Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Edgar Mulogo Mugema
ID: UNCST-2023-R008170
 Improving business continuity for health services following extreme weather events (RESilience in HeAlth Post-Extreme weather events-RESHAPE Study)
REFNo: HS5370ES

Overall Objective

The primary objective of the proposed study is to develop and deploy the tools that will help healthcare services to better prepare for EWEs, cope better when affected by such events, and recover more effectively afterwards.


Specific Aims
Aim 1: Describe the healthcare systems in the Kasese District, and its served communities and how both have been affected by and responded to EWEs to provide a foundation for locally relevant insights into processes and adaptations, and their influence on health outcomes

Aim 2: Develop, with local partners, through business continuity planning, resilience engineering and participatory research methods, protocols for EWE preparedness, response and recovery, and guidance on good practices, knowledge exchange, and interventions development as a process for enhancing resilient healthcare delivery

Uganda 2024-12-23 11:10:15 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bamidele Olaiya Charles
ID: UNCST-2024-R003262
 OPTIMIZATION OF MECHANICAL AND THERMAL PROPERTIES OF SANDCRETE-BRICKS INCORPORATING SAWDUST AND BANANA-LEAF ASH USING GENETIC ALGORITHM AND ARTIFICIAL-NEURAL-NETWORK
REFNo: SIR366ES

i. To characterize the Sawdust Ash (SDA) and Banana Leaf Ash (BLA)
ii. To examine the effects of varying percentages of sawdust and banana-leaf ashes on the mechanical (compressive strength, flexural strength) and thermal properties of sandcrete bricks.
iii. To develop an optimization approach using a combination of Genetic Algorithm (GA) and Artificial Neural Network (ANN) to determine the optimal mix proportions for sandcrete bricks with improved mechanical and thermal properties.
iv. To evaluate the mineralogical and microstructural properties of the sandcrete bricks made with the SDA and BLA.
v. To provide insights into the sustainable and energy-efficient production of sandcrete bricks incorporating sawdust and banana-leaf ash

 Nigeria 2024-12-23 11:08:48 2027-12-23 Engineering and Technology Non-Clinical Trial Degree Award
Gertrude Nakigozi
ID: UNCST-2023-R007979
 CLIMATE SHOCK PILOT STUDY
REFNo: NS890ES

Validate the climate shock survey for Lake Victoria basin/ South western Uganda and examine determinants of climate variability impact, and conduct a comparison on the effects of Climate variability by community and occupation Climate variability
 Uganda 2024-12-23 11:07:21 2027-12-23 Natural Sciences Non-Clinical Trial Non-degree Award
Julia Harrison
ID: UNCST-2024-R004345
 Neonatal and Pediatric HIV and Sepsis on a Pediatric Surgery Ward in Uganda: A Prospective Study Standardizing HIV Testing and Sepsis Resuscitation and Treatment Algorithm to Guide Clinical Care
REFNo: HS5416ES

Main Objective 1. The general objective of this project is to determine the prevalence of sepsis, the underlying etiologies leading to sepsis, and the prevalence of HIV among patients with sepsis on the pediatric surgery ward at Mulago hospital. Additionally, our objective is to implement the 2020 surviving sepsis campaign guidelines on the pediatric surgery ward at Mulago Hospital. Specific Objectives 1. We will identify the etiologies leading to sepsis on the pediatric surgery ward at Mulago Hospital by examining the underlying pathologies in patients diagnosed with sepsis over a period of 7 months 2. We will determine the prevalence of HIV among patients with sepsis on the pediatric surgery ward at Mulago Hospital by testing patients with sepsis for HIV over a period of 7 months 3. We will implement the 2020 Surviving Sepsis Campaign Guidelines on the pediatric surgery ward at Mulago Hospital over a period of 1 month 4. We will determine the prevalence of sepsis on the pediatric surgery ward at Mulago Hospital by tracking patients diagnosed with sepsis over a period of 7 months
 USA 2024-12-23 11:05:56 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
SIYA AGGREY
ID: UNCST-2019-R001737
 WATER HYACINTH’S EXTENT ON FRESHWATER SITES WITHIN QUEEN ELIZABETH NATIONAL PARK, UGANDA; IMPLICATIONS ON WATER QUALITY AND WILDLIFE HEALTH
REFNo: NS894ES

i) To assess the spatial extent and distribution of Water hyacinth (Pontederia crassipes) in Lake Edward, Lake George and the Kazinga Channel
ii) To examine the determinants of Water hyacinth (Pontederia crassipes) distribution within Lake Edward, Lake George and the Kazinga Channel
iii) To assess impact of Water hyacinth (Pontederia crassipes) on water quality within Lake Edward, Lake George and the Kazinga Channel
iv) To analyze policies that would support management of Water hyacinth (Pontederia crassipes) invasion within Lake Edward, Lake George and the Kazinga Channel.

