Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Immaculate  Nankya Lillian
ID: UNCST-2020-R014784
Assessment of response to antiretroviral therapy and prevalence of Dolutegravir-associated drug resistance among HIV patients on the National Treatment Program
REFNo: HS7262ES

1. To compare the rates of viral suppression between an NNRTI-based regimen and a DTG-based regimen
2. To assess the rates of DTG-associated failures over time
3. To assess the major mutational pathways conferring resistance to DTG among subtypes A and D.

Uganda 2026-04-10 19:19:30 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Beingana  Kenneth Muntu
ID: UNCST-2025-R019659
Institutional Support, Career self efficacy and employability of University graduates in South-Western Uganda
REFNo: SS5061ES

To assess the of institutional support to graduate employability in Southwestern Uganda

To analyze the role of career self efficacy in shaping graduates employability outcomes in Southwestern Uganda

To examine the influence of gender on the relationship between institutional support, career self efficacy and graduate employability in Southwestern Uganda

To investigate the moderating effect of career self efficacy on the relationship between institutional support and graduate employability in Southwestern Uganda
Uganda 2026-04-10 19:18:40 2029-04-10 Social Science and Humanities Non-Clinical Trial Degree Award
Hassan Mulema
ID: UNCST-2020-R014061
Assessing Community Knowledge, Client Satisfaction, and Effective Communication Strategies for Cervical Cancer Prevention among the CANCAP communities in Uganda.
REFNo: HS7384ES

Main Objective
To assess community knowledge, client satisfaction, and communication strategies for cervical cancer prevention in Uganda.

Specific Objectives
1. To determine the level of knowledge and associated factors among community members regarding cervical cancer, its risk factors, and prevention strategies.
2. To examine the client satisfaction with cervical cancer screening services.
3. To explore the effectiveness of various communication and awareness channels used under the National Cancer Management and Capacity Building Project.

Uganda 2026-04-10 19:17:23 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Francis Matovu
ID: UNCST-2026-R023956
community participation and sustainability of government programs in Uganda. A case of youth livelihood program in Kiboga District.
REFNo: SS5069ES

To examine the relationship between program design and sustainability of youth livelihood program in Kiboga District

To analyze the relationship between program implementation and sustainability of youth livelihood program in Kiboga District.

To determine the relationship between program monitoring and evaluation and sustainability of youth livelihood program in Kiboga District.
Uganda 2026-04-10 19:16:05 2029-04-10 Social Science and Humanities Non-Clinical Trial Degree Award
Fred Ariho
ID: UNCST-2025-R022515
Prevalence and Factors Associated with Low Completion Rates of Eight Antenatal Care Visits Among Postpartum Women in Buhweju District, Uganda
REFNo: HS7381ES

1. To determine the proportion of mothers who attended eight antenatal care visits among postpartum women in Buhweju District, Uganda. 2. To examine women related factors associated with low completion rates of eight antenatal care visits among postpartum women in Buhweju District, Uganda 3. To establish the interpersonal factors contributing to low completion rates of eight antenatal care visits among postpartum women in Buhweju District, Uganda 4. To examine institutional factors influencing the low completion rates of eight antenatal care visits among postpartum women in Buhweju District, Uganda
Uganda 2026-04-10 19:15:07 2029-04-10 Medical and Health Sciences Non-Clinical Trial Degree Award
Robert Mboizi Baldwin
ID: UNCST-2020-R014356
Field performance of the Global Alignment of Immunization Safety Assessment in Pregnancy (GAIA) Maternal and Neonatal Outcome Case Definitions for the Evaluation of Adverse Events in pregnancy in clinical trials in low resource settings.
REFNo: HS7349ES

1. To assess the applicability of the GAIA case definitions for adverse events in maternal immunisation trials conducted in Uganda. 2. Determine the highest level of diagnostic level of certainty for each GAIA case definition. 3. To assess the limitations of the GAIA case definitions for adverse events in maternal immunisation trials conducted in Uganda.
Uganda 2026-04-10 19:13:33 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Peterson Kikomeko Kato
ID: UNCST-2019-R000881
Reassessing Mid-Upper Arm Circumference as a Predictor of Nutritional Status and Pregnancy Outcomes among Pregnant Adolescents in Bundibugyo District, Uganda
REFNo: HS7233ES

