Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Christine Aanyu
ID:
EQUITABLE MATERNAL CARE FOR WOMEN WITH DISABILITY (EMeralD) STUDY
REFNo: HS722ES

1) Specific Aim 1. Conduct an analysis of disability, pregnancy and birth outcomes, and maternal health care utilization data for pregnant women with disabilities in Uganda.
2) Specific Aim 2. Understand the needs and perceptions of pregnant women with disabilities and identify availability of, and barriers to accessing, maternal health care services.
3) Specific Aim 3. Formulate and develop a model for disability-friendly services for pregnant women.

Uganda 2020-10-07 2023-10-07 Medical and Health Sciences Non-degree Award
David Serwadda -
ID:
Characterizing community exposure to SARS-CoV-2 in Uganda, and assessing biological determinants of virus spread
REFNo: HS878ES

1.Assess the diagnostic sensitivity and specificity of the CoronaChekTM rapid COVID-19 IgM/IgG lateral flow test (CoronaChekTM by Hangzhou Biotest Biotech Co Ltd) for anti- SARS-CoV-2 antibodies detection in Uganda.
2.Conduct enhanced surveillance of COVID19-like symptoms in the context of an existing population cohort and assess the predictive value of prevailing symptoms for COVID-19 exposure based on rapid serological testing in this region.
3.Determine rates of sero-reactivity/positivity among key health care workers at high-volume health centers III and IV and also among PCR-negative contacts of confirmed COVID-19 cases in the region.
4.Explore ‘prior importation of COVID-19 infection in Uganda”/ pre-existing sero-reactivity (may due to ‘related’ coronavirus strains/shared epitopes) in purposively selected archived sera, prioritizing from truck drivers and commercial sex workers that was collected before the lockdown in Uganda / Rakai region.

Uganda 2020-10-06 2023-10-06 Medical and Health Sciences Non-degree Award
Richard Idro
ID: UNCST-2021-R013599
Dihydroartemisinin-Piperaquine or Sulphadoxine-Pyrimethamine for the Chemoprevention of Malaria in Children with Sickle Cell Anaemia in eastern and southern Africa: a double blind randomised trial (the CHEMCHA trial)
REFNo: HS709ES

Primary objective
The general objective is to determine the efficacy and safety of malaria chemoprevention with weekly single day courses of DP compared to monthly single courses of SP in children with SCA in eastern and southern Africa.

Secondary objectives
1. Assess the feasibility and stakeholder perceptions on the uptake (acceptability) and the potential for future roll-out of weekly DP vs monthly SP.
2. Determine the safety of cumulative dosing of DP, especially on cardiac function.
3. Monitor the development of malaria parasite resistance to DP in clinical isolates over time.
Assess patients’ health-related quality of life, cost-effectiveness, equity and economic implications of using weekly courses of DP vs monthly courses of SP as chemoprevention in SCA.
5. Assess acceptability of weekly courses of DP for malaria chemoprevention in SCA vs monthly courses of SP as chemoprevention in SCA.
6. Conduct policy advocacy to engage key stakeholders on policy decisions on using weekly courses of DP or monthly courses of SP for the chemoprevention of malaria in SCA.
Uganda 2020-10-02 2023-10-02 Medical and Health Sciences Non-degree Award
Richard Idro
ID: UNCST-2021-R013599
Hydroxyurea therapy for Neurological and Cognitive Protection in Pediatric Sickle Cell Anemia in Uganda: A single arm open label trial, “BRAIN SAFE II”
REFNo: HS846ES

The primary objective is to determine the impact of daily oral hydroxyurea therapy, 20- 30mg/kg/day, on the frequency and severity of Sickle Cell Vasculopathy(SCV) in a cohort of children treated for three years, as measured by 3 distinct outcomes: abnormal TCD, neurocognitive impairment and primary stroke, compared with baseline.

Secondary objectives
1.Evaluate the impact of Hydroxyurea therapy on structural SCV using MRI and MRA in a randomly selected subset of this cohort.
2.Assess changes to anemia, CRP and malnutrition status during hydroxyurea therapy, over time, compared with baseline levels.