 Uganda 2024-12-23 11:03:12 2027-12-23 Natural Sciences Non-Clinical Trial Non-degree Award
Solomon Kibudde
ID: UNCST-2021-R013747
 PHASE II RANDOMIZED NON-INFERIORITY TRIAL OF HYPOFRACTIONATED RADIOTHERAPY FOR LOCALLY ADVANCED CERVICAL CANCER IN UGANDA.
REFNo: HS5348ES

1) To compare the incidence of grade 3+ gastrointestinal and genitourinary toxicity at 1 year post-treatment with hypofractionated radiotherapy (40 Gy in 16 fractions) and conventional fractionated radiotherapy (45 Gy in 25 fractions) in women with cervical cancer in Uganda.
2) To evaluate and compare local control and cervical cancer-specific survival rates at 1 year after hypofractionated radiotherapy (40 Gy in 16 fractions) versus conventional radiotherapy (45 Gy in 25 fractions).
3) To determine the association between stage-adjusted mean squamous cell carcinoma antigen (SCC-Ag) at 1-month post-treatment with the Progression-free survival at 1- year post-treatment with hypofractionated radiotherapy (40 Gy in 16 fractions) or conventionally fractionated radiotherapy (45 Gy in 25 fractions).
4) To compare the costs of healthcare to patients with cervical cancer treated with hypofractionated radiotherapy (40 Gy in 16 fractions) versus conventional fractionated radiotherapy (45 Gy in 25 fractions).
5) To evaluate patient-reported outcomes and quality of life in patients with cervical cancer treated with hypofractionated radiotherapy (40 Gy in 16 fractions) versus conventional fractionated radiotherapy (45 Gy in 25 fractions).

 Uganda 2024-12-23 11:01:22 2027-12-23 Medical and Health Sciences Clinical Trial Degree Award
Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
 Investigation of mpox transmission, disease sequel, and molecular epidemiology in Uganda (Mpoxep)
REFNo: HS5387ES

Primary Objectives
1. To characterize the socio-demographic, clinical, immunological, and virologic epidemiology of Mpox cases in Uganda.
2. To describe the natural history and asymptomatic transmission dynamics of Mpox among contacts.
3. To assess risk factors for clinical hospitalization, ICU admission, and fatal Mpox outcomes.
4. To investigate long-term sequelae among Mpox survivors.

Secondary Objectives
1. To determine the incidence and prevalence of Mpox among high-risk populations (long-distance truck drivers, commercial sex workers, refugees, and PLHA).
2. To assess infection risk and asymptomatic transmission using serology among contacts.
3. To identify risk factors for infection among ‘de novo’ cases with no documented epidemiological link.
4. To explore socio-anthropological factors influencing Mpox transmission, prevention, and care-seeking behavior.
5. To identify potential animal reservoirs of MPXV in Uganda.
6. To describe histopathologic features of Mpox skin lesions and localization of MPXV in different body organs and tissues.

 Uganda 2024-12-23 10:56:56 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Wycliff Odude
ID: UNCST-2024-R002431
 Small-scale field evaluation of the efficacy, residual activity and acceptability of Sovrenta® 15WP against Malaria Vectors in Adjumani district, West Nile, Uganda.
REFNo: HS5300ES

1. To determine the susceptibility levels of both wild-type and Kisumu strain malaria vectors to Sovrenta® 15WP insecticide in Adjumani District, West Nile, Uganda.
2. To determine the comparative residual activity of Sovrenta® 15WP and Actellic 300CS insecticides on common wall-type surfaces in Adjumani, West Nile, Uganda over 10 months.
3. To generate specific information related to the acceptability of Sovrenta® 15WP insecticide as a new product by the community in Adjumani, West Nile, Uganda.
4. To assess the ease of use of the Sovrenta by the spray operators under field conditions in Adjumani District, West Nile, Uganda.

Uganda 2024-12-10 16:05:33 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Roy Mayega William
ID: UNCST-2022-R010983
 Africa Regional Education System Resilience Observatory (ARESRO) Study - A Case Study of Uganda
REFNo: SS3453ES

General objective
To contribute to the improvement of the education system resilience in Uganda through evidence-informed programming.
Specific objectives
1) To explore the meanings and practices of education system resilience in Uganda
2) To explore the potential impact of future shocks and stressors, risk, vulnerability, and capacities (absorptive, adaptive, and transformative) on the future education ecosystems and outcomes in Uganda
3) To identify effective approaches and planning to address the future shocks and stressors, risks, vulnerabilities, and capacity for better education system resilience in Uganda

 Uganda 2024-12-10 16:04:12 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
ALEX ARIO RIOLEXUS
ID: UNCST-2024-R002455
 DEATHS AND INFECTIONS AVERTED, A COST - EFFECTIVENESS ANALYSIS AND FACTORS THAT INFLUENCE ADOPTION AND IMPLEMENTATION OF THE 7-1-7 TARGETS IN UGANDA: A case study of three Priority diseases
REFNo: HS5278ES