i. To determine maternal hemoglobin status during pregnancy, MUAC across gestation, and gestational weight gain among pregnant adolescents and adult women attending ANC in Bundibugyo District, Uganda. ii. To determine the rate of increase in MUAC and compare MUAC trajectories between pregnant adolescents and adult women across gestational stages among those attending ANC in Bundibugyo District, Uganda. iii. To examine dietary intake patterns and their association with MUAC, gestational weight gain, and maternal hemoglobin status among pregnant adolescents and adult women attending ANC in Bundibugyo District, Uganda. iv. To determine optimal MUAC cut-off points for identifying undernutrition risk among pregnant adolescents attending ANC in Bundibugyo District, Uganda at different gestational stages. v. To evaluate associations of MUAC levels, rate of MUAC increase, gestational weight gain, and maternal hemoglobin status with key pregnancy outcomes (birthweight, preterm birth, small-for-gestational-age status, and maternal complications) among pregnant adolescents and adult women attending ANC in Bundibugyo District, Uganda. vi. To explore health workers’ and stakeholders’ perceptions, practices, and challenges regarding the use of MUAC for assessing maternal nutrition among pregnant adolescents and adult women, to contextualize and triangulate the quantitative findings.
Uganda 2026-04-10 19:12:34 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Susan Lamunu Shereni
ID: UNCST-2025-R022324
Assessment and development of infectious diseases institute environment, social, and governance strategy, policy, and net zero roadmap
REFNo: SS5056ES

To assess and develop a comprehensive sustainability framework for the Infectious Diseases Institute (IDI) that strengthens institutional resilience, compliance, and accountability in alignment with local and international standards.1. To identify sustainability risks, gaps, opportunities, and strengths relative to Ugandan legal requirements, funder expectations, and international standards (e.g., GRI, IFRS, SDGs). 2. To map and engage key internal and external stakeholders to understand sustainability priorities, perceptions, and expectations of IDI’s sustainability performance. 3. To evaluate IDI’s environmental impact, including greenhouse gas (GHG) emissions, waste management, and resource utilisation. 4. To develop an institutional sustainability strategy, policy, and implementation roadmap. 5. To develop a Net Zero plan and monitoring and evaluation (M&E) matrix. 6. To develop an Environmental Aspects and Impacts Register to guide ongoing environmental management and compliance.
Uganda 2026-04-10 19:10:56 2029-04-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Ponsiano Ocama
ID: UNCST-2019-R000440
Hepatitis B and HIV Cure Consortium (BICC): A Multi-Country Prospective Observational Cohort of People with HIV and Hepatitis B (PWHHB) and People with HBV (PWHB)
REFNo: HS7337ES

The primary objective of this protocol is to establish a multi-country prospective observational cohort of people with HIV and Hepatitis B virus (PWHHB) and people with HBV (PWHB) to establish a repository of data and specimens to accelerate HBV cure research.
Uganda 2026-04-10 19:09:27 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Deogratius Ssemwanga
ID: UNCST-2025-R021563
Pathogen Genomics in Community and Aircraft Wastewater for Outbreak Preparedness and Response in Uganda
REFNo: HS7430ES


The main objective is to establish an integrated wastewater-based surveillance system using NGS and AI-based machine learning (ML) models to detect, monitor and predict the spread of pathogens of public health importance and AMR in Uganda.
To characterize the diversity and temporal patterns of pathogens present
in wastewater collected from community, abattoir and aircraft sources
over a 12-month period.
ii. To detect and profile AMR genes in wastewater samples.
iii. To develop and validate AI-based analytical pipelines for processing,
interpretation, and forecasting infectious disease trends in Uganda over
the study period.
iv. To track seasonal trends in circulating pathogens and AMR genes by
integrating genomic data with epidemiological and clinical data
v. To develop and validate an optimized long-read mNGS pipeline using the
Oxford Nanopore MinION platform for detection and characterization of
pathogens and associated AMR in wastewater samples collected from
community and aircraft sources in Uganda.
Uganda 2026-04-10 19:07:13 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Daniel Omuna
ID: UNCST-2025-R019635
CLIMATE VARIABILITY AND WATER SECURITY AMONG SELECTED COMMUNITIES IN KUMI DISTRICT, EASTERN UGANDA
REFNo: NS1160ES

i. To determine the effect of climate variability on surface and groundwater availability in Kumi district using GIS and remote sensing.
ii. To examine the effects of climate variability on accessibility to water in selected communities in Kumi district.
iii. To determine the portable water quality of both surface and ground water in Kumi district.
iv. To establish community resilience and adaptability to water insecurity caused by climate variability in Kumi district.

