Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
ASINAI LILIAN
ID: UNCST-2024-R016497
 STRATEGIC FINANCIAL MANAGEMENT PRACTICES AND SERVICE DELIVERY IN NATIONAL WATER AND SEWERAGE CORPORATION: THE CASE OF KAMPALA METRO-POLITAN REGION
REFNo: SS4102ES

Main objective: The study's general objective is to examine the effect of strategic financial management practices on service delivery at National Water and Sewerage Corporation, Kampala Metropolitan Region. Specific objectives i. To determine the significant effect of strategic planning on service delivery at National Water and Sewerage Corporation, Kampala Metropolitan Region. ii. To identify the significant effect of strategic budgeting on service delivery at National Water and Sewerage Corporation, Kampala Metropolitan Region. iii. To investigate the significant effect of strategic managing of risks and service delivery at National Water and Sewerage Corporation, Kampala Metropolitan Region. iv. To assess the significant effect of strategic ongoing procedures on service delivery at National Water and Sewerage Corporation, Kampala Metropolitan Region. v. To examine the moderating role of staff commitment on strategic financial management practices and service delivery at National Water and Sewerage Corporation, Kampala Metropolitan Region.
Uganda 2025-09-17 13:30:37 2028-09-17 Social Science and Humanities Non-Clinical Trial Degree Award
MARILYN BAKO ARUMADRI
ID: UNCST-2024-R002256
 IMPLEMENTATION OF THE UNITED NATIONS SECURITY COUNCIL RESOLUTION 1325 AND REPRESENTATION OF WOMEN IN LEADERSHIP POSITIONS IN SECURITY INSTITUTIONS IN UGANDA
REFNo: SS4324ES

3. Identify challenges perceived and related to women involvement in decision-making leadership positions in security institutions in Uganda.,2. Examine the impact of the implementation of UNSCR 1325 on women’s representation in the security institutions in Uganda; and,1. Examine the adoption and implementation of UNSCR 1325 in the security institutions in Uganda;,The broad aim of the study is to examine the implementation of UNSCR 1325 and representation of women in decision-making leadership positions in the security institutions of Uganda.,
 Uganda 2025-09-17 13:29:27 2028-09-17 Social Science and Humanities Non-Clinical Trial Degree Award
Joseph Ngonzi
ID: UNCST-2019-R001579
 PACO Heart Evaluation and Risk Tracking (PACO-HEART)
REFNo: HS5985ES

Main objective: 1. Determine whether women with HIV taking DTG during pregnancy are more likely to experience hypertension, have elevated cardiovascular disease risk factors, and demonstrate vascular dysfunction postpartum.

Sub-Objectives:
1. Prospectively assess postpartum cardiovascular disease risk factors in women with HIV on DTG versus women with HIV on efavirenz (EFV), women who took PrEP in pregnancy, and women without HIV participating in the PACO cohort.
2. Assess vascular function in women with HIV on DTG versus women with HIV on efavirenz (EFV), women who took PrEP in pregnancy, and women without HIV participating in the PACO cohort.
3. Quantify and compare biomarkers of cardiovascular disease in peripheral plasma in women with HIV on DTG versus women with HIV on efavirenz (EFV), women who took PrEP in pregnancy, and women without HIV participating in the PACO cohort.
4. Examine association between placenta pathological features (already measured in PACO cohort participants) and postpartum hypertension, vascular function, and biomarkers of cardiovascular disease


 Uganda 2025-09-17 13:26:00 2028-09-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Stella Kyohairwe Baketuraki
ID: UNCST-2024-R004001
 The Cost of Doing Politics: Gender Aspects of Political Violence
REFNo: SS3887ES

Aim/Overall objective: This project aims to better understand how gender shapes the scope, form, and consequences of political violence targeted at politicians, as well as to develop response strategies to reduce the problem.
RQ 1: How does gender shape the scope and form of political violence? What are the gendered dimensions of violence in political parties’ election campaigns and in the parliamentary arena?
RQ2: What are the gendered consequences of political violence on political representation in political party recruitment – and at parliamentary arenas?
RQ 3: What are the most effective and gender-sensitive responses to different forms of political violence in political party recruitment -and in the parliamentary sphere?
 Uganda 2025-09-17 13:24:26 2028-09-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
NORBERT BYARUHANGA MUSISI
ID: UNCST-2024-R002079
 PREVALENCE AND FACTORS ASSOCIATED WITH ADVERSE PERINATAL OUTCOMES AMONG WOMEN WITH LATE ANTENATAL CARE BOOKING AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS5772ES

