Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Jackson Mukonzo
ID: UNCST-2021-R013916
Safety of COVIDEX™ Therapy in adults: in Uganda: A randomized controlled open- label phase 1 clinical trial.
REFNo: HS6540ES

Overall aim
To validate the safety of COVIDEX™ therapy in adult Ugandans.

Specific objectives
Primary objective
To evaluate and document adverse events associated with COVIDEX™ among adults
in Uganda.

Secondary objective:
To determine the plasma concentration of berberine in adults receiving COVIDEX™ at
three different dose levels.
Uganda 2025-11-21 14:11:01 2028-11-21 Medical and Health Sciences Clinical Trial Non-degree Award
William Worodria Ofuti
ID: UNCST-2022-R010915
Candidate Clinical Correlate as Prognostic Outcome for TB (C3PO) Study
REFNo: HS6545ES

Our specific aims are: 1. To evaluate end-of-treatment (EOT) biomarkers as predictors of recurrent TB 2. To evaluate novel cough and activity biomarkers as predictors of post-TB lung health
Uganda 2025-11-21 13:53:39 2028-11-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Doreen Rubatsimbira Katangaza
ID: UNCST-2024-R004595
Social economic determinants of energy poverty at household level in Uganda
REFNo: SS4062ES

To what extend do socioeconomic factors determine energy poverty?
What are the energy poverty hotspots in Uganda?
What are the socioeconomic conditions of the most vulnerable households to energy poverty?
Uganda 2025-11-21 13:49:30 2028-11-21 Social Science and Humanities Non-Clinical Trial Non-degree Award
DANIEL ELAMU
ID: UNCST-2025-R020928
PREVALENCE OF MALARIA AND HIV IN UGANDAN CHILDREN WITH TRAUMATIC BRAIN INJURY; AN EARLY OUTCOME STUDY.
REFNo: HS6781ES

Primary objective: To determine the prevalence of malaria (by RDT and PCR) and HIV among children presenting with traumatic brain injury at Mulago National Referral Hospital in 8 months.
Secondary Objective: To assess the impact of malaria parasitemia and/or HIV co-infection on short-term functional recovery, measured by Health-Related Quality of Life (HRQoL) at one-month post-discharge.
Uganda 2025-11-21 13:47:46 2028-11-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eugene Ruzagira
ID: UNCST-2023-R008282
A Phase 3, Randomized, Active-Controlled, Double-Blind Clinical Study to Evaluate the Efficacy and Safety of MK-8527 Oral Once-Monthly as HIV-1 Preexposure Prophylaxis in Women
REFNo: HS6565ES

To evaluate the efficacy of MK-8527 qm compared to FTC/TDF qd for the prevention of HIV-1 infection as assessed by the incidence rate per year of adjudicated HIV-1 infections To evaluate the safety and tolerability of MK-8527 qm compared to FTC/TDF qd.
Uganda 2025-11-21 11:18:30 2028-11-21 Medical and Health Sciences Clinical Trial Non-degree Award
Francis Ssebiryo
ID: UNCST-2019-R001250
Mid-Term Evaluation for the Stand Up for Sexual and Reproductive Health Rights Project
REFNo: SS4574ES

To establish a midline value for key performance indicators outlined in the project’s Performance Measurement Framework(PMF), allowing for a direct comparison with the baseline data. To assess progress toward the Outcome Indicators. To establish a midline value for tracking progress against these outcome indicators, as detailed in the project’s Performance Measurement Framework (PMF). To provide recommendations for strategic project improvements
Uganda 2025-11-19 8:42:04 2028-11-19 Social Science and Humanities Non-Clinical Trial Non-degree Award
Eddy Walakira Joshua
ID: UNCST-2022-R009077
MULTI-COUNTRY OPERATIONAL RESEARCH ON NEW AND EVOLVING FORMS OF VIOLENCE AGAINST WOMEN AND GIRLS LIVING WITH HIV IN UGANDA, KENYA AND TANZANIA
REFNo: SS4545ES

Aim
To conduct a multi-country operational research that examines how new and evolving forms of violence against WLHIV affect their participation in leadership and collective organising within feminist movements in Uganda, Kenya, and Tanzania.

