Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
sandra etumah omon
ID: UNCST-2024-R003992
 Assessment of the Nutritional Profile and Biochemical Adaptation of Zea mays L. Grown around Kilembe Mining Area, Kasese, Uganda
REFNo: NS809ES

1. To assess the Physicochemical characteristics of the soil and heavy metal content such as copper, lead, cobalt, Nickel, Cadmium, Mercury, chromium, and arsenic at the research site.
2. To analyze the heavy metals content (copper, lead, cobalt, Nickel, Cadmium, Mercury, chromium, and arsenic) of the maize plant grown at the mining site and their translocation.
3. To analyze the nutritional profile: proximate analysis (carbohydrates, protein, fats/oil, crude fiber, moisture, and ash), mineral element (iron, magnesium, manganese, calcium, sodium, phosphorus, sulfur, and potassium), and Vitamins (thiamine, niacin, riboflavin, retinol, cobalamin, pyridoxine, tocopherol, ascorbic acid, and cholecalciferol) of the maize grown around the mining site.
4. To assess the oxidative stress markers (malondialdehyde, tocopherol, and proline) and the enzymatic antioxidant capacity (glutathione peroxidase, superoxide dismutase, and catalase) in the leaves during the vegetative stage of the maize plant.
5. To quantitatively determine the hormonal levels (ABA, auxins, and brassinosteroids) in the leaves during the vegetative stage of the maize
6. To determine bioremediation options from the culturable rhizospheric soil bacteria isolated from around the mining site.

 Nigeria 2024-12-10 14:44:20 2027-12-10 Natural Sciences Non-Clinical Trial Degree Award
Maria Magdalene Namaganda
ID: UNCST-2021-R004319
 Development of a machine learning model for prediction of virological failure in a resource-limited setting
REFNo: HS3982ES

Sub-study 1 To identify the risk factors associated with virological failure among PLWH in east Africa from 2014 to 2024. Sub-study 2 To analyse the trends of ART use and incidence of virological failure rates among PLWH in TASO-Uganda health centres from 2014 to 2024. Sub-study 3 To develop and validate machine learning models for prediction of virological failure. Sub-study 4 To evaluate the practical utility of the HIV virological failure predictive models developed in a clinical setting.
Uganda 2024-12-10 14:40:45 2027-12-10 Medical and Health Sciences Non-Clinical Trial Degree Award
Jackson Orem
ID: UNCST-2021-R012016
 A Phase III, Randomized, Open-Label, Non-Inferiority Study of Paclitaxel and Pegylated Liposomal Doxorubicin for Treatment of HIV-related Kaposi Sarcoma in Resource-Limited Settings
REFNo: HS4073ES

To describe the incremental cost-effectiveness ratio per QALY gained (as assessed by PROPr) between PLD and PTX,To assess quality of life across PROMIS domains (i.e., cognitive function, physical function, fatigue, pain interference, depressive symptoms, anxiety, ability to participate in social roles and activities, and sleep disturbance) with the PROPr tool at start of therapy, mid-treatment, and after treatment with PLD and PTX ,To describe the cost of therapy across AMC sites in sub-Saharan Africa to deliver both PLD and PTX by micro-costing analysis for goods and time-in-motion analysis for services. ,To estimate the objective response rate (defined as the sum of complete and partial responses) for AIDS-KS, response duration and overall survival in each treatment arm. ,To evaluate whether there is sufficient evidence to conclude that PLD is non-inferior to PTX in people with severe AIDS-associated KS receiving concomitant ART in resource-limited settings. ,
 Uganda 2024-12-10 14:39:24 2027-12-10 Medical and Health Sciences Clinical Trial Non-degree Award
Adelline Twimukye
ID: UNCST-2019-R000117
 HIV CARE AND ANTENATAL HEALTH SEEKING BEHAVIOUR PATTERNS OF PREGNANT AND BREAST-FEEDING WOMEN DURING PREVIOUS COVID-19 PANDEMIC IN UGANDA
REFNo: SS3219ES

To document the challenges faced by pregnant and breastfeeding women with HIV in accessing healthcare services in the COVID-19 period.,To interrogate the effects of COVID-19 pandemic to adherence to routine clinic appointments and antiretroviral therapy (ART) among pregnant and breast-feeding women living with HIV.,To examine the social or cultural norms that influence access to care among pregnant or breast-feeding women HIV during the COVID-19 pandemic.,To investigate health care worker’s knowledge, attitude, and practices about COVID-19 among pregnant and breast-feeding women living with HIV in Uganda.,The purpose of the study is to explore HIV care and antenatal seeking behavior patterns of pregnant and breast-feeding women during response and control of COVID-19 pandemic in Uganda.,
 Uganda 2024-12-10 14:37:39 2027-12-10 Social Science and Humanities Non-Clinical Trial Degree Award
VICENT MWESIGYE
ID: UNCST-2024-R002866
 LYMPHEDEMA: CAUSATIVE AGENTS, PATIENT AND CARETAKER KNOWLEDGE, SELF-REPORTED HEALTHCARE NEEDS AND PREVENTIVE STRATEGIES IN KAMWENGE DISTRICT.
REFNo: HS5335ES

