Grace Mirembe
ID: UNCST-2022-R008850
|
RV 591 entitled “A Phase I, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Immunogenicity of an Ad26.Mos4.HIV and CH505 TF chTrimer (Env) Combination to Mimic Acute HIV Viral Replication Kinetics in Healthy Adults”
REFNo: HS2891ES
To assess the safety, reactogenicity and tolerability of two vaccination regimens: rapid dose-escalation of CH505 TF chTrimer+ALFQ and Ad26.Mos4.HIV or co-administration of CH505 TF chTrimer+ALFQ and Ad26.Mos4.HIV
|
Kampala, Central
|
Uganda |
2023-07-14 9:49:16 |
2026-07-14 |
50 |
Healthy male and female participants, aged 18 to 50 years |
The Surgeon General, Department of the Army |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Joy Gumikiriza- Onoria Louise
ID:
|
Development of a Caregiver Centered Psychotherapy (CCPT) in addressing patient care for older persons with Alzheimer’s Disease and Related Dementias (ADRD) in Uganda.
REFNo: HS2909ES
1. To explore ways in which older people in the community of Wakiso district conceptualize ADRD and what informs their opinions. 2. To assess caregiver distress, non-professional techniques of patient care, quality of life and the associated factors among family caregivers of persons with ADRD in Wakiso district.To adapt and pre-test the WHO-iSupport for family caregivers of persons with ADRD in Wakiso, Uganda4. To determine the effectiveness of A-iSupport in the alleviation of distress among family caregivers of persons with ADRD in Wakiso, Uganda
|
Wakiso, Busukuma
Wakiso, Nansana
|
Uganda |
2023-07-14 9:40:03 |
2026-07-14 |
180 |
All residents of Wakiso district aged 60 years and older, includidng caregivers of persons with ADRD |
BRAIN health |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
|
Nixon Niyonzima
ID: UNCST-2020-R014577
|
A PHASE III, RANDOMIZED, OPEN-LABEL STUDY EVALUATING THE EFFICACY AND SAFETY OF GIREDESTRANT IN COMBINATION WITH PHESGO VERSUS PHESGO AFTER INDUCTION THERAPY WITH PHESGO-TAXANE IN PATIENTS WITH PREVIOUSLY UNTREATED HER2-POSITIVE, ESTROGEN RECEPTOR-POSITIVE LOCALLY-ADVANCED OR METASTATIC BREAST CANCER (HeredERA)
REFNo: HS2968ES
To identify and/or evaluate biomarkers that are predictive of response to Phesgo and giredestrant (i.e., predictive biomarkers), are early surrogates of efficacy, are associated with progression to a more severe disease state (i.e., prognostic biomarkers), are associated with acquired resistance to Phesgo and giredestrant, are associated with susceptibility to developing adverse events or can lead to improved adverse event monitoring or investigation (i.e., safety biomarkers), can provide evidence of Phesgo and giredestrant activity (i.e., pharmacodynamic biomarkers), or can increase the knowledge and understanding of disease biology and drug safety,To evaluate potential effects of ADAs,To evaluate the immune response to pertuzumab, trastuzumab, and rHuPH20,To evaluate the potential relationships between Phesgo and giredestrant exposure and the safety, efficacy, immunogenicity, or biomarker endpoints.,To characterize the giredestrant, pertuzumab, and trastuzumab PK profile when given in combination,To evaluate the safety of Phesgo plus giredestrant compared with Phesgo from the participant's perspective,To evaluate health utility of participants treated with Phesgo plus giredestrant compared with Phesgo to generate utility scores for use in economic models,To evaluate effects of Phesgo plus giredestrant compared with Phesgo on work productivity and activity,To evaluate the safety of Phesgo plus giredestrant compared with Phesgo,To evaluate the efficacy of Phesgo plus giredestrant compared with Phesgo,
|
Kampala, Mulago
|
Uganda |
2023-07-14 12:43:26 |
2026-07-14 |
20 |
This study will enrol patients with locally advanced or metastatic receptor positive breast cancer above 18 years of age |
La Roche Hoffman |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Angella Natukunda
ID:
|
DETERMINANTS OF NUTRITION STATUS AMONG ADOLESCENTS IN SELECTED SECONDARY SCHOOLS OF KANUNGU DISTRICT SOUTH WEST REGION UGANDA
REFNo: SS1812ES
Broad obective
To investigate the determinants of nutrition status among adolescents in selected secondary schools in Kanungu District South West Uganda.
