Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Kamya Moses
ID: UNCST-2020-R014203
COVID-19 sydromic and sero-surveillance using established Uganda malaria surveillance sites.
REFNo: HS1125ES

To establish COVID-19 syndromic surveillance through existing Uganda Malaria Surveillance sites by collecting additional data on COVID-19 specific symptoms.

To perform enhanced surveillance for COVID-19 and assess for serological evidence of past infection with SARS-CoV-2 in patients, in order to estimate disease burden and map the geographic spread of the epidemic.

Uganda 2021-01-20 2024-01-20 Medical and Health Sciences Non-degree Award
Edgar Agaba
ID:
One Nutrition in Complex Environments (ONCE), a cluster-randomized trial of nutrition education and access to simple supportive technologies in improving agricultural practices and water quality management
REFNo: HS492ES

Aim 1: Implement and test a social and behavior change (NIPP) program alone (free-standing) and in combination with a “value-added” approach (NIPP+). The latter includes access to innovative low-cost tools and technologies relating to WASH and agriculture.

Aim 2: Identify best-practices emerging from the implementation of both approaches through process and program monitoring for effective integration, implementation, scale-up, and uptake of multi-sectoral and multi-level packages in complex environments to ascertain potential for scale up.

Aim 3: Study the sustained impact of the NIPP approach and the “value added” package (NIPP+) on knowledge and practices by gender within participating households, environmental risk factors, child health and nutritional status through a rigorous impact evaluation and longitudinal monitoring system.
Uganda 2021-01-12 2024-01-12 Medical and Health Sciences Non-degree Award
Henry Ddungu
ID: UNCST-2019-R000966
A Phase 2b Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease.
REFNo: HS1078ES

Primary Objectives:
(a)To evaluate the fetal hemoglobin (HbF) response to IMR-687 versus placebo
(b)To evaluate the safety of IMR-687 versus placebo.
Secondary Efficacy Objectives
(a)To evaluate the effect of IMR-687 versus placebo on HbF-associated biomarkers
(b)To evaluate the effect of IMR-687 versus placebo on indices of red cell hemolysis
(c)To evaluate the effect of IMR-687 versus placebo on indices of white blood cell (WBC)
adhesion
(d)To evaluate the effect of IMR-687 versus placebo on the incidence of vaso-occlusive crises(VOCs)
(e)To evaluate the effect of IMR-687 versus placebo on quality of life measures

Pharmacokinetic Objectives
(i)To evaluate the PK of IMR-687 and any major circulating metabolites

Exploratory Efficacy Objectives
(ii)To evaluate the effect of IMR-687 versus placebo on changes in red blood cell (RBC)
characteristics and total Hb
(iii)To evaluate the effect of IMR-687 versus placebo on renal function
(iv)To evaluate the effect of IMR-687 versus placebo on indices associated with
cardiovascular pathophysiology and ischemic stroke risk.
Uganda 2021-01-12 2024-01-12 Medical and Health Sciences Non-degree Award
Kamya Moses
ID: UNCST-2020-R014203
Impact of long-lasting insecticidal nets (LLINs) treated with pyrethroid plus pyriproxyfen vs LLINs treated with pyrethroid plus piperonyl butoxide on malaria incidence in Uganda: a cluster-randomised trial
REFNo: HS1097ES

Primary Objective:
To evaluate the impact of LLINs treated with a pyrethroid insecticide plus pyriproxyfen (PPF LLINs), as compared to LLINs treated with a pyrethroid plus piperonyl butoxide (PBO LLINs), on malaria incidence in Uganda. We will test the hypothesis that malaria incidence will be lower in intervention clusters (randomised to receive PPF LLINs) than in control clusters (randomised to receive PBO LLINs).

Secondary Objectives:
To evaluate the impact of PPF LLINs vs PBO LLINs on parasite prevalence, anaemia, and vector density.
To estimate the cost-effectiveness of delivering PPF LLINs, as compared to PBO LLINs
To assess net durability, survivorship and use of PPF LLINs vs PBO LLINs.