3. To explore the lymphedema-related knowledge, lived experiences and healthcare needs of patients and their caretakers and preventive strategies in Kamwenge district, South Western Uganda.,2. To determine the causative agents of lymphedema among patients with lymphedema in Kamwenge district, South Western Uganda.,1. To describe the Preventive strategies, their effectiveness in patients with Lymphedema based on Scoping review globally.,To determine the causative agents, patient and caretaker knowledge, self-reported healthcare needs and preventive strategies amongst Lymphedema patients in Kamwenge District South Western Uganda.,
 Uganda 2024-12-10 14:35:45 2027-12-10 Medical and Health Sciences Non-Clinical Trial Degree Award
Tess Lallemant
ID: UNCST-2023-R007159
 How do Firms Hire? A Demand-Side Experiment to Reduce Matching Frictions in Uganda Labor Markets
REFNo: SS3487ES

1. Answer the research question: How do firms navigate the hiring process for graduate workers?
2. Answer the research question: How are firms identifying their employment needs?
3. Answer the research question: How are firms communicating their employment needs?
4. Answer the research question: To what extent are these hiring frictions affecting match quality?
5. Answer the research question: Do firms learn about hiring and adapt their search strategies to achieve higher match quality?
 USA 2024-12-10 14:24:53 2027-12-10 Social Science and Humanities Non-Clinical Trial Degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 Optimizing the Implementation and Scale-Up of the WHO Treatment-Decision Algorithms for Children with Pulmonary Tuberculosis in Sub-Saharan Africa (OPTIC-TB)
REFNo: HS5246ES

1) To compare the effectiveness of TDA versus the Standard of Care strategies in routine non-research programmatic conditions.
2) To identify processes and contextual factors that influence the effectiveness and fidelity in the implementation of TDA.
3) To compare the costs, cost-effectiveness, and population-level impact of the TDA strategies on the burden of TB.
4. To estimate/validate the diagnostic performance (sensitivity, specificity, negative and positive predictive values) of the TDAs for TB in children under 10 years old in various healthcare system settings and in various clinical contexts (i.e, such as HIV, malnourished children, facility level, gender, rural, urban etc.

Uganda 2024-12-10 14:06:31 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Vianney Tushabe John
ID: UNCST-2024-R015708
 Development of Multiplex Molecular Test for S. mansoni and P. falciparum Duplex using LAMP assay and Pit Latrine metagenomic sampling for community assessment
REFNo: SIR445ES

- Development of the Multiplex Malaria – Schistosomiasis assay
- Latrine Metagenomics for community diagnostics assessment 
- Validation of Molecular duplex assay technology 
 Uganda 2024-12-10 14:04:09 2027-12-10 Engineering and Technology Non-Clinical Trial Degree Award
Manon Delvaux Alizee
ID: UNCST-2024-R002311
 Cultivating Cooperation: The Impact of Formalizing Land Rental Contracts on Refugee-Host Interactions and Agricultural Production in Rural Uganda
REFNo: SS3408ES

In northern Uganda, food insecurity is high for many refugees, who cultivate land for their subsistence in the vicinity of the settlements. A large majority of these refugees do not have a formal written land rental contract with their landlords. While informal institutions and agreements can have enforcement power in socially and culturally homogeneous groups, their efficiency tends to decrease with social and cultural distance. In this setting of cohabitation between Ugandans and refugees, the absence of clearly defined terms of trade often limits successful farming outcomes, as refugees’ rights to what they earn, produce, and consume are more vulnerable to changes. Suggestive evidence indicates that formal land contracts grant greater security, which can lead to increased farm profitability, investment and credit opportunities, and greater economic diversification and growth.

We will conduct a randomized pilot evaluation to measure the impact of formalized land rental contracts between refugee tenants and host community landlords. In the treatment groups, the landlords and tenants will receive support to formalize their land rental agreement. In the control group, landlords and tenants will remain with verbal and informal land rental agreements. We will evaluate indicators such as trust, social cohesion, agricultural practices, and food security. The study will also investigate why formalized land rental contracts are not more widespread in rural Uganda. The sample will include tenants from the Bidibidi, Imvepi and Rhino refugee settlements and landlords from the host communities.
 France 2024-12-10 14:03:00 2027-12-10 Social Science and Humanities Non-Clinical Trial Degree Award
SAM ALI
ID: UNCST-2020-R014824
 A Noncontact Bed-Based Platform for Passive Longitudinal Monitoring of Maternal and Fetal Cardiovascular Physiology in Uganda
REFNo: HS5320ES

Main objective
• To monitor maternal and fetal heart rate, respiratory rate, fetal movement, and sleep patterns among selected pregnant women enrolled in the iTECH study using noncontact bed sensors with the goal of better understanding both maternal and fetal physiology.