Specific objectives
To assess the nutrition status of adolescents in the selected secondary schools of Kanungu District South West Region Uganda.
To determine the social demographic and economic factors influencing nutrition status of adolescents in the selected secondary schools of Kanungu District South West Region Uganda.
To determine the diet-related factors influencing nutrition status of adolescents in the selected secondary schools of Kanungu District South West Region Uganda.
To determine the level of adolescent nutrition knowledge associated with nutrition status among adolescents in the selected secondary schools of Kanungu District South West Region Uganda.
|
|
Uganda |
2023-07-14 12:34:44 |
2026-07-14 |
370 |
The study population will constitute of adolescents both male and female studying in secondary schools of Kanungu district 12 to 19 years. |
Natukunda Angella |
Social Science and Humanities |
Clinical Trial |
Degree Award |
|
Rhoda Wanyenze
ID: UNCST-2021-R013352
|
A Hybrid Implementation-Effectiveness Trial of Game Changers for Cervical Cancer Prevention (GC-CCP) in Uganda
REFNo: SS1873ES
1. Conduct a multisite RCT of the GC-CCP network-based advocacy strategy to evaluate effects on CC screening uptake, access to early-stage treatment and prevention of advanced disease among unscreened alters across urban/rural and public/private clinics,4. Evaluate the cost-effectiveness of Implementing GC-CCP to increase CC screening and low cost, early-stage treatment, and prevent advanced disease, compared to enhanced usual care.,3. Examine mediators and moderators (among index, alter and network characteristics) of intervention effects on (a) alter CC screening; and (b) engagement in CC prevention advocacy of index and alter (1st and 2nd degree) to better understand its multiplier effect on diffusion of advocacy throughout a network.,2. Use a mixed methods approach (semi-structured interviews and administrative clinic data) to examine clinic-, provider-, and client-level barriers and facilitators of GC-CCP Implementation and Sustainment.,
|
Kampala, Nsambya
Kampala, Kawempe
Buikwe, Buikwe
Kayunga, Kayunga
|
Uganda |
2023-07-13 11:13:19 |
2026-07-13 |
1400 women |
Women recently screened for Cancer of the Cervix and aged 25 years and above will be enrolled as index participants, Women who have not screened for Cancer of the Cervix but are network members of index participants will be enrolled as alter participants, Clinic leadership and providers of Cervical Cancer services will participate in qualitative interviews. |
National Institute of Mental Health |
Social Science and Humanities |
Clinical Trial |
Non-degree Award |
|
Nixon Niyonzima
ID: UNCST-2020-R014577
|
A Phase III, Randomized, Open-Label, Multicenter Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared with Physician’s Choice of Adjuvant Endocrine Monotherapy in Patients with Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (Lidera)
REFNo: HS2193ES
Main Objective
1. To demonstrate superiority of giredestrant over the control treatment.
Specific Objectives
1. To evaluate the efficacy of giredestrant compared with Therapy of Physician's Choice
2. To evaluate the safety of giredestrant compared with Therapy of Physician's Choice
3. To characterize giredestrant Pharmacokinetics
4. To evaluate health status utility scores of participants treated with giredestrant compared with Therapy of Physician's Choice
5. To evaluate the tolerability of giredestrant compared with Therapy of Physician's Choice
6. To identify and/or evaluate biomarkers that are predictive of response to giredestrant (i.e., predictive biomarkers), are early surrogates of efficacy, are associated with progression to a more severe disease state (i.e., prognostic biomarkers), are associated with acquired resistance to giredestrant, are associated with susceptibility to developing adverse events or can lead to improved adverse event monitoring or investigation (i.e., safety biomarkers), can provide evidence of giredestrant activity (i.e., pharmacodynamic biomarkers), or can increase the knowledge and understanding of disease biology and drug safety
|
Kampala, Mulago
|
Uganda |
2023-07-13 10:07:44 |
2026-07-13 |
18 |
women aged 18 years of age and over with histologically confirmed breast cancer |
Hoffman La Roche |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Flavia Matovu Kiweewa
ID: UNCST-2021-R013337
|
A Phase 2/3, Open-Label Study of the Pharmacokinetics, Safety, and Antiviral Activity of the GS-9883/Emtricitabine/Tenofovir Alafenamide (GS9883/F/TAF) Fixed Dose Combination (FDC) in HIV-1 Infected Adolescents and Children.
