Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
George Alaneme Uwadiegwu
ID: UNCST-2024-R003261
 ARTIFICIAL INTELLIGENCE PREDICTIVE MODELLING OF MECHANICAL AND RHEOLOGICAL PROPERTIES OF GEOPOLYMER-CONCRETE MADE FROM BLENDED BAGASSE AND BANANA-PEEL-ASH
REFNo: SIR365ES

i. To characterize Bagasse ash (BA) and Banana peel ash (BPA) as a geopolymer precursor
ii. To ascertain the optimal combination of the concrete mixture incorporating Bagasse ash (BA) and Banana peel ash (BPA) to replace ordinary Portland cement.
iii. To determine the mechanical and rheological properties of Bagasse ash (BA) and Banana peel ash (BPA) and blended geopolymer concrete matrix.
iv. To develop soft computing predictive models of ANN, GEP and ANFIS to explore the relationships between the Alkalis-activated binder blend and the rheological and mechanical strength response.
v. To compare and validate the models developed in (iv).

 Nigeria 2024-12-23 12:28:18 2027-12-23 Engineering and Technology Non-Clinical Trial Degree Award
Sarah Wambete Namee
ID: UNCST-2024-R003551
 Effectiveness Of A Health Belief Model (HBM)-Based Educational Intervention On Tuberculosis (TB) Treatment Adherence Among Tb Patients In Two Hospitals In Kampala, Uganda: A Randomized Control Trial
REFNo: HS4558ES

To assess the effectiveness of a Health Belief Model (HBM)-based educational intervention on TB treatment Adherence level among TB patients in two hospitals in Kampala, Uganda. 1.To assess the level of TB knowledge among TB patients in two hospitals in Kampala, Uganda. 2.To assess the health beliefs of TB patients towards tuberculosis in two hospitals in Kampala, Uganda 3.To assess the quality of life of TB patients in two hospitals in Kampala, Uganda.
Uganda 2024-12-23 12:26:18 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Christine Piloya Ruth
ID: UNCST-2024-R003592
 Patriarchy and Women Engagement in Environmental Conservation in Northern Uganda: A Case of Gulu District
REFNo: SS2986ES

4. To propose a framework or a model for effective engagement of women in environmental conservation in patriarchal societies.,3. To establish the effectiveness of the strategies used by stakeholders in fostering women’s engagement in environmental conservation within a patriarchal setting in Gulu district.,2. To investigate the extent to which the distinguishing features of patriarchy affect women’s engagement in environmental conservation in Gulu district.,1. To examine in context, the socio-cultural roles performed by women in environmental conservation within the patriarchal structure in Gulu district. ,To examine the extent to which patriarchy affects women\'s engagement in environmental conservation in Gulu district.,
 Uganda 2024-12-23 12:24:42 2027-12-23 Social Science and Humanities Non-Clinical Trial Degree Award
Henry Mugerwa
ID: UNCST-2019-R000420
 A Phase 1b, Age De-Escalation/Dose Escalation Trial to Evaluate Safety, Tolerability, and Pharmacokinetics of MAM01 in an African Population of Adults and Children in a Setting of Perennial Malaria Transmission
REFNo: HS5298ES

Primary Objective. To assess the safety and tolerability of MAM01. Secondary Objectives. To assess the safety of MAM01. To characterize the PK of MAM01 following SC, IV, and IM administration of MAM01. To assess the formation of anti-drug antibodies (ADAs) to MAM01. Exploratory Objectives. To assess the protective efficacy of a single dose of MAM01 over 182 days against Pf infection, as detected by blood smear microscopy compared to a placebo. To assess the protective efficacy of a single dose of MAM01 over 182 days against Pf infection, as detected by blood smear microscopy compared to placebo. To assess the protection of MAM01 against events of malaria illness (first/only and all episodes). To correlate MAM01 concentration with Pf infection risk. To assess the complexity of Pf infection following administration of MAM01 or placebo.
Uganda 2024-12-23 12:23:27 2027-12-23 Medical and Health Sciences Clinical Trial Non-degree Award
Eleanor Namusoke Magongo
ID: UNCST-2021-R013199
 Outcome Evaluation of the Young People and Adolescent Peer Support (YAPS) program Implementation in Uganda
REFNo: HS4809ES