Specific objectives
1. To describe the maternal respiratory and heart rate profiles among selected pregnant women enrolled into the iTECH study.
2. To describe the fetal respiratory and heart rate profiles among selected pregnant women enrolled into the iTECH study.
3. To demonstrate the feasibility of measuring and extracting fetal movement signals among selected pregnant women enrolled into the iTECH study.
 Uganda 2024-12-09 13:22:54 2027-12-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
DAVID KATEETE PATRICK
ID: UNCST-2020-R004018
 Disentangling the population structure of MRSA in an urban low-income settings
REFNo: HS4699ES

1. To define the population structure of MRSA in hospital and community settings in Kampala, and identify risk factors for MRSA carriage among inpatients and individuals in the community.

2. To Investigate the probable coexistence between HA-MRSA and CA-MRSA in hospital and community in Kampala.
 Uganda 2024-12-02 17:33:35 2027-12-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Brian Turigye
ID: UNCST-2021-R012569
 QUALITY OF MATERNAL AND NEWBORN CARE; A CASE STUDY OF KASESE AND BUNDIBUGYO DISTRICTS, MIDWESTERN UGANDA
REFNo: HS5213ES

1. To describe existing evidence on the quality of Provision of Obstetric and newborn care in Uganda
2. To establish the quality of provision of Obstetric and newborn care in Midwestern Uganda
3. To explore the determinants and drivers of the quality of provision of Obstetric and newborn care in Midwestern Uganda
4. To analyze critically the existing strategies on improving the provision of Obstetric and newborn care in Midwestern Uganda and develop relevant alternatives

 Uganda 2024-12-02 17:32:38 2027-12-02 Medical and Health Sciences Non-Clinical Trial Degree Award
Damari Atusasiire
ID: UNCST-2024-R002645
 Lively Minds Together Range and Listenership Estimation
REFNo: SS3435ES

To gather data on the signal strength of radio programs of interest,To provide evidence-based recommendations on geographic locations and radio programming for the future rollout and evaluation of the Lively Minds Together project.,To understand preferences, popularity, and other media sources related to radio programming.,To collect general information on radio listenership habits.,To gather data on the number of listeners for the radio programs of interest.,
 Uganda 2024-12-02 17:31:19 2027-12-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Idris Sanusi
ID: UNCST-2024-R003856
 EVALUATION OF THE CONCENTRATIONS OF PHARMACEUTICALS AND HEALTH RISK ASSESSMENT IN GROUND AND SURFACE WATERS IN KAMPALA AND MBARARA REGIONS OF UGANDA
REFNo: HS5235ES

I. To assess the physicochemical parameters (pH, water temperature, electrical conductivity, total dissolved solids, total suspended solids, total solids, chlorides, nitrate, phosphate and sulphate) in the collected water samples from the selected areas as pollution indices. II. To determine the concentrations of iron, copper, mercury, cadmium, manganese and lead in surface water and groundwater of the study regions. III. To determine the concentrations of the pharmaceuticals (sulfamethoxazole, ciprofloxacin, ibuprofen, amoxicillin, cotrimoxazole, metronidazole, artemether/lumefantrine, acetaminophen, caffeine, and carbamazepine) in surface water and groundwater of the study regions. IV. To assess the spatio-temporal variation of heavy metals and pharmaceuticals in the water samples collected from the regions. V. To assess the health risks associated with the exposure to pharmaceuticals and heavy metals in the water samples collected.
Nigeria 2024-12-02 17:29:38 2027-12-02 Medical and Health Sciences Non-Clinical Trial Degree Award
Ibrahim Kasujja
ID: UNCST-2021-R013169
 Food Insecurity and Mental Health among Children and Adolescents: Mixed Methods Study in Uganda
REFNo: HS4997ES

Objectives:

(1) to conduct a formative qualitative study to explore the children’s and teachers’ perceptions of food insecurity experiences and child and adolescent mental health
(CAMH) to ultimately build a framework which links food insecurity and CAMH in schools in Uganda,

(2) to conduct a reliability and validation study to assess the psychometric properties of the day scholars food insecurity experience scale (DSFIES) by examining test-retest reliability and criterion validity in
schools in Uganda, and

(3) to conduct a prospective cohort study to unpack the causal mechanisms linking food insecurity and CAMH by examining bidirectional temporal associations among seven to 13 years old children in Uganda.
 Uganda 2024-12-02 17:28:44 2027-12-02 Medical and Health Sciences Non-Clinical Trial Degree Award
Timothy Opobo
ID: UNCST-2023-R006042
 The Prevalence of Violence against Children in School and the Effectiveness of Reporting, Tracking, Referral and Response Mechanisms in Schools in Karamoja Sub-Region
REFNo: SS3414ES

1. Establish the prevalence and nature of VAC/VACiS among children, including their age, sex, grade, and vulnerability/disability status.
2. Identify, describe and quantify structures that children report cases of violence to when they occur
3. Identify existing mechanisms for referral, response and tracking cases of violence against children in schools?