1. To determine the prevalence of adverse perinatal outcomes among women with late ANC booking at Mbarara regional referral hospital.
2. To determine the factors associated with adverse perinatal outcomes among women with late ANC booking at Mbarara regional referral hospital

 Uganda 2025-09-17 13:22:53 2028-09-17 Medical and Health Sciences Non-Clinical Trial Degree Award
Catriona  Waitt John
ID: UNCST-2019-R001068
 Drug Optimisation for LMICs in Pregnant HIV mothers and their INfants: temporary switch to CAB/RPV long acting injections in postpartum period
REFNo: HS5982ES

To characterise drug exposure in breast milk, and drug transfer to infants through breastfeeding, as well as infant drug elimination. To characterise the elimination of CAB/RPV by describing PK profiles of IM CAB/RPV LA after last injection between 48 and 96 weeks. To establish strategies on how to safely re-establish oral ART after discontinuation of IM CAB/RPV LA at 48 weeks and switch back to daily oral ART. To explore early postpartum PK of CAB/RPV in maternal plasma and breastmilk. To demonstrate antiviral activity and impact on retention in HIV care of temporarily switching to CAB/RPV LA compared with continuation of daily oral ART over 48 weeks.,
 UK 2025-09-17 13:21:16 2028-09-17 Medical and Health Sciences Clinical Trial Non-degree Award
Catriona  Waitt John
ID: UNCST-2019-R001068
 Acceptability and feasibility of long-acting injectable antiretroviral therapy (LAI-ART) as a bridging strategy for postpartum mothers living with HIV in South Africa and Uganda
REFNo: HS5944ES

3. To assess the feasibility of adopting LAI-ART into national ART programmes and healthcare facilities, identifying programmatic considerations for optimal LAI-ART deployment.,2. To explore patient acceptability of LAI-ART during breastfeeding and as a postpartum bridging strategy to enhance adherence.,1. To develop and validate a tool for identifying and supporting women at risk of poor ART adherence postpartum.,
 UK 2025-09-17 13:19:23 2028-09-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Wenceslaus Sseguya
ID: UNCST-2019-R000877
 Feasibility of clinical nuance implemented using value-based community financing for the management of diabetes and hypertension in primary health care in rural South-Western Uganda
REFNo: HS6153ES

3. To assess the willingness of the community to contribute to risk pooling towards clinically nuanced VBID,2. To understand the perspectives of health workers in implementing clinically nuanced care for diabetes and hypertension in the community.,1. To explore the community’s perception of clinically nuanced VBID in the prevention and management of diabetes and hypertension.,To investigate the potential of a community-level, value-based insurance design (VBID) in enhancing clinical management and prevention of hypertension and diabetes within primary health care,
 Uganda 2025-09-17 13:17:21 2028-09-17 Medical and Health Sciences Non-Clinical Trial Degree Award
Mercy Wanyana Wendy
ID: UNCST-2025-R016999
 Barriers and facilitators to implementing one health approach for visceral leishmaniasis control in the Karamoja Region.
REFNo: HS6125ES

To examine barriers and facilitators to implementing one health approach for visceral leishmaniasis control in the Karamoja,2025.
 Uganda 2025-09-17 13:05:50 2028-09-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Lillian Mugisha
ID: UNCST-2025-R018187
 Impact of a Co-designed School-Based Intervention on 24-Hour Movement Behaviour and Selected Health Indicators Amongst Female Adolescents in Wakiso District, Uganda
REFNo: SS3966ES

1. Determine the level of adherence to 24-HMB guidelines among adolescent girls aged 15-18 years in mixed-boarding secondary schools in Wakiso district, Uganda.
2. Explore the determinants of adherence to 24-HMB guidelines among adolescent girls aged 15-18 years in mixed-boarding secondary schools in Wakiso district, Uganda.
3. Co-design a SBMB intervention with adolescent girls and teachers, targeted to enhance 24-HMB among adolescent girls aged 15-18 years in secondary schools in Wakiso District, Uganda.
4. Determine the association between accelerometer-measured 24-HMB and selected health indicators (CRF, BMI, WHtR, and BP) among adolescent girls aged 15-18 years in secondary schools in Wakiso District, Uganda.
5. Determine the impact of a co-designed SBMB intervention program on 24-HMB, and selected health indicators (CRF, BMI, WHtR and BP) among adolescent girls aged 15-18 years in mixed-boarding secondary schools in Wakiso district, Uganda

 Uganda 2025-09-17 13:03:31 2028-09-17 Social Science and Humanities Non-Clinical Trial Degree Award
Mugumya  Kabaja Lawrence Kabaja
ID: UNCST-2024-R002956
 Evaluating the effect of Caregiver DOTs on viral re-suppression among children in Kigezi region
REFNo: HS6505ES