1. To assess fidelity of the YAPS program implementation by different stakeholders (MoH, Implementing Partners, Districts, Facilities, and YAPS personnel)
2. To establish the effect of the YAPS program on the clinical cascade for Adolescents and Young People Living with HIV.
3. To explore perspectives of YAPS and other stakeholders on the effectiveness of the YAPS program.
4. To estimate the incremental costs of implementing the YAPS model at the different levels of implementation (National, District and health facility)

 Uganda 2024-12-23 12:17:40 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
DANLADI MAKERI
ID: UNCST-2024-R005300
 Characterization of Staphylococcus aureus Isolated from Foot Ulcers of Diabetic Patients Attending Kampala International University Teaching Hospital, Bushenyi District, Uganda
REFNo: HS4836ES

v. To determine the molecular phylogeny of Staphylococcus aureus isolated from foot ulcers of Diabetic patients attending Kampala International University Teaching Hospital Bushenyi district, Uganda,iv. To determine the antibiogram profile of Staphylococcus aureus isolated from foot ulcers of Diabetic patients attending Kampala International University Teaching Hospital Bushenyi district, Uganda,iii. To assess the phenotypic distribution of Staphylococcus aureus in foot ulcers of Diabetic patients attending Kampala International University Teaching Hospital Bushenyi district, Uganda.,ii. To determine factors associated with diabetic foot infections among Diabetic patients with foot ulcers attending Kampala International University Teaching Hospital Bushenyi district, Uganda ,i. To determine the prevalence of diabetic foot infection among Diabetic patients with foot ulcers attending Kampala International University Teaching Hospital Bushenyi district, Uganda,To characterize Staphylococcus aureus isolated from foot ulcers of Diabetic patients attending Kampala International University Teaching Hospital Bushenyi district, Uganda ,
 Nigeria 2024-12-23 12:15:59 2027-12-23 Medical and Health Sciences Non-Clinical Trial Degree Award
Francis Omujal
ID: UNCST-2019-R000428
 DOCUMENTATION OF BATWA INDIGENOUS PEOPLE AND LOCAL COMMUNITIES’ KNOWLEDGE FOR BIO-PROSPECTING FOR THERAPEUTICS PRODUCTS
REFNo: NS658ES

c) To identify priority natural medicinal resources that can be used by BIP for development of therapeutic products for specific diseases ,b) To assess the availability status of medicinal resources used for TMK by the BIP,a) To document the traditional medicine practices of the BIP,To document TMK of the Batwa indigenous people for the development of therapeutic products.,
 Uganda 2024-12-23 12:14:59 2027-12-23 Natural Sciences Non-Clinical Trial Non-degree Award
Edgar Mulogo Mugema
ID: UNCST-2023-R008170
 Epidemiology of pediatric severe malaria in the Kasese District of western Uganda
REFNo: HS5367ES

Study Objectives The overarching goal of this proposed project is to describe the epidemiology of severe malaria among children in the Kasese District of western Uganda. Our scientific objective is to determine if the demographic, clinical, and laboratory characteristics of children admitted to a more urban level IV health center are different from our previous findings at a rural level III health center. To test this hypothesis, we propose to: AIM 1: Describe the demographic characteristics of children admitted to SPHC with a diagnosis of malaria. We will conduct a prospective, observational study, enrolling children admitted to the IPD. Participating caregivers will complete a questionnaire documenting basic demographic factors as well as information about the household (e.g., location, LLIN access and use). We hypothesize that most children will be (i) <12 years of age, (ii) from areas within 20km of SPHC, and (iii) have previously sought care at lower-level facilities. AIM 2: Document the clinical and laboratory characteristics of children admitted to SPHC with a diagnosis of malaria: We will elicit a history of illness from the caregiver and record relevant information including vital signs, results of laboratory testing (e.g., malaria RDT, hemoglobin, etc.), along with treatments administered during the hospitalization. We hypothesize that nearly all children will receive ≥24 hours of intravenous artesunate, but there may be substantial variation in dosing. AIM 3: Estimate measures of severe malaria incidence and associated morbidity and mortality among children presenting to SPHC with malaria. We will record the results of laboratory testing for malaria in the OPD to determine the malaria positivity rate and incidence of SM (i.e., proportion with a positive RDT who are admitted). Among those who are admitted, we will document disposition (e.g., discharge, transfer, death) and complete follow up at 14, 30, 45, and 60 days post-discharge. We hypothesize that mortality will be greatest among children referred from lower-level facilities and those with delayed presentations
Uganda 2024-12-23 12:12:56 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Justus Asasira
ID: UNCST-2021-R012092
 Socioeconomic and Environmental Impacts of Biomass Briquettes and Solar Cooking Technologies Acceptance by Households in Southwestern Uganda
REFNo: SS2319ES