Specific objectives
1.To assess the lived experiences of WLHIV regarding new and evolving forms of violence, and their impact on participation, leadership, and collective organising within feminist movements in Uganda, Kenya, and Tanzania.
2.To examine the experiences of WLHIV who seek or do not seek assistance after experiencing violence, including their access to shelters and support services, and how these factors influence movement-building participation and their advocacy.
3.To analyse, by root cause, how existing barriers hinder WLHIV from receiving assistance and participating meaningfully in coalition-building, advocacy spaces, and feminist leadership.
4.To generate feminist, practice-based evidence and approaches to strengthen inclusive coalitions, leadership pathways, and evidence-informed advocacy under the THRIVE Project at regional levels.
Uganda 2025-11-19 16:37:11 2028-11-19 Social Science and Humanities Non-Clinical Trial Non-degree Award
Mary Kaakyo
ID: UNCST-2025-R019146
Impact of Differentiated Service Delivery (DSD) Approaches on Viral Suppression and Retention in Care among Adolescents Aged 10-19 Living with HIV in Masaka Region, Uganda
REFNo: HS6682ES

1.Determine the impact of the DSD approaches on viral suppression and retention in care among adolescents aged 10-19 living with HIV in the Masaka region. 2.Explore mechanisms and pathways through which DSD approaches have impacted (or not) viral suppression and retention in care among adolescents aged 10-19 years living with HIV in the Masaka region and the contextual factors that influence these pathways. 3.Estimate the incremental cost-effectiveness of DSD approaches on viral suppression and retention in care among adolescents aged 10-19 years living with HIV in Masaka region.
Uganda 2025-11-13 17:13:46 2028-11-13 Medical and Health Sciences Non-Clinical Trial Degree Award
JULIET ANENA
ID: UNCST-2025-R022055
Monitoring the Diversity and Metabolic Shift of Gut Microbes during Fermented Cassava Feeding in an in Vitro Human Colonic Model
REFNo: A667ES

i. To assess the microbial population dynamics during anaerobic fermentation of cassava tubers
ii. To analyse the physicochemical properties and nutrient bioavailability of anaerobically fermented cassava flour
iii. To evaluate the effect of fermented cassava on gut microbial population, diversity, and microbial metabolites

Uganda 2025-11-13 17:10:56 2028-11-13 Agricultural Sciences Non-Clinical Trial Degree Award
Aisha Nanyiti
ID: UNCST-2021-R013489
Exploring the option for co-existence of Mabira Forest and the booming economic activity
REFNo: SS4462ES

The main objective is to examine how informational programs can promote co-existence in forest management practices by evaluating their impact on forest community attitudes and conservation behaviors. Precisely.Specific objectives
1. Assess the influence of targeted awareness interventions on forest community members' knowledge of the benefits of optimal forest cover by measuring changes in awareness levels over a 12-month period.
2. Determine the impact of conservation information on the willingness of forest community members to engage in sustainable forest biomass care, quantified by changes in self-reported willingness and observed conservation actions within six months of intervention.
3. Evaluate the behavioral changes in conservation practices among the forest community, specifically tracking actions like reduced logging and increased forest maintenance over 18 months, to establish a direct link between informational programs and sustainable forest stewardship.

Uganda 2025-11-13 17:08:30 2028-11-13 Social Science and Humanities Non-Clinical Trial Non-degree Award
Karlo Ojok
ID: UNCST-2025-R019912
Maize Commodity Chain and Livelihood Outcomes among Smallholder Farmers in Northern Uganda
REFNo: SS4628ES

(i) To explore the nature of smallholder involvement in the maize commodity chain in northern Uganda.
(ii) To assess the institutional factors affecting farmers’ participation in the maize commodity chain in northern Uganda.
(iii) To explore ways of enhancing livelihood outcomes for smallholders in the maize commodity chain.
(iv) To establish the effects of participation in the maize commodity chain on livelihood outcomes of farming households in northern Uganda.

