Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Ephrance  Namugenyi Eunice
ID:
Adaptive Network Communications Architecture for Transmission of Sensor Data in the Framework of Beehive Management.
REFNo: SIR382ES

Objective 1: Conduct Requirements Analysis and Design: Identify and analyze the requirements for an adaptive network communications architecture tailored for beehive monitoring units, focusing on the transmission of sensor data with specified communication modules (LoRa, Wi-Fi, and GSM) for various environmental test case scenarios. Document the requirements and design specifications within the first year, ensuring the design addresses the unique challenges of remote beekeeping environments and utilizing existing knowledge and technology to outline feasible network requirements and designs.,To design, develop, and evaluate a reliable adaptive network communications architecture that optimizes the transmission of sensor data for efficient and intelligent monitoring of beehive management, based on real-time environmental conditions, resource availability, and application-specific requirements over a three-year period., Objective 2: Develop and Integrate Machine Learning Optimization Algorithms: Develop and integrate machine learning algorithms that optimize the network\'s operation modes and data transmission prioritization based on real-time environmental conditions and network resource availability. Implement and test these algorithms in a controlled setting, leveraging existing machine learning frameworks and expertise. Enhance the adaptability and efficiency of the network to ensure it is suitable for energy-constrained and variable environments. Finalize the development and initial testing by the end of the second year., Objective 3: Evaluate Network Performance and Effectiveness: Conduct simulations, experimental analyses, and field demonstrations to evaluate the performance and effectiveness of the developed adaptive hybrid backhaul network (LoRa, Wi-Fi, and GSM) for different deployment scenarios in beehive management. Measure key performance indicators such as data throughput, latency, power consumption, and reliability across various scenarios. Use simulation tools and real-world testing environments to gather relevant data. Validate the network\'s performance to ensure it meets the requirements for efficient sensor data transmission in beehive monitoring. Complete all evaluations, analyses, and demonstrations by the end of the third year.,
 Uganda 2024-08-29 13:29:16 2027-08-29 Engineering and Technology Non-Clinical Trial Degree Award
Paul Lutaakome
ID:
DIETARY QUALITY AND ITS CORRELATES AMONG PATIENTS DIAGNOSED WITH CARDIOVASCULAR DISEASES AT THE UGANDA HEART INSTITUTE – KAMPALA UGANDA
REFNo: HS3899ES

4. To establish the institutional correlates of dietary quality among patients diagnosed with cardiovascular diseases at the Uganda heart institute – Kampala Uganda,3. To determine the intra-household correlates of dietary quality among patients diagnosed with cardiovascular diseases at the Uganda heart institute – Kampala Uganda,2. To identify intrapersonal correlates of dietary quality among patients diagnosed with cardiovascular diseases at the Uganda heart institute – Kampala Uganda,1. To determine the proportion of patients diagnosed with cardiovascular diseases at the Uganda heart institute, who have satisfactory dietary quality,To assess dietary quality and its correlates among patients diagnosed with cardiovascular diseases at the Uganda heart institute – Kampala Uganda.,
 Uganda 2024-08-29 11:01:41 2027-08-29 Medical and Health Sciences Non-Clinical Trial Degree Award
GUMA  ASHIRAF
ID:
PREVALENCE, PATTERNS AND CORRELATES OF GENERAL JOINT PAIN AMONG PATIENTS WITH DIABETES MELLITUS ATTENDING DIABETIC CLINIC AT MBARARA REGIONAL REFFERRAL HOSPITAL
REFNo: HS3963ES

To determine the prevalence of general joint pain among patients with DM attending diabetes clinic at MRRH.To determine the patterns of joint pain among patients with DM attending diabetes clinic at MRRH.To determine the associated factors to general joint pain among patients with DM attending diabetes clinic at MRRH.
 Uganda 2024-08-29 10:59:36 2027-08-29 Medical and Health Sciences Clinical Trial Degree Award
Esther Bibangambah Mulungi Nabatanzi
ID: UNCST-2024-R004669
 Health Related Quality of Life of children with Cerebral Palsy in Wakiso District: An Explorative interventional study
REFNo: HS4516ES