Uganda 2020-10-02 2023-10-02 Medical and Health Sciences Non-degree Award
Sarah Kiguli
ID: UNCST-2021-R013020
Nutritional Treatment in Pneumonia Trial. (NuTiP)
REFNo: HS911ES

To establish whether supplementary feeding for 56-days (8 weeks) using Ready to Use Therapeutic Feeds (RUTAFA) in children between 6 months and 12 years with respiratory distress complicated by hypoxia versus usual standard care will improve outcome at 90-days.
Uganda 2020-10-02 2023-10-02 Medical and Health Sciences Non-degree Award
mariam Namutebi
ID:
TEENAGE FIRST TIME MOTHERS’ PERCEPTIONS ABOUT THEIR HEALTH CARE NEEDS AND THE GAPS IN POSTPARTUM CARE.
REFNo: HS780ES

General objective:
To explore the teenage first time mothers’ perceptions about their postpartum care needs and the gaps in the facility based postpartum care
Specific Objectives:
1. To explore the teenage first time mothers’ perceptions about their postpartum care needs.
2. To identify the current gaps in the facility based postpartum care provided to teenage first time mothers.

Uganda 2020-10-01 2023-10-01 Medical and Health Sciences Non-degree Award
Joseph Kagaayi
ID: UNCST-2024-R015946
Impact of COVID-19 Lockdown on HIV and Reproductive, Maternal, Neonatal and Child Health services in Masaka region, Uganda
REFNo: HS865ES

1 Goal
The overall goal of the study is to assess the effect of the COVID-19 lockdown on demand and utilization of RMNCH and HIV services and assess coping mechanisms in order to make evidence-based recommendations for mitigation of the impact during the COVID-19 epidemic and future health emergencies and disasters.

Specific aims
1) To determine the effect of COVID-19 lockdown on discontinuation of Antiretroviral therapy (ART) among patients receiving antiretroviral drugs in 12 districts of the Masaka region.
2) To determine the effect of COVID-19 lockdown on Antenatal care (ANC) attendance, facility deliveries, contraception, immunization, EID, HIV testing among all pregnant women and initiation of option B+ among HIV-positive ANC attendees.
3) To determine the effect of the COVID-19 response on viral load monitoring, intensive adherence counseling and HIV viral suppression among clients in the Masaka region,.
4)To explore clients’, district, and health facility knowledge, attitude and experiences (KAE) and coping mechanisms for sustained ART, and RMNCH services. Qualitative exploration of KAE will provide useful pathways for the effect of lockdown measures on demand and utilization of services.

Uganda 2020-10-01 2023-10-01 Medical and Health Sciences Non-degree Award
Cissy  Kityo
ID: UNCST-2021-R013663
Validation of SARS-CoV-2 detection by Rapid AirJump RNA Amplification (RARA) COVID Test method
REFNo: HS888ES

We will carry out validation of RARA assay in the laboratory before the field evaluation in testing of SARS-CoV-2.
We intend to understand the inherent characteristics of this assay with regard to accuracy (diagnostic sensitivity, diagnostic specificity), Precision (reproducibility), Limit of detection (LOD), Predictive value (negative and positive), and Assay Efficiency.
Uganda 2020-10-01 2023-10-01 Medical and Health Sciences Non-degree Award
KarenBeth Bohan Heikkinen
ID:
Assessment of Online Modules to Increase Knowledge of Geriatric Care in Health Care Professionals RefNo: MAKSHSREC-2020-6
REFNo: HS727ES

To determine the pharmacists’ satisfaction with pharmacy geriatric online training.,To determine the learning preference in terms of online compared to live educational sessions before and after using the online modules for professional development,To determine the retention of knowledge of geriatric care at three months after completion of all five online educational modules.,To assess the improvement of pharmacy professionals’ knowledge of geriatric care after participating in online educational modules.,
USA 2020-09-29 2023-09-29 Medical and Health Sciences Non-degree Award
Ignatius Odongo Odongo
ID:
Youth Entrepreneurship in South Africa and Uganda: An Investigation of the Influence of Mental Triggers
REFNo: SS487ES