Uganda 2026-04-10 19:05:54 2029-04-10 Natural Sciences Non-Clinical Trial Degree Award
Flavia Zalwango Kabuye
ID: UNCST-2025-R022929
The role of participatory communication strategies in enhancing uptake of childhood routine immunization vaccines in intersectionally vulnerable communities in Uganda
REFNo: SS4954ES

1. To understand health communication preferences and patterns on Koome main island

2. To explore stakeholders’ perceptions of the effectiveness of participatory vaccine communication strategies used on Koome main island between 2020 and 2025

3. To propose culturally appropriate participatory strategies to enhance vaccine communication among intersectionally vulnerable communities in Uganda

Uganda 2026-04-10 19:01:37 2029-04-10 Social Science and Humanities Non-Clinical Trial Degree Award
Anthony Nsubuga Mutebi
ID:
The consequences of biodiversity loss and land use change on infectious disease emergence
REFNo: NS1176ES

Objectives
This project focuses on the understanding of epidemic emergence by dissecting the most initial processes and dynamics of infectious disease emergence in rural settings of seeding regions based on a multi-host and multi-pathogen system. Specifically, we will concentrate on the transition from pre-emergence to emergence based on a comprehensive and multidisciplinary approach by linking the fields of human and veterinary medicine, clinical virology, molecular biology, disease ecology and modelling. We aim to detect and model arbovirus infection and transmission patterns in mosquitoes, livestock (cattle and goats as hosts for Rift Valley fever virus and chicken as hosts for West Nile virus) and humans (hosts for Dengue virus, Chikungunya virus, Zika virus and Yellow fever virus) under varying ecological and socioeconomic conditions at the interface to natural biodiversity hotspots in order to identify common patterns and drivers of emerging diseases.
Defining early transmission dynamics is most critical for prevention and containment of local outbreaks before they cause epidemics or pandemics. Our specific objectives are:
(i) To provide a thorough phenotypic and molecular characterization of pre-epidemic virus variants including previously unknown viruses isolated from mosquitoes, livestock and humans from rural regions in Uganda at the interface to the main African ecosystem types, tropical lowland, gallery and montane forest. Pre-epidemic variants will be compared to their cosmopolitan counterparts aiming at identifying distinguishing characteristics evolved during the emergence process.
(ii) To study the genetic adjustment of pre-epidemic variants by analysing intra- and inter-host genetic diversity and selective pressures as drivers for virus evolution and diversification after spillover infections to new vectors and hosts.
(iii) To probe the host transcriptome response to infection with pre-epidemic arboviruses at the single cell level aiming to gain insight into the evolutionary fine scaling of arboviruses in the transition from pre-emergence to emergence.
(iv) To assess the influence of different socioeconomic and ecological factors for the risk of virus transmission and disease outbreaks through phylogeographic reconstruction of the virus spatial movement and ecological niche factor analysis.
(v) To model virus and host distribution as well as infection risk under current and future climatic and land use scenarios based on collected field data.

Uganda 2026-04-10 18:57:00 2029-04-10 Natural Sciences Non-Clinical Trial Non-degree Award
RONALD ALIIJA
ID: UNCST-2025-R022107
ADOPTION OF DIGITAL FINANCIAL INNOVATIONS, FINANCIAL INCLUSION, AND FINANCIAL PERFORMANCE OF SMALL AND MEDIUM ENTERPRISES IN KAMPALA CAPITAL CITY, CENTRAL UGANDA
REFNo: SS5110ES

1) To examine the relationship between adoption of digital financial innovations and financial performance of SMEs in Kampala Capital City, Central Uganda. 2) To examine the relationship between adoption of digital financial innovations and financial inclusion among SMEs in Kampala Capital City, Central Uganda. 3) To find out the relationship between financial inclusion and the financial performance of SMEs in Kampala Capital City, Central Uganda. 4) To establish the mediating role of financial inclusion in the relationship between adoption of digital financial innovations and the financial performance of SMEs in Kampala Capital City, Central Uganda.
Uganda 2026-04-10 18:55:32 2029-04-10 Social Science and Humanities Non-Clinical Trial Degree Award
Salaviruse Ahimbisibwe
ID: UNCST-2022-R011048
Landscape analysis of the One Health ecosystem supporting interventions against zoonotic diseases in Uganda
REFNo: SS5023ES

Main Objective
1. To characterise the perceptions of different stakeholders relevant to Taenia Solium control to support co-design of a SUSTAIN-specific acceptability and feasibility framework for use in the trial evaluation.
Specific Objectives
1. Review the policy document and health activities landscape associated with One Health, public and veterinary health campaigns and the stakeholder environment in the SUSTAIN study districts relevant for zoonotic and Neglected Tropical Disease activities in Uganda.
2. Validate local systems, governance and stakeholder mapping with relevant stakeholders in Uganda.
3. Understand the distribution of and roles and responsibilities of key stakeholders involved in the knowledge generation and translation, decision-making and policy development, and programme planning and implementation relevant for Taenia Solium and NTDs in Uganda, using SUSTAIN as a case study
4. Ensure the most relevant district-level human and animal health officials are able to communicate and have a good understanding of the cross-sector system surrounding, and rationale for, SUSTAIN intervention for Taenia Solium control. Especially appreciating the different perspectives and any potential shared objectives across sectors.
5. Develop and validate a theory of change for the joint MDA strategy, especially identifying the elements of One Health implementation i.e. priorities for communication, co-ordination and collaboration and any capacity gaps that may need addressing to fulfil these.
6. Identify indicators of acceptability and evaluate prospective (perceived) acceptability for implementers and recipients through pre-intervention consultation (Key Informant Interviews and Focus Group Discussions), mapped against the seven domains of the theoretical framework of acceptability.
7. Document any opportunities, barriers and facilitators to implementing cross-sectoral control programmes such as SUSTAIN.
Uganda 2026-04-10 18:54:29 2029-04-10 Social Science and Humanities Non-Clinical Trial Degree Award
Richard Nokes Scott
ID: UNCST-2025-R019672
From Orature to Digital Publishing in Medieval Literature
REFNo: SS5107ES

