Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Freddy Kitutu Eric
ID: UNCST-2020-R014751
 Availability and use of essential medicines and health supplies
REFNo: HS1122ES

4. Explore the effect of centralized funding mechanism on the availability of essential medicines in private not for profit facilities,3. Assess the impact of SPARS on the quality of HMIS health facility logistics data.,2. Determine the effect of SPARS on the availability of essential medicines and health supplies in public and private not for profit health facilities,1. Determine the effect SPARS has had on medicines management practices within health facilities during the scale-up period beyond one year,
 Uganda 2021-03-16 2024-03-16 Medical and Health Sciences Non-degree Award
Achilles Katamba
ID: UNCST-2019-R000540
 Understanding the trajectories of individuals in Uganda with trace M. tuberculosis nucleic acid in sputum- The TURN-TB study (Trace Ultra Result iNsight in TB screening)
REFNo: HS1177ES

1.To characterize baseline evidence for current or past TB disease and infection among individuals with Ultra-trace-positive sputum.
2.To longitudinally evaluate the incidence of TB and the dynamics of molecular, imaging, and immunological findings among individuals with trace-positive Ultra but no active TB at study entry.
3.To quantitatively and qualitatively explore the implications of trace-positive results and associated patient trajectories for active TB case finding strategies.

Uganda 2021-03-16 2024-03-16 Medical and Health Sciences Non-degree Award
Stephen  Ojiambo Wandera
ID: UNCST-2021-R012147
 Parent-Child Communication on Sexual and Reproductive Health in border districts of Eastern Uganda
REFNo: SS748ES

The aim of the study is to assess parents’ knowledge, attitudes, and practices (KAP) and preferred approaches to PCC on sexual and reproductive health in eastern Uganda. Specific objectives are:
1. To assess parents’ knowledge, attitudes, and practices about parent-child communication about sexual and reproductive health in eastern Uganda.
2. To determine the prevalence and determinants of PCC on SRH in eastern Uganda using survey data.
3. To examine the facilitators and barriers of PCC on SRH using qualitative data among parents in eastern Uganda.
4. To identify parents’ and children’s preferred approaches to PCC on SRH in eastern Uganda.

 Uganda 2021-03-16 2024-03-16 Social Science and Humanities Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 Strategies for resolving the gap in Adolescent TB care in Uganda: A pilot cluster randomized-controlled trial
REFNo: HS1042ES

1.To develop an adolescent friendly TB screening package in Ugandan health facilities.
2.To evaluate the effectiveness of an adolescent friendly screening package for TB in Ugandan health facilities
3.To ascertain the cost effectiveness of rolling out an adolescent friendly TB screening intervention in Ugandan health facilities

 Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
Immaculate  Nankya Lillian
ID: UNCST-2020-R014784
 Validation of an Antigen ELISA based assay for the detection of SARS-CoV-2 RNA: A COVID-19 rapid diagnostic test method
REFNo: HS1103ES

• Demonstrate the ability of the AirJump ESP Platform, a simplified RNA isolation method to extract SARS COV-2 RNA from patient samples
• Evaluate an ELISA based assay to detect RNA converted to cDNA and bound to biotin labeled primers
• Assess accuracy of the ELISA assay in detecting SARS-CoV-2 from paired Nasal Pharyngeal swabs and saliva samples collected from COVID-19 positive and negative participants.
• Determine the Reproducibility of the Antigen ELISA Assay

 Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
JOSEPH SSUUNA
ID: UNCST-2024-R016102
 Epidemiology and impact of HIV, NCD and urbanization syndemic in Africa.
REFNo: HS1188ES

Aim 1: Characterize HIV-related and -unrelated risk factors for cardiopulmonary non-communicable diseases (CP-NCDs) in a novel Rural-to-Urban (R2U) African cohort.

Aim 2: Characterize the impact of air pollution and moderating effects of HIV on cardiopulmonary clinical outcomes among R2U migrants.

Aim 3: Assess HIV and CP-NCDs health services utilization patterns among R2U migrants and design an integrated HIV/CP-NCD intervention.

 Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
CHRISTOPHER  OPIO KENNETH
ID:
Knowledge, Attitudes and Practice of doctors in Uganda regarding screening, diagnosis and management of colorectal cancer.
REFNo: HS1198ES

To improve early detection, screening and the management of colorectal cancer in Uganda,
 Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
Amanda Murungi Eunice
ID:
Comparing the two transition feeding approaches in management of severe acute malnutrition among children 6-59 months: a randomized controlled trial (RCT)
REFNo: HS1200ES

To compare the effectiveness and outcomes of two transition phase feeding approaches (RUTF supplemented with F75 and RUTF only) children 6-59 months hospitalized with severe acute malnutrition in Mulago National Referral Hospital
 Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Degree Award
Yahaya Gavamukulya
ID: UNCST-2019-R001017
 EVALUATION OF THE ANTI-SARS-CoV-2 ACTIVITY OF COMPOUNDS FROM Tephrosia linearis, Zanthoxylum chalybeum and Albizia coriaria AND FORMULATION OF HERBAL PRODUCT(S) FOR MANAGEMENT OF COVID-19
REFNo: HS1222ES

The general objective
To evaluate the antiviral potential of Tephrosia linearis, Zanthoxylum chalybeum and Alibizia coriaria, against SARS-CoV-2 and formulate herbal product(s) for management of COVID -19.