REFNo: HS2931ES
The primary objective of this study is to confirm the dose of B/F/TAF FDC in HIV-1 infected pediatric participants, to confirm the dose of B/F/TAF TOS in HIV-1 infected pediatric participants and to evaluate the safety and tolerability these medications.
|
Kampala,
|
Uganda |
2023-07-06 17:23:47 |
2026-07-06 |
5 |
Adolescents and children |
Gilead Sciences |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Thomas McHale
ID: UNCST-2022-R008812
|
Optimizing the Dose of Flucytosine for Cryptococcal Meningitis
REFNo: HS2940ES
Determine if 50 mg/kg/day of 5-FC has a similar mortality benefit compared to 100 mg/kg/day,Reduce the cost and supply burden of treating an individual with cryptococcal meningitis,Determine if 50 mg/kg/day of 5-FC is a safer dosage compared to 100 mg/kg/day of 5-FC,Determine if 50 mg/kg/day of 5-FC is has a similar rate of cryptococcal clearance from CSF compared to 100 mg/kg/day,Determine the optimal dose of 5-FC for for management of induction phase of therapy for cryptococcal meningitis,
|
Kampala,
Mbarara,
|
USA |
2023-07-05 11:41:24 |
2026-07-05 |
The target sample size is 50 participants |
The study will enroll adults with HIV who are over 18 years old and sick with cryptococcal meningitis. |
National Institute of Health, United States |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
|
Daniella Akellot
ID:
|
EVALUATION OF THE EFFECTIVENESS OF CLORPACTIN IN COMPARISON WITH OTHER WOUND DRESSING AGENTS USED AT SIGN SUPPORTED HOSPITALS IN UGANDA
REFNo: HS2769ES
To determine the effectiveness of Clorpactin in wound dressing at Kumi Orthopaedic Center and St. Mary’s hospital, Lacor.,
|
Kumi, Booma South
Gulu, ForGod
|
Uganda |
2023-07-03 13:32:54 |
2026-07-03 |
546 patients |
Patients admitted at Kumi Orthopaedic Center and St. Mary’s hospital, Lacor with surgical wound sepsis, infected open fractures, diabetic wounds, chronic osteomyelitis. |
SIGN Fracture Care International |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Ezekiel Mupere
ID: UNCST-2023-R008637
|
Earlier prime-BOOST schedule to improve MEasles protection in high burden settings (BoostME)
REFNo: HS2883ES
Safety Objectives
1.To assess the safety and reactogenicity profile of the vaccine when given at different ages
2.To assess the number of measles infections throughout the study.
Primary Objectives
1.To compare protective measles antibody concentrations at 2.5 years of age in infants receiving an early (6 months) compared to standard (9 month) dose of MCV, and a booster dose at 18 months of age.
2.To compare protective measles antibody concentrations one month after a second dose of MCV given at 12 months (early) compared to standard (18 months), in those who received an early (6 months) first dose.
Secondary Objectives
•To describe the measles antibody concentrations one month after first dose in infants receiving an early (6 months) compared to standard (9 month) dose of MCV.
•To describe the effect of maternal antibodies on infant humoral and cellular immune response to first and second doses in children vaccinated under different schedules.
•To describe the effect of maternal HIV infection on infant antibody responses post MCV1 and MCV2 given at different schedules
•To describe the impact of different vaccination schedules on responses to the rubella component of the vaccine.
