Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
Search By Approval Date:
Clear Filter Total: 6,261
Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Martin  Muhereza
ID:
Policy and Structural reforms of Electricity in Uganda in the context of social economic welfare
REFNo: SS424ES

1.To examine the alignment of electricity reforms in Uganda with theoretical benefits of power sector reforms
2. To analyze the relationship of electricity reforms with the levels of electricity accessibility,reliability,and affordability in informal settlements.
3.To generate knowledge beneficial to policy makers and planners interested in the contribution of electricity to the development trajectory
Uganda 2020-06-04 2023-06-04 Social Science and Humanities Degree Award
FREDRICK MAKUMBI
ID:
Performance Monitoring for Action (PMA) Uganda
REFNo: HS625ES

General objective
To monitor change in contraceptive availability and use in Uganda and increase understanding of the factors contributing to that change through panel surveys in order to support FP program monitoring and improve performance.

Specific objectives
Specifically, the project aims to conduct cross-sectional and panel surveys at the female, household, and service delivery levels, with a focus on actionable programmatic data on contraceptive availability and use dynamics in targeted geographic areas in order:
1. To measure and monitor key family planning indicators of programmatic relevance cross-sectionally on an annual basis including contraceptive prevalence rate and stocks of contraceptive commodities in Service Delivery Points serving the Enumeration Areas
2. To assess the determinants and consequences of contraceptive availability and use dynamics in Uganda.
3. To evaluate factors associated with a change in contraceptive use states including: Contraceptive acceptor (non-user to user), Contraceptive discontinuer (user to non-user), and Contraceptive switcher (user of one method to a different method)

Uganda 2020-06-04 2023-06-04 Medical and Health Sciences Non-degree Award
ANNET NAGUUDI
ID: UNCST-2022-R009395
CLIENT EXIT INTERVIEWS (CEIs) UNDER THE WOMEN INTEGRATED SEXUAL HEALTH (WISH) PROGRAMME IN UGANDA
REFNo: HS591ES

The specific objectives are to:
1. Characterize users of family planning (FP) services
2. Estimate the percentage of users of FP services by WISH (Women Integrated Sexual Health) service delivery points who are under-age 20
3. Estimate the percentage of clients of FP services provided by WISH service delivery points who are living in poverty
4. Provide information needed to estimate the number of additional users of modern methods of contraception contributed by WISH
5. Estimate the percentage of WISH FP clients counselled on a range of methods and potential side effects as defined by the method information index
6. Estimate the percentage of FP clients who would recommend the WISH services as evidenced by the net promoter score (NPS)
7. Estimate the percentage of WISH clients who demonstrated positive attitudes, practices and community support in relation to FP and SRHR
8. Estimate