4. Evaluate the impact of both hospital-based and community-based early intervention program on Health-Related Quality of Life of children with Cerebral Palsy and the depression anxiety and stress level of their primary caregivers. ,3. Define the depression, anxiety and stress of primary caregivers of children with Cerebral Palsy in Wakiso, Uganda,2. Define the Health-Related Quality of Life of children with CP in Wakiso, Uganda,1. Define the epidemiology of Cerebral Palsy in Wakiso, Uganda,We aim to establish a cohort of children with CP in the Wakiso district of Uganda to define the epidemiology of CP, describe the HRQoL of the children with CP and depression, anxiety and stress level their primary caregivers to evaluate the impact of any community-based early intervention. ,
 Uganda 2024-08-28 18:51:55 2027-08-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
ACEN CATHERINE BOKELLO
ID: UNCST-2024-R004924
 Internal Control Systems and Public Financial Management in Selected Local Governments in Uganda
REFNo: SS2809ES

To determine the significant relationship between monitoring and public financial management in selected local governments in Uganda.,To establish the influence of communication on public financial management in selected local governments in Uganda,To establish the effect of control activities on public financial management in selected local governments in Uganda,To establish the influence of risk assessment on public financial management in selected local governments in Uganda.,To determine the effects of control environment on public financial management in selected local governments in Uganda,To assess the effects of internal control systems on public financial management in selected Local Governments, in Uganda.,
 Uganda 2024-08-28 18:49:02 2027-08-28 Social Science and Humanities Non-Clinical Trial Degree Award
Beatrice Kyasiimire
ID:
Living near Uganda’s Queen Elizabeth National Park; evaluating alternative livelihood initiatives
REFNo: NS830ES

Assess communities\' governance structures and systems\' impacts on alternative livelihoods around the park.,Assess community and external actors\' perceptions of the enabling conditions for alternative livelihood projects around the park.,Evaluate the enabling conditions for alternative livelihood projects in communities around Queen Elizabeth National Park.,The overall aim of this study is to understand the enabling conditions influencing the implementation and effectiveness of alternative livelihoods around Queen Elizabeth National Park. ,
 Uganda 2024-08-28 18:46:54 2027-08-28 Natural Sciences Non-Clinical Trial Degree Award
SHAFIGA BABIRYE
ID: UNCST-2024-R004302
 LEVEL AND PREDICTORS OF CATASTROPHIC HEALTH EXPENDITURE AMONG RECIPIENTS OF AMBULATORY SURGICAL SERVICES AT KYABIRWA SURGICAL CENTER
REFNo: SS2900ES

To establish the intra-household predictors of Catastrophic Health Expenditure among recipients of ambulatory surgical care services at Kyabirwa surgical center,To analyze the clinical predictors of Catastrophic Health Expenditure among recipients of ambulatory surgical care services at Kyabirwa surgical center,To assess the intrapersonal predictors of Catastrophic Health Expenditure among recipients of ambulatory surgical care services at Kyabirwa surgical center,To determine the prevalence of Catastrophic Health Expenditure among recipients of ambulatory surgical care services at Kyabirwa surgical center,To assess the level and predictors of Catastrophic Health Expenditure among recipients of ambulatory surgical care services at Kyabirwa surgical center,
 Uganda 2024-08-28 18:41:10 2027-08-28 Social Science and Humanities Non-Clinical Trial Non-degree Award
Patrick Kagurusi Tumusiime
ID: UNCST-2021-R012687
 Exploring the Nexus of Clean Water Access and Sexual Reproductive Health among Women and Girls in Rural Uganda
REFNo: SS2829ES

1. How do socio-cultural contexts, such as traditional gender roles and community expectations, shape the challenges women and girls face when accessing clean water?
2. How do power dynamics influence the management, utilization, and involvement of women in activities related to water access?
3. What role does education play on the awareness and implementation of Sexual Reproductive Health practices among women and girls?