Uganda 2025-11-13 16:57:57 2028-11-13 Social Science and Humanities Non-Clinical Trial Degree Award
Losira Nasirumbi
ID: UNCST-2021-R013084
Farmer Perceptions and Preferences for Perennial Sorghum in the Drylands of Eastern Uganda
REFNo: A659ES

General objective: To generate knowledge for the promotion of the adoption of perennial sorghum varieties. Specific Objectives: 1. Identify the agronomic traits most valued by smallholder farmers in perennial sorghum varieties, such as yield, drought resistance, maturity period, and ease of harvesting, to guide the development of locally adapted perennial sorghum lines. 2. Analyze the socio-cultural perceptions and attitudes of smallholder farmers toward perennial sorghum, and to examine how gender dynamics, household decision-making, and youth involvement influence the adoption of perennial sorghum cropping systems. 3. Assess the key barriers and opportunities for the adoption of perennial sorghum among smallholder farmers, including factors such as access to seeds, labor requirements, market access, and the availability of agricultural support services. 4. Investigate the economic dynamics influencing the adoption of perennial sorghum, including market access, price trends, income generation, and the potential for value-added products, to determine the economic viability of perennial sorghum systems for smallholder farmers. 5. Evaluate the role of agricultural extension services, public and private institutions, and other stakeholders in supporting smallholder farmers in the adoption and management of perennial sorghum, with a focus on the effectiveness of training and access to resources.
Uganda 2025-11-13 16:54:58 2028-11-13 Agricultural Sciences Non-Clinical Trial Non-degree Award
Andrew Kanyike Marvin
ID: UNCST-2020-R014554
Assessing the Burden, Prehospital care pathways, and Management of Trauma Patients in Eastern Uganda: A cross-sectional study.
REFNo: HS6754ES

4. To evaluate how pain is assessed and managed in trauma patients at Jinja Regional Referral Hospital and Iganga General Hospital in Eastern Uganda.,3. To determine the prehospital care pathways and referral patterns followed by trauma patients presenting to Jinja Regional Referral Hospital and Iganga General Hospital in Eastern Uganda.,2. To determine the most common injury patterns and mechanisms of injury of trauma patients presenting to Jinja Regional Referral Hospital and Iganga General Hospital in Eastern Uganda.,1. To determine the sociodemographic and clinical characteristics of trauma patients presenting to Jinja Regional Referral Hospital and Iganga General Hospital in Eastern Uganda.,To characterise the presentation, prehospital care pathways, and in-hospital pain assessment and management of trauma patients at Jinja Regional Referral Hospital and Iganga General Hospital in Eastern Uganda.,
Uganda 2025-11-13 16:53:10 2028-11-13 Medical and Health Sciences Non-degree Award
Paul Okeny
ID: UNCST-2021-R012931
PADER Study - Polyp and Adenoma DEtection Rate and colonoscopy yield in Uganda – a retrospective cross-sectional Study.
REFNo: HS6256ES

To identify factors associated with ADR, including age, sex, colonoscopy indication, and bowel preparation quality.,To describe the overall colonoscopy yield, including detection of Inflammatory bowel disease (IBD) and colorectal cancer (CRC) among patients undergoing colonoscopy at Mulago National Referral Hospital and St. Mary’s Hospital Lacor.,To determine the polyp detection rate (PDR) and adenoma detection rate (ADR) among patients undergoing colonoscopy at two large hospitals in Uganda.,
Uganda 2025-11-13 16:51:31 2028-11-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kirsten Nielsen Milo Tromborg
ID: UNCST-2025-R019351
Vital waste: A case study of informal waste management, urban infrastructure, and future-making in Gulu
REFNo: SS4342ES

The aim of the proposed research is to create new empirical insights into municipal and citizen-led waste management in Africa using ethnographic research methods. The proposed project also intends to break new theoretical ground by putting the empirical findings into conversation with existing literature on waste, infrastructure, and urbanity.
Denmark 2025-11-13 16:50:31 2028-11-13 Social Science and Humanities Non-Clinical Trial Degree Award
Catherine Abaasa N
ID:
ASSESSING RIFT VALLEY FEVER PREVENTION AND CONTROL PREPAREDNESS AND REPORTING DYNAMICS: A CASE OF KASHARI COUNTY MBARARA, UGANDA
REFNo: NS797ES