Community Objectives
To assess the effect of a measles vaccination clinical trial on public perceptions of measles immunisation
|
Kampala, Kawaala
Kampala, Kisenyi
Kampala, Komamboga
Kampala, Mulago
|
Uganda |
2023-06-23 7:46:04 |
2026-06-23 |
450 infants |
Any infant aged 6 months (23-28 weeks) at screening visit and has
not received prior vaccination against measles |
University of Oxford Research Governance, Ethics and Assurance Joint Research Office Boundary Brook House Churchill Drive Headington Oxford OX3 7GB United Kingdom, and funded by Bill and Melinda Gates Foundation. |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Tonny Kiyimba
ID:
|
Efficacy of polyphenols from Tamarindus indica fruit juice on cardiometabolic health of patients living with HIV and elevated triglycerides: A study protocol
REFNo: HS2923ES
3. To establish dose response dynamics of long-term intake of T. indica fruit juice polyphenols on selected cardiometabolic risk markers of PLWH.,2. To assess the effect of an acute, single-dose intake of T. indica fruit juice on vascular function, lipid profile and plasma levels of procyanidin metabolites.,1. To produce and evaluate the sensory acceptability of T. indica fruit juice.,To determine the efficacy of T. indica fruit juice on selected cardiometabolic risk markers of PLWH in HIV community care model in Wakiso district, Uganda.,
|
Wakiso, Kajjansi
Wakiso, Kajjansi
|
Uganda |
2023-06-20 11:05:36 |
2026-06-20 |
240 |
Participants will be adult(30-50 years) male and female patients living with HIV (PLWH) managed under the community-based model (Community Drug Distribution Points-CDDPs) in Wakiso district, central Uganda. The district encircles Kampala, Uganda's capital city with an estimated population of over 2.9 million people. The district has the highest prevalence (10%) of HIV in Uganda. Over 3,801 PLWH are currently receiving the HIV care from CDDPs in Wakiso District. The study inclusion and exclusion criteria are presented in Table 1. |
VLIROUS |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
|
Betty Mwesigwa
ID: UNCST-2020-R014667
|
SABIN-002: A Phase 2, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Safety, Tolerability, and Immune Responses of an Investigational Monovalent Chimpanzee Adenoviral-Vectored Marburg Virus Vaccine in Healthy Adults
REFNo: HS2838ES
To evaluate the safety and tolerability of
cAd3-Marburg vaccine
|
Kampala, Nakasero
|
Uganda |
2023-06-14 11:06:46 |
2026-06-14 |
80 |
Male and female adults, 18-70 Years |
Sabin Vaccine Institute |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
NANKWASA SAILAS
ID:
|
RANDOMIZED CONTROLLED FOR NON USE OF ANTIBIOTIC AFTER UNCOMPLICATED VAGINAL BIRTH AND POST-PARTUM ENDOMETRITIS AT ST FRANCIS HOSPITAL NSAMBYA
REFNo: HS2768ES
3. To determine the factors that may predict the likelihood of infection after uncomplicated vaginal birth at St. Francis Nsambya Hospital,2. To determine the incidence of perineal tear/episiotomy wound breakdown among women who received antibiotic and those who do not at St. Francis Nsambya Hospital,1. To determine the incidence of post-partum endometritis after uncomplicated vaginal birth in women who receive antibiotic compared to those who do not at St. Francis Nsambya Hospital,To determine whether not providing an antibiotic after uncomplicated vaginal birth is associated with increased incidence of post-partum endometritis at St. Francis Nsambya Hospital,
|
Kamuli, Nsambya
|
Uganda |
2023-06-06 7:53:44 |
2026-06-06 |
260 participants |
adult post delivery mothers with uncomplicated vaginal birth |
NANKWASA SAILAS |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
|
RICHARD MPANGO STEPHEN
ID:
|
Adaptation and Evaluation of the New Forest Parenting Program (NFPP) in the
management of ADHD among Children and Adolescents infected with HIV (CA-HIV) in
Uganda (Formative phase)
REFNo: SS1721ES
i) To adapt and evaluate the effectiveness of the NFPP in the management of ADHD among Children and adolescents infected with HIV (CA-HIV).
ii) To evaluate the acceptability and feasibility of NFPP in the management of ADHD among CA-HIV.
|
Masaka, NOT APPLICABLE
Kampala, NOT APPLICABLE
|
Uganda |
2023-05-29 20:36:58 |
2026-05-29 |
44 |
Twenty-two (22) participants; ten (10) Child and adolescent mental health specialists’ and HIV clinicians (representing a range of professional disciplines including psychiatrists, psychologists, psychiatric clinical officers, psychiatric nurses, experienced HIV counsellors and HIV clinicians); ten (10) parents / grandparents / teachers /day-mothers / guardians / caregivers; two (2) facilitators |
CHILD Global Research |
Social Science and Humanities |
Clinical Trial |
Degree Award |
|
Richard Idro
ID: UNCST-2021-R013599
|
Dihydroartemisinin-piperaquine and azithromycin for the post-discharge management of children with severe anaemia in Malawi, Kenya and Uganda; A, multicentre, parallel-group, two-arm, randomised, double-blind superiority trial.