Uganda 2021-01-11 2024-01-11 Medical and Health Sciences Non-degree Award
Robert Opika Opoka
ID: UNCST-2021-R014036
The Influence of Comprehensive Follow-Up in Pediatric Sickle Cell Disease in an African Setting: a retrospective cohort Study
REFNo: HS636ES

General Objectives: To compare a set of sickle cell-related outcomes (mortality, stroke, blood transfusions, and hospitalizations) between children with SCA on a comprehensive follow up schedule under clinical trials setting and that of a cohort of children with SCA receiving routine care at a specialized sickle cell clinic.


Primary Objective: To compare sickle cell-related outcomes in the NOHARM children who were on the placebo arm to those of children of similar age group from the MHSCC who fulfilled the inclusion criteria for the NOHARM study at the time the study was recruiting patients but who were not enrolled.

Secondary Objectives: To assess the added effect of hydroxyurea therapy (in addition to comprehensive follow up schedule) on sickle cell-related outcomes. This shall be done by comparing sickle cell related outcomes in
1) NOHARM children randomized to hydroxyurea arm and that of the cohort of non-study MHSCC children with SCA over the time period of the NOHARM study (calendar years 2015-17).
2) NOHARM children on the MTD dose of hydroxyurea to that of the cohort of non-study MHSCC children with SCA over the time period of the MTD study (calendar years 2018-19).

Uganda 2021-01-08 2024-01-08 Medical and Health Sciences Non-degree Award
JANE  BWIRUKA FRIDA
ID:
Student teachers Narratives on Pedagogical Practices that inform their Competences at Makerere University, Uganda
REFNo: SS518ES

1)Explore the narratives of student teachers on teaching practices that inform their competences at Makerere University.
2)Explore the narratives of student teachers on mentoring practices that inform their competences at Makerere University.
3)Explore the narratives of student teachers on supervision practices that inform their competences at Makerere University.
Uganda 2021-01-08 2024-01-08 Social Science and Humanities Degree Award
ANNETTEE NAKIMULI OLIVIA
ID: UNCST-2022-R011194
Using new genomic approaches to investigate causes of maternal sepsis among women delivering in sub-Saharan Africa
REFNo: HS969ES

Primary objectives
1)To compare the pathogen profiles using routine microbiology (blood cultures, urinalysis, malaria tests, complete blood count) among women with fever at delivery and those without fever at KNRH
2)To compare the prevalence of Streptococcus agalactiae in placental samples using qPCR among women with fever at delivery and those without fever at KNRH

Secondary objectives
1)To compare the composition and diversity of the nasal and ano-vaginal microbiota among women with fever at delivery and those without fever at KNRH
2)To compare the composition and diversity of the nasal and ano-vaginal microbiota among newborns of women with fever at delivery and the newborns of those without fever at KNRH
3)To compare the single-cell RNA-seq transcriptome of the placentae of women with placental malaria and those without placental malaria at Kawempe National Referral Hospital (KNRH).


Uganda 2021-01-08 2024-01-08 Medical and Health Sciences Non-degree Award
Moreen Kiiza
ID:
The Right to Rehabilitation for the Survivors of Torture: A Case Study of Urban Refugees in Katwe-Kinyolo, Kampala-Uganda
REFNo: SS630ES

1. To assess the adequacy of the legal and policy framework governing rehabilitation for refugee survivors of torture in Uganda.
2. To ascertain the rehabilitation needs of refugee survivors of torture in Uganda.
3. To establish the adequacy of available mechanisms for the rehabilitation of refugee survivors of torture in Uganda.
4. To establish the challenges to the rehabilitation of refugee survivors of torture in Uganda.

