Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
Search By Approval Date:
Clear Filter Total: 6,248
Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Priscilla Namaganda
ID: UNCST-2019-R001653
Molecular characteristics of Non-Hodgkin�s Lymphoma at the Uganda Cancer Institute: a comparative study between HIV-infected and HIV- uninfected patients.
REFNo: HS8153ES

To describe treatment outcomes/response and survival of patients living with and without HIV presenting with NHL at Uganda Cancer Institute.
2. To determine the prevalence of Ha�s algorithm-based, a modification of Gene expression profiling subtypes of Diffuse Large B-cell lymphoma among patients living with and without HIV presenting with NHL at Uganda Cancer Institute.
3. To determine the proportion of High-grade B cell non-Hodgkin�s Lymphoma using low-cost modified fluorescence in situ hybridization (FISH) called chromogenic in situ hybridization (CISH) or next Generation sequencing (NGS) among patients living with and without HIV presenting with NHL at Uganda Cancer Institute.
4. To determine the prevalence of oncogenic viral protein positivity using immunohistochemistry, a modification of FISH, among patients living with and without HIV presenting with NHL at Uganda Cancer Institute.


Uganda 2026-07-24 9:01:14 2029-07-24 Medical and Health Sciences Non-Clinical Trial Degree Award
Susan  Nabadda Ndidde
ID: UNCST-2020-R014331
Field Evaluation of the STANDARD Q HBsAg Rapid Diagnostic Test for Detection of Hepatitis B Virus (HBV) in Uganda: A Performance and Operational Assessment.
REFNo: HS8117ES

Assess Acceptability and Usability of the STANDARD Q HBsAg RDT among healthcare workers and patients across diverse settings in Uganda. Identify performance variability of the STANDARD Q HBsAg test kit in stratified cohorts. Assess Real-World Usability of STANDARD Q HBsAg test kit at selected facilities in Uganda. Determine the diagnostic accuracy of STANDARD Q HBsAg test in detecting hepatitis B surface antigen compared to the routinely used standard (Abbott HBsAg) confirmed by under field conditions in Uganda health facilities. To evaluate the field performance and operational feasibility of the STANDARD Q HBsAg Rapid Diagnostic Test (RDT) under real-world settings in Uganda.
Uganda 2026-07-24 8:56:58 2029-07-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Zuwena Namaganda
ID: UNCST-2026-R024328
LEGAL PROTECTION AGAINST SEXUAL VIOLENCE IN UGANDA: LESSONS FROM KENYA AND CANADA
REFNo: SS5576ES

Aim of the Study To critically examine and compare the legal frameworks for the protection of women against sexual violence in Uganda, Kenya, and Canada, with a view to identifying gaps, challenges, and best practices that can inform law reform and improve justice outcomes for survivors. Objectives of the study To examine and compare the legal frameworks governing protection against sexual violence in Uganda, Kenya, and Canada. To assess the effectiveness of the implementation and enforcement of laws relating to sexual violence in Uganda, Kenya, and Canada. To analyse the legal, institutional, and socio-cultural barriers that hinder women's access to justice in cases of sexual violence in the three jurisdictions. To identify lessons and best practices from the Kenyan and Canadian legal systems that may strengthen legal protection against sexual violence in Uganda.
Uganda 2026-07-24 8:51:04 2029-07-24 Social Science and Humanities Non-Clinical Trial Degree Award
Junior Kasima Senyonga
ID: UNCST-2023-R005699
EVALUATION OF BLACK SOLDIER FLY LARVAE-BASED MEAL AS AN ALTERNATIVE PROTEIN SOURCE IN PIG DIETS
REFNo: A790ES

1 To determine the effect of four post-harvest processing methods on nutritional quality of black soldier fly larvae raised on different substrates.
2 To determine the effect of processing of pig feeds containing BSFL-based meal on the shelf-stability of pig feeds containing black soldier fly larvae meal
3 To determine the effect of black soldier fly larvae meal-based diets on the performance of grower pigs
4 To assess the economic feasibility of using black soldier fly larvae meal-based diets in feeding grower pigs.
Uganda 2026-07-24 8:46:38 2029-07-24 Agricultural Sciences Non-Clinical Trial Degree Award
Aloysious Ssemaganda
ID: UNCST-2023-R008046
SARS-CoV-2 as a Model Pathogen for Rapid Immunosurveillance of Severe Acute Respiratory Illnesses (SARI) and Influenza-Like Illnesses (ILI) in Uganda: A Pilot Platform
REFNo: HS7938ES