 Uganda 2024-12-02 17:24:47 2027-12-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Godfrey Ejuu
ID: UNCST-2021-R013978
 IMPACT OF THE UNLOCK LITERACY PROJECT MODEL ON THE READING RESULTS FOR GIRLS AND BOYS IN EARLY GRADES IN UGANDA
REFNo: SS3379ES

7. To find out the challenges to implementing the Unlock literacy model in primary schools,6. To determine the cost of the UL model in the Ugandan setting,5. To identify the key lessons so far learned during implementation of the UL model.,4. To establish whether the Unlock literacy model contributes to increased support by education authorities for children\'s reading,3. To assess the extent to which the Unlock literacy model interventions are influencing support by parents or guardians and communities for children\'s reading.,2. To establish whether the Unlock literacy model contributes to strengthened teaching instruction in Primary 1–3.,1. To determine the extent to which the Unlock literacy model contributes to increased reading results of children.,The main purpose of this study is to examine the impact of the UL Project Model on the reading results for girls and boys in early grades in selected World Vision implementing districts in Uganda.,
 Uganda 2024-12-02 17:21:46 2027-12-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Salvatore Ssemmanda
ID: UNCST-2024-R004583
 KNOWLEDGE OF ALARM SIGNS OF STROKE AMONG CARETAKERS OF STROKE PATIENTS AND FIRST CONTACT HEALTH CARE PROVIDERS AT TWO TERTIARY REFERRAL HOSPITALS IN UGANDA
REFNo: HS5181ES

General objective.

To describe how well the alarm stroke signs summarized in the BE-FAST mnemonic are known by acute stroke patients’ caretakers and first contact stroke health care providers and how this knowledge by the acute stroke patients’ caretakers affects time of arrival of stroke patients to stroke services in the two major stroke referral hospitals in the country.

Specific objectives:

> To describe the knowledge of the BE-FAST acute stroke symptoms and signs by the first contact stroke health care providers in the two major stroke referral hospitals in Kampala, Uganda

> To describe the knowledge of the BE-FAST acute stroke symptoms and signs by the acute stroke patients’ bedside caretakers in the two major stroke referral hospitals in Kampala, Uganda.

> To demonstrate the relationship between knowledge of BE-FAST acute stroke alarm signs by stroke patient caretakers and time of arrival of their stroke patients to hospital stroke services in in
the two major stroke referral hospitals in Kampala, Uganda.
 Uganda 2024-12-02 17:19:44 2027-12-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Obinna Barah Onyebuchi
ID: UNCST-2024-R002664
 Investigation of Tribomechanical Properties of Aluminium (AA6061) Reinforced with Hybridized Agro-Marine Waste for Automotive Applications
REFNo: SIR428ES

Main Objective
This research aims to investigate the tribomechanical properties of Aluminum (AA6061) reinforced with hybridized agro-marine waste particle composites (AMWPCs) for enhanced automotive applications.
Specific Objectives
1. To assess tensile, compressive strength, and hardness characteristics of AMWPCs for ascertaining the material\'s strength under various loading conditions, and resistance to indentation or scratching respectively.
2. To investigate flexural strength, impact, and fatigue resistance of AMWPCs under dynamic loading conditions.
3. To evaluate the tribological effects and wear resistance of AMWPCs in enduring wear and friction.
4. To examine the material\'s microstructure and elemental composition using FTIR, SEM/EDS.
5. To Analyze AMWPCs phase transitions and thermal stability using DTA, and TGA.
 Nigeria 2024-12-02 17:18:19 2027-12-02 Engineering and Technology Non-Clinical Trial Degree Award
Hannington Ngabirano
ID: UNCST-2024-R003312
 Improving Pesticide Use in Food Crop Growing in Kigezi Sub-Region in South-western, Uganda. RefNo: KABREC-2024-238
REFNo: NS873ES

2. Training farmers and dealers in agro-inputs on pesticide use in food crops in Kabale, Rukiga, Rubanda, Kisoro, Kanungu and Rukungiri Districts.,1. Investigate pesticide use in food crops in south-western Uganda,
 Uganda 2024-12-02 17:16:00 2027-12-02 Natural Sciences Non-Clinical Trial Non-degree Award
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