Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Catriona  Waitt John
ID: UNCST-2019-R001068
 Acceptability and feasibility of long-acting injectable antiretroviral therapy (LAI-ART) as a bridging strategy for postpartum mothers living with HIV in South Africa and Uganda
REFNo: HS5944ES

3. To assess the feasibility of adopting LAI-ART into national ART programmes and healthcare facilities, identifying programmatic considerations for optimal LAI-ART deployment.,2. To explore patient acceptability of LAI-ART during breastfeeding and as a postpartum bridging strategy to enhance adherence.,1. To develop and validate a tool for identifying and supporting women at risk of poor ART adherence postpartum.,
 UK 2025-09-17 13:19:23 2028-09-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Wenceslaus Sseguya
ID: UNCST-2019-R000877
 Feasibility of clinical nuance implemented using value-based community financing for the management of diabetes and hypertension in primary health care in rural South-Western Uganda
REFNo: HS6153ES

3. To assess the willingness of the community to contribute to risk pooling towards clinically nuanced VBID,2. To understand the perspectives of health workers in implementing clinically nuanced care for diabetes and hypertension in the community.,1. To explore the community’s perception of clinically nuanced VBID in the prevention and management of diabetes and hypertension.,To investigate the potential of a community-level, value-based insurance design (VBID) in enhancing clinical management and prevention of hypertension and diabetes within primary health care,
 Uganda 2025-09-17 13:17:21 2028-09-17 Medical and Health Sciences Non-Clinical Trial Degree Award
Mercy Wanyana Wendy
ID: UNCST-2025-R016999
 Barriers and facilitators to implementing one health approach for visceral leishmaniasis control in the Karamoja Region.
REFNo: HS6125ES

To examine barriers and facilitators to implementing one health approach for visceral leishmaniasis control in the Karamoja,2025.
 Uganda 2025-09-17 13:05:50 2028-09-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Lillian Mugisha
ID: UNCST-2025-R018187
 Impact of a Co-designed School-Based Intervention on 24-Hour Movement Behaviour and Selected Health Indicators Amongst Female Adolescents in Wakiso District, Uganda
REFNo: SS3966ES

1. Determine the level of adherence to 24-HMB guidelines among adolescent girls aged 15-18 years in mixed-boarding secondary schools in Wakiso district, Uganda.
2. Explore the determinants of adherence to 24-HMB guidelines among adolescent girls aged 15-18 years in mixed-boarding secondary schools in Wakiso district, Uganda.
3. Co-design a SBMB intervention with adolescent girls and teachers, targeted to enhance 24-HMB among adolescent girls aged 15-18 years in secondary schools in Wakiso District, Uganda.
4. Determine the association between accelerometer-measured 24-HMB and selected health indicators (CRF, BMI, WHtR, and BP) among adolescent girls aged 15-18 years in secondary schools in Wakiso District, Uganda.
5. Determine the impact of a co-designed SBMB intervention program on 24-HMB, and selected health indicators (CRF, BMI, WHtR and BP) among adolescent girls aged 15-18 years in mixed-boarding secondary schools in Wakiso district, Uganda

 Uganda 2025-09-17 13:03:31 2028-09-17 Social Science and Humanities Non-Clinical Trial Degree Award
Mugumya  Kabaja Lawrence Kabaja
ID: UNCST-2024-R002956
 Evaluating the effect of Caregiver DOTs on viral re-suppression among children in Kigezi region
REFNo: HS6505ES

1. To establish the viral re-suppression rates among children on the CAGDOTS strategy in Kigezi Region. 2. To find out the factors associated with viral load re-suppression among the CALHIV) in Kigezi region.
Uganda 2025-09-17 12:36:18 2028-09-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Timothy Makumbi Kabanda
ID: UNCST-2021-R011760
 MICRO RNAS PROFILING: BIOPATHOLOGIC CHARACTERIZATION AND SURVIVAL OF EARLY ONSET BREAST CANCER AMONG UGANDAN Ref No. Mak-SOMREC-2021-272
REFNo: HS3699ES

iii) To correlate aberrantly expressed miRNAs profiles with associated survival among women with EOBC.,ii) To determine the association between MicroRNAs dysregulation and the clinical pathological characteristics among women with EOBC. ,i) To determine the prevalence of dysregulated MicroRNAs expression profiles among women with EOBC.,To determine the prevalent profiles of aberrantly expressed(dysregulated) miRNAs and how they influence the specific pathological characteristics, and survival after mastectomy breast surgery for early onset breast cancer (EOBC),
 Uganda 2025-09-17 12:32:26 2028-09-17 Medical and Health Sciences Non-Clinical Trial Degree Award
Andrew Mujugira
ID: UNCST-2019-R000871
 Integrating HIV prevention with TB household contact evaluation in Uganda (TB PrEP)
REFNo: HS6341ES

Aim 1: Assess the implementation and effectiveness of home- based HIV self-testing and PrEP initiation versus clinic referral on PrEP initiation and continuation during household TB contact investigation.

