Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
JOHN ISIIKO
ID: UNCST-2022-R011328
 Dose Rounding of Parenteral Chemotherapy Drugs at Uganda Cancer Institute: A Cost-Saving Strategy
REFNo: HS7273ES

To determine the potential cost-savings associated with a 10% dose rounding at the UCI – MRCC.,To identify the drugs with high cost-saving potential after a 10% dose rounding at the UCI – MRCC.,To determine the proportion of prescribed chemotherapy doses that qualify for dose rounding at the UCI – MRCC. ,The study aims to evaluate the feasibility of a 10% dose rounding of chemotherapy drugs as a cost-saving strategy at the UCI – MRCC. ,
 Uganda 2026-04-10 18:33:33 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
AMBROSE SSERUNJOGI
ID: UNCST-2025-R017987
 ANALYSIS OF TRICYCLE PASSENGER CAR UNIT VALUES FOR ENHANCED TRAFFIC FLOW IN KAMPALA CITY UGANDA.
REFNo: SIR629ES

i. To determine static Passenger Car Unit (PCU) values for passenger and cargo tricycles at selected Kampala intersections, targeting a precision of ±0.1 PCU. ii. To compare the derived tricycle PCU values against local values for motorcycles (boda-bodas) and passenger cars to quantify their relative impact on saturation flow. iii. To model the influence of dynamic factors specifically congestion level (V/C ratio), time of day, and wet/dry pavement conditions on tricycle PCU estimates.
 Uganda 2026-04-10 18:31:17 2029-04-10 Engineering and Technology Non-Clinical Trial Degree Award
Emmanuel Sendaula
ID: UNCST-2020-R014767
 A Stepped-Wedge Evaluation of an Integrated Maternal and Newborn Health Model for Pastoralist Communities in Karamoja, Uganda
REFNo: HS7225ES

Assess the effectiveness, feasibility, acceptability, fidelity, equity, and scalability of the integrated intervention using a stepped-wedge design.,Improve birth preparedness, early care-seeking, and timely referral through participatory women’s groups and community-managed emergency transport.,Strengthen emergency maternal and newborn care capacity among health workers, Village Health Teams, and Traditional Birth Attendants through simulation-based Helping Babies Breathe and Helping Mothers Survive training and continuous mentorship.,To evaluate the effectiveness and implementation of an integrated maternal and newborn health model aimed at reducing preventable maternal and newborn morbidity and mortality in the pastoralist districts of Moroto and Napak.,
 Uganda 2026-04-10 18:29:56 2029-04-10 Medical and Health Sciences Non-degree Award
Ibrahim Twinomujuni
ID: UNCST-2024-R001873
 Facilitators and barriers for enrollment of Non-suppressing Children and Adolescents living with HIV into Integrated Community Service Delivery Model (ICSDM) and its treatment outcomes in rural public HIV clinics – East central region Uganda.
REFNo: HS7088ES

To determine enrollment, retention, viral load suppression, and associated factors among non -suppressing CALHIV enrolled on ICSDM in rural public HIV clinics between October 2023 to date.
To explore facilitators and barriers to enrollment of non-suppressing CALHIV into the ICSDM in rural public HIV clinics between October 2023 to date

 Uganda 2026-04-10 18:28:02 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ibrahim Ali Fauzi
ID: UNCST-2022-R010478
 Assessing Snakebite Envenoming in Rural Gulu, Uganda: Prevalence, Impact, and Climate Change Implications
REFNo: HS7325ES

Main Objective: To determine the burden and prevalence of SBE and to determine the extent of community understanding and awareness regarding climate change as a potential driver of snakebite incidence in rural Gulu District, Uganda Specific Objectives: 1. To determine the prevalence and health outcomes of SBE in rural Gulu District. 2. To determine the burden associated with SBE at the individual and community level. 3. To determine community knowledge, attitudes, and awareness regarding SBE and climate change as a potential driver of its incidence.
 Uganda 2026-04-10 18:26:00 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
BONIFACE OJOK
ID: UNCST-2023-R006075
 Youth Futures: Youth-led initiatives for gender justice & peacebuilding in Uganda
REFNo: SS5048ES

4.4. General Objective

The general objective of the Youth Futures project is to use video documentation and participatory video approaches to identify, document, assess, and amplify the needs of children born of war in the Acholi sub-region, and to provide them with necessary livelihood skills in filmmaking, knowledge production, and advocacy.

