Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Bruce Kirenga J
ID: UNCST-2019-R001460
AIr Pollution Effects on Transmission of Mycobacterium tuberculosis in Urban Slum Communities in Uganda.
REFNo: HS3084ES

Overall, the purpose of the study is to ensure the development team have a deep understanding of the considerations surrounding use of a respiratory treatment device. This includes the most significant challenges and opportunities in use of a respiratory treatment device. As such, the present study will form the foundation of concept ideation for a respiratory treatment device. Specific study objectives include the following: (1) Capture potential end user needs in both urban and rural locations (2) Capturing participant’s COVID-19 pandemic experience (3) Gaining an understanding of the COVID-19 pandemic response, and (4) Gaining an understanding of the healthcare system in which a respiratory device may be distributed/prescribed/administered/used/disposed.,4.2.2 Specific objectives I. To enroll subjects with active pulmonary TB (index cases) and assess their source strength in an urban slum community in Uganda II. To enroll household contacts (HC) of index cases and measure Mtb transmission to Mtb-naïve (those with negative Mtb infection tests) household contacts (people living in the same home as the index case) in an urban slum community in Uganda III. To characterize exposures to air pollution in both TB index cases and their household contacts in an urban slum community in Uganda,Main Objective The overall purpose of this study is to determine the extent to which particulate matter (PM) air pollution exposure affects the source strength (quantity of Mtb (Mycobacterium tuberculosis) in respiratory aerosol) of persons with active tuberculosis (TB) and the susceptibility to infection with Mycobacterium tuberculosis in their contacts. Both source strength and susceptibility determine transmission of Mtb in the community,
Uganda 2024-05-31 18:24:06 2027-05-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isidore Dorpenyo Kafui
ID:
Exploring local literacies, pedagogies, and teacher perceptions in Ugandan university writing courses.
REFNo: SS2614ES

This study has two main goals: a) it explores the local pedagogies in Uganda's university Academic English writing courses and b) it explores the attitudes that English writing instructors and curriculum designers have toward Academic English writing.
Ghana 2024-05-31 18:21:59 2027-05-31 Social Science and Humanities Non-Clinical Trial Degree Award
Samuel Kyobe
ID: UNCST-2019-R000108
DSpace: Utilizing Data Science to Predict and Improve Health Outcomes in Pediatric HIV
REFNo: HS4003ES

Use explainable machine learning algorithms to integrate multi-omics data with temporal EHRs to improve the diagnosis of active TB in HIV-infected children,Use machine learning to integrate temporal EHRs with genomic data to predict the longitudinal risk of MetS among African children on life-long ART,How can Data Science be utilized to integrate large temporal electronic health records with multiomics data to predict and improve health outcomes of HIV-infected children in Africa.,
Uganda 2024-05-31 18:19:52 2027-05-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Godfrey  Siu
ID: UNCST-2021-R005439
An Evaluation of the Effectiveness of the Parenting for Respectability Programme on Early Childhood Development among Children aged 0-6 years in Uganda
REFNo: HS4168ES

Main Objective
To conduct an effectiveness trial of an adapted (shorter) version of the PfR programme on ECD outcomes nested within wide scale implementation.
Specific Objectives
1.To estimate the effectiveness of the Parenting for Respectability programme on improving ECD specific outcomes (gross motor, fine motor, language and social development) among children aged 0-6 years after 6 months of intervention.
2.To estimate the observed improvement in parental knowledge, practices and parent-child relationships after 6 months of PfR programme interventions.

Uganda 2024-05-31 18:18:53 2027-05-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JUDITH AKELLO
ID: UNCST-2024-R003967
Unpacking the Influence of Women's Economic Empowerment Initiatives through Uganda Women’s Entrepreneurship Program on Livelihoods and Cultural Dynamics, Amolatar Sub-Region
REFNo: SS2635ES

Main objective
To explore whether and how economic impact of women's entrepreneurship program initiatives, is influenced by cultural norms and traditions on their engagement in entrepreneurial activities, in Amolatar sub-region.
Specific objectives
1. Analyse the economic impact of women's entrepreneurship programme initiatives in Amolatar sub-region. This involves tracking changes in women's income levels, employment opportunities, and access to financial services as a result of participating in these programs. The study will also evaluate the sustainability of economic improvements over time.
2. Explore the influence of cultural norms and traditions on women's engagement in women entrepreneurship programme activities within Amolatar sub-region. This will involve interviews to understand how cultural beliefs, roles, and expectations shape women's economic opportunities and choices. This study will also examine any shifts in these norms resulting from entrepreneurship program initiatives.
3. Establish the complex interplay between women's entrepreneurship program initiatives and cultural dynamics in Amolatar sub-region. This objective will involve a comparative analysis of the data gathered under the first two objectives to identify areas of alignment and tension between economic empowerment efforts and cultural norms. Additionally, we will investigate the strategies and mechanisms used by empowerment programs to navigate and influence these cultural dynamics.

