Jef VanPuyenbroeck
ID: UNCST-2025-R017911
|
Monitoring anthelmintic resistance in goats in Nwoya District, Uganda
REFNo: A617ES
Main objective:
To assess the efficacy of anthelmintics commonly used by goat farmers in Nwoya district.
Specific Objectives:
1. To determine the prevalence of GIN infesting goats in Nwoya district.
2. To determine nematode species infesting goats in Nwoya district, through coproculture and molecular speciation.
3. To compare the expenses to perform routine FECRT, with McMaster and Mini-FLOTAC, for monitoring anthelmintic resistance in Uganda.
4. To assess the efficiency of survey designs and fecal egg count methods to determine drug efficacy at a certain cost and endemicity.
|
Nwoya, All
Nwoya, All
Nwoya, All
|
Belgium |
2025-09-26 18:06:25 |
2028-09-26 |
383 |
All goat herds, kept for livelihood purposes, in Nwoya District will be considered to be included in this study.
|
Ghent University |
Agricultural Sciences |
Clinical Trial |
Degree Award |
|
KANIKA Jean-Claude MASSAMBA
ID:
|
effectiveness of vaginal misoprostol versus vaginal dinoprostone among pregnant women undergoing labor induction at Jinja regional Referral Hospital.
(REC Approval: BSU-REC-2023-244)
REFNo: HS4007ES
To assess the Peripartum fetal complications as well as the maternal obstetrics outcomes in vaginal misoprostol group versus vaginal dinoprostone group at Jinja Referral Regional Teaching-Hospital maternity ward. ,The main goal of this study is to compare the effectiveness of vaginal misoprostol to vaginal dinoprostone and identify the feto-maternal complications in women undergoing labor induction at Jinja Referral Regional Teaching-maternity Hospital\'s unit.,
|
Jinja, Jinja
|
Democratic Republic of Congo |
2024-03-28 18:36:47 |
2027-03-28 |
136 |
Pregnant women between 37 weeks + 0 day to 41 weeks + 6 days of gestation attending antenatal clinic at Jinja RRH and who have indications of labor induction and consent to participate in the study. |
Principal Investigator |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
|
Dominik Biesalski
ID:
|
The Drivers, Effects and Measurement of Time Use Among the Urban Poor: Evidence from Uganda
REFNo: SS1674ES
Get insights into the time use patterns of urban workers and understand their effects on productivity and well-being.
|
Kampala, Kampala
|
Germany |
2023-05-11 14:41:00 |
2026-05-11 |
200 |
Workers who are older than 18 years old, both men and women of all tribes |
Private Enterprise Development in Low-Income Countries (PEDL) |
Social Science and Humanities |
Clinical Trial |
Degree Award |
|
Sharon Pang Sze Lu
ID:
|
Transform Randomised Controlled Trial in Uganda
REFNo: SS1823ES
To evaluate the impact of the Transform program on the key indicators in values, health and livelihood in Uganda
|
|
Hong Kong |
2023-08-25 8:07:30 |
2026-08-25 |
4800 |
The study population will include participants aged 18 to 90 years old. Both male and female participants are included in the study. ICM will first choose communities and identify 30 ultra-poor households for its Transform program (administered across control and treatment groups). Eligibility for Transform is determined using poverty assessment via an asset-based scoring and self-reported household income. Historically, there have been an average of 30 households per community. With a target sample size of 160 communities, we will have approximately 4,800 households in the study. ICM targets communities to receive a Transform program based on the proportion of community members living in ultra-poverty (less than USD $0.50/person/day).Participants who are above the threshold using the poverty assessment will be excluded from the study. Households also cannot participate in the study if they have previously received the Transform program, unless the implementation team overrides the score due to specific circumstances that only affect a minority of participants. |
International Care Ministries |
Social Science and Humanities |
Clinical Trial |
Non-degree Award |
|
John Kellett Gale
ID:
|
Can continuous non-invasive monitoring of movement predict and detect clinical deterioration of hospital patients earlier and more efficiently than traditional intermittent observations?