1. To collect and record traditional narratives of Ugandan orature from selected communities through interviews and storytelling sessions with storytellers, elders, and other cultural knowledge holders. 2. To analyze the themes, structures, and patterns in these narratives, including the relationships among different versions of similar stories. 3. To compare Ugandan orature with medieval literary traditions from other regions of the world and assess how it can broaden or revise existing understandings of the global Middle Ages. 4. To produce accessible materials based on Ugandan orature that instructors and students can use in world literature and medieval studies courses in Uganda and the rest of the world.
USA 2026-04-10 18:52:35 2029-04-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Joseph Okello Ayo
ID: UNCST-2025-R023213
Identifying Policy Avenues to Facilitate the Transition to Large-Scale Operations in Developing Countries: Lessons from Large Firms in Uganda
REFNo: SS4993ES

This study aims to document evidence about large firm’s growth trajectories in selected districts across Uganda, with particular attention to the barriers faced by these firms in their growth journey, and how these barriers were overcome.
Uganda 2026-04-10 18:50:41 2029-04-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jonah Im
ID: UNCST-2025-R022465
Assessing the Health, Educational, and Psychosocial Impact of Rainwater Purification Systems in Kijoto Parish, Uganda
REFNo: HS7133ES

The purpose of this research is to evaluate the social, psychological, and health-related impact of newly installed rainwater catchment, purification, and storage systems at three primary schools in Kitojo Parish, Uganda. These systems were implemented by the Healthy Hands Initiative and Raising the Communities in February 2025 to address water insecurity and its associated burdens in rural areas.
This study has the following specific aims:

Aim 1:
Assess the impact of clean water access on community quality of life, mental health, and safety.
We will examine how rainwater systems influence the day-to-day lives of community members, with a focus on time savings, perceived improvements in health and well-being, reduced anxiety around water access, and improved safety (e.g., reduced long-distance water collection, particularly for women and children).

Aim 2:
Explore the effects of clean water systems on educational outcomes and student well-being.
We will investigate how water access affects teacher-reported attendance, student focus, and general classroom dynamics. We hypothesize that improved access to clean water correlates with higher attendance and fewer health-related absences.

Aim 3:
Identify implementation factors that affect system adoption and sustainability.
Using qualitative methods grounded in implementation science frameworks (e.g., RE-AIM or CFIR), we will explore what factors support or hinder successful adoption and long-term maintenance of the rainwater systems. These factors may include local leadership involvement, cultural attitudes, system usability, and perceptions of ownership.

Aim 4:
Compare current water quality with prior community sources.
Water samples will be collected from the new systems and compared with samples from previously used sources to evaluate improvements in water safety.


USA 2026-04-10 18:49:20 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Denis Tindyebwa
ID: UNCST-2025-R018639
Impact of nurturing care interventions on neonatal and child health outcomes in Eastern Uganda: A population-based mother-baby cohort
REFNo: HS7136ES

To evaluate the effect of implementation of the Nurturing Care Interventions on neonatal, child, and maternal health outcomes in Eastern Uganda,
Uganda 2026-04-10 18:47:28 2029-04-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isa Egiri
ID: UNCST-2026-R023342
Rebels with a Pause: Youth, Generation and Cycles of Guerrilla Violence in Rwenzori, Uganda, 1960s-1993.
REFNo: SS4973ES

•What practices, institutions and symbols were established by the Rwenzururu Movement of the 1960s?
•How has the legacy of those practices, institutions and symbols been reproduced discursively in popular memory and narratives in ways that shape successive rebel groups?
•Does youth leadership result in particular characteristics of armed groups?
•Is there a relationship between the liminality of border regions and the liminality of youth that drives conflict?
•Does the border shape the vulnerability of the youth to joining conflict?
Uganda 2026-04-10 18:36:05 2029-04-10 Social Science and Humanities Non-Clinical Trial Degree Award
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