4.5. Specific Objectives

The specific objectives of the project are:

1. To document and analyze the experiences of children born of war in the Acholi sub-region, including their challenges, needs, and aspirations.

2. To assess the impact of humanitarian, health, and education interventions on the well-being of children born of war in the Acholi sub-region.

3. To enhance youth engagement in research and peacebuilding processes, promoting the participation and empowerment of children born of war.

4. To provide livelihood skills in filmmaking, knowledge production, and advocacy to youth participants, enabling them to become agents of change in their communities.
 Uganda 2026-04-10 18:24:09 2029-04-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Paul Lobe
ID: UNCST-2025-R022156
 UNSYSTEMATIC RISK FACTORS, AUDIT COMMITTEE EFFECTIVENESS AND FINANCIAL PERFORMANCE OF COMMERCIAL BANKS IN UGANDA
REFNo: SS4998ES

1-To establish the effect of credit risk on the financial performance of commercial banks in Uganda
2-To examine the effect of liquidity risk on the financial performance of commercial banks in Uganda
3-To determine the effect of operational risk on the financial performance of Commercial banks in Uganda
4a. To investigate the moderating effect of audit committee effectiveness on the relationship between credit risk and the financial performance of commercial banks in Uganda
4b. To determine the moderating effect of audit committee effectiveness on the relationship between liquidity risk and the financial performance of commercial banks in Uganda
4c. To examine the moderating effect of audit committee effectiveness on the relationship between Operational risk and the financial performance of commercial banks in Uganda

 Uganda 2026-04-10 18:21:31 2029-04-10 Social Science and Humanities Non-Clinical Trial Degree Award
Daniel  Emoru Reagan
ID: UNCST-2025-R020048
 Adaptation and Validation of the Pictorial Fit-Frail Scale Among Older Persons Living with HIV At the Infectious Disease Institute, Kampala.
REFNo: HS7239ES

General Objective: To culturally adapt and validate the standard Pictorial Fit-Frail Scale(self-assessment) against the Fried Frailty Phenotype Scale for frailty screening among OPLWH aged ≥50 years at the Infectious Disease Institute, Kampala.

Specific Objectives
To culturally adapt and validate the standard Pictorial Fit-Frail Scale(self-assessment) against the Fried Frailty Phenotype Scale for frailty screening among OPLWH aged ≥50 years at the Infectious Disease Institute, Kampala.
1.4.2. SPECIFIC OBJECTIVES
(i) To culturally adapt the PFFS among OPLWH aged ≥ 50 years at the infectious disease institute, Kampala, by assessing comprehension of its 14 pictorial domains and modifying images as needed for the Ugandan context.
(ii) To determine the diagnostic validity of the PFFS compared to FFP scale for frailty screening among OPLWH aged ≥50 years at the Infectious Disease Institute, Kampala.
(iii) To determine the level of agreement between frailty classifications obtained using the PFFS and FFP among OPLWH aged ≥50 years at the Infectious Disease Institute, Kampala.


 Uganda 2026-04-10 18:20:22 2029-04-10 Medical and Health Sciences Non-Clinical Trial Degree Award
John Mugwanya Mulo
ID: UNCST-2026-R023496
 Digital Media and Malaria Vaccine: Perceptions of Parents with Children Under Five in Wakiso and Karenga Districts, in Uganda
REFNo: SS5060ES

In general, the research will understand the perceptions of parents with children under five years of age on the influence of digital media on the uptake of the malaria vaccine in Wakiso and Karenga Districts. Specifically, it will: explore how parents of children under five in Wakiso and Karenga Districts in Uganda perceive the influence of digital media on malaria vaccine acceptance, identify barriers and facilitators to malaria vaccine uptake shaped by digital media exposure and develop qualitative insights and recommendations for leveraging trusted digital media channels to enhance malaria vaccine uptake, complementing interventions like vector control, case management, chemoprevention and surveillance.
 Uganda 2026-04-10 18:17:56 2029-04-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
William Worodria Ofuti
ID: UNCST-2022-R010915
 Program for Rifampicin-Resistant Disease with Stratified Medicine for TB” (PRISM-TB)
REFNo: HS7398ES