REFNo: HS2765ES
To determine if continuously collected accelerometer data can indicate and identify clinical deterioration of acutely ill hospitalised patients before intermittently collected vital signs.
|
Masaka, Ssenyange
|
Ireland |
2023-05-02 22:11:25 |
2026-05-02 |
1100 |
All non-pregnant patients aged 18 years or over admitted to the medical ward for any medical condition who are competent to provide consent to participate in the study or have a surrogate decision maker who can consent on their behalf. Patients may decide to participate or withdraw from the study at any time during their hospitalization. |
Dr John Kellett |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Martha Musyoka Mbenia
ID:
|
PREDICTORS OF ADVERSE FETO-MATERNAL OUTCOMES AMONG MOTHERS ADMITTED WITH ANTEPARTUM HEMORRHAGE AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS1450ES
To describe adverse outcomes and determine predictors of adverse feto-maternal outcomes in mothers with antepartum hemorrhage at Mbarara Regional Referral Hospital
|
Mbarara, Mbarara
|
Kenya |
2021-09-09 |
2024-09-09 |
107 |
All women of childbearing age presenting with antepartum hemorrhage at Mbarara Regional Referral Hospital |
Self. No conflict of interest anticipated |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
|
Beatrice Onyango Ekesa
ID:
|
Bio-efficacy of Pro-Vitamin A-rich banana to improve vitamin A status among children in Uganda living in an area with a high burden of inflammation
REFNo: HS2721ES
3. Establish the stability of retinol isotopes on DSS at room temperature in the determination of TBS of vitamin A.,2. Assess the effect of inflammation and nutritional status on vitamin A absorption and TBS assessment among school-aged Ugandan children.,1. Determine the bio-efficacy of carotenoids in Pro-Vitamin A rich bananas in improving TBS in children aged 6-14years.,This study will determine the bio-efficacy of carotenoids in Pro-Vitamin A-rich banana-based diets and their potential in improving the vitamin A body stores by the RID technique among school-going children aged 6-14years living in Tororo district, an area with a high burden of inflammation.,
|
Tororo, Aturukuk
|
Kenya |
2023-04-19 12:44:24 |
2026-04-19 |
110 |
The study will be conducted among school going children aged 6-14 years because the school setting facilitates the feeding trial and monitoring, and the age group forms the youngest group available in an organised setting that can easily be engaged for a long period. In addition, this age group is not involved in the current national vitamin A supplementation programs. |
International Atomic Energy Agency (IAEA) |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Moffat Nyirenda Joha
ID: UNCST-2020-R019333
|
Development and Evaluation of an Integrated Community-based Management Model for HIV, Diabetes, and Hypertension in Tanzania and Uganda (The INTE-COMM study)
REFNo: HS2278ES
To determine the effectiveness of community-based integrated management of HIV, diabetes, and hypertension in comparison to clinic-based integrated management of these conditions in terms of patient outcomes, acceptability, and potential cost-effectiveness.
|
Kampala, N/A
Wakiso, N/A
Mpigi, N/A
Lwengo, N/A
|
Malawi |
2022-07-13 16:33:33 |
2025-07-13 |
1,736 participants |
Assuming an intra-class coefficient, rho of 0.02, we need to form 116 groups, each comprising 12 persons (8 with diabetes or hypertension and 4 with HIV). This will provide over 80% power to detect an absolute difference in risk of diabetes and hypertension control of 10% (i.e. 50% versus 60% achieving good control in the 2 arms would be statistically significant at the 5% two-sided significance level). Power will be very high for differences larger than this. For the HIV viral suppression endpoint, we assume that viral suppression is close to 90% and that the primary aim is to show non-inferiority with the community-care arm (and secondary analyses will compare superiority). The trial will have over 80% power to show non-inferiority with a margin of delta= 8.5%, 7.5%, and 5.5% assuming viral suppression is 85%, 90% and 95% respectively. To allow for losses to follow-up, our target for enrolment is 124 groups each comprising 14 participants (i.e. a total of 1,736 participants). |
National Institute of Health Research (NIHR) |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Wietse Tol
ID: UNCST-2021-R013085
|
AlCohol use in HumanitariAN settings: a programme of work to address alcohol use disorders and associated adversities among conflict-affected populations in UGanda and UkrainE (CHANGE)
REFNo: SS1596ES
• To identify strategies and techniques from evidence-based alcohol use therapies which can be integrated into PM+, and to develop a new intervention called PM+A (Problem Management Plus Alcohol)
