Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Agnes Kiragga
ID:
Locating disengaged HIV positive women on Option B+ and ascertainment of outcomes among their infants
REFNo: HS175ES

1. To describe the pregnancy outcomes and HIV care status among women (and their exposed infants) who initiate Option B+ 2. To correct 6 week and 18 month estimates of MTCT through tracing of a random sample of HIV positive women who initiated Option B+ during pregnancy and disengaged from care. 3. To identify factors associated with HIV sero-positivity among infants born to women initiated on Option B+. 4. To establish the frequency of Multiclass Resistance among HIV positive infants born to women initiated on Option B+ 5. To estimate the proportion of disengaged women with viral failure and correct estimates of viral suppression (3 rd UN 90 goal) in the facilities.
Uganda 2018-04-04 2021-04-04 Medical and Health Sciences Non-degree Award
ANNET MAGOLO KISAKA
ID:
INFLUENCE OF ORGANISATIONAL CULTURE ON EMPLOYEE PERFORMANCE IN PUBLIC UNIVERSITIES IN UGANDA
REFNo: SS155ES

1. To examine the extent to which organizational mission influences employee performance in public Universities in Uganda 2.To assess the extent to which consistency affects employee performance in public Universities in Uganda 3. To establish how employee involvement influences performance in public universities
Uganda 2018-04-04 2021-04-04 Social Science and Humanities Degree Award
Erik Serrao
ID:
A Clinical Study to Validate the Accuracy and Usability of HemoTypeSCTM, Which is a Novel, Low-Cost, Rapid Diagnostic Test for Sickle Cell Disease
REFNo: HS158ES

The objective of this evaluation protocol is to determine the clinical accuracy of HemoTypeSC in diagnosing SCD-relevant Hb phenotypes (A/A, A/S, A/C, S/S, S/C, and C/C) as compared to “gold standard” HPLC/IEF laboratory testing methodology.
USA 2018-03-27 2021-03-27 Medical and Health Sciences Non-degree Award
Richard Batamwita
ID:
Utilization of obulamu interventions by sex workers and men who have sex with men: a retrospective analysis of services delivery data.
REFNo: HS189ES

To determine changes in the levels of utilization of HIV and STI services by MSM and FSW before and after OBULAMU campaign in Uganda and to compare their utilisation levels with those of the general population (non-MSM and non-FSW population).
Uganda 2018-03-27 2021-03-27 Medical and Health Sciences Non-degree Award
CORDELIA MBOIJANA KATUREEBE
ID:
Developing and Validating a Pediatric and Adolescent HIV Testing Eligibility Screening Tool for Health Care Providers in Uganda
REFNo: HS155ES

General Objective 1) To develop, validate and field test a Pediatric and Adolescent HIV Testing Eligibility Screening Tool (PATEST) for use in outpatient departments within health facilities in Uganda Specific Objectives 1) To develop a Pediatric and Adolescent HIV Testing Eligibility Screening Tool (PATEST) for use in outpatient departments within health facilities in Uganda. 2) To determine the sensitivity, specificity, positive predictive value and negative predictive value of the PATEST among individuals aged 18 months to 19 years in selected study health facilities in Uganda. 3) To assess the perceptions and experiences of use of the PATETST among health care workers, caregivers and adolescents attending outpatient departments within selected study health facilities in Uganda.
Uganda 2018-03-15 2021-03-15 Medical and Health Sciences Non-degree Award
Joanne Corbin Nancy
ID:
Effects of armed conflict and displacement on men's socio-cultural and economic roles in northern Uganda
REFNo: SS119ES

• To examine the impact of armed conflict and internal displacement on men’s socio-cultural and economic roles in Northern Uganda. • To examine this phenomenon from subjective experiences. • To explore the adaptations that men have made to deal with any socio-cultural and economic impacts from armed conflict and internal displacement. • To disseminate the findings from this study in appropriate venues as recommended by Ugandan colleagues and produce an article on the results of this research.
USA 2018-03-14 2021-03-14 Social Science and Humanities Non-degree Award
Innocent Besigye Kabahena
ID: UNCST-2019-R001025
Identifying gaps in screening, diagnosis, clinical practice guidelines and improving hypertension management in primary care facilities in Tororo District
REFNo: HS176ES

1. To identify the gaps in the health facility minimum requirements for successful screening, diagnosis and management of hypertension in Tororo district primary care facilities. 2. To establish the gap between hypertension management guidelines and clinical practice in Tororo district primary care facilities 3. To describe what needs to change for improved care of hypertension in primary care facilities in Tororo District.
Uganda 2018-03-14 2021-03-14 Medical and Health Sciences Non-degree Award
Julie  Nabweteme
ID:
A Post Mortem review of hospital-based suspected Hepatocellular cancer deaths in Uganda to examine the relationship with Schistosomiasis
REFNo: HS116ES