Uganda 2024-08-28 18:39:31 2027-08-28 Social Science and Humanities Non-Clinical Trial Non-degree Award
Hadijah Yahyah
ID:
Assessing the Environmental Sustainability Implications of Farm-Level Persistent Organic Pollutant Pesticide Use in Uganda
REFNo: SS2683ES

1. To examine the pathways for the transmission of POPs pesticides into Mukono District;
2. To evaluate the trends and characteristics of farm level use of POP pesticides into Mukono District;
3. To assess the role and level of knowledge, attitudes and practices of farmers in decision making for POPs pesticide use in Mukono District;
4. To assess the adequacy of the existing structures , tools, and approaches for the regulation of importation and farm-level use of POP pesticides in Uganda;

 Uganda 2024-08-28 18:31:37 2027-08-28 Social Science and Humanities Non-Clinical Trial Degree Award
Catherine Nakaye
ID: UNCST-2021-R013222
 FEASIBILITY, ACCEPTABILITY, AND PERSISTENCE OF COMMUNITY DRUG SHOP-BASED HIV SELF-TESTING AND ORAL PREP DELIVERY AMONG FEMALE SEX WORKERS IN KITEBI, KAMPALA CAPITAL CITY, CENTRAL UGANDA (DROP-D).
REFNo: HS4556ES

Examine FSW and community drug shop PrEP providers’ experiences, preferences, barriers, and facilitators related to the community drug shop based HIVST and oral PrEP delivery model,Assess persistence of community drug shop-based HIVST and oral PrEP delivery among FSW in Kampala,Assess the feasibility and acceptability of utilising community drug shops to offer HIVST and oral PrEP delivery among FSW in Kampala,
 Uganda 2024-08-28 18:28:21 2027-08-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ronald Semyalo Paul Ddumba
ID: UNCST-2021-R012585
 RISING INEQUALITIES OCCASIONED BY COVID-19 IMPACTS IN URBAN INFORMAL SETTLEMENT IN UGANDA (CASE STUDY OF ACCESS AND USE OF SAFE WATER IN KAMPALA SLUM AREAS)
REFNo: NS746ES

To assess microbiological and physicochemical water quality both at the source and household reserves, as well as carryout sanitation risk assessment of the different water sources in Kisenyi.,To assess the patterns of access to and utilization of safe water among households in Kisenyi, Central Division, examining the changes that occurred before, during, and after the COVID-19 pandemic.,To investigate the diverse socio-economic determinants of households in Kisenyi which influences their choice of water source and how this was impacted by COVID-19.,Examine the multifaceted impact of the COVID-19 pandemic on the exacerbation of social and economic inequalities among the urban poor, with a specific focus on access to Water, Sanitation, and Hygiene (WASH) services, as a means to gain insights and inform strategies for addressing these disparities.,
 Uganda 2024-08-28 18:19:09 2027-08-28 Natural Sciences Non-Clinical Trial Non-degree Award
ERINAH MUDONDO -
ID:
Liquidity management practices and Financial performance of banking institution in Kampala metropolitan - Uganda
REFNo: SS2872ES

To establish the influence of liquidity risk on the financial performance of banking institutions in Kampala Metropolitan.,To investigate the influence of liquidity management practices on financial performance of banking institutions in Kampala Metropolitan, Uganda.,
 Uganda 2024-08-28 18:17:15 2027-08-28 Social Science and Humanities Non-Clinical Trial Degree Award
Robert Downing George
ID: UNCST-2020-R014615
 A prospective, multi-centre study to evaluate the diagnostic sensitivity and specificity of the Determine Syphilis Advanced test.
REFNo: HS4648ES


The primary objective of this study is:
• To determine the diagnostic sensitivity and specificity of the Determine Syphilis Advanced test results using fingerstick capillary whole blood, venous whole blood, serum and venous plasma, when the test is performed by professional users.

The reference test will be Elecsys® Syphilis test (Roche). This test is an electrochemiluminescence immunoassay for the qualitative determination of total antibodies against Treponema pallidum. Samples with a negative Elecsys Syphilis result will be considered reference test-negative. Samples with a positive Elecsys Syphilis result will be confirmed by Treponema Pallidum Particle Agglutination (TPPA) testing. The TPPA result must be positive for the sample to be considered reference test-positive. Samples with a positive Elecsys Syphilis result but a negative or indeterminate TPPA result will be considered indeterminate and excluded from the study analyses. Potential discrepant result resolution using the Abbott Architect i1000SR Syphilis chemiluminescent microparticle immunoassay may be conducted for study reference test-positive or reference test-negative samples with discrepant investigational test results. The results from potential discrepant result resolution testing will be presented as table footnotes only. In addition to these treponemal tests, non-treponemal RPR testing will also be conducted for the reference test-positive participants, and the results may be stratified also by RPR status. All discrepant specimens shall be repeated using the same lot of RDT, and then on all available lots and any variability noted.