This study aims at assessing the preparedness level of Kashari County to effectively respond to a potential Rift Valley Fever (RVF) outbreak and to identify and analyze the barriers and facilitators influencing the reporting of RVF signals among various stakeholders in Kashari County, Mbarara district ,I. To assess the preparedness level of Kashari County to effectively respond to a potential Rift Valley Fever (RVF) outbreak. II. To identify and analyze the barriers and facilitators influencing the reporting of RVF signals among various stakeholders within Kashari County,
Uganda 2025-11-13 16:48:09 2028-11-13 Natural Sciences Non-Clinical Trial Non-degree Award
Kazunari Ushida
ID:
Conservation science of African Grey Parrot
REFNo: NS744ES

African Grey Parrot is endangered bird species. Their physiological and genetic characteristics must be known for the better conservation. As Chubu University and UWEC start the joint conservation project for African Grey Parrot with the finance from Japanese goverment (Japan International Cooperation Agency, JICA). We focus on the role of zoo in the ex-situ African Grey Parrot conservation in which development of the nutrition science, the breeding science, the behavior science, and the veterinary science toward this particular species are essential for the future success of ex-situ conservation.
Japan 2025-11-13 16:46:55 2028-11-13 Natural Sciences Non-Clinical Trial Non-degree Award
Ali Waiswa
ID: UNCST-2025-R020882
ARTIFICIAL INTELLIGENCE AND DEEP LEARNING BASED IRIDOLOGY FOR DETECTION OF COLORECTAL CANCER
REFNo: HS6756ES

To determine the sensitivity of AI and deep learning based iridology for detection of colorectal cancer in Uganda over a period of one year.
To determine the specificity of AI and deep learning based iridology for detection of colorectal cancer in Uganda over a period of one year.

Uganda 2025-11-13 16:40:17 2028-11-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
HAKIIMU KAWALYA
ID: UNCST-2025-R020311
Sickle Cell Modifier Genes Across Diverse Human Populations
REFNo: HS6710ES

1) To profile the most common fetal hemoglobin associated sickle cell disease modifier genes 2) To determine population specific gene expression patterns of fetal hemoglobin associated sickle cell disease modifier genes 3) To characterize inter-population Allele Frequencies of fetal hemoglobin associated sickle cell disease modifier gene variants 4) To analyze selection signals in fetal hemoglobin associated sickle cell modifier genes using human whole genome sequencing data
Uganda 2025-11-13 15:27:46 2028-11-13 Medical and Health Sciences Non-Clinical Trial Degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
Partial Analytical and Clinical Performance Study focusing on Specimen Type Equivalence, Diagnostic Sensitivity and Specificity, and Usability Evaluation of ConfiSign HCV Pro.
REFNo: HS6742ES

3. Qualification of usability for professional use of ConfiSign HCV Pro through a label comprehension study and a results interpretation study which are to be completed by at least 3 laboratory professionals and at least 4 lay providers/healthcare workers.,2. Establish part of the clinical performance (diagnostic sensitivity and specificity) of ConfiSign HCV Pro using capillary whole blood samples.,1. Demonstrate the specimen type equivalence between capillary whole blood, venous whole blood, serum and plasma samples while using ConfiSign HCV Pro.,The general objective of this study is the partial evaluation of both clinical and analytical performance as well as qualification of usability for professional use of the ConfiSign HCV Pro according to parts of WHO TSS-16 (Part 1 - section 1.2.1, Part 2a - sections 2a.1.1 to 2a.1.3, Part 3a - sections 3a.1.1 to 3a.1.2) and CS (Annex I - Part I and Part II and Annex V - Table 2). For further details, see section 7.4.,
Uganda 2025-11-07 5:14:01 2028-11-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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