REFNo: HS2815ES
To determine if PDMC with four courses of monthly AZ treatment in combination with four months of weekly DP is superior to PDMC with weekly DP-alone in reducing non-malaria SCCV by six months post-discharge in children aged <5 years admitted with severe anaemia (Hb<5g/dl) who are ready to be discharged and are clinically stable and able to switch to oral medication,
|
Jinja, Jinja City
Kitgum, Municipality
|
Uganda |
2023-05-25 12:04:54 |
2026-05-25 |
958 |
Children aged less than 5 years, with severe anemia. |
Training and Research Unit of Excellence, Blantyre, Malawi |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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|
David Meya Bisagaya
ID: UNCST-2019-R000837
|
Platform Trial For Cryptococcal Meningitis - PLATFORM-CM
REFNo: HS2649ES
The purpose of this study is to know whether this oral form of amphotericin (MAT2203) is safe and effective in the treatment of people sick with cryptococcal meningitis.
|
Mbarara, Mbarara
Masaka, Masaka
Kampala, Kampala
|
Uganda |
2023-05-25 12:01:51 |
2026-05-25 |
270 |
Adult (18 years and above) males and females HIV-infected persons with cryptococcal meningitis. |
Matinas BioPharma Nanotechnologies, Inc. |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Dominik Biesalski
ID:
|
The Drivers, Effects and Measurement of Time Use Among the Urban Poor: Evidence from Uganda
REFNo: SS1674ES
Get insights into the time use patterns of urban workers and understand their effects on productivity and well-being.
|
Kampala, Kampala
|
Germany |
2023-05-11 14:41:00 |
2026-05-11 |
200 |
Workers who are older than 18 years old, both men and women of all tribes |
Private Enterprise Development in Low-Income Countries (PEDL) |
Social Science and Humanities |
Clinical Trial |
Degree Award |
|
James Davis KATUMBA
ID:
|
Uncontrolled asthma among adolescents in selected secondary schools in Kampala City: Prevalence, associated factors, in-school needs, pathways to care and effectiveness of an mHealth Self-management app
REFNo: HS2791ES
To determine the effectiveness, acceptability and feasibility of the KmAsthma self-management app in improving the control of asthma among day scholar secondary school adolescents 12-19 years old in Kampala City Uganda.,To examine pathways to asthma care and their influence on asthma control among secondary school adolescents with asthma in Kampala City Uganda ,To establish the in-school needs associated with asthma control among adolescents in selected secondary schools in Kampala City Uganda ,To determine the prevalence of and factors associated with uncontrolled asthma among adolescents in selected secondary schools in Kampala City Uganda ,To establish the prevalence of and factors associated with uncontrolled asthma, in-school needs, pathways to asthma care, and effectiveness of KmAsthma Self-management app intervention to control asthma among adolescents in selected secondary schools in Kampala City Uganda,
|
Kampala, Kawempe, Rubaga, Makindye, Kampala Central, Nakawa
|
Uganda |
2023-05-02 22:22:49 |
2026-05-02 |
323 |
Secondary school adolescents in Kampala City Uganda who will provide written informed consent (or assent plus consent from parents in case of minors) during the time of the study. |
Self Sponsored |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
|
John Kellett Gale
ID:
|
Can continuous non-invasive monitoring of movement predict and detect clinical deterioration of hospital patients earlier and more efficiently than traditional intermittent observations?
REFNo: HS2765ES
To determine if continuously collected accelerometer data can indicate and identify clinical deterioration of acutely ill hospitalised patients before intermittently collected vital signs.
|
Masaka, Ssenyange
|
Ireland |
2023-05-02 22:11:25 |
2026-05-02 |
1100 |
All non-pregnant patients aged 18 years or over admitted to the medical ward for any medical condition who are competent to provide consent to participate in the study or have a surrogate decision maker who can consent on their behalf. Patients may decide to participate or withdraw from the study at any time during their hospitalization. |
Dr John Kellett |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Grace Ndeezi
ID: UNCST-2019-R001802
|
Nutritional management of growth faltering in infants aged under six months. Study protocol for an individually randomised trial
REFNo: HS2766ES
To determine the effect of nutritional supplementation plus intensive breastfeeding support compared with intensive breastfeeding support alone on mortality, morbidity and growth in infants aged 0-6 months with growth faltering in low resource settings in South Asia and Sub-Saharan Africa.
|
Iganga,
Iganga,
Iganga,
Iganga,
Iganga,
Mayuge,
Mayuge,
|
Uganda |
2023-04-26 11:15:23 |
2026-04-26 |
900 infants |
Pregnant women (and adolescents) aged 15 to 45 years. Their babies will be enrolled at birth for a nutritional intervention. Both female and male babies will be enrolled. There will be no exclusion based on tribe as long as they comprehend English and Lusoga. |
World Health Organisation |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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