1.To estimate the number of deaths and cases from prioritized diseases (EVD, anthrax, Measles and Rift Valley fever disease) averted if 7-1-7 targets are met in Uganda
2.To conduct a cost-effectiveness analysis for Uganda’s Ministry of Health implementing the 7-1-7 framework in responding to prioritized diseases (EVD, anthrax, Measles and Rift Valley fever disease) using societal perspective.
3.To explore and profile the factors that influence the adoption and implementation of 7-1-7 targets among different stakeholders in Uganda
 Uganda 2024-12-10 16:02:45 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Violet Nkwanzi
ID: UNCST-2024-R002493
 Examining the Impact of Adverse Childhood Experiences on Human Trafficking Vulnerability and the Long-term Mental Health Outcomes of Women Survivors of Trafficking (18-35 years) in Uganda.
REFNo: SS3451ES

Aim 1: To quantitatively examine the association between ACEs, human trafficking vulnerability, and long-term mental health outcomes (anxiety, depression, PTSD). Aim 2: To determine the factors that moderate the effects of ACEs on human trafficking vulnerability and the long-term mental health outcomes of women survivors of trafficking. Aim 3: To qualitatively explore sources of resilience and gaps in existing policies and services for women affected by human trafficking in Uganda To inform comprehensive survivor centered interventions, this study will collect additional data on quality of life, gender-based violence, substance use and financial capability of survivors of trafficking.
Uganda 2024-12-10 16:01:57 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Akusa Patrice Mawa
ID: UNCST-2024-R015660
 Service availability and readiness assessment for establishing biobanks of patient left-over samples from routine healthcare provision in Uganda and Kenya
REFNo: HS5328ES

1. To assess the current practices with left-over samples in hospitals and the attitude, willingness, and acceptability of stakeholders towards biobanking.
2. To audit human resources, laboratory infrastructure, governance, and data systems to understand available resources to support the establishment of left-over sample biobanks in health facilities
3. Undertake a detailed analysis of costs that will be needed to sustain operational activities on a yearly basis for either a federated or centralised approach of biobanking left-over samples in Uganda and Kenya
4. Assess the regulatory environment and engage relevant national regulatory bodies to adapt guidelines for left-over sample biobanking in Uganda and Kenya.


 Uganda 2024-12-10 16:00:04 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Stephen Tukwasibwe
ID: UNCST-2022-R011535
 Surveillance of P. falciparum Drug and Diagnostic Resistance in Refugee Populations
REFNo: HS5230ES

To conduct comprehensive malaria molecular surveillance in refugee populations to generate high quality molecular, epidemiological and entomologic data for monitoring geographic and temporal trends and thereby inform interventions to best protect refugee and local host populations.
Uganda 2024-12-10 15:59:04 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jude  Nicholars Iyke
ID: UNCST-2023-R007962
 THE EFFECTS OF PERSONALITY TRAITS ON THE ACCEPTANCE OF BIOMETRIC CONTROLLED HEALTH INFORMATICS IN PUBLIC HOSPITALS IN UGANDA
REFNo: SIR430ES

The purpose of this sequential mixed-method design study is to assess the relationship between the personality traits and acceptance of Biometric Controlled Health Informatics in Gulu and Soroti Regional Referal public Hospitals in Uganda that will help health strategists and policy makers evaluate how the personality traits of health workers affect their acceptance of biometric controlled health informatics (BCHI) for secure access for clinical and non-clinical health workers to patient records in public hospitals in Uganda . ,To examine how personality traits affect the acceptance of Biometric Controlled Health Informatics in these public hospitals using the acceptance model that was developed for that purpose,To determine the connection between acceptances of Biometric Controlled Health Informatics and personality traits in these public hospitals.,To establish health workers’ awareness of Biometric Controlled Health Informatics in these public hospitals,
 Nigeria 2024-12-10 15:54:44 2027-12-10 Engineering and Technology Non-Clinical Trial Degree Award
Susan Nayiga
ID: UNCST-2020-R014642
 Managing AMR: Everyday experience with antibacterial drug resistant infections in central Uganda
REFNo: SS3469ES

1. To track the trajectories of illness, care, recovery or decline of patients diagnosed with antibacterial drug resistant infections.
2. To link the social, economic and illness histories and opportunities of patients with their onward trajectories with antibacterial drug resistant infections
3. To identify equity dimensions of the how systems manage antibacterial drug resistant infections and points for intervention to support recovery

 Uganda 2024-12-10 15:53:27 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Francis Kakooza
ID: UNCST-2024-R002803
 Evaluation of capture enrichment for viral sequencing in a remote setting in Uganda.
REFNo: HS5270ES