Primary Objective To pilot and establish an integrated immunological surveillance platform in Uganda and the East African region for the real-time functional characterization of circulating variants of SARS-CoV-2 as a model pathogen, creating a scalable framework for future expansion to other SARI and ILI threats. Specific Objectives 1. To develop and implement standardized operating procedures (SOPs) for the screening, recruitment, sample collection, transportation, and biobanking of clinical specimens from at least 200 participants presenting with SARI and ILI in Uganda over a 12-month period. 2. To assess the phenotypic immune escape potential of circulating and newly emergent SARS-CoV-2 variants by quantifying their sensitivity to neutralization by antibodies derived from vaccinated and naturally infected individuals, thereby establishing a workflow applicable to future Influenza and RSV surveillance. 3. To build sustainable local capacity by training at least 2 NHLDS-CPHL staff in all aspects of the high-throughput pipeline and successfully isolating, expressing, and characterizing variant-specific monoclonal antibodies (mAbs).
Uganda 2026-07-24 8:40:56 2029-07-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rawlance  Ndejjo
ID: UNCST-2022-R010993
Win Win in the Wetlands for Climate Resilience: Consolidating and Scaling Health, Social, and Economic Impacts of Wetlands Conservation and Restoration in rural as well as urban Uganda
REFNo: HS8087ES

3. To evaluate the impact of training programs in strengthening the technical and evaluative capacity of district and city teams to contribute to wetland restoration,2. To co-design, pilot, and evaluate an evidence-based intervention for urban wetland conservation/restoration,1. To evaluate the climate, health, social, and economic impacts of wetland conservation/restoration. ,To systematically evaluate the climate, health, social, and economic benefits of wetland conservation under the BRC project, and adapt and evaluate a participatory restoration model to urban wetlands in Uganda. ,
Uganda 2026-07-24 8:36:43 2029-07-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
George Kasule William
ID: UNCST-2023-R006891
Performance Evaluation of the Pluslife MiniDock MTB Test for Detection of Mycobacterium tuberculosis in high TB/HIV settings in Uganda
REFNo: HS7953ES

GENERAL OBJECTIVE To evaluate the diagnostic accuracy of the Pluslife MiniDock MTB Test for the detection of Mycobacterium tuberculosis in a high TB-HIV setting in Uganda. SPECIFIC OBJECTIVES 1. To determine the diagnostic accuracy of Pluslife MiniDock MTB Test compared to GeneXpert MTB/RIF Ultra and mycobacterial culture as reference standards for detection of Mycobacterium tuberculosis in a high TB/HIV setting in Uganda. 2. To compare diagnostic performance of Pluslife MiniDock MTB Test between tongue swab and sputum specimens for MTB detection in hign TB/HIV setting in Uganda. 3. To evaluate operational characteristics of Pluslife MiniDock MTB Test including result turnaround time, invalid/error rate, and ease of use among health facility operators and laboratory personnel. 4. To assess the feasibility and acceptability of Pluslife MiniDock MTB implementation at peripheral health facility level within Uganda's TB diagnostic pathway.
Uganda 2026-07-24 8:33:36 2029-07-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Tonny Kiggundu Kiggundu
ID: UNCST-2025-R018920
CORPORATE ENVIRONMENTAL SUSTAINABILITY OF LARGE MANUFACTURING FIRMS IN UGANDA
REFNo: SS5550ES

1. To contextualize Corporate Environmental Sustainability in large manufacturing firms. 2. To explore how stakeholders, perceive company’s commitment to environmental wellbeing. 3. To discover how participants, understand the interaction between stakeholder expectations, corporate environmental governance, and CES. 4. To explore how institutional pressures, shape Corporate Environmental Sustainability in large manufacturing firms. 5. To analyze how corporate environmental governance, process institutional pressures to shape CES within large firm. 6. To investigate how corporate environmental governance shapes corporate environmental sustainability outcomes.
Uganda 2026-07-24 8:30:18 2029-07-24 Social Science and Humanities Non-Clinical Trial Degree Award
Munezero Jonasi
ID: UNCST-2025-R023113
ELUCIDATING THE THERAPEUTIC POTENTIAL OF Markhamia lutea ETHANOLIC AND AQUEOUS EXTRACTS IN A TESTOSTERONE-INDUCED RAT MODEL OF BENIGN PROSTATIC HYPERPLASIA
REFNo: NS1315ES