Uganda 2024-05-31 18:05:38 2027-05-31 Social Science and Humanities Non-Clinical Trial Non-degree Award
ERIC WOBUDEYA
ID: UNCST-2019-R001047
Shortened RegiMen for Drug-susceptIbLE TB in Children
REFNo: HS4030ES

Primary
1. To determine if an 8-week HPZM regimen in children with presumed drug-susceptible TB disease has non-inferior efficacy to 8-weeks of HRZ(E) plus 8- or 16-weeks of HR(E) for achieving treatment success.
2. To evaluate the safety of the 8-week HPZM regimen in comparison to the 16- or 24- week HRZ(E) regimen among children with and without HIV.
Secondary
1. To evaluate the tolerability of the 8-week HPZM regimen in comparison to the 16- or 24- week HRZ(E) regimen among children with and without HIV.
2. To determine the weight-banded dosing of rifapentine and moxifloxacin taken as part of the HPZM regimen.
3. To evaluate the palatability and acceptability of the 8-week HPZM regimen in comparison to the 16- or 24-week HRZ(E) regimen among children with and without HIV.
4. To evaluate adherence to the 8-week HPZM regimen in comparison to the 16- or 24- week HRZ(E) regimen among children with and without HIV.
5. To evaluate clinical and laboratory characteristics and drug exposures associated with unsuccessful treatment outcomes (treatment failure or death).
6. To evaluate the cost and cost-effectiveness of the 8-week HPZM regimen relative to the 16- or 24-week HRZ(E) standard of care regimen, using a societal approach.
Exploratory
1. To characterize rifapentine and moxifloxacin PK parameters in malnourished children.
2. To evaluate the effect of rifapentine or rifampin, taken as part of the HPZM or HRZ(E) regimen, on the PK of dolutegravir.
3. To evaluate virologic control (less than 200 copies/mL) at 24- and 48-weeks among children with HIV taking a dolutegravir-based ARV treatment regimen co-administered with either HPZM or HRZ(E).
4. To collect and store biospecimens from consented participants for the purpose of future TB research.

Uganda 2024-05-31 18:02:19 2027-05-31 Medical and Health Sciences Clinical Trial Non-degree Award
Bernard Kikaire
ID:
Improving identification of new HIV infections and primary drug resistance among adolescents' girls, young women and their sexual partners in Uganda.
REFNo: HS4283ES

To improve identification of HIV infection, describe transmitted drug resistance mutations and HIV transmission network among AGYW and their sexual partners in Uganda.
Uganda 2024-05-31 17:57:30 2027-05-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Francis Eswap
ID:
Skepticism Over Refugee Quest to Realise the Right to Skills Development; the Case of South Sudan Adolescents in Adjumani-Uganda
REFNo: SS2659ES

1 To find out if adolescent refugees are accessing skills training programmes in a supportive social ecological system and if there are barriers and whether human rights legal regimes are effectively applied for their realisation of the right to skills development.
2 To assess skills training programmes for adolescent refugees to realise their right to skills development
3 To evaluate whether there is a Social Ecological System that supports adolescent refugees’ realisation of the right to Skills Development
4 To analyse the Barriers to adolescent refugees’ realisation of the right to skills development
5 To Examine the effectiveness of legal regimes in the Adolescent Refugee realisation of the Right to Skills Development

Uganda 2024-05-31 17:52:27 2027-05-31 Social Science and Humanities Non-Clinical Trial Degree Award
Ponsiano Ocama
ID: UNCST-2019-R001799
Assessment of Research Integrity Environment at Makerere University College of Health Sciences
REFNo: HS4131ES

To explore students and staff’s knowledge and attitudes towards research misconduct at MakCHS,To assess the magnitude of focus on research integrity issues among MakCHS regulatory structures,To determine the factors associated with research misconduct practices at MakCHS.,To identify the different types of research misconduct practices at MakCHS.,To assess the current research integrity frameworks at Makerere University College of Health Sciences and develop interventions to address research misconduct.,
Uganda 2024-05-31 17:48:32 2027-05-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Clovice Kankya
ID: UNCST-2020-R010154
Understanding the Barriers to Adoption and Active Use of Digital Services Provided via FarmDirect
REFNo: HS4305ES