Aim 2: Examine processes of implementing HIV self-testing and PrEP initiation during household TB contact evaluation using qualitative methods.

Aim 3: Estimate the cost-effectiveness of implementing home- based HIV testing and PrEP initiation for household members of people with TB in Uganda compared to clinic referral.

 Uganda 2025-09-17 12:30:43 2028-09-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
NUWAGIRA KENETH
ID: UNCST-2025-R016664
 FINANCIAL INCLUSION AND GROWTH OF MICRO, SMALL AND MEDIUM-SIZED ENTERPRISES (MSMES) IN KAMPALA CITY, UGANDA.
REFNo: SS3991ES

Main Objectives
The purpose of the study is to investigate the effect of financial inclusion on growth of micro, small and medium-sized enterprises (MSMEs) in Kampala City, Uganda.

1.4 Specific objectives
i) To determine the effect of credit accessibility on the growth of MSMEs in Kampala City, Uganda.
ii) To establish the effect of mobile money services on the growth of MSMEs in Kampala City, Uganda.
iii) To explore the effect of financial literacy on the growth of MSMEs in Kampala City, Uganda.

Uganda 2025-09-17 12:28:56 2028-09-17 Social Science and Humanities Non-Clinical Trial Degree Award
Twinamasiko Specioza
ID: UNCST-2022-R008954
 Empowering Ugandan Refugee–Host Communities in Becoming Climate Resilient: The Case Studies of Nakivale and Rhino Camp Refugee Settlements
REFNo: NS983ES

1. To assess the resilience of refugees and their host communities to water access and land tenure in Nakivale and Rhino Camp
2. To monitor water quality within the refugee settlements and host communities of Nakivale and Rhino Camp.
3. To analyze hazards and farming practices within the refugee settlements and host-communities of Nakivale and Rhino Camp refugee-host communities
4. To document the different traditional practices and indigenous knowledge on agriculture, water source preservation and forest conservation prevalent among the refugee and host communities of Nakivale and Rhino Camp Refugee settlements.
5. To identify ways in which traditional environmental practices and indigenous knowledge can complement the contemporary modern scientific policies of environmental conservation and protection in refugee-host communities

 Uganda 2025-09-17 12:27:48 2028-09-17 Natural Sciences Non-Clinical Trial Degree Award
Sadia Mohamed Mahad
ID: UNCST-2024-R004826
 Prevalence and Factors Associated with Substance Use Among Refugees In Nakivale Settlement South-Western Uganda
REFNo: HS6217ES

i. To determine the prevalence of substance, use among refugees in Nakivale Refugee Settlement. ii. To identify and describe the modifiable and non-modifiable factors associated with substance use among refugees in Nakivale Refugee Settlement.,
 Somalia 2025-09-17 12:08:46 2028-09-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jazira Tumusiime
ID: UNCST-2024-R003664
 EXPLORING CAREGIVERS AND HEALTH WORKERS’ PERCEPTIONS TOWARDS HPV VACCINATION AT MBARARA REGIONAL REFERRAL HOSPITAL ADOLESCENT CLININC AND BWIZIBWERA HEALTH CENTRE IV, UGANDA
REFNo: HS6193ES

To identify the barriers and facilitators influencing the uptake of HPV vaccination among adolescents at Mbarara Regional Referral Hospital and Bwizibwera Health Centre IV in southwestern Uganda.,To assess caregivers\' and healthcare workers\' knowledge and perceptions about HPV vaccination at Mbarara Regional Referral Hospital and Bwizibwera Health Centre IV in southwestern Uganda.,To explore caregivers’ and healthcare workers’ perceptions of HPV vaccination and identify the barriers and facilitators affecting the uptake of the HPV vaccine among adolescents at Mbarara Regional Referral Hospital and Bwizibwera Health Centre IV in southwestern Uganda.,
 Uganda 2025-09-17 11:22:16 2028-09-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Miria Nandera
ID: UNCST-2021-R012140
 SCHOOL CLIMATE AND WORK ENGAGEMENT MEDIATED AND MODERATED BY WORK-LIFE BALANCE AND JOB EMBEDDEDNESS OF PRE-PRIMARY TEACHERS IN CENTRAL UGANDA
REFNo: SS4033ES