• To adapt PM+A to local circumstances, and to examine the feasibility, acceptability, perceived effectiveness, and preliminary impact of PM+A
• To evaluate effectiveness and cost-effectiveness of PM+A through two single-blind randomised controlled trials in Uganda and Ukraine
• To explore the process of implementation, and to identify, characterise and explain mechanisms that promote or inhibit the delivery and take-up of PM+A in both settings
• To examine the potential for scaling-up PM+A in Uganda and Ukraine
|
Arua, Ofua zone Rhino Camp
|
Netherlands |
2023-02-17 12:18:30 |
2026-02-17 |
60 |
Adult South Sudanese men (>18 years) who meet all the following criteria.;
Alcohol Use Disorder Identification Test (AUDIT) score 8-19 (Saunders et al., 1993)
2) Elevated levels of psychological distress (Kessler Psychological Distress Scale (ten item version) (K10 >6) (Kessler et al., 2002)
|
Wellcome Trust and the Department of Health and Social Care, through the National Institute for Health Research |
Social Science and Humanities |
Clinical Trial |
Non-degree Award |
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|
Mohammed Lamorde
ID: UNCST-2019-R001293
|
Drug Interactions between Dolutegravir (DTG) and escalating-doses of Rifampicin (RIF) Study
REFNo: HS1376ES
The secondary objectives of the trial are to determine the safety and tolerability of the DTG/RIF combination, the PK of RIF, induction of PgP and CYP3A4 and effect of DTG on appetite,Primary Objective The primary objective of the study is to determine changes to the PK parameters of DTG when administered with standard, medium and high doses of RIF in HIV-negative, TB-monoinfected participants coming to the end of continuation TB therapy with standard doses of RIF and INH over a 10 week period,
|
Kampala, Mulago 1
|
Nigeria |
2021-06-23 |
2024-06-23 |
18 |
Inclusion Criteria
• Ability to give informed consent prior to participation
• Willing and able to comply with all study requirements
• Receiving standard doses of RIF and INH
• HIV antibody negative
• Male or non-pregnant, non-breastfeedin |
University of Liverpool |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
ISMAHIL ADENIYI ADEKUNLE
ID: UNCST-2024-R002602
|
EFFECTS OF ETHYL-ACETATE FRACTION OF Bidens pilosa LEAVES ON TESTES AND PITUITARY GLAND OF MALE MICE EXPOSED TO BISPHENOL A
REFNo: HS5372ES
The purpose of this study is to evaluate the impact of B. pilosa on testicular integrity and the pituitary gland of male mice exposed to BPA.
1.3.1 Specific Objectives
i. To assess the effect of B. Pilosa on spermatogenic metrics of the testes such as sperm motility, sperm count, morphology, agglutination, and vitality using routine and extended semen analysis.
ii. To determine the impact of B. pilosa on serum concentration of follicle-stimulating hormone, testosterone, and luteinizing hormone using enzyme-linked immunosorbent assay (ELISA) following BPA exposure.
iii. To assess the changes in testicular oxidative stress biomarkers (such as CAT, SOD, and GSH) and lipid peroxidation using MDA.
iv. To assess the histology, histochemical, and immunohistochemical changes in the testes and pituitary gland following treatment with B. pilosa in BPA exposure using Masson Trichrome, Periodic Acid Schiff (PAS), Hematoxylin and Eosin (H&E), Caspase 3, antiproliferating cell nuclear antigen (PCNA), Bcl-2, alpha-smooth muscle actin (α-SMA), and Bax.
|
Bushenyi, Kampala International University, Western Campus
|
Nigeria |
2025-03-03 11:40:21 |
2028-03-03 |
30 animals |
Animals will be divided into five groups, with six animals in each group (n=6).
Group 1 is the control, 2 ml/kg bw of distilled water.
Group 2—100 mg/kg/day of BPA
Group 3—100 mg/kg/day of BPA + low dose of B. pilosa (250 mg/kg).
Group 4—100 mg/kg/day of BPA + medium dose of B. pilosa (500 mg/kg).
Group 5: 100 mg/kg/day of BPA + high dose of B. pilosa (1000 mg/kg)
All administration will be done via oral administration for 5 weeks (35 days) because sperm maturation in mice takes about 35 days; B. pilosa will be administered after 1 hour of treatment with BPA. At the conclusion of the administration period on the 35th day, as per the approved protocol, animals from all groups will be euthanized after receiving ketamine. Blood samples will be collected from the animals via cardiac puncture and transferred to a plain sample bottle to allow coagulation of the cellular components of the blood. The blood sample is then centrifuged for the collection of serum. The collected serum will be used for hormonal assay (testosterone, LH, and FSH) and determination of oxidative stress biomarkers (CAT, SOD, and GSH).