Specific objectives
i. To determine the in vitro anti-SARS‐CoV‐2 activity of the three selected medicinal plants in singular and in combination using SARS‐CoV‐2 infected mammalian cell lines (VeroE6).
ii. To determine the cytotoxicity and acute toxicity of the active medicinal plant(s) on mammalian cell lines (VeroE6) and swiss albino mice respectively.
iii. To determine the effects of the extracts on the immunological profile of cell lines
iv. To formulate and evaluate herbal product (s) from the most active medicinal plants for management of COVID-19.

Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
Kelly Mannion Ray
ID:
Understanding how variation in food effort and intake correlate with tool use in Bugoma Forest Chimpanzees
REFNo: NS155ES

To understand the potential drivers of tool use and how ecology plays a role
 USA 2021-03-15 2024-03-15 Natural Sciences Degree Award
Allen Kabagenyi
ID:
Adolescent Motherhood, Vulnerability Assessment and Newborn care practices, in Eastern Uganda (AMNEP)
REFNo: HS1248ES

The general objective of this study is to develop and test adolescent motherhood vulnerability assessment tool and to examine the knowledge, behavioral practices and perceptions of maternal and new born care among adolescent mothers in Luuka District.
Specific objectives
1. To examine the knowledge levels and awareness of maternal and newborn care among adolescent mothers and the community in Luuka District
2. To develop and test a community based adolescent mothers Vulnerability Assessment Tool
3. To assess the pre and postnatal maternal and newborn care practices and among adolescent mothers and the community in Luuka District
4. To explore the perceptions, vulnerability risk and barriers to unborn and newborn care management among adolescent mothers and the community in Luuka District

 Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Degree Award
Sebastian Linnemayr
ID: UNCST-2021-R012696
 INcentives and ReMINDers to Improve Long-term Medication Adherence (INMIND)
REFNo: HS1286ES

We propose to test INMIND in a pilot, 3-arm randomized controlled trial (RCT) in Uganda with two intervention groups. All participants (including in the control group) will receive information about the importance of behavioral routines, as is part of the standard adherence counseling for treatment initiators, and create personalized ART adherence anchoring strategies. In the first intervention group, participants will additionally receive text messages to keep adherence and their anchoring strategy salient. In the second group, we add small incentives awarded conditionally on taking ART pills within a time window that corresponds to participants’ personalized anchoring strategy to increase the immediate rewards of adherence.

The Specific Aims
1.Develop the intervention using the ADAPT-ITT framework and evaluate the feasibility and acceptability of INMIND.
2: Test the preliminary effectiveness of the intervention, including the relative effectiveness of two different implementation approaches
3. Collect data in preparation for a subsequent R01 application
 USA 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
Dickens Akena Howard
ID: UNCST-2019-R000179
 The effect of psycho-education on clinical outcomes among patients with a first episode psychosis in central Uganda - A pilot randomized control trial
REFNo: HS1026ES

The study objectives are to (a) Conduct formative work and develop a manual for delivering psycho-education messages by Village Health Team (VHTs) members to individuals with first episode psychosis (FEP) and their families in central Uganda. (b) Examine the efficacy of psycho-education on symptom severity, stigma and retention in care. (c) Document feasibility and acceptability of implementing this intervention as well as barriers to its implementation
Uganda 2021-03-12 2024-03-12 Medical and Health Sciences Non-degree Award
JOSEPH Ngonzi
ID:
Quality Improvement Initiative in the Department of Obstetrics and Gynaecology
REFNo: HS967ES

1) To measure current health outcomes in the unit
2) To describe and analyze current process, behaviors, resources and availability
3) To develop and implement changes in current practices to improve outcomes while maximizing resources.
4) To monitor and evaluate health outcomes in the department of OB/GYN

 Uganda 2021-03-12 2024-03-12 Medical and Health Sciences Non-degree Award
Margaret Joanita Mutumba Nakalembe
ID:
Multi-level Analysis on Implementation of Low-Cost IVF in Sub-Saharan Africa: A Case Study of Uganda.
REFNo: HS1214ES