1. To examine the influence of school climate on teacher work engagement of pre-primary teachers in Central Uganda.
2. To assess the influence of school climate on work-life balance of pre-primary teachers in Central Uganda.
3. To analyse the influence of work-life balance on teacher work engagement of pre-primary teachers in Central Uganda.
4. To test the mediating role of work-life balance on the influence of school climate on teacher work engagement of pre-primary teachers in Central Uganda.
5. To find out the moderating effect of job embeddedness on the influence school climate on teacher work engagement of pre-primary teachers in Central Uganda.
 Uganda 2025-09-17 11:19:34 2028-09-17 Social Science and Humanities Non-Clinical Trial Degree Award
Ibrahim Adabara
ID: UNCST-2025-R019039
 AGENTIC AI FOR CYBERSECURITY: A FRAMEWORK FOR THE DESIGN AND GOVERNANCE OF RESILIENT AUTONOMOUS DEFENSE SYSTEMS
REFNo: SIR547ES

1.3 Main Objective

The primary objective of this research is to construct a theoretically grounded and ethically aligned framework for conceptualizing, simulating, evaluating, and governing AAI systems in cybersecurity. The framework will serve as a strategic model for autonomous defensive agents, focusing on secure, transparent, and accountable operation in adversarial environments, in alignment with legal and normative expectations.

1.4 Specific Objectives

i. To develop a reference model for agentic AI systems integrating autonomy, ethical responsiveness, and adaptive reasoning by synthesizing existing literature and formalizing the framework within the first phase of the study.

ii. To design and implement a simulation-based methodology that models adversarial threat scenarios and tests agentic AI responses within a defined experimental period, using performance and ethical indicators as measurable outputs.

iii. To construct a multi-criteria evaluation framework that defines and measures agentic system performance in terms of transparency, latency, proportionality, and normative alignment, validated through simulated test cases in the second phase.

iv. To propose and validate a governance and ethical oversight model for agentic AI deployment, incorporating regulatory review, stakeholder auditability, and normative safeguards by the final phase of the project, following empirical evaluation.
 Nigeria 2025-09-17 11:18:20 2028-09-17 Engineering and Technology Non-Clinical Trial Degree Award
Ronald Bisegerwa
ID: UNCST-2022-R011022
 Accuracy of Pulse Oximeters with Profound Hypoxia
REFNo: HS6506ES

To generate two to three evidence-based recommendations to regulatory and procurement bodies within six months of study completion to guide pulse oximeter selection for diverse populations.,To collect and contribute data on pulse oximeter accuracy across diverse skin tones to an open-access device performance database by the study’s end, enabling manufacturers to refine pulse oximeter technology and ensure equitable performance across all skin tones, especially in low-resource settings.,To replicate the UCSF Hypoxia Lab in Uganda by establishing a fully equipped and operational facility within a year to evaluate pulse oximeter accuracy across diverse skin tones and hypoxia levels.,To evaluate the accuracy of pulse oximeters under controlled hypoxic conditions in a diverse population in Uganda, with a focus on understanding and addressing disparities in device performance related to skin pigmentation.,
 Uganda 2025-09-12 17:03:12 2028-09-12 Medical and Health Sciences Clinical Trial Non-degree Award
Pauline Amuge Mary
ID: UNCST-2023-R005532
 LC-REVITALIZE – A Long Covid Repurposed Drug Study
REFNo: HS6370ES

-To assess the efficacy of repurposed drugs compared to their
respective placebos in reducing standardized symptom severity scores
in participants with Long Covid.
-To compare the symptom burden (e.g., anxiety, depression, overall
well-being) in participants with Long Covid treated with repurposed
drugs versus their respective placebos.
- To assess whether symptom burden worsens in participants with Long
Covid treated with study drugs versus placebo, specifically when
symptoms are reported across multiple scales.
- To assess changes in exercise capacity over time of participants with
Long Covid treated with study drugs versus their respective placebos.
- To measure specific Long Covid pathophysiological biomarkers of study
drugs versus their respective placebos.