|
Adeniyi A. Ismahil (self sponsored) |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
|
Mohamed Farah Mohamud
ID: UNCST-2025-R016841
|
EFFECTIVENESS OF INTRAVENOUS PETHIDINE VERSUS INTRAVENOUS TRAMADOL FOR PERIOPERATIVE ANALGESIA IN UTERINE EVACUATION PROCEDURES AT JINJA REGIONAL REFERRAL HOSPITAL
REFNo: HS5960ES
1. To assess the effectiveness of intravenous pethidine versus intravenous tramadol for perioperative analgesia in uterine evacuation procedure at Jinja Regional Referral Hospital
2. To compare the secondary outcomes encountered among women administered with intravenous pethidine versus those with Intravenous Tramadol for perioperative analgesia in uterine evacuation procedures at Jinja Regional Referral Hospital
3. To compare the level of patient satisfaction with intravenous pethidine versus Intravenous tramadol in uterine evacuation procedures at Jinja Regional Referral Hospital
|
Jinja, rippon
|
Somalia |
2025-04-30 7:27:21 |
2028-04-30 |
170 |
t All adult women with an indication for uterine evacuation admitted on gynecology ward of Jinja Regional Referral Hospital |
selfsponser |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
|
Daniella Ferguson
ID:
|
A Retrospective Analysis of Suramin Treatment forStage 1 Trypanosoma Brucei Rhodesiense Human African Trypanosomiasis (S1 TBR HAT) in Uganda and Malawi
REFNo: HS2582ES
Primary objectives
The primary objective is to determine whether standard of care treatment with suramin, as currently practiced in Uganda and Malawi, leads to better health outcomes in patients with S1 TBR HAT than observed in an untreated natural history cohort with source data from a published epidemiologic study.
Secondary objectives
The secondary objective is to evaluatethe safety and tolerability of suramin.
|
Kaberamaido, Lwala
|
South Africa |
2022-12-19 12:17:26 |
2025-12-19 |
150 -200 patients |
The study will include TBR HAT patients treated with suramin between 2000 and 2020 in Uganda and Malawi. The study will include all of the approximately 150 - 250 patients evaluated through chart review who are deemed eligible and have sufficient data. A natural history cohort composed of source data from approximately 200 patients from a published epidemiological study will be used as a comparator. |
PaxMedica, Inc. 303 South Broadway Suite 125 Tarrytown, NY |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Eun Seok Kim
ID:
|
Cross-sectional prevalence study of schistosomiasis and soil-transmitted helminthiasis with nested open-label randomised controlled study of evaluating the impact of fatty meal co-administration and double-dosing on albendazole effectiveness against hookworm infection among school-aged children in Mayuge district: Implications for Mayuge NTDs Elimination (MANE) Project
REFNo: HS1411ES
Objective 1: To determine the effect of albendazole administration with a fatty meal such as avocado, versus albendazole administration without a fatty meal, on hookworm cure rate and egg reduction rate.
Objective 2: To determine the effectiveness of dual-dose (400mg/day, two consecutive days) versus single-dose (400mg) albendazole treatment regimens on hookworm cure rate and egg reduction rate.
Objective 3: To identify and evaluate environmental, social and cultural variables affecting hookworm infection, and cure rate and egg reduction rate of albendazole against hookworm.
|
Mayuge, All parish
,
|
South Korea |
2021-08-16 |
2024-08-16 |
1650 |
Age: P4 and P5 grade students (approximately 9-10 years old)
Sex: an approximately equal number of both male and female
|
Korea International Cooperation Agency (KOICA) |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
|
Susanne Guidetti Gittel Eleonora
ID: UNCST-2021-R012422
|
Participation in everyday life - A randomized controlled trial of
mobile phone-supported and family-centred rehabilitation after
stroke in Uganda
REFNo: HS1528ES
General objective (Overall aim)
To implement and evaluate the effects a mobile phone supported and family-centred rehabilitation intervention F@ce 2.0 aiming to enable performance in daily activities and participation in everyday life among persons who have had a stroke and their family members both in urban (Kampala and its surroundings) and rural (Greater Masaka) areas.
Specific objectives
• To describe the perceived impact of stroke and perceived participation in everyday life in a sample of people with stroke in rural Uganda. (Study 1)
• To evaluate the effects of F@ce in comparison with ordinary rehabilitation among persons with stroke in urban and rural Uganda regarding a) self-efficacy b) perceived performance and participation in everyday activities c) independence in ADL, d) healthcare utilization and e)their families´ perceived participation in everyday activities.(Study 2)
• To explore and describe the experiences of people with stroke and family members of participating in the F@ce (Study 3)
• To evaluate the implementation process of F@ce and to gain knowledge on the mechanisms of impact as well as the contextual factors that might influence the implementation process and its outcome. (Study 4)
• To determine the cost of delivering the F@ce intervention in comparison with the usual rehabilitation (Study 5)
|
Kampala,
Masaka,
Iganga,
|
Sweden |
2022-01-19 |
2025-01-19 |
174 |
The sample size will accommodate for an attrition rate of 10%, based on our pilot study in Uganda, therefore will require the inclusion of a total of 174 participants with stroke, 15 health professionals and 15 caregivers (family members). The study will |
The Swedish Research Council |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Johanna Blomgren
ID: UNCST-2021-R012309
|
MIDWIZE - Strengthening midwives to implement and sustain quality improvements to optimise maternity care: A longitudinal observational study in Uganda
REFNo: HS1885ES
This PhD project aims to explore how midwives can take the lead in implementing or enhancing QI components within maternal health care in Uganda.