Main Objective
To elucidate the therapeutic potential of Markhamia lutea ethanolic and aqueous extracts in a testosterone-induced rat model of benign prostatic hyperplasia
Specific objectives
The specific objectives of this study are to:
1.Determine the phytochemical compounds of Markhamia lutea ethanolic and aqueous extracts using liquid chromatography-mass spectrometry
2. Determine the safety of the aqueous and ethanolic bark extracts of Markhamia lutea in testosterone-induced rat model of benign prostatic hyperplasia (BPH) using biochemical tests, hematological and histopathological examination of tissues
3. Assess the therapeutic efficacy of the aqueous and ethanolic bark extracts of Markhamia lutea in testosterone-induced rat model of Benign Prostatic Hyperplasia (BPH) using oxidative, hormonal, and inflammatory markers
4. Elucidate the mechanism of action of the identified bioactive compound using Androgen Receptor (AR) and 5α-Reductase (SRD5A2) proteins.
Uganda 2026-07-24 8:27:19 2029-07-24 Natural Sciences Non-Clinical Trial Degree Award
Peter Kisaakye
ID:
Co-designing Health Innovations to reach Mobile Men with Co-Morbidities in Uganda
REFNo: HS8036ES

Building on promising approaches to men’s health in sub-Saharan African countries, the HIMM project aims to co-design and validate the feasibility of an intervention to improve men’s access to care for NCD-ID co-morbidity within mobility contexts. Our objectives and research questions are:
1. To explore the spaces, mobility patterns, actors, and livelihood assets shaping men’s access to care for NCD-ID co-morbidities in urban settlements and border towns
RQ1: What social, spatial, and infrastructural factors shape men’s mobility cycles, and how do livelihood assets along these cycles influence health-seeking for NCD-ID co-morbidities?

2. To assess the burden of diabetes, hypertension, and HIV among mobile men and their reported access to screening and treatment
RQ2: What is the burden of diabetes, hypertension, and HIV among mobile men and what are the associations between patterns of mobility and self-reported co-morbidities with clinical assessments of diabetes, hypertension, and HIV?

3. To examine how the evolving agenda on NCD-ID integration is being implemented at the health systems and services level, and experienced by mobile men
RQ3: How responsive are evolving NCD-ID integration policies to men’s mobility in Uganda?

4. To adapt promising strategies for delivering health care services to men for NCD-ID co-morbidities among mobile men
RQ4: How can co-design methodologies be adapted to engage mobile men in developing interventions for their unmet NCD/ID care needs?

5. To validate the feasibility and acceptability of the co-designed intervention and explore contextual factors likely to affect implementation and engagement.
RQ5: What is the perceived feasibility and acceptability of a co-designed intervention to improve access to NCD/ID screening and care for mobile men and what contextual factors are likely to influence implementation and engagement with the intervention?


Uganda 2026-07-24 8:25:43 2029-07-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rukundo vicent
ID: UNCST-2025-R023088
TERPENOID QUANTIFICATION AND PRODUCT FORMULATION FROM AERIALPARTS OF AMARANTHUS VIRIDIS FOR THE MANAGEMENT OF SITOPHILUS ZEAMAIS
REFNo: NS1254ES

i. To isolate triterpenoids from aerial parts of A. viridis extracts.
ii. To determine the insecticidal repellency of the isolated triterpenoids against S. zeamais.
iii. To determine the composition and quantity of triterpenoids from aerial parts of A. viridis.
iv. To characterize the chemical structure of the isolated triterpenoids for repelling S. zeamais.
v. To formulate a product using the isolated triterpenoids for the management of S. zeamais.


Uganda 2026-07-24 8:02:57 2029-07-24 Natural Sciences Non-Clinical Trial Degree Award
Alfred Yayi
ID: UNCST-2025-R019850
Prevalence, Attitudes, and Use of Complementary and Alternative Medicine (CAM) Among Medical Doctors in Asia and Africa.
REFNo: HS7686ES

1.To survey CAM use among Medical Doctors in selected hospitals in Asia and Africa.
2.To investigate Medical Doctors’ attitudes toward CAM in both regions.
3.To examine Medical Doctors’ perceptions of CAM safety, effectiveness, and clinical utility.
4.To compare cross-regional differences in CAM use and predictors of Medical Doctors recommendation.
5.To explore how Medical Doctors’ perceptions and attitudes influence their communication with patients regarding CAM.