 Uganda 2025-09-12 17:00:13 2028-09-12 Medical and Health Sciences Clinical Trial Non-degree Award
Viola  Nyakato Nilah
ID: UNCST-2021-R013698
 Caregiver-Adolescent Sexuality Communication among Refugee and Host Communities in Southwestern and Northern Uganda (CONNECT)
REFNo: SS4216ES

3. Policy and community engagement objective: To establish and evaluate the contribution of multi-sectorial and development partners’ working committee in translation, sustainability, and scalability of the impacts of the caregiver-adolescent SRH communication intervention with resultant improvement in adolescent SRH policy and programming within refugee and host communities’ context in Southwestern and Northern Uganda. ,2. Gender Transformative Objective: To assess the social, economic, and cultural factors that influence the effective implementation of a gender-equitable caregiver-adolescent SRH communication and family functioning intervention within a multinational and multicultural refugee and host community context in Southwestern and Northern Uganda. ,1. Research objective: To contextualize, design, implement, and evaluate the effectiveness of caregiver-adolescent SRH communication intervention in refugee and host communities’ settings in Southwestern and Northern Uganda. ,The general objective of the project is to implement and evaluate a parent/caregiver-adolescent communication intervention on sexual and reproductive health (SRH), targeting social and cultural gender norms that hinder parental involvement in sexuality education among refugees and host communities in Nakivale and Bidi Bidi Refugee Settlements, Uganda. The project will assess the intervention\'s effectiveness in addressing the challenges faced by displaced and dysfunctional families in refugee and host community settings.,
 Uganda 2025-09-12 16:55:54 2028-09-12 Social Science and Humanities Non-Clinical Trial Non-degree Award
Barnabas Atwiine
ID: UNCST-2022-R010629
 Status of Haemophilia Care and Management in Uganda: A Situation Analysis
REFNo: HS6293ES

3. To explore health workers’ knowledge and attitudes towards haemophilia care and management in Uganda. ,2. To assess the availability of equipment, supplies, and medicines used in the diagnosis and management of Haemophilia patients in Uganda.,1. To assess the proportion of health facilities that care for people with haemophilia in Uganda.,To assess the status of haemophilia care and management among health facilities in Uganda.,
 Uganda 2025-09-12 16:54:23 2028-09-12 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Winnifred Namazzi Birabwa
ID: UNCST-2025-R017998
 AN ASSESSMENT FOR THE APPROPRIATE CULTURALLY RESPONSIVE PEDAGOGY IN IMPLEMENTING THE COMPETENCY BASED CURRICULUM AMONG INDIGENOUS BATWA COMMUNITIES IN UGANDA
REFNo: SS4097ES

1. What Batwa culturally responsive learning experiences can teachers integrate in teaching to effectively implement the CBC in Batwa heterogeneous classrooms? 2. How can the teachers utilize Batwa learners’ cultural backgrounds to address their learning needs when implementing the CBC in Batwa heterogeneous classrooms? 3. How can teachers integrate culturally responsive teaching methods to enable effective implementation of the CBC in Batwa heterogeneous classrooms? 4. What are the challenges of integrating CRP into the implementation of the competency based curriculum in Batwa heterogeneous classrooms?
 Uganda 2025-09-12 16:53:22 2028-09-12 Social Science and Humanities Non-Clinical Trial Degree Award
Grace Ahimbisibwe Miriam
ID: UNCST-2021-R012129
 Assessing the Effects of Immune Suppression of Pregnancy on the HIV Latent Reservoir in African Women with HIV Participating in P1078 (IMPAACT NWCS 663).
REFNo: HS6371ES

1.Evaluate changes in inflammation and immune activation markers in black African WWH from the antepartum through 48 weeks postpartum periods.
a. Describe participant level changes in inflammation and immune activation markers from the antepartum through 48 weeks postpartum periods.
2.Evaluate changes in the HIV latent Reservoir (LR) size in black African WWH from the antepartum through 48 weeks postpartum periods.
a. Describe participant level changes in HIV LR size from the antepartum through 48 weeks postpartum periods.
3.Identify immune correlates of the HIV LR from the antepartum through 48 weeks postpartum periods in black African WWH.

 Uganda 2025-09-12 16:50:35 2028-09-12 Medical and Health Sciences Non-Clinical Trial Non-degree Award
FRANCIS WENANI MWISAKA
ID: UNCST-2025-R018729
 ENHANCING TVET- INDUSTRY COLLABORATION FOR MARKETABLE SKILLS DEVELOPMENT IN EASTERN UGANDA.
REFNo: SIR542ES

1. To identify industry-specific skill gaps and requirements to guide collaborative training initiatives.
2. To assess the effectiveness of existing partnerships between TVET institutions and industries in fostering market-relevant skills.
3. To explore barriers to effective collaboration between TVET institutions and industries

4. To design a strategic framework for strengthening partnerships and aligning training programs with industry needs.


 Uganda 2025-09-12 16:42:50 2028-09-12 Engineering and Technology Non-Clinical Trial Degree Award
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