1. To explore the stakeholders’ perceptions about adopting biomass briquettes for cooking in Southwestern Uganda.
2. To assess the influence of business models on the acceptance and economic feasibility of biomass briquettes and solar technologies for cooking in Southwestern Uganda.
3. To compare the environmental impacts and benefits of producing and using solar technologies with non-renewable sources of energy for cooking in Southwestern Uganda.
4. To identify the design attributes that make biomass briquettes and solar cooking technologies socially acceptable by households in Southwestern Uganda.

 Uganda 2024-12-23 12:11:58 2027-12-23 Social Science and Humanities Non-Clinical Trial Degree Award
OSCAR AYUYA INGASIA
ID: UNCST-2024-R002553
 Gender Analysis; Address gendered aspects of awareness of lower-risk plant protection products/technologies in Uganda
REFNo: A534ES

To explore the roles men and women play in pest management and the products used for pest management in potato farming,To assess the differences between men, women, and young people\'s, values, power dynamics and behaviors which shape their access to and use of digital tools.,To examine the traditional pest prevention technologies, and the gendered obstacles faced by men women and young people,To respond to the needs of farmers and the systems that support them, by helping countries predict, prevent, and prepare for plant health threats, thereby reducing crop losses. ,
 Kenya 2024-12-23 12:09:26 2027-12-23 Agricultural Sciences Non-Clinical Trial Non-degree Award
Isaac Kitone
ID: UNCST-2024-R002847
 Kabale University (KAB) Sustainable Energy Generation System (KSEG) Project
REFNo: SIR421ES

To test the automated non-fossil fuel driven power generator,To construct an automated non-fossil fuel driven power generator ,To design an automated non-fossil fuel driven power generator ,To collect data on existing generator power needs in three western Ugandan districts, Kabale, Mbarara and Ntungamo,To design and construct an automated non-fossil fuel driven power generator ,
 Uganda 2024-12-23 12:07:01 2027-12-23 Engineering and Technology Non-Clinical Trial Non-degree Award
Andrew Mujugira
ID: UNCST-2019-R000871
 UNMET ORAL HEALTH NEEDS AND BARRIERS TO ORAL HEALTH AND SEXUAL HEALTH SERVICE UTILISATION AMONG MEN WHO HAVE SEX WITH MEN AND TRANSGENDER PEOPLE IN UGANDA: A MIXED METHODS PILOT STUDY
REFNo: HS5226ES

Objective 1: Estimate the prevalence of oral diseases, HIV, OHPV,
and self-reported STIs and their impact on oral health conditions in
MSM/TGP.
Objective 2: Identify the key barriers to health service utilization
experienced by MSM/TGP.
 Uganda 2024-12-23 12:05:34 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JOYCE NAMWASE
ID: UNCST-2024-R005002
 FEASIBILITY AND EFFECTIVENESS OF A TRAINING INTERVENTION FOR INFORMAL CAREGIVERS OF PEOPLE LIVING WITH DEMENTIA IN RURAL UGANDA (FETIC-DU)
REFNo: HS5165ES

3. To evaluate the feasibility and effectiveness of the training program in improving knowledge and skills of informal care givers for persons with dementia in rural Uganda. 1.4 Research questions
Uganda 2024-12-23 12:04:08 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Daniel Murokora Murokora
ID: UNCST-2024-R002689
 Outcomes Evaluation of Reproductive, Maternal and Newborn Care Interventions Implemented by BAMA in Uganda
REFNo: HS5155ES

General Objective
To evaluate the outcomes of Reproductive, Maternal and Newborn Care interventions at BAMA Supported Sites in Uganda.