Uganda 2026-07-24 8:01:37 2029-07-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kemigisha  Grace
ID:
Determinants of malaria vaccine acceptability in a pre-introduction setting: A Baseline study among caregivers in Mpererwe, Kawempe Division, Kampala District.
REFNo: HS7730ES

The main objective is to assess the determinants of malaria vaccine acceptability among children’s caregivers in Mpererwe Parish, Kawempe Division, Kampala District. Specific objectives 1. To evaluate the level of knowledge regarding the malaria vaccine among caregivers in a pre-introduction setting. 2. To determine the prevalence of vaccine acceptability (behavioural intent) among caregivers before the commencement of the immunisation programme. 3. To explore the perceived barriers and facilitators that influence a caregiver's decision to accept a prospective malaria vaccine. 4. To identify factors associated with the acceptability of malaria vaccine among the child caregivers in Mpererwe Parish.
Uganda 2026-07-24 7:55:53 2029-07-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Mathew Amollo
ID: UNCST-2025-R022152
Psychological Distress among Victims of Violence Against Children in Uganda: Prevalence, Enablers and Barriers to Help Seeking in Uganda
REFNo: HS6872ES

a) To determine the prevalence of psychological distress among adolescents (13-17 years) who experience violence in Uganda. b) To examine the association between lifetime childhood violence exposure and psychological distress. Does help seeking mediate the association? c)To explore the enablers and barriers to accessing services for psychological distress among adolescents (13-17 years) who experienced lifetime violence in Uganda.
Uganda 2026-07-24 7:40:29 2029-07-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Nazarius Tumwesigye Mbona
ID: UNCST-2019-R000664
ASSESSMENT OF STATISFACTION OF THE VILLAGE HEALTH TEAMS AND COMMUNITY MEMBERS WITH THE CAPACITY BUILDING FOR COMMUNITY HEALTH WORKERS PROJECT IN CENTRAL UGANDA
REFNo: HS8168ES

2. To assess the level of satisfaction among household and community members with the VHT services delivered under the CHW project in Masaka City, Masaka District, and Bukomansimbi District,1. To assess the level of VHT satisfaction with the support provided under the CHW project in Masaka City, Masaka District, and Bukomansimbi District. ,To assess the impact of the investments made by KOFIH on the performance of VHTs and the satisfaction of community members with VHT-provided services, following multiple trainings, equipment provision, mentorships, referrals, and integrated outreaches.,
Uganda 2026-07-24 12:50:17 2029-07-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Robert MPIIRA
ID: UNCST-2022-R005391
A Pilot Study on Workers’ Exposure to Air, Noise and Water Pollution, Heat, Flooding, and Waste across Homes, Workplaces and Commutes, and Its Effects on Their Health, Productivity, and Behavior in Kampala Metropolitan Area.
REFNo: SS5590ES

(i) To assess objective and perceived (self-reported) exposure to water, noise and air pollution, heat (temperature, humidity), flooding and waste at the home, at the workplace, and along the commute for prime-age workers in two contrasting parishes of the Kampala Metropolitan Area.
(ii) To characterise the socio-economic gradient of this joint exposure — the association between exposure and respondents' occupation, sector of employment, formality, earnings, and education.
(iii) To examine workers' beliefs about environmental conditions, pay, and working conditions at workplaces other than their own; compare these beliefs against the objective measurements and quantify the resulting perceived–objective exposure gaps ("information mismatches").
(iv) To analyse the association between joint environmental exposure and self-reported outcomes — including health (recent illness, respiratory and heat-related symptoms), productivity (work hours, days affected), and protective practices (actions taken at home, at the workplace, and along the commute).
(v) To validate the operational feasibility of the sampling, listing, survey, and monitoring protocol — measured by listing rates, eligibility rates, refusal rates, interview duration, item non-response, and monitor compliance — for deployment at scale in the subsequent full-scale study.