The objective of this study is to explore how LCIVF has been implemented in the public health system of Uganda. The more specific questions include; 1) How has LCIVF been operationalized at the micro-level within the clinical practice? 2) How has the public hospital at the meso-level organized itself to facilitate the implementation and provision of LCIVF? 3) How have macro-level factors influenced the implementation of LCIVF within the public health system? 4) How effective has the implementation of LCIVF been in addressing accessibility and affordability of infertility services in Uganda?
 Uganda 2021-03-12 2024-03-12 Medical and Health Sciences Degree Award
Nixon Niyonzima
ID: UNCST-2020-R014577
 MUTATIONAL PROFILE OF TRIPLE NEGATIVE BREAST CANCER IN WOMEN SEEKING CARE AT THE UGANDA CANCER INSTITUTE
REFNo: HS1264ES

1. To describe the mutational profile of triple negative breast cancer in women seeking care at the Uganda Cancer Institute
2. To describe the relationship between the mutational load and the primary tumor size of triple negative breast cancer in women seeking care at the Uganda Cancer Institute
3. To describe the differences in mutational profile by histological type in patients with triple negative breast cancer in women seeking care at the Uganda Cancer Institute

 Uganda 2021-03-12 2024-03-12 Medical and Health Sciences Degree Award
Nathan Kenya-Mugisha
ID: UNCST-2021-R013752
 An Evaluation of the Pediatric Care Process in Uganda for Improvement of Quality of Care
REFNo: HS1227ES

The primary objective of this study is to evaluate the typical pediatric care process at a representative sample of hospitals in Uganda
 Uganda 2021-03-11 2024-03-11 Medical and Health Sciences Non-degree Award
Peter Olupot-Olupot
ID:
Severe MAlaria A Research and Trials consortium: A protocol for a prospective case control observational study
REFNo: HS1231ES

To characterise the contemporary epidemiology (including features at presentation and the diagnostic and treatment pathway) of severe malaria presenting to hospital for admission in children in Africa, through conducting a prospective multicentre observational study across 7 sites in 6 countries, enrolling two cohorts of hospitalised children (i.e. stratified) with severe and non-severe malaria. For this study, severe malaria will be defined as children with a positive POC pHRPT2 test (Paracheck) meeting WHO criteria or Teule criteri. For severe malaria, we will characterise the proportions presenting with different severe complications, or combination of any of or all of these, and compare these proportions across sites. Secondary Objectives i. To compare baseline characteristics of admitted children with severe and non-severe malaria. ii. To document time from presentation to the hospital ‘gateway’ (e.g. outpatients or emergency/triage centre) to ward admission and time to first dose of parenteral artesunate to assess whether delays in initiating definitive antimalarial treatment could contribute to malaria severity. iii. To estimate the incidence of significant post-discharge events to day-180 including readmission (all-cause and for malaria (i.e. relapse)) and all-cause mortality in severe and non-severe malaria. iv. To develop (year 1) and evaluate (years 2 and 3) a point-of-care quantitative plasma Plasmodium falciparum histidine-rich protein2 (pfHRP2) test for estimating total body parasite burden, which could be used to swiftly identify those at greatest risk of poor outcomes.
Uganda 2021-03-11 2024-03-11 Medical and Health Sciences Non-degree Award
Tom Lutalo
ID:
Measuring adult health and mortality in Low- and Middle-Income Countries
REFNo: HS640ES

1. To evaluate the accuracy of survey data on adolescent and adult mortality collected retrospectively through siblings’ survival histories (SSH), compared to the reference mortality data collected prospectively.
2. To test whether the siblings of respondents can be reached and interviewed via mobile phone, in order to collect data on the risk factor of adult mortality

 Uganda 2021-03-10 2024-03-10 Medical and Health Sciences Non-degree Award
Levicatus Mugenyi
ID: UNCST-2020-R014759
 Understanding Factors Associated with IPT Completion among Recipients of Care on ART/IPT Aligned Multi-month Refills across the Differentiated Service Delivery Models
REFNo: HS1228ES

The primary objective is to understand factors associated with completion of IPT among clients in MoH’s integrated IPT/ART models.
Specific objectives:
1.To compare IPT completion rates amongst clients across the five DSD models: Facility-Based Individual Management (FBIM), Facility-Based Group (FBG), Fast Track Drug Refill (FTDR), Community Client Led ART Delivery (CDDP), and Community Drug Distribution Points (CCLAD).
2.To understand individual and facility level factors associated with IPT completion across the different DSD models
3.To compare IPT uptake across the different DSD models
4.To compare the frequency of adverse events (AEs) reported by clients on IPT across the different DSD models
5.To document patient and service provider KAP towards the IPT/ART integrated model

 Uganda 2021-03-10 2024-03-10 Medical and Health Sciences Non-degree Award
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