Specific Objectives
1. To evaluate the impact of NMH interventions on IMMR and IPMR since 2015
2. To explore factors influencing mortality trends since 2015
3. To document the optimum package of MNH interventions that impacted MMR and PMR
4. To assess the impact of BAMA interventions on HPV vaccination uptake for out-of-school girls as well general population (women aged 25-49) cervical cancer screening and linkage to appropriate services
5. To assess the effect of BAMA project interventions on infant development outcomes and adolescent mother’s physical, social, and mental wellbeing outcomes
6. To determine the feasibility and sustainability of MRP
7. To assess the impact of the implementation of MPS transport solution on MNH outcomes
8. To assess the design and impact of the mentor midwives model on MNH outcomes
9. To determine optimum mentorship package and its impact on quality of care and clinical outcomes

 Uganda 2024-12-23 12:03:10 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Winnifred Kansiime Kimara
ID: UNCST-2021-R012131
 Faecal exposure behaviours, risk profiles, and predicted efficacy of Water Sanitation and Hygiene interventions in Imvepi, Uganda and Cox’s Bazar, Bangladesh refugee settings
REFNo: HS5190ES

4. To predict the efficacy of suggested interventions on reducing faecal exposure in the private domain in Imvepi and Cox’s Bazar refugee settings (Study IV),3. To determine the factors associated with faecal exposure among children and adults in Imvepi and Cox’s Bazar refugee settings (Study III),2. To determine the faecal exposure risk profile of children and adults in the private and public domain of Imvepi and Cox’s Bazar refugee settings (Study II),1. To explore faecal exposure behaviours and pathways of children and adults in the private and public domain of Imvepi and Cox’s Bazar refugee settings (Study I),To establish the faecal exposure profiles and associated factors in the private and public domain and predict the efficacy of suggested interventions in Imvepi, Uganda and Cox’s Bazar, Bangladesh refugee settings so as to guide exposure reduction interventions.,
 Uganda 2024-12-23 12:01:21 2027-12-23 Medical and Health Sciences Non-Clinical Trial Degree Award
DANIEL BUGEMBE LULE
ID: UNCST-2024-R015332
 DEVELOPMENT OF NOVEL APPROACHES FOR HIV DRUG RESISTANCE DETECTION USING NANOPORE SEQUENCING TECHNOLOGY
REFNo: HS5352ES

Objectives and Hypothesis
Primary Objective
To develop an end-to-end nanopore NGS workflow for the routine clinical detection of HIV drug
resistance (HIVDR).
Secondary Objective
To compare the HIVDR scoring between Sanger and Nanopore sequencing method of matched samples
to evaluate their concordance for detecting drug resistance mutations.
Exploratory Objectives
1. To develop a method for PCR amplification of low plasma viral load samples, genotype these
with the nanopore method and derive HIVDR mutations.
2. To identify improvements to the nanopore base-calling algorithms that may obviate high error
rates.
3. Provide an expeditious end-to-end analysis pipeline for analysis of HIVDR of Nanopore generated
sequences.
4. To establish if the various base-calling errors of the Nanopore sequencing are occurring in a
stochastic or non-stochastic manner.
 Uganda 2024-12-23 11:59:00 2027-12-23 Medical and Health Sciences Non-Clinical Trial Degree Award
Edgar Mulogo Mugema
ID: UNCST-2023-R008170
 Identifying Barriers to Infection Prevention & Control Guideline Adherence in Western Uganda.
REFNo: HS5360ES