To contribute to the existing discourse on youth entrepreneurship, by introducing a new applied framework from which youth entrepreneurship can be developed based on the influences of mental triggers. The new framework will include, inter alia, a description of the following:
• the environment that can potentially stimulate youth entrepreneurship;
• the kind of entrepreneurship education that will stimulate and provide requisite skills for the nascent youth entrepreneur; and
• the personal characteristics that can be nurtured for entrepreneurial success.
Armed with this new framework, the stakeholders that areresponsible for youth development, particularly in developing countries, will be able to deal with the psychological and other barriers that impede the youth from venturing and succeeding in entrepreneurship.

Uganda 2020-09-29 2023-09-29 Social Science and Humanities Degree Award
Victoria Nankabirwa
ID: UNCST-2021-R011871
Preventing Infant Malnutrition with Early Supplementation (PRIMES)
REFNo: HS825ES

Aim 1. To describe local experiences and beliefs related to breastfeeding, breast milk expression, non-maternal food sources and infant weight and health.

Aim 2. To determine the range of newborn weight changes, the typical age at which a newborn returns to birth weight, and any association of newborn weight change with early dietary intake, clinical and demographic characteristics, and breastfeeding behaviors.

Uganda 2020-09-29 2023-09-29 Medical and Health Sciences Non-degree Award
Fred Bulamba
ID: UNCST-2019-R000026
Mapping perioperative care pathways to support surgical treatment in Low-and-Middle Income Countries
REFNo: HS642ES

The aim of this project is to understand the context of perioperative health systems in Uganda, including the main barriers encountered in the delivery of care.

Objectives:
1. Develop a collaborative approach to perioperative care pathway mapping
2. Carry out a rapid appraisal to map 5 pathways (three “Bellwether procedures and two elective procedures) in Uganda.
3. Refine the process and extend to three low- and middle-income countries

Uganda 2020-09-28 2023-09-28 Medical and Health Sciences Non-degree Award
marie nanyanzi
ID: UNCST-2019-R001553
Point Of Entry Sauti Za Wananchi (Voices of the citizens)Extension Survey
REFNo: SS468ES

To understand the COVID-19 effects on the citizens’ experience and key services they receive during this era of COVID-19 especially ▪ Establish citizen access to safe water; ▪ Establish citizen access and usage of health services and knowledge, Attitudes and Practices (KAPs); ▪ Find out level of participation/involvement/interaction in development and public activities /institutions; ▪ Find out access and usage of financial services amongst citizens; ▪ Find out how; what and when citizen access different type of information including government and development information. ▪ Establish the knowledge, Attitudes and Practices (KAPs) of citizens on different guidelines, policies; laws and regulations etc
Uganda 2020-09-28 2023-09-28 Social Science and Humanities Non-degree Award
mariam Namutebi
ID:
POSTPARTUM CARE: FACILITY READINESS, MIDWIVES’ PERSPECTIVES AND THE EFFECT OF USING INDIVIDUALIZED CARE PLANS ON POSTPARTUM OUTCOMES.
REFNo: HS773ES

General Objective

To assess the facility readiness for the provision of Postpartum care, explore the midwives’ perspectives about postpartum care and evaluate the effect of using individualized care plans on the postpartum outcomes in the greater Mpigi region.
Specific objectives
1. To assess the facility readiness to provide postpartum care in selected facilities in the greater Mpigi region.
2. To explore the midwives’ perspectives towards postpartum care in the greater Mpigi region.
3. To evaluate the effect of using individualized care plans in the immediate and early postpartum period on the monitoring assessments, physical examination and health education of postpartum women in the greater Mpigi region.
4. To describe the postpartum women’s perspectives and midwives’ experiences of postpartum care provided using individualized care plans

Uganda 2020-09-28 2023-09-28 Medical and Health Sciences Degree Award
Esther Buregyeya
ID: UNCST-2020-R014116
Using the human-centred design model to inform local adaptation of COVID-19 prevention measures among high-risk populations in Malaba and Mutukula points of entry in Uganda
REFNo: HS848ES