To identify, among participants with fluoroquinolone-susceptible multidrug-resistant/rifampicin-resistant tuberculosis (FQ-S MDR/RR-TB), the preferred BPaLM strategy of 13 or 17 weeks for participants stratified to receive shorter treatment and 17 or 24 weeks for participants stratified to receive longer treatment, as defined by a prespecified stratification algorithm, and to evaluate whether this BPaLM strategy has noninferior efficacy to the control strategy at Week 73.

1. To evaluate whether a BPaLM strategy of 17 weeks for participants stratified to receive shorter treatment and 24 weeks for participants stratified to receive longer treatment, as defined by a prespecified stratification algorithm, has superior DOOR probability to the control strategy combining efficacy at the end of follow-up (a minimum of 28 weeks post-randomization) and safety at 28 weeks post-randomization.
2. To evaluate whether a BPaLM strategy of 17 weeks for all participants has superior DOOR probability to the control strategy combining efficacy at the end of follow-up (a minimum of 28 weeks post-randomization) and safety at 28 weeks post-randomization.
3. To evaluate whether a BPaLM strategy of 13 weeks for participants stratified to receive shorter treatment and 24 weeks for participants stratified to receive longer treatment, as defined by a prespecified stratification algorithm, has superior DOOR probability to the control strategy combining efficacy at the end of follow-up (a minimum of 28 weeks post-randomization) and safety at 28 weeks post-randomization.
4. To evaluate whether a BPaLM strategy of 13 weeks for participants stratified to receive shorter treatment and 17 weeks for participants stratified to receive longer treatment, as defined by a prespecified stratification algorithm, has superior DOOR probability to the control strategy combining efficacy at the end of follow-up (a minimum of 28 weeks post-randomization) and safety at 28 weeks post-randomization.
5. To compare the proportion of participants who experience grade 3 or higher adverse events by Week 28 in the preferred BPaLM strategy to the control strategy.
6. To compare the proportion of participants who experience adverse events of special interest by Week 28 in the preferred BPaLM strategy to the control strategy.
7. To compare the proportion of participants who experience a TB-related unfavorable outcome at Week 73 on the preferred BPaLM strategy with the control strategy, among participants stratified to receive shorter treatment.
8. To compare the proportion of participants who experience a TB-related unfavorable outcome at Week 73 on the preferred BPaLM strategy with the control strategy, among participants stratified to receive longer treatment.
9. To evaluate the pharmacokinetics of all drugs in the BPaLM regimen with an additional focus on bedaquiline elimination (Stages 1 and 2).
10. To determine the dose-response and exposure-response relationships between study drug estimated PK parameters with efficacy and toxicity (Stages 1 and 2).
11. To evaluate the feasibility and acceptability of treatment stratification in the context of treatment for MDR/RR-TB from the participant and the health system perspective (Stages 1 and 2).
 Uganda 2026-04-10 18:15:27 2029-04-10 Medical and Health Sciences Clinical Trial Non-degree Award
Kimuli NamyaloAngella
ID: UNCST-2025-R022072
 PREVALENCE OF HELICOBACTER PYLORI, ASSOCIATED FACTORS AND MAGNITUDE OF RESISTANCE AGAINST FIRST LINE ANTIBIOTICS AMONG CHILDREN PRESENTING WITH GASTRO-INTESTINAL SYMPTOMS AT HOLY INNOCENTS CHILDREN’S HOSPITAL, SOUTHWESTERN UGANDA
REFNo: HS6980ES

1. To determine the prevalence of H. pylori infection among children aged 1-16 years at Holy Innocents Children’s Hospital, southwestern Uganda 2. To assess the factors associated with the presence of H. pylori among children presenting with gastrointestinal symptoms at Holy Innocents Children’s Hospital, Southwestern Uganda 3. To determine the proportion of H. pylori strains that possess resistance genes to Amoxicillin, metronidazole and clarithromycin among the children population at Holy Innocents Children’s Hospital, Southwestern Uganda
 Uganda 2026-04-10 18:12:39 2029-04-10 Medical and Health Sciences Non-Clinical Trial Degree Award
ASIPHAS OWARAGANISE
ID: UNCST-2026-R023544
 Licensing Foreign Trained Doctors and Dentists in Uganda: Performance and Stakeholder Perspectives, 2015-2025.
REFNo: HS7299ES