Primary Objectives The primary objective of the proposed project is to demonstrate the effects of limited physical facility infrastructure, diminished supplies, and gaps in IPC knowledge amongst HCP and how they may relate to IPC practice implementation at the health facility level to inform efficient and effective future improvement efforts. Specific Aims AIM 1: Evaluate adherence to national IPC guidelines across a variety of healthcare facility levels in Western Uganda via a standardized observation protocol through facility-level evaluations. 1A. Guided by Uganda’s national IPC best practices for healthcare facilities and a standardized facility-level checklist adopted from the World Health Organization, we will perform observations of the facility’s physical characteristics, healthcare supplies, and healthcare personnel workflow, including observations of hand hygiene adherence with a standardized checklist. AIM 2: Assess IPC knowledge, attitudes, and practices of healthcare personnel at multiple levels of Uganda’s national healthcare system, identifying primary barriers to National IPC Guideline adherence. 2A. Healthcare Personnel Surveys: Surveys will consist of both qualitative and quantitative elements to ascertain information on their awareness of foundational IPC concepts within national guidelines, circumscribe a working understanding of the implementation of IPC measures across different healthcare facility settings before and after the COVID-19 pandemic, and determine health facility-level attributes that may prevent rigorous adherence to IPC guidelines. 2B. Healthcare Personnel Focus Group Discussions: Focus group discussions will be oriented in such a manner as to ascertain common themes and information on awareness of foundational IPC concepts, gain a perspective on the experience of IPC practices across a variety of facility levels and HCP roles, and understand what limitations are experienced by HCP during their daily patient care-oriented activities. Through these discussions, we hope to gain a working understanding of the implementation of IPC measures across different healthcare facility settings before and after the COVID-19 pandemic, and determine health facility-level attributes, gaps in IPC education and/or training, and HCP workflow concerns that may prevent rigorous adherence to IPC guidelines.
Uganda 2024-12-23 11:57:43 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joyce Kambugu Balagadde
ID: UNCST-2020-R014996
 Stakeholder perspectives for the approach to treatment recommendations for kids presenting with advanced or incurable cancer
REFNo: HS5203ES

Using the instrument described in 1.1, identify personal, professional, and contextual factors influencing the perspectives and decision-making approaches of key non-physician stakeholders in Uganda in the upfront care of children diagnosed with advanced or incurable cancer through qualitative data collection and analysis.,To adapt an existing instrument for use in Uganda that helps explore the personal, professional, and contextual factors that influence the perspectives and decision-making approaches of key non-physician stakeholders (patients, families, multidisciplinary clinicians), specifically with respect to recommending upfront curative treatment versus non curative treatment (for example, with palliative-intent) in children diagnosed with advanced or incurable cancer in LMICs.,
 Uganda 2024-12-23 11:55:35 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Julius Duula Waiswa
ID: UNCST-2024-R015879
 BURDEN AND SPATIAL DYNAMICS OF TICK SPECIES AMONG CATTLE GRAZING ALONG THE BUFFER ZONE OF LAKE NAKUWA IN KALIRO DISTRICT
REFNo: A529ES

1. Determine the burden of tick species infesting cattle grazing along the buffer zone of Lake Nakuwa.
2. Determine spatial dynamics of the different tick species infesting cattle grazing along the buffer zone of Lake Nakuwa
3. Identify factors promoting and maintaining high tick infestation burdens along the buffer zone of Lake Nakuwa.

Uganda 2024-12-23 11:54:12 2027-12-23 Agricultural Sciences Non-Clinical Trial Degree Award
Edith Namakula
ID: UNCST-2022-R006923
 Pethidine versus Morphine use for management of postoperative pain in Mulago National Referral Hospital, Uganda
REFNo: HS5240ES

1. To determine the prevalence of pethidine versus morphine prescription for the management of postoperative pain in MNRH, Uganda.
2. To explore the side effects experienced during the use of pethidine versus morphine for the management of postoperative pain in MNRH, Uganda.
3. To determine the factors associated with pethidine prescription for the management of postoperative pain in MNRH, Uganda.
4. To explore barriers and facilitators of pethidine versus morphine prescription in the management of postoperative pain in MNRH, Uganda.

 Uganda 2024-12-23 11:53:21 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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