Another primary study objective is to compare the performance of the Determine Syphilis Advanced test with two commercially available similar tests, to meet the regulatory requirements in Japan. These two commercially available tests will be the TPPA test (SERODIA-TPPA, Fujirebio, Japan) and the Determine Syphilis TP test (Abbott). This analysis will be performed using 60 reference test-positive samples and 60 reference test-negative samples. The testing will be performed using plasma.

One study secondary objective is to evaluate the usability through completion of a user experience questionnaire (healthcare and laboratory staff).

Another study secondary objective is to determine the stability of venous whole blood, serum and plasma samples for use with Determine Syphilis Advanced, after refrigeration of the venous whole blood, serum and plasma at 2-8 degrees Celsius during 7 days before testing.

 UK 2024-08-28 17:34:38 2027-08-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Hillary Agaba
ID:
Understanding experiences of participating in a farmer research network from multiple perspectives in the Agroecology - Landscape project in Eastern Uganda
REFNo: SS2707ES

Provide an overview of the diversity of experiences across the Collaborative Resilient Food Systems (CRFS) countries, and different projects within countries, in ESAf. ,Gain more understanding of how FRN groups have developed and are functioning from the perspectives of those involved, ,Document the experience of participating in Farmer Research network (FRN) from multiple perspectives: farmers, researchers, NGO field staff and extension workers;,
 Uganda 2024-08-28 17:32:34 2027-08-28 Social Science and Humanities Non-Clinical Trial Non-degree Award
Dennis Muhanguzi
ID: UNCST-2019-R001101
 Comparing the Diagnostic Performance of the Rapid Tick Exposure Test (RaTexT®) and Larval Packet Test [LPT] for Acaricide Resistance Management in Uganda
REFNo: NS843ES

The general objective of this study will be to determine the diagnostic performance of RaTexT® compared to larval packet technique, test a mobile application for its ability to capture acaricide resistance data generated by RaTexT® and transmit it to end users as dynamic maps of acaricide resistance as well as determine the gender roles that are likely to underpin successful RaTexT® introduction. The specific objectives of this acaricide study will be to determine:
i.Laboratory and field diagnostic performance [specificity, sensitivity, negative and positive predictive values] of RaTexT® when used to detect acaricide resistance in tick populations isolated from different agro-ecological zones of Uganda.
ii. Possibility of integrating RaTexT® -generated acaricide resistance | susceptibility data into a mobile phone app to allow end-users to create dynamic maps of acaricide resistance in different African ecologies.
iii.Gender-based drivers of successful introduction and sustainable utilisation of RaTexT®

 Uganda 2024-08-28 17:31:08 2027-08-28 Natural Sciences Non-Clinical Trial Non-degree Award
Ruth Namazzi
ID: UNCST-2020-R014305
 Zinc for Infection Prevention in Sickle cell anemia ZIPS-2
REFNo: HS4824ES

The primary objective of the study is to determine if zinc supplementation at 20mg daily is safe and efficacious at reducing all-cause infection in Ugandan children 1.00-4.99 years of age with SCA.Secondary objectives 1. To determine the incidence of adverse events requiring discontinuation of study drug in children ages 1-4.99 supplemented with 20mg of daily zinc vs placebo 2. To determine the incidence of stroke or death in children ages 1-4.99 supplemented with 20mg of daily zinc vs placebo 3. To determine the incidence of infections requiring hospitalization in children ages 1-4.99 supplemented with 20mg of daily zinc vs placebo 4. To determine the incidence of vaso-occlusive crises in children ages 1-4.99 supplemented with 20mg of daily zinc vs placebo 5. To determine the change in transcranial Doppler (TCD) velocity from enrollment to 6-month study endpoint in children ages 1-4.99 supplemented with 20mg of daily zinc vs placebo 6. To determine change in serum zinc deficiency status from enrollment to 6-month study endpoint in children ages 1-4.99 supplemented with 20mg of daily zinc vs placebo 7. To determine the incidence of serious adverse events in children ages 1-4.99 supplemented with 20mg of daily zinc vs placebo 8. To determine the incidence of adverse events in children ages 1-4.99 supplemented with 20mg of daily zinc vs placebo
Uganda 2024-08-28 17:29:12 2027-08-28 Medical and Health Sciences Clinical Trial Non-degree Award
Esther Nakyaze
ID:
Provider Perspectives on the PrEP Ring (“ProPrEP”): views from a maternal and child health program (“BAMA”) serving young mothers in rural Uganda.
REFNo: HS4468ES