Our overarching goal is to generate robust, mixed-methods evidence detailing trends, grades, and the perspectives of FTDs and their examiners to inform the professional council’s policies on licensure and workforce integration. Specifically, we will i) characterize the structural attributes and outcome performance of FTDs seeking licensure in Uganda, and ii) explore stakeholder experiences and perceptions of the medical licensure process for FTDs, situating findings within the context of evolving regional health workforce policies
 Uganda 2026-04-10 18:11:34 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sally Hargreaves
ID: UNCST-2025-R022294
 Designing for Immunization: A Co-design Thinking Approach to Improving Catch-up Vaccination among South Sudanese Refugees in Uganda (TUKU-VAC Study)
REFNo: HS7289ES

This project aims to explore the drivers of catch-up vaccination uptake among South Sudanese refugees in Uganda and to co-design community-led solutions using a participatory, design thinking research approach. Refugees often face significant challenges in accessing vaccinations, including limited healthcare access, vaccine hesitancy, misinformation, and systemic barriers. This study seeks to gain a deeper understanding of these issues and develop culturally appropriate, sustainable strategies to improve uptake of essential catch-up vaccines. The study will utilise an adapted version of the World Health Organization’s Behavioural and Social Drivers (BeSD) of vaccination framework to examine the key social behavioural factors influencing vaccine uptake among migrants and refugees’ population. This framework considers four key domains: individuals’ cognitive and emotional responses to vaccine-preventable diseases and vaccines, the influence of social norms and recommendations, the level of motivation and willingness to be vaccinated, and the practical barriers individuals encounter when attempting to access vaccination services. In parallel, a complementary healthcare provider survey adapted from a CDC-developed knowledge, attitudes, and practices (KAP) survey on catch-up vaccination, previously implemented in a national study in the United States will be used to assess the knowledge, practices, and system-level barriers affecting the delivery of catch-up vaccination services to refugees. This tool covers four core domains: demographic and professional characteristics; knowledge and awareness of catch-up vaccination; service delivery practices; and perceived enablers and barriers to vaccine provision. The research will be conducted in collaboration with refugee communities and healthcare providers to ensure that interventions are locally relevant, practical, and effective. Through qualitative interviews and participatory co-design workshops, refugees and healthcare providers will collectively identify challenges and develop solutions that align with their needs and lived experiences.
 UK 2026-04-10 18:09:36 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Richard Idro
ID: UNCST-2021-R013599
 Dihydroartemisinin-piperaquine for the post-discharge management of children with severe acute malnutrition in Malawi and Uganda; A multicentre, parallel-group, two-arm, randomised, double-blind superiority trial [Short Title: Post-discharge Malaria Chemoprevention - SAM (PDMC-SAM)]
REFNo: HS7291ES

To determine if 4 months of PDMC with dihydroartemisinin piperaquine (DP) compared to placebo is superior in reducing hospital readmissions and death by 6 months in children aged <5 years admitted with ‘SAM’ who are clinically stable and ready to be discharged to OTC.,
 Uganda 2026-04-10 18:06:21 2029-04-10 Medical and Health Sciences Clinical Trial Non-degree Award
alfred andama andama
ID: UNCST-2022-R011051
 Evaluation of a novel molecular platform for MTB detection using contrived oral swab samples
REFNo: HS6821ES

To compare the performance of the BLINK X shaker with the reference lysis method,To optimize the lysis protocol for MTB detection from contrived oral samples using the BLINK X Shaker,To estimate the analytical sensitivity of the BLINK dPCR laboratory detection platform for MTB detection using contrived oral swab samples.,
 Uganda 2026-04-10 18:02:52 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Geofrey Emesu
ID: UNCST-2025-R021670
 UTILIZATION OF CERVICAL CANCER SCREENING SERVICES AMONG WOMEN LIVING WITH HIV IN RURAL NORTH EASTERN UGANDA; A CASE OF SOROTI AND KATAKWI DISTRICTS
REFNo: HS7217ES