Uganda 2026-07-24 11:46:25 2029-07-24 Social Science and Humanities Non-Clinical Trial Non-degree Award
Richard Kica Ocaya
ID: UNCST-2026-R026002
Preventive health practices for Reducing Under-Five Mortality in the Refugee and the Rural Host Communities in Palabek Settlement, Uganda
REFNo: SS5566ES

i) To determine the level of knowledge of cause, symptoms and preventive measures for malaria among the refugee and host community households;

ii) To determine the attitude of the refugee and the host community households towards preventive health practices for malaria;

iii) To determine the extent of practice of preventive health behaviors and related challenges for malaria in the refugee and host community households; and

iv) To develop knowledge, attitude and practice (KAP) based primary prevention model for reduction of U5M for the refugee and the rural host communities.

Uganda 2026-07-24 11:39:56 2029-07-24 Social Science and Humanities Non-Clinical Trial Degree Award
JOYCE NAMWASE
ID: UNCST-2024-R005002
STRENGTHENING GERIATRIC SERVICES AT BUTABIKA NATIONAL REFERRAL MENTAL HOSPITAL: A SITUATIONAL ANALYSIS AND IMPLEMENTATION OF AN INTEGRATED CARE FOR OLDER PEOPLE (ICOPE)–BASED SCREENING AND CARE PATHWAY
REFNo: HS7950ES

III. To introduce and implement a routine standardized geriatric health screening and care pathway for patients aged 60 years and above at BNRMH using integrated care for older people (ICOPE).,II. To identify the potential barriers and facilitators of a geriatrics screening and care pathway at BNRMH.,I. To determine the prevalence of geriatric health conditions ands individuals screened in the past 12 months at Butabika NRMH.,
Uganda 2026-07-24 11:33:57 2029-07-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Lauren Hookham
ID: UNCST-2024-R016386
Characterising colonisation and transmission of Multi-Drug-Resistant Gram-negative organisms in maternal care in Uganda - GRam negative Resistance In Pregnancy (GRIP)
REFNo: HS8128ES

Overall aim: To characterise colonisation and transmission of multi-drug-resistant Gram-negative bacteria (MDR-GNB) within the maternity unit at Kawempe National Referral Hospital (KNRH), Kampala, Uganda, and evaluate interventions to reduce environmental contamination and improve infection prevention and control (IPC) practices.

Work Package 2: Characterise MDR-GNB colonisation in women undergoing elective and emergency caesarean section, their newborns, and the maternity hospital environment at KNRH; identify individual, clinical and environmental risk factors for maternal colonisation; and examine genetic similarity between environmental and patient-derived MDR-GNB strains.

Work Package 3: Explore how systemic and environmental context, resource availability, infrastructure, supervision, attitudes, perceptions, roles, responsibilities, training needs, communication and feedback influence IPC and cleaning practices among healthcare workers, cleaning staff and supervisors.

Work Package 4: Use Intervention Mapping to conduct a needs assessment and identify behavioural and environmental determinants; implement structured training for cleaning staff using the WHO Environmental Cleaning Toolkit; assess changes in the burden of Gram-negative and MDR Gram-negative bacteria in the maternity/postnatal environment before and after training; and explore the feasibility of a contextually appropriate supervision or audit tool.



UK 2026-07-24 11:30:42 2029-07-24 Medical and Health Sciences Non-Clinical Trial Degree Award
Eric Okwir
ID: UNCST-2025-R019992
Greening the tea? Ecolabelling, anticlimax, and the remaking of conservation people in Uganda
REFNo: SS5586ES

Objectives: Main Objective 1. This study interrogates whether and how local tea producers advance beyond the failure of ecolabelling, to adapt its elements into locally-defined environmental ideals that transform tea production and conservation in the KNP landscape. Specific Objectives 1. In what ways do conservation and political-economic processes intersect to produce conditions befitting the introduction of ecolabelling around KNP? 2. How does the nesting of ecolabel discourses with KNP’s contextual discourses produce anticlimax? 3. What rationalities do tea producers draw on to navigate the anticlimax of ecolabelling and does this remake them into new conservation people? 4. In what ways do these alternative rationalities support the transition to more transformative conservation?
Uganda 2026-07-24 10:12:52 2029-07-24 Social Science and Humanities Non-Clinical Trial Degree Award
View Sort By:

"A prosperous Science and Technology Led Ugandan Society."