Objectives (a) General Objective: The overarching objective of this study is to diagnose and solve the behavioral barriers and leverage enablers to the adoption and active use of FarmDirect’s services amongst farmers in Uganda. (b) Specific Objective: To explore how we increase the awareness of FarmDirect amongst unregistered farmers 1. To identify the sought-after attributes of their desired marketing channel 2. To explore the levels of comprehension and interest in a digital marketing channel 3. To understand the intention and willingness to undertake actions to use a digital marketing channel
Uganda 2024-05-30 11:30:32 2027-05-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Robert Downing George
ID: UNCST-2020-R014615
Usability Evaluation of the ANC Panel (Professional Use)
REFNo: HS4262ES

The primary objectives of this usability study are:
• To evaluate professional users’ ANC Panel test labelling comprehension (n=15 healthcare professionals). This evaluation will assess the professional users’ understanding of the key messages from the ANC Panel product packaging and labelling. The evaluation will be questionnaire-based and will comprise an evaluation of the users’ understanding of:
o The key warnings and test limitations and/or restrictions
o The test procedure
o The test result interpretation

• To evaluate the ability of professional users to interpret the ANC Panel test results (n=15 healthcare professionals). This evaluation will assess the professional users’ ability to interpret pre-prepared, static ANC Panel test results. The results will comprise a range of test results, including weak-positive results and tests with failed control lines. Each user will interpret five different test results, with three tests in each test result, in randomised order.

UK 2024-05-30 11:27:23 2027-05-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Emmanuel Awori Siryoyi
ID:
Determinants of export performance of maize farmer organizations in Busia district, Uganda
REFNo: A440ES

To establish the effect of import bans and tariffs on the export performance of maize farmer groups in Busia district, Uganda. ,To illustrate the effect of infrastructural development on the export performance of maize farmer groups in Busia district, Uganda,To demonstrate the effect of middlemen on the export performance of maize farmer groups in Busia district, Uganda,To establish the effect of farmer group capacity on the export performance of maize farmer groups in Busia district, Uganda. ,
Uganda 2024-05-30 11:26:40 2027-05-30 Agricultural Sciences Non-Clinical Trial Degree Award
Jerome  Barry Bamugaya
ID:
INCLUSIVE COMMUNITY GROUPS’ INITIATIVES TO SUSTAINABLE RURAL LIVELIHOOD SECURITY IN TESO SUB-REGION IN UGANDA
REFNo: SS2597ES

I. To establish the contribution of local community groups’ initiatives in reducing livelihood insecurities in Teso region in Uganda
II. To ascertain men and women’s perceptions and views on local groups’ initiatives towards rural livelihood security
III. To determine existing challenges, and threats that impede community initiatives to sustainable rural livelihoods among Iteso
IV. To establish applicable and tenable model for effective community groups’ operations

Uganda 2024-05-30 11:23:14 2027-05-30 Social Science and Humanities Non-Clinical Trial Degree Award
WATAKA WILLIES
ID:
HUMAN RESOURCE PRACTICES AND EMPLOYEE TURNOVER IN CITY COUNCILS OF MBALE AND JINJA, EASTERN UGANDA
REFNo: SS2476ES

iv) To establish the effects of employee motivation on employees’ turnover in City Councils of Mbale and Jinja.,iii) To examine the effects of employee health and safety on employees’ turnover in City Councils of Mbale and Jinja.,ii) To establish the effects of employee career growth management on employees’ turnover in City Councils of Mbale and Jinja.,i) To determine the effects of employee reward management on employees’ turnover in City Councils of Mbale and Jinja.,The purpose is to assess how Human Resource Practices have influenced employees’ turnover in City Councils in Eastern Uganda.,
Uganda 2024-05-30 10:41:59 2027-05-30 Social Science and Humanities Non-Clinical Trial Degree Award
Denis Byarugaba Karuhize
ID: UNCST-2023-R006496
Severe acute respiratory infections (SARI) surveillance in hospitalized patients in Uganda
REFNo: HS4166ES

i) To better understand SARI etiology (influenza and other respiratory viruses), severity and risk factors among hospitalized patients with SARI from all age groups
ii) Contribute to Uganda’s and global response and management of SARI
iii) Contribute to international capabilities and collaboration to integrate clinical virological and genomic influenza and other respiratory pathogens surveillance data through the WHO Global Influenza Surveillance and Response System (GISRS) to support intervention and better SARI management and response including influenza vaccine selection, vaccine escape as well other respiratory virus vaccines
iv) Support international alert and response system for emerging strains of pandemic potential