The overall goal of this project is to improve the health of women and newborns. The way to achieve this is through enhancing the quality of care by capacitating midwives.
Sub-study 1 - Co-creating and developing the intervention and the implementation
Specific objectives: To explore multisectoral stakeholders' perspectives and ideas on how to strengthen midwives' capacity to implement QI components.
To explore which QI components the midwives will implement or enhance.
Sub-study 2 - Implementation and evaluating the sustainability of the implementation
Specific objectives:
-To measure the uptake of evidence-based QI components when midwives lead, organise and provide enhanced intra- and postpartum care.
-To measure the long-term sustainability of the midwives' QI projects.
Sub-study 3 – Process evaluation
Specific objective: To evaluate the process of strengthening midwives' capacity to implement QIs in maternal care.
|
Kampala,
|
Sweden |
2022-03-21 |
2025-03-21 |
668 |
Study 1
Midwives at Naguru hospital, women and their relatives, other professionals and managers, multisectoral stakeholders (professional association, education, policymakers)
Study 2
Pregnant women above 18 years in the uptake area. However, dependin |
Karolinska Institutet |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
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|
Jenny Löfgren
ID: UNCST-2024-R005428
|
Simulation-based training for mesh inguinal hernia repair under local anaesthesia - a randomized trial
REFNo: HS4058ES
Assess the learning curve of mesh inguinal hernia repair for novice learners and how it is affected by simulation based training prior to supervised surgery on patients.
|
Soroti,
Mubende,
Iganga,
|
Sweden |
2024-05-02 12:38:06 |
2027-05-02 |
440 |
Trainees: intern doctors with an interest in surgery and who are not already routinely performing inguinal hernia mesh repair
Patients: Adult (18 years and above), otherwise healthy (ASA 1-2) men with primary, reducible, groin hernia |
Karolinska Institutet |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
|
Jenny Löfgren
ID: UNCST-2024-R005428
|
Outcomes of paediatric inguinal hernia repair performed by surgeons versus medical officers
REFNo: HS4508ES
Calculate and compare costs and cost-effectiveness between the two groups. ,Compare patient related outcomes between the group that has been operated on by medical officers versus those who were operated by general surgeons. ,The general objective of the proposed study is to investigate the possibility of task sharing between general surgeons and medical officers in inguinal hernia repair in children in Uganda. ,
|
Soroti,
Mubende,
Iganga,
|
Sweden |
2024-07-23 15:30:50 |
2027-07-23 |
341 |
Children, both girls and boys, 1-12 years old. |
Swedish Research Council |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
|
Atupele Mlangwa Subira
ID:
|
PREVALENCE AND FACTORS ASSOCIATED WITH PROLONGED HOSPITAL STAY FOLLOWING CAESEREAN DELIVERY AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: NS383ES
2. To determine the factors associated with prolonged hospital stay following caesarean delivery at MRRH,1. To determine the prevalence of prolonged hospital, stay following caesarean delivery at MRRH,To determine the prevalence and factors associated with prolonged hospital stay following caesarean delivery at MRRH,
|
Mbarara, Medical Cell
|
Tanzania |
2022-07-26 11:29:37 |
2025-07-26 |
427 |
Adult women delivered by caesarian section at Mbarara Regional Referral Hospital |
Atupele Subira Mlangwa |
Natural Sciences |
Clinical Trial |
Degree Award |
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|
Rachel Brathwaite
ID:
|
Assessing the Feasibility of Economic Approaches to Prevention of Substance
Abuse among Adolescents
REFNo: HS2683ES
Aim 1. Examine the prevalence and consequences of ADU in a cohort of 200 AYLHIV (ages 18-24) seen at six (6) HIV clinics in southwestern Uganda.
Aim 2. Using a mixed methods approach, identify the multi-level (individual, interpersonal, community and structural) factors associated with ADU among AYLHIV.
Aim 3. Using a subset of the sample, explore the feasibility and short-term effects of a family-based economic empowerment intervention on ADU among AYLHIV.
|
Masaka,
|
Trinidad and Tobago |
2023-03-02 15:32:31 |
2026-03-02 |
230 |
220 Adolescents and youths living with HIV aged 18-24 years. 10 healthcare providers aged >18 years. |
National Institute on Alcohol Abuse and Alcoholism |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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