Objective 2: Evaluate Analytical Performance in Uganda. NGS testing of blood samples from confirmed clinical cases and suspected clinical samples will be conducted. This includes de-identified archived blood samples collected from a sepsis cohort among participants who consented for their samples to be used for future research related to sepsis in Fort Portal, Uganda, at Fort Portal Regional Referral Hospital, which has enhanced biosafety capabilities. ,Objective 1: Develop and Optimize NGS Platform To pilot the use of a field-deployed portable next-generation sequencing for testing of archived sepsis blood samples in Uganda to search for hantavirus or bunyavirus infections. The project plans to field test the Oxford Nanopore Technologies (ONT) platform with archived blood samples. Phylogenetic trees will be developed, and virus clades and variants or new viruses will be described. The performance of enriched-NGS to detect the virus will be compared to index testing with RT-PCR when there are 5 or more positive results.,
 Uganda 2024-12-10 15:52:01 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Anke Weisheit
ID: UNCST-2024-R004890
 ETHNO BOTANICAL SURVEY OF MEDICINAL PLANTS USED IN THE TREATMENT OF WOUNDS IN GULU DISTRICT
REFNo: SS2928ES

To investigate the preparation and application methods of these medicinal plants for wound healing purposes.,To identify and document medicinal plants used by the local communities in Gulu district for treating various types of wounds.,The aim of this study is to conduct an ethnobotanical survey to document the traditional knowledge and use of medicinal plants for treating wounds among the communities in Gulu district, Uganda.,
 Germany 2024-12-10 15:50:43 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Irene Nakayenga Mutesi
ID: UNCST-2024-R004951
 Global Corridor, Urbanisation, Everydaylife and Techno-social Differentiation
REFNo: SS2860ES

2. To explore the everyday assembling of Corridor Urbanization to assess how investment in infrastructure is generating intra-urban and inter-urban relations/material connections between urban regions., To explain the global, urban geography of infrastructural corridors in reshaping the urbanization process in order to set a new agenda for global research,3. To investigate the everyday experiences of Corridor Urbanization within urban regions in order to understand the differentiated ways in which infrastructure is operated and accessed,1. To assess the global, urban geography and selected history of new corridors and the ways these projects are assembled in order to understand the role of urban regions,The aim of GlobalCORRIDOR is to address the challenge of how we understand Corridor Urbanization and to assess how these infrastructure led transformations are shaping urban inequality, as an everyday experience of techno-social differentiation,
 Uganda 2024-12-10 15:50:00 2027-12-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Joseph Ngonzi
ID: UNCST-2019-R001579
 OPTIMIZATION, VALIDATION AND ASSESSMENT OF FEASIBILITY AND ACCEPTABILITY OF HPV TESTING USING CODA
REFNo: HS4734ES

To develop and establish a novel rapid multi-modal algorithm (CANOPY) for screening and treatment of cervical cancer integrating multiple (CODA, VIA, ML) screening modalities to improve diagnostic yield. ,To gather design feedback to improve CODA workflow and device design, and refine CODA device, assay, and workflow using this critical feedback provided by Ugandan stakeholders,To evaluate the feasibility and acceptability of CODA in a clinical setting in Uganda based on feedback from clinical, public health, and patient stakeholders,To evaluate HPV testing using CODA in comparison to other (VIA, ML, ATILA System) devices for clinicians and patients engaged in community-based cervical cancer screening. ,To determine the diagnostic accuracy of CODA a clinical setting, using FP rate and comparison with gold-standard HPV tests and cytology,We will optimize, validate and assess the feasibility and acceptability of HPV testing using CODA and develop and validate a multimodal cervical cancer screening algorithm to optimize diagnostic yield (CANOPY).,
 Uganda 2024-12-10 15:49:00 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Anxious   Niwaha Jackson.
ID: UNCST-2023-R008010
 Investigating the pancreas pathology underlying Lean Sub Saharan African Diabetes in Uganda
REFNo: HS5340ES

a. To compare the beta cell mass in pancreata obtained at autopsy in lean diabetes cases
versus lean controls
b. To evaluate the degree of pancreatic immune infiltration (Insulitis) in lean diabetes cases
and lean controls
c. To quantify the degree of misfolded protein stress in pancreata obtained at autopsy in lean
diabetes cases and lean controls
d. To evaluate beta cell dedifferentiation in lean SSA diabetes
e. To examine the exocrine pancreas for chronic pancreatitis and pancreatic duct calcification
in pancreata obtained at autopsy in lean diabetes cases versus lean controls
f. To determine the concentration of POPs in pancreata obtained at autopsy in lean diabetes
cases and lean controls.
g. To establish a pancreata and related tissue (blood and mesenteric fat) platform to enable
further studies related to diabetes and other metabolic diseases.

 Uganda 2024-12-10 15:47:20 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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