1. To estimate the level of uptake of cervical cancer screening among women living with HIV attending ART clinics at Tiriri health center IV and Katakwi General hospital 2. To identify Individual and health facility factors associated with utilization of cervical cancer screening among women living with HIV attending ART clinics at Tiriri health center IV and Katakwi General hospital 3. To explore multi-level barriers and facilitators of cervical cancer screening among women living with HIV attending ART clinics at Tiriri health center IV and Katakwi General hospital
Uganda 2026-04-10 18:01:11 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Patience Atyang Eunice
ID: UNCST-2025-R021360
 FACTORS INFLUENCING INITIATION OF KANGAROO MOTHER CARE AMONG MOTHERS OF PRE-TERM BABIES IN HEALTH FACILITIES OF YUMBE DISTRICT
REFNo: HS7228ES

i. To assess the initiation practices to KMC among mothers of Pre-term babies in the health facilities of Yumbe district, Uganda. ii. To determine the maternal factors associated with initiation to KMC among mothers of Pre-term babies in the health facilities of Yumbe district, Uganda. iii. To determine the healthcare provider factors associated with initiation to KMC among mothers of Pre-term babies in the health facilities of Yumbe district, Uganda.
Uganda 2026-04-10 17:51:06 2029-04-10 Medical and Health Sciences Non-Clinical Trial Degree Award
Kaleab Moges Tesfaye
ID: UNCST-2025-R019103
 Congenital Central Nervous System(CNS) and non CNS Anomalies in Children at Cure Children’s Hospital of Uganda
REFNo: HS7204ES

1.2.1 Primary Objective To describe the congenital CNS and non-CNS anomalies in children treated at CCHU from July 2025 to July 2027 1.2.2 Specific Objectives 1. To determine the burden of congenital CNS anomalies in children treated at CCHU. 2. To describe the epidemiology of congenital CNS anomalies in children treated at CCHU. 3. To describe the common congenital non-CNS anomalies in children with congenital CNS anomalies treated at CCHU. 4. To create a pictorial-clinical illustrative album of the congenital anomalies in children treated at CCHU.
 Ethiopia 2026-04-10 17:49:46 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Simon Peter Okiror
ID: UNCST-2025-R022830
 Building Artificial Intelligence Models for predicting TB risk among HIV/AIDS patients using routine clinical data at the Joint Clinical Research Centre, Kampala-Uganda
REFNo: HS7054ES

1. To assess the feasibility of applying AI-driven TB risk prediction tools at the Joint Clinical Research Centre. 2. To develop an AI-based predictive model for predicting TB risk among HIV/AIDS patients using routinely collected patient data. 3. To evaluate the performance of the developed models in predicting TB risk among HIV/AIDS patients.
Uganda 2026-04-10 17:48:29 2029-04-10 Medical and Health Sciences Non-Clinical Trial Degree Award
Sanya Donald
ID: UNCST-2025-R016737
 FAMILY PLANNING SERVICES UTILIZATION AND HEALTH RELATED QUALITY OF LIFE IN UGANDA: A CASE OF SELF-SETTLED URBAN REFUGEE AND MIGRANT WOMEN IN WEST NILE SUB-REGION.
REFNo: SS4707ES

i. To examine the impact of access to FPS on HRQoL among self-settled urban refugee and migrant women in Uganda, West Nile Sub-Region.
ii. To analyze the influence of availability of FPS on HRQoL among self-settled urban refugee and migrant women in Uganda, West Nile Sub-Region.
iii. To assess the casual association between FPS education (knowledge, information & awareness) and HRQoL among self-settled urban refugee and migrant women in Uganda, West Nile Sub-Region;
iv. To evaluate the moderating effect of patient factors on FPS and HRQoL among self-settled urban refugee and migrant women in Uganda, West Nile Sub-Region.

Uganda 2026-04-10 17:47:19 2029-04-10 Social Science and Humanities Non-Clinical Trial Degree Award
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