Primary: • To investigate the prevalence of schistosomiasis based on histopathology findings among suspected hepatocellular carcinoma cases. Secondary: • To validate the diagnosis of hepatocellular carcinoma (HCC) among cases of the larger study, which is defined by clinician’s suspicion of HCC and/or presence of liver masses on ultra sound scan with liver mass histopathology obtained at the time of autopsy. • To pathologically correlate the level of liver fibrosis due to schistosomiasis among the HCC deaths adjusting for geographical location and HIV co-infection.
Uganda 2018-03-12 2021-03-12 Medical and Health Sciences Non-degree Award
Chienwen Kao Jennifer
ID:
Mapping Social Networks of Child Caregiving in Uganda: A Formative Mixed Methods Study
REFNo: SS137ES

1. Use qualitative interviews to better understand the caregiving networks of female Ugandan child caregivers 2. Pilot and receive feedback on a novel social network measure designed to measure caregiving networks quantitatively 3. A preliminary exploration of how the captured social network relates to the caregiver’s depression
Taiwan 2018-03-12 2021-03-12 Social Science and Humanities Degree Award
Charles Namisi Patrick
ID: UNCST-2019-R001073
DEVELOPMENT OF A MEASURE TO EMPOWER ADULT PEOPLE WITH HIV IN STIGMA MANAGEMENT, UGANDA
REFNo: SS146ES

This study is conceptualised within empowerment framework, with the purpose to develop and evaluate a measure for empowering adult people in stigma management in Uganda. Specifically, the study will address the three related objectives below; Objective 1, to determine the prevalence and associated factors for Internalized HIV-related stigma among adult PLHIV (Sub study 1). Objective 2, to develop a measure for empowering people living with HIV in stigma management among adults with HIV (sub study 2). Objective 3 a) to evaluate psychometric properties of the Empowerment Questionnaire for HIV-related Stigma Management (EQ-HSM) (Sub study 3).
Uganda 2018-03-09 2021-03-09 Social Science and Humanities Degree Award
Philipp Trotter
ID:
Optimal energy planning in Uganda
REFNo: SIR7ES

There are three major aims of the study: 1. Understand the electricity consumption patterns and current energy situation for Ugandan households in different regions in Uganda 2. Understand the requirements and desires of Ugandan households with regards to Uganda’s energy future 3. Construct an optimization model of the Ugandan electricity infrastructure which analyses different energy future pathways
UK 2018-03-06 2021-03-06 Engineering and Technology Degree Award
Patricia NAHIRYA Ntege Nahirya
ID: UNCST-2019-R001117
HPTN 084 - A Phase 3 Double Blind Safety and Efficacy Study of Long-Acting Injectable Cabotegravir Compared to Daily Oral TDF/FTC for Pre-Exposure Prophylaxis in HIV-Uninfected Women
REFNo: HS147ES

Primary Objectives • Efficacy: To evaluate the relative efficacy of oral CAB/CAB LA (oral run-in and injections, Steps 1 and 2) vs. daily oral TDF/FTC for HIV prevention (Steps 1 and 2). • Safety: To evaluate the relative safety of oral CAB/CAB LA (oral run-in and injections, Steps 1 and 2) vs. daily oral TDF/FTC for HIV prevention (Steps 1 and 2). Secondary Objectives • To compare HIV incidence among participants receiving oral CAB/CAB LA vs. daily oral TDF/FTC (Steps 1, 2 and 3). • To evaluate relative efficacy of oral CAB/CAB LA vs. oral TDF/FTC in subgroups defined by the baseline factors of: age, herpes simplex virus-2 (HSV-2) serostatus, contraceptive method, and body mass index (BMI). • To describe and model the relationship between HIV incidence and drug concentration, within each arm. • To describe the distribution and correlates of drug concentration, within each arm. • To compare the acceptability of and preferences for CAB LA vs. oral TDF/FTC. Tertiary Objectives • To estimate and compare sexual risk behaviors, as measured by self-report and rates of incident sexually transmitted infections (STIs), between study arms. • To compare Grade >2 AE rates in women with baseline BMI
Uganda 2018-03-06 2021-03-06 Medical and Health Sciences Non-degree Award
Simon  Sensalire
ID:
Assessment of Effectiveness and Cost-effectiveness of the Quality Improvement Guide on Maternal and Newborn Care in Uganda
REFNo: HS162ES

1 Evaluate the change in QI-related actions (defined as; establishing improvement team, identifying gaps in quality of care and particular barriers causing the gap, deciding what to improve, plan, test and implement interventions to address identified gap, routinely monitor the progress of improvement and institutionalize improvement and successful changes in the facility) and knowledge among health care providers and managers from targeted health facilities using different implementation strategies vs business as usual (control group). 2 Determine the change in quality of maternal and newborn care processes (defined as every patient receiving the recommended services every time it is appropriate) and outcomes from pre-intervention to post-intervention in health facilities which have been exposed to the three different implementation strategies. 3 Determine the incremental cost-effectiveness ratio of the different implementation strategies in terms of expenditure per unit of patient care improvement achieved by the implementation strategy to each other and the control group with no incremental costs related to particular control group strategy. 4 Explore key informants perceptions of and experiences with the different intervention strategies.
Uganda 2018-03-06 2021-03-06 Medical and Health Sciences Non-degree Award
Susan Whyte Reynolds
ID:
Aging as a Human Condition: Radical Uncertainty and the Search for the Good (Old) Life
REFNo: SS150ES