1. To determine knowledge and risk-perceptions on COVID-19 measures among high-risk populations in Malaba and Mutukula points of entry.
2. To assess uptake of recommended COVID-19 prevention measures measures among high-risk populations in Malaba and Mutukula points of entry.
3. To explore the facilitators and barriers to uptake of the COVID-19 prevention measures measures among high-risk populations in Malaba and Mutukula points of entry.
4. To design, pilot and evaluate localized behavioural interventions to foster uptake of the COVID-19 prevention measures measures among high-risk populations in Malaba and Mutukula points of entry.
Uganda 2020-09-28 2023-09-28 Medical and Health Sciences Non-degree Award
Kirsten Beyer M
ID: UNCST-2021-R013472
Geospatial Analysis of Kampala Cancer Registry Data
REFNo: HS873ES

Objective 1: Identify spatial and spatiotemporal patterns of cancer in Uganda. a) Use geospatial mapping techniques to estimate cancer burdens across geographic space and through time. b) Create visual representations of cancer patterns (maps, graphs). Objective 2: Examine relationships between social and environmental factors and cancer outcomes in Uganda. a) Use statistical analysis techniques to determine associations between environmental factors and cancer outcomes. Objective 3: Pilot the collection of new KCR variables a) For each new case, we will attempt to acquire marital status, education level, occupation, religion, national Identification number (NIN) (new in Uganda), and precise geographic location information. Objective 4: Determine the true spatial extent of KCR data collection potential. a) Identify the number of cases that are discovered and excluded under current practice, as well as the individual’s parish of residence.
USA 2020-09-28 2023-09-28 Medical and Health Sciences Non-degree Award
Catherine Mwesigwa
ID: UNCST-2019-R000988
THE DENTAL WORKFORCE IN UGANDA: A SITUATION ANALYSIS
REFNo: HS532ES

1. To take a census of the dental professionals in Uganda
2. To determine the recruitment levels into public/private employment and retention rates of dental surgeons and specialists in Uganda.
3. To determine the factors which influence attraction to, retention within and attrition from the health care system among dental surgeons and specialists
4. To examine the spatial distribution of actively practising dental professionals and public health dental officers relative to urban- rural and public-private characteristics

Uganda 2020-09-23 2023-09-23 Medical and Health Sciences Non-degree Award
John Tabuti Robert Stephen
ID: UNCST-2024-R002181
Development of a Safe and Efficacious Anti-malarial drug from Traditional medicine (DESAT)
REFNo: HS685ES

The aim of this study is to develop an effective anti-malarial phytomedicine. The specific objective are 1) to prioritize malaria treating plants, and to determine 2) efficacy of commonly used herbal medicines, 3) safety of commonly used herbal medicines, and 4) the active compounds in the selected phytomedicines.
Uganda 2020-09-23 2023-09-23 Medical and Health Sciences Non-degree Award
Thereza Piloya Were
ID: UNCST-2019-R000491
Effect of the COVID-19 pandemic on access to community health care services for common childhood illnesses among children under five years in Wakiso District, Uganda
REFNo: HS802ES

Primary Objectives 1. To determine the utilisation of Integrated childhood community Management (ICCM) services for children aged under 5 years seeking care at the VHTs in three sub-counties in Wakiso district between January and June 2020
2. To determine the outcomes of the sick children under 5 years seen by the VHTS in three sub-counties in Wakiso district.
Secondary objective
3. To determine the utilisation of health facility level services for sick children aged under 5 years referred from the VHTS in Wakiso district during the period of January to June 2020


Uganda 2020-09-23 2023-09-23 Medical and Health Sciences Non-degree Award
Eve  Namisango
ID: UNCST-2021-R014038
Preparedness to face the COVID-19 pandemic in African hospices and palliative care services: A rapid assessment
REFNo: HS806ES

To determine the preparedness and capacity of palliative care service providers in Africa to respond to the COVID-19 pandemic

To explore the potential consequences of the COVID-19 pandemic on palliative care services and service providers in Africa.

Uganda 2020-09-23 2023-09-23 Medical and Health Sciences Non-degree Award
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