Uganda 2021-01-08 2024-01-08 Social Science and Humanities Degree Award
VICTOR BEWAYO
ID: UNCST-2024-R003092
ASSESSMENT OF THE LEVEL OF REPORTING ADVERSE DRUG REACTIONS AND ASSOCIATED FACTORS AMONG HEALTH CARE PROFESSIONALS IN COMMUNITY PHARMACY PRACTICE IN KAMPALA CITY, UGANDA
REFNo: HS956ES

1. To establish the proportion of community pharmacy staff that have reported an ADR in the past one year in Kampala City
2. To identify the factors associated with ADR reporting among community pharmacy staff in Kampala City

Uganda 2021-01-07 2024-01-07 Medical and Health Sciences Degree Award
Erica Harrison
ID:
COVID-19 VACCINE UPTAKE STUDY IN UGANDA
REFNo: SS661ES

Research Questions
What is the public’s knowledge, attitude and perceptions towards COVID-19 vaccine in Africa?
Is there an association between the public perception of COVID-19 vaccine and background vaccine confidence and hesitancy levels.

Specific Objectives
Examine the public’s knowledge of COVID-19 and a future COVID-19 vaccine.
Assess the public’s background vaccine confidence and hesitancy levels.
Assess the public’s perceived risks/benefits of a future COVID-19 vaccine.
Determine the willingness of the public to accept and or recommend a future COVID-19 vaccine.
Examine the influence of the knowledge and perceptions of COVID-19 vaccine on the expected uptake of a potential vaccine.
Examine the public’s handling of COVID-19 related rumors.

UK 2021-01-07 2024-01-07 Social Science and Humanities Non-degree Award
Mariam Namasaba
ID:
A school-based resilience training program for caretakers of children with disabilities in Uganda: a cluster-randomized controlled study
REFNo: HS1027ES

To examine the impact of a resilience training program on the mental well-being and coping strategies of caretakers of CWDs in schools in Uganda.

To assess the impact of a resilience training program on the sense of self-efficacy of school caretakers of CWDs in schools in Uganda.
Uganda 2021-01-06 2024-01-06 Medical and Health Sciences Degree Award
Yvonne Mugerwa Kidza Kitego
ID:
The Kampala Slum Maternal Newborn (MaNe) Project - Innovating for Better Referral Systems: an implementation research protocol
REFNo: HS962ES

• To harness the public and private facility mix to provide quality and affordable maternal and newborn care services to the urban poor.
• To strengthen referral linkages between public and private health facilities for MNH care.
• To educate mothers, caretakers of newborns and spouses about appropriate actions on what MNH services to seek and from where
Uganda 2021-01-06 2024-01-06 Medical and Health Sciences Non-degree Award
NORAH IKINYOM
ID:
THE POTENTIAL OF NUTRI-MEDICINAL PLANTS IN THE MANAGEMENT OF OPPORTUNISTIC INFECTIONS ASSOCIATED WITH HIV/AIDS
REFNo: HS983ES

(a)To determine availability of Nutri-medicinal plant species in Acholi sub region and understand traditional methods and formulations being used in quality assurance of nutri-medicinal plant preparations by Traditional medicine practitioners
(b) to determine chemical composition and nutritional characteristics of nutri-medicinal plants, to be conducted according to good laboratory practices (GLPs)
(c) To evaluate the efficacy of Nutri-medicinal plants in managing the HIV/AIDS Opportunistic infections, to be conducted according to good laboratory practices (GLPs)
Uganda 2021-01-06 2024-01-06 Medical and Health Sciences Degree Award
Laban Musinguzi Kashaija
ID: UNCST-2020-R014407
Rapid Assessment of Key Sexual and Reproductive Health Rights needs for LGBT+ persons & quality of available services to LGBT+ persons
REFNo: SS687ES

1. Conduct an assessment of the SRH Needs of LGBT+ Persons in Uganda

2. Conduct an assessment of the quality of SRHR available services to LGBT+ persons in Uganda

3. Generate information on barriers to access and the SRHR needs of LGBT+ persons

Uganda 2021-01-06 2024-01-06 Social Science and Humanities Non-degree Award
Nelson Sewankambo K
ID: UNCST-2020-R014578
Assessment of Health Professional Education Capacity in Uganda during the COVID-19 pandemic (ASHPECC)
REFNo: SS644ES

General Objective
To assess the readiness for and identify barriers and possible solutions to the implementation of the national guidelines for continuity of health professionals training in a safe manner during the COVID-19 pandemic

Specific Objectives
❖ To assess the readiness of HPTIs in Uganda to implement national guidelines for ODeL and in-person training.
❖ To identify the barriers to implementing national guidelines for ODeL and in-person trainings for learners and teachers among health professional training institutions in Uganda
❖ To identify possible solutions for existing barriers to the implementation of national guidelines for ODeL and in-person training at HPTIs in Uganda
❖ To identify the equity implications of different proposed models of learning?
Uganda 2021-01-05 2024-01-05 Social Science and Humanities Non-degree Award
Achilles Katamba
ID: UNCST-2019-R000540
Using human-centered design to develop a novel TB medication adherence technology
REFNo: HS1138ES

1. To design and prototype novel TB medication adherence technologies using research insights gained from previous human-centered design research.
2. To Obtain feedback on novel TB medication adherence technologies from TB patients, caregivers, family members, and health workers using an iterative prototyping approach.

Uganda 2021-01-04 2024-01-04 Medical and Health Sciences Non-degree Award
Sarah Richardson Elizabeth
ID:
A MULTIMETHOD EXAMINATION OF THE STATUS OF EMERGENCY CARE IN UGANDAN HEALTH FACILITIES
REFNo: HS559ES

Broad objective: To maximise the in-depth understanding of the current status of emergency care delivery in Uganda, in order to inform the effective, efficient and sustainable implementation of the components of the WHO ECS toolkit and other emergency care interventions throughout the country. Specific objectives/aims: 1. To describe and establish the current knowledge, attitudes and beliefs of stakeholders towards emergency care. 2. To evaluate barriers and facilitators to the provision of emergency care in Ugandan facilities 3. To evaluate factors that will influence the implementation of emergency care education and implementation packages such as the WHO toolkit 4. To evaluate the current quality and process of the provision of emergency care and the associated total and preventable patient morbidity and mortality in emergency facilities
UK 2020-12-24 2023-12-24 Medical and Health Sciences Degree Award
Nazarius Tumwesigye Mbona
ID: UNCST-2019-R000664
Satisfaction and Knowledge on Emergency Medical services among Health providers and users in facilities implementing a Health System Strengthening project in Masaka and Bukomansimbi districts
REFNo: HS1136ES

 To assess the level satisfaction among health providers who were trained in EMS course under strengthening community health care system project in Masaka region
 To assess the level knowledge among health providers who were trained in EMS course under strengthening community health care system project in Masaka region
 To evaluate the change in the client satisfaction with EMS in facilities that are implementing strengthening community health care system project in Masaka region

Uganda 2020-12-24 2023-12-24 Medical and Health Sciences Non-degree Award
Esther Bayiga Diana Zziwa
ID:
PEDESTRIAN SAFETY AND THE BUILT ENVIRONMENT IN KAMPALA CITY, UGANDA
REFNo: HS960ES

1. To examine the pattern in the spatial and temporal distribution of pedestrian safety in Kampala city, Uganda
2. To examine the influence of the built environment on the distribution pattern of pedestrian safety in Kampala city, Uganda
3. To explore perceptions of different categories of road users in Kampala city, Uganda on the significance of the different built environment variables to pedestrian safety.

Uganda 2020-12-24 2023-12-24 Medical and Health Sciences Degree Award
Mark Kaddumukasa
ID: UNCST-2020-R001798
Prevalence, semiology and risk factors of seizures among elderly patients attending Kiruddu Medical Outpatients in Uganda.
REFNo: HS970ES

Specific objectives
1. To determine the prevalence of seizures among elderly patients attending neurology clinic at Kiruddu hospital.
2. To describe the seizure semiology among elderly patients with seizures.

Secondary objectives
1. To determine the associated risk factors for seizures among elderly patients with cognitive deficts.
2. To determine the cognitive levels of elderly patients attending the neurology clinic at Kiruddu.
3. To explore the stigma associated with dementia among caregivers/families of AD patients.

Uganda 2020-12-24 2023-12-24 Medical and Health Sciences Non-degree Award
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