General Objective
The study will deepen our understanding of provider perspectives on use of the PrEP vaginal ring among young mothers living in rural areas of Uganda.
Specific Objectives
1. Identify preliminary areas for education and outreach to improve both provider and end-user understanding/knowledge of the new vaginal ring technology, thus increasing likelihood of quality counseling and uptake among a vulnerable population of young mothers.
2. Explore the reception by health care personnel of promotional and information/education/counseling (IEC) materials developed by the multilateral “Catalyst” study (funded by PEPFAR through USAID) for ring launch, especially in rural regions having distinct health services resources; identify areas for possible adaptation or elaboration for best uptake and use by health workers
3. Expand understanding of facilitators and barriers faced by young mothers in accessing HIV prevention information and services, especially:
a. community and peer-based stigma
b. provider attitudes
c. models of service provision linking maternal health and HIV prevention/care

Uganda 2024-08-26 18:29:44 2027-08-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
BOSCO AGABA BEKIITA
ID: UNCST-2019-R000549
 Epidemiological Profile of Malaria and Molecular Characterization to Assess Presence and Potential Contribution of Emerging Parasite Populations to Malaria Epidemics in Epidemic Districts in Eastern Uganda
REFNo: HS4786ES

General objective
To describe the epidemiological profile of malaria and assess presence and potential contribution of new emerging parasite populations to persistent epidemics in malaria
epidemic districts in Eastern Uganda
Specific objectives
1. To describe the trend and epidemiological profile of malaria in five epidemic districts in Eastern
Uganda over the past 5-year period
2 . To assess presence and potential contribution of emerging parasite species to epidemics by
molecular characterization of malaria parasite populations in epidemic districts in Eastern Uganda
3 . To assess presence and potential contribution of emerging parasite populations harboring
molecular markers of artemisinin resistance to persistent epidemics in malaria epidemic districts
in Eastern Uganda
4 . To assess presence and potential contribution of emerging parasite populations harboring pfhrp2
and pfhrp3 gene deletions to the persistent epidemics in malaria epidemic districts in Eastern Uganda
 Uganda 2024-08-26 18:28:33 2027-08-26 Medical and Health Sciences Non-Clinical Trial Degree Award
MUGISHA TAREMWA IVAN
ID: UNCST-2024-R004274
 Assessment of Transfusion Safety and Efficacy among Cancer Patients in Uganda and Caregivers’ Perceptions on Blood Use.
REFNo: HS4848ES

Specific objectives: (i). To assess the level of bacterial contamination in stored whole blood and blood components intended for transfusion to patients with cancer at Mbarara Regional Referral Hospital and Uganda Cancer Institute. (ii). To determine the prevalence of, and the factors associated with immune sensitization among patients with hematological malignancies at Mbarara Regional Referral Hospital and Uganda Cancer Institute. (iii). To identify the specificities of anti-RBC alloantibodies in patients with hematological malignancies at Mbarara Regional Referral Hospital and Uganda Cancer Institute (iv). To determine the incidence of acute and delayed serologic or delayed hemolytic transfusion reactions among patients with cancer at Mbarara Regional Referral Hospital and Uganda Cancer Institute (v). To describe the caregivers' perceptions of blood use and availability in southwestern Uganda. Main objective: To assess transfusion safety and efficacy among patients with cancer in Uganda and caregivers’ perceptions of blood use.
 Uganda 2024-08-26 18:26:57 2027-08-26 Medical and Health Sciences Non-Clinical Trial Degree Award
Edward  Tumwesige
ID: UNCST-2024-R003855
 Assessing Community Willingness and Acceptance to Utilize Locally Developed Vaccines
REFNo: SS2875ES

• Assess the community's level of knowledge and awareness regarding locally developed vaccines.
• Explore trust and willingness of the community to utilise locally developed vaccines.
• Identify factors contributing to positive or negative perceptions of locally developed vaccines.
• Explore the most effective communication channels for sharing information about locally developed vaccines.

 Uganda 2024-08-26 18:25:34 2027-08-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
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