1. To establish the viral re-suppression rates among children on the CAGDOTS strategy in Kigezi Region. 2. To find out the factors associated with viral load re-suppression among the CALHIV) in Kigezi region.
Uganda 2025-09-17 12:36:18 2028-09-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Timothy Makumbi Kabanda
ID: UNCST-2021-R011760
 MICRO RNAS PROFILING: BIOPATHOLOGIC CHARACTERIZATION AND SURVIVAL OF EARLY ONSET BREAST CANCER AMONG UGANDAN Ref No. Mak-SOMREC-2021-272
REFNo: HS3699ES

iii) To correlate aberrantly expressed miRNAs profiles with associated survival among women with EOBC.,ii) To determine the association between MicroRNAs dysregulation and the clinical pathological characteristics among women with EOBC. ,i) To determine the prevalence of dysregulated MicroRNAs expression profiles among women with EOBC.,To determine the prevalent profiles of aberrantly expressed(dysregulated) miRNAs and how they influence the specific pathological characteristics, and survival after mastectomy breast surgery for early onset breast cancer (EOBC),
 Uganda 2025-09-17 12:32:26 2028-09-17 Medical and Health Sciences Non-Clinical Trial Degree Award
Andrew Mujugira
ID: UNCST-2019-R000871
 Integrating HIV prevention with TB household contact evaluation in Uganda (TB PrEP)
REFNo: HS6341ES

Aim 1: Assess the implementation and effectiveness of home- based HIV self-testing and PrEP initiation versus clinic referral on PrEP initiation and continuation during household TB contact investigation.

Aim 2: Examine processes of implementing HIV self-testing and PrEP initiation during household TB contact evaluation using qualitative methods.

Aim 3: Estimate the cost-effectiveness of implementing home- based HIV testing and PrEP initiation for household members of people with TB in Uganda compared to clinic referral.

 Uganda 2025-09-17 12:30:43 2028-09-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
NUWAGIRA KENETH
ID: UNCST-2025-R016664
 FINANCIAL INCLUSION AND GROWTH OF MICRO, SMALL AND MEDIUM-SIZED ENTERPRISES (MSMES) IN KAMPALA CITY, UGANDA.
REFNo: SS3991ES

Main Objectives
The purpose of the study is to investigate the effect of financial inclusion on growth of micro, small and medium-sized enterprises (MSMEs) in Kampala City, Uganda.

1.4 Specific objectives
i) To determine the effect of credit accessibility on the growth of MSMEs in Kampala City, Uganda.
ii) To establish the effect of mobile money services on the growth of MSMEs in Kampala City, Uganda.
iii) To explore the effect of financial literacy on the growth of MSMEs in Kampala City, Uganda.

Uganda 2025-09-17 12:28:56 2028-09-17 Social Science and Humanities Non-Clinical Trial Degree Award
Twinamasiko Specioza
ID: UNCST-2022-R008954
 Empowering Ugandan Refugee–Host Communities in Becoming Climate Resilient: The Case Studies of Nakivale and Rhino Camp Refugee Settlements
REFNo: NS983ES

1. To assess the resilience of refugees and their host communities to water access and land tenure in Nakivale and Rhino Camp
2. To monitor water quality within the refugee settlements and host communities of Nakivale and Rhino Camp.
3. To analyze hazards and farming practices within the refugee settlements and host-communities of Nakivale and Rhino Camp refugee-host communities
4. To document the different traditional practices and indigenous knowledge on agriculture, water source preservation and forest conservation prevalent among the refugee and host communities of Nakivale and Rhino Camp Refugee settlements.
5. To identify ways in which traditional environmental practices and indigenous knowledge can complement the contemporary modern scientific policies of environmental conservation and protection in refugee-host communities

 Uganda 2025-09-17 12:27:48 2028-09-17 Natural Sciences Non-Clinical Trial Degree Award
Sadia Mohamed Mahad
ID: UNCST-2024-R004826
 Prevalence and Factors Associated with Substance Use Among Refugees In Nakivale Settlement South-Western Uganda
REFNo: HS6217ES

i. To determine the prevalence of substance, use among refugees in Nakivale Refugee Settlement. ii. To identify and describe the modifiable and non-modifiable factors associated with substance use among refugees in Nakivale Refugee Settlement.,
 Somalia 2025-09-17 12:08:46 2028-09-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jazira Tumusiime
ID: UNCST-2024-R003664
 EXPLORING CAREGIVERS AND HEALTH WORKERS’ PERCEPTIONS TOWARDS HPV VACCINATION AT MBARARA REGIONAL REFERRAL HOSPITAL ADOLESCENT CLININC AND BWIZIBWERA HEALTH CENTRE IV, UGANDA
REFNo: HS6193ES

