7051ES

4. To gain more understanding through existing literature/research about Lantana camara (LC) plants and other repellent/herbal plants in relations to vector borne diseases, especially malaria control/prevention in rural Uganda.
5. To collect information regarding attitude, knowledge, beliefs, and behaviours about Lantana camara (LC) plants and possibly other repellent plants in relation to malaria prevention in rural Uganda.
6. To explore factors associated with implementing the use of plant-based repellent products like Lantana plant extracts or other repellant plants as alternatives to control or prevent malaria in rural Uganda, including the feasibility, acceptability and sustainability of such approaches.

Uganda 2026-02-18 12:32:51 2029-02-18 Medical and Health Sciences Non-Clinical Trial Degree Award
raymond Kihumuro bernard
ID: UNCST-2021-R013303
Depression Assessment in Adolescents and Young People Living with HIV in Uganda using Interactive Voice Response (DAIVR): A Pilot Feasibility Study
REFNo: HS7107ES

2. Evaluate the feasibility, acceptability, performance, and screening yield of DAIVR.,1. Explore healthcare workers’ (HCW) and AYPLHIV’s preparedness for integrating IVR-based PHQ-2 screening into routine care.,
Uganda 2026-02-18 12:28:27 2029-02-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
DAVID KITYA
ID: UNCST-2022-R009620
Quality of life in postoperative neurosurgical patients: decompressive hemicraniectomy with delayed cranioplasty versus hinge craniotomy in low-resource settings
REFNo: HS6653ES

Provide Recommendations: Develop evidence-based guidelines for surgical practices in resource-limited settings, prioritizing interventions that optimize long-term QoL,Analyze Contextual Factors: Identify patient and caregiver demographic and clinical factors influencing QoL outcomes.,Evaluate Caregiver Impact: Examine how the two surgical interventions affect caregiver QoL, including their psychological well-being and caregiving burden.,Assess QoL: Use modifications of validated surveys (e.g., Neuro-QoL surveys) to evaluate physical, cognitive, emotional, and social QoL outcomes in patients.,To compare and evaluate the long-term QoL outcomes of patients undergoing DHC without cranioplasty and HC, focusing on physical, cognitive, emotional, and social domains, as well as the perspectives of their caregivers​.,
Uganda 2026-02-18 12:22:28 2029-02-18 Medical and Health Sciences Non-degree Award
moiti MoitiEriya
ID: UNCST-2024-R016141
LIFE HISTORY TRAITS OF VARROA MITE (Varroa destructor) AND ITS EFFECT ON HONEYBEE COLONY PERFORMANCE IN SELECTED AGRO-ECOLOGICAL ZONES IN UGANDA
REFNo: NS1167ES

To determine the effect of Varroa infestation levels on colony performance of Apis mellifera colonies in Lake Victoria crescent and the Eastern agro-ecological zones of Uganda.,To assess the effect of honeybee hygienic behavior and swarming behaviour on Varroa infestation levels in Apis mellifera colonies in Lake Victoria crescent and the Eastern agro-ecological zones of Uganda.,To assess life history traits of Varroa mites infesting Apis mellifera colonies in Lake Victoria crescent and the Eastern agro-ecological zones of Uganda.,To assess temporal Varroa infestation levels in Apis mellifera colonies in Lake Victoria crescent and the Eastern agro-ecological zones of Uganda.,To evaluate Varroa reproductive success so that its impact on honeybee colony performance is established.,
Uganda 2026-02-18 12:20:50 2029-02-18 Natural Sciences Non-Clinical Trial Degree Award
Mark Jordans
ID: UNCST-2020-R014861
MENTAL HEALTH SYSTEMS AND A MENTAL HEALTH CARE PACKAGE FOR CHILDREN IN SELECTED REFUGEE SETTLEMENTS IN UGANDA (PAMOJA TUNAWEZA): PARTICIPATORY SYSTEM DYNAMICS AND CLIENT JOURNEYS
REFNo: SS4795ES

Objectives: 
This study aims to identify and evaluate key factors affecting the implementation and performance of a mental health care system in real-world settings.
Specific Research objectives and research questions:
1. To assess how well the mental health care system integrates and is compatible with existing mental healthcare services, infrastructure, and practices, both formal and informal with a particular focus on adolescent mental health.  
Research Question 1: Exploring how the mental health care system integrates, or is compatible, with existing mental health systems for adolescent mental health

2. To examine client experiences within the care system and identify opportunities to optimize service delivery and outcome.
Research Question 2: Evaluating the client experience, how this can be optimized within the care system

Netherlands 2026-02-18 12:19:41 2029-02-18 Social Science and Humanities Non-Clinical Trial Non-degree Award
Bernard Mwesigye
ID: UNCST-2024-R016003
Delayed Door-to-Doctor time and associated factors among high acuity patients at the Accidents and Emmergency Unit of Mbarara Regional Referral Hospital
REFNo: HS6376ES

General:To assess the proportion of patients with delayed Door-to-Doctor time and associated factors among high acuity patients at the Accidents and Emergency Unit at Mbarara Regional Referral Hospital.
Specific objectives:
•To determine the proportion of high acuity patients with delayed Door-to-Doctor time at the Accidents and Emergency Unit of Mbarara Regional Referral Hospital.
●To determine the factors associated with delayed Door-to-Doctor time of high acuity patients at the Accidents and Emergency Unit of Mbarara Regional Referral Hospital.

Uganda 2026-02-18 12:16:08 2029-02-18 Medical and Health Sciences Non-Clinical Trial Degree Award
Moses Joloba Lutaakome
ID: UNCST-2022-R011558
LONG TERM CARDIAC AND PULMONARY CONSEQUENCES OF TB (LONG TB)
REFNo: HS6945ES

Establish a sample repository for future: a) host and M.tb whole genome sequencing for genome wide association studies, b) non-targeted multi-omic (transcriptome, proteome, metabolome) analysis and, c) targeted inflammatory/immunological pathway analysis,Characterize the prevalence, clinical presentation, and progression of sub-clinical CVD – a surrogate measure for subsequent PTCVD risk – among successfully treated adult drug-sensitive pulmonary TB cases,Characterize the prevalence, clinical presentation, and progression of PTLD among successfully treated adult drug-sensitive pulmonary TB cases,The overarching goal of this proposal is to establish a well characterized cohort of pulmonary TB patients with prospective cardio-pulmonary assessments and sample repository during and after treatment for comprehensive clinical phenotyping and immunological endotyping of post-TB sequelae,
Uganda 2026-02-18 12:14:31 2029-02-18 Medical and Health Sciences Non-degree Award
Natalia Marina Maure Marina
ID: UNCST-2024-R003148
Burden of cardiovascular disease risk factors among patients with tuberculosis in the karamoja sub-region of uganda. A cross-sectional survey
REFNo: HS6547ES

Primary objective: •Estimate the burden of CVD risk factors among TB patients at Matany and Moroto hospitals Secondary objectives: •Compare the burden of CVD risk factors between TB patients at Matany and Moroto hospitals and the burden of CVD risk factors in the Ugandan general population •Contrast the burden of CVD risk factors among TB inpatients and outpatients •Secondary Endpoint 2: Prevalence of CVD risk factors in TB inpatients and outpatients •Determine the 10-year cardiovascular event risk using the WHO/ISH risk prediction charts •Describe the associations between TB disease characteristics (pulmonary vs. extrapulmonary, drug-resistant vs. drug-susceptible, HIV co-infection status) and cardiovascular risk profiles
Italy 2026-02-18 12:13:03 2029-02-18 Medical and Health Sciences Non-Clinical Trial Degree Award
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