Uganda 2024-05-29 9:45:45 2027-05-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
Secondary use of Uganda Population-based HIV Impact Assessment (UPHIA) samples and associated data for micronutrient surveillance
REFNo: HS4333ES

2. Assess for associations between micronutrient status with HIV status and related indicators using 2020 - 2021 UPHIA metadata,1. Determine national and sub-national prevalence estimates for MND using 2020 - 2021 UPHIA samples,
Uganda 2024-05-29 9:42:49 2027-05-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sherifah Nabikande
ID: UNCST-2022-R009631
Uptake of HIV prevention interventions among adolescent girls and young women in slum settings in Kampala district, Uganda
REFNo: HS4015ES

3) To explore the barriers and facilitators of condom use, HIV testing and Pre-exposure prophylaxis as HIV prevention interventions among AGYW in slum settings in Kampala district, Uganda,2) To determine the factors associated with condom use, HIV testing and Pre-exposure prophylaxis as HIV prevention interventions among AGYW in slum settings in Kampala district, Uganda,1) To determine the proportion of AGYW who use condoms, HIV testing and Pre-exposure prophylaxis as HIV prevention interventions in slum settings in Kampala district, Uganda,To determine the uptake of condoms, HIV testing and Pre-exposure prophylaxis as HIV prevention interventions and factors associated among AGYW in slum settings in Kampala district, Uganda ,
Uganda 2024-05-29 9:40:25 2027-05-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Adoke Yeka
ID: UNCST-2021-R004300
A randomized, open-label, multicenter study to compare efficacy, safety and tolerability of KLU156 with Coartem® in the treatment of uncomplicated Plasmodium falciparum malaria in adults and children ≥ 5 kg body weight followed by an Extension phase with repeated KLU156 treatment.
REFNo: HS3732ES

This study aims to confirm the efficacy, safety and tolerability of KLU156, a fixed dose combination of ganaplacide (KAF156) and a solid dispersion formulation of lumefantrine (lumefantrine-SDF), when administered once daily for three days in adults and children ≥ 5 kg body weight and ≥ 2 months of age suffering from uncomplicated P.Falciparum malaria (with or without other plasmodium spp. co-infection). In the Extension phase, the safety, tolerability and efficacy of repeated treatment with KLU156 will be assessed for a maximum of two years in patients who did not experience early treatment failure(ETF), who did not experience any study treatment-related SAE (Serious Adverse Event) previously and who gave informed consent to participate in the Extension phase.
Uganda 2024-05-29 9:37:35 2027-05-29 Medical and Health Sciences Clinical Trial Non-degree Award
Christine kisubi Esther
ID:
ENVIRONMENTAL JUSTICE IN UGANDA’S OIL AND GAS UPSTREAM SUB-SECTOR DECISION-MAKING
REFNo: SS2634ES

To critically examine the legal frameworks and their implementation concerning environmental justice and community participation in decision-making processes within Uganda\'s oil and gas upstream sub-sector.,
Uganda 2024-05-27 9:01:35 2027-05-27 Social Science and Humanities Non-Clinical Trial Degree Award
Nakacwa Patricia Florence
ID: UNCST-2024-R004518
Student\'s Academic Resilience and Competence Based Curriculum: A case study of Secondary Schools in Mukono and Kayunga District.
REFNo: SS2605ES

iv. To evaluate the moderating influence of emotional intelligence on the relationship between academic resilience and competency-based learning in secondary schools in Mukono and Kayunga districts.,iii. To analyze the effect of academic coordination on competency-based learning in secondary schools in Mukono and Kayunga districts.,ii.To examine the relationship between academic confidence and competency-based learning in secondary schools in Mukono and Kayunga districts.,i.To assess the relationship between academic commitment and competency-based learning in secondary schools in Mukono and Kayunga districts.,The study intends to examine the relationship between academic resilience and competency-based learning to develop a model to support quality education in secondary schools in Uganda.,
Uganda 2024-05-27 9:00:16 2027-05-27 Social Science and Humanities Non-Clinical Trial Degree Award
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