To identify the barriers and facilitators influencing the uptake of HPV vaccination among adolescents at Mbarara Regional Referral Hospital and Bwizibwera Health Centre IV in southwestern Uganda.,To assess caregivers\' and healthcare workers\' knowledge and perceptions about HPV vaccination at Mbarara Regional Referral Hospital and Bwizibwera Health Centre IV in southwestern Uganda.,To explore caregivers’ and healthcare workers’ perceptions of HPV vaccination and identify the barriers and facilitators affecting the uptake of the HPV vaccine among adolescents at Mbarara Regional Referral Hospital and Bwizibwera Health Centre IV in southwestern Uganda.,
 Uganda 2025-09-17 11:22:16 2028-09-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Miria Nandera
ID: UNCST-2021-R012140
 SCHOOL CLIMATE AND WORK ENGAGEMENT MEDIATED AND MODERATED BY WORK-LIFE BALANCE AND JOB EMBEDDEDNESS OF PRE-PRIMARY TEACHERS IN CENTRAL UGANDA
REFNo: SS4033ES

1. To examine the influence of school climate on teacher work engagement of pre-primary teachers in Central Uganda.
2. To assess the influence of school climate on work-life balance of pre-primary teachers in Central Uganda.
3. To analyse the influence of work-life balance on teacher work engagement of pre-primary teachers in Central Uganda.
4. To test the mediating role of work-life balance on the influence of school climate on teacher work engagement of pre-primary teachers in Central Uganda.
5. To find out the moderating effect of job embeddedness on the influence school climate on teacher work engagement of pre-primary teachers in Central Uganda.
 Uganda 2025-09-17 11:19:34 2028-09-17 Social Science and Humanities Non-Clinical Trial Degree Award
Ibrahim Adabara
ID: UNCST-2025-R019039
 AGENTIC AI FOR CYBERSECURITY: A FRAMEWORK FOR THE DESIGN AND GOVERNANCE OF RESILIENT AUTONOMOUS DEFENSE SYSTEMS
REFNo: SIR547ES

1.3 Main Objective

The primary objective of this research is to construct a theoretically grounded and ethically aligned framework for conceptualizing, simulating, evaluating, and governing AAI systems in cybersecurity. The framework will serve as a strategic model for autonomous defensive agents, focusing on secure, transparent, and accountable operation in adversarial environments, in alignment with legal and normative expectations.

1.4 Specific Objectives

i. To develop a reference model for agentic AI systems integrating autonomy, ethical responsiveness, and adaptive reasoning by synthesizing existing literature and formalizing the framework within the first phase of the study.

ii. To design and implement a simulation-based methodology that models adversarial threat scenarios and tests agentic AI responses within a defined experimental period, using performance and ethical indicators as measurable outputs.

iii. To construct a multi-criteria evaluation framework that defines and measures agentic system performance in terms of transparency, latency, proportionality, and normative alignment, validated through simulated test cases in the second phase.

iv. To propose and validate a governance and ethical oversight model for agentic AI deployment, incorporating regulatory review, stakeholder auditability, and normative safeguards by the final phase of the project, following empirical evaluation.
 Nigeria 2025-09-17 11:18:20 2028-09-17 Engineering and Technology Non-Clinical Trial Degree Award
Ronald Bisegerwa
ID: UNCST-2022-R011022
 Accuracy of Pulse Oximeters with Profound Hypoxia
REFNo: HS6506ES

To generate two to three evidence-based recommendations to regulatory and procurement bodies within six months of study completion to guide pulse oximeter selection for diverse populations.,To collect and contribute data on pulse oximeter accuracy across diverse skin tones to an open-access device performance database by the study’s end, enabling manufacturers to refine pulse oximeter technology and ensure equitable performance across all skin tones, especially in low-resource settings.,To replicate the UCSF Hypoxia Lab in Uganda by establishing a fully equipped and operational facility within a year to evaluate pulse oximeter accuracy across diverse skin tones and hypoxia levels.,To evaluate the accuracy of pulse oximeters under controlled hypoxic conditions in a diverse population in Uganda, with a focus on understanding and addressing disparities in device performance related to skin pigmentation.,
 Uganda 2025-09-12 17:03:12 2028-09-12 Medical and Health Sciences Clinical Trial Non-degree Award
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