Through a comparative ethnographic research design, we explore the universal and the culturally specific in experiences of aging, with an eye to how local cultural resources and social structures can both afford and constrain people’s search for the good life in later years. The specific objectives are to explore experiences of four main themes: the mindful body, intimate others, time lived, and home space
USA 2018-03-06 2021-03-06 Social Science and Humanities Non-degree Award
Aya Tsubota
ID:
Work empowerment of Health Care Workers in the Republic of Uganda
REFNo: HS172ES

This research aims to identify effective factors of work empowerment for health care workers in the Republic of Uganda using the Focus Group Interview method.
Japan 2018-03-06 2021-03-06 Medical and Health Sciences Degree Award
KYALIMPA Paul
ID:
LEADERSHIP COMPETENCIES AND SUSTAINABLE FUNDING OF NON-GOVERNMENTAL ORGANISATIONS IN UGANDA
REFNo: SS156ES

1.To determine the competences of Nocal NGO (LNGO) leaders in Uganda; 2.To establish the level of LNGO financial sustainability in Uganda; and 3.To establish the influence of competences of LNGO leaders on sustainable funding of LNGOs in Uganda.
Uganda 2018-03-06 2021-03-06 Social Science and Humanities Degree Award
John Sentongo Luyimbazi
ID:
Increasing Efficiency and Improving Quality of Secondary Education in Sub Saharan Africa: A Case Study of Uganda
REFNo: SS163ES

Review and document evidence, background literature and policies on school efficiency in the secondary education context, 2. Develop a theoretical framework to structure evidence and approaches to improving school level efficiency, 3. Assess how secondary schools are governed, managed, resourced, monitored and how resources are allocated and utilized against a benchmark or a framework, 4. Identify opportunities to increase the efficiency and effectiveness of secondary schools through implementation of local solutions and actionable interventions, and 5. Recommend contextually relevant and innovative school efficiency measures to empower schools to sustainably finance, effectively govern, and improve the quality of secondary education.
Uganda 2018-03-06 2021-03-06 Social Science and Humanities Non-degree Award
Vitaliano Cama
ID:
Evaluation of the Diagnostic Tests in Areas Hypoendemic for Onchocerciasis –Uganda
REFNo: HS90ES

) Evaluate the distribution of anti-OV-16 antibody and other markers of O. volvulus infection in multiple age groups. Data from this study may allow to determine the force of infection (rate at which susceptible individuals acquire an infection) using catalytic models
USA 2018-02-21 2021-02-21 Medical and Health Sciences Non-degree Award
Payal Chakraborty
ID:
Characterizing Treatment/Management and Patient Outcomes of Epilepsy in Uganda: A Prospective Cohort Study
REFNo: HS99ES

1. Characterize management of epilepsy in Mulago National Referral Hospital (MNRH), Butabika National Mental Hospital (BNMH), and Mbarara Regional Referral Hospital (MRRH). 1a. To assess treatment options available for epilepsy patients by site (MNRH, BNMH, and MRRH). 1b. To assess knowledge, attitudes, and other factors associated with treatment barriers. 2. Characterize treatment outcomes in hospital-based epilepsy care, specifically at MNRH, BNMH, and MRRH. 2a. To determine etiological risk factors and common seizure patterns associated with epilepsy that present in patients at study sites. 2b. To determine the seizure severity, quality of life, and seizure outcomes among patients with epilepsy. 2c. To determine the adherence levels and factors associated with non-adherence of anti-epileptic drugs.
USA 2018-02-21 2021-02-21 Medical and Health Sciences Degree Award
Alicia Rich Michelle
ID:
Chimpanzee Highways: Gene Flow and Connectivity at Itwara Forest Reserve
REFNo: NS36ES

This study will focus on a chimpanzee metapopulation, which likely spans several protected areas in western Uganda by utilizing Itwara Forest Reserve (hereafter ‘Itwara’) as a connective corridor. Contrasting environments characterize at least two of those areas; closed-forest habitat dominates Itwara Forest Reserve (Howard 1991), while closely neighboring Toro-Semliki is usually described as an “open habitat,” (Hunt and McGrew 2002). Initial observations suggest that chimpanzees utilize a connective corridor of ~4 km between those two reserves, not only for rare dispersal events, but also for regular ranging within a single community’s territory (Rich et al. in prep). Here we are proposing to test whether chimpanzees do use a connective corridor between the two reserves, where the chimpanzee-selected corridor is, and what motivates travel through it (i.e. dispersal, foraging, etc.). We will examine the evolutionary and conservation-based implications of corridor-use by Toro-Semliki/Itwara chimpanzees and lay the groundwork for long term, multi-species connectivity research in and around Itwara Forest Reserve using indirect methods. If chimpanzees are using this corridor, then we will expand our research to examine other potential connective corridors that extend from Itwara Forest Reserve into other protected areas such as Kibale National Park and Muhangi Forest Reserve.
USA 2018-02-21 2021-02-21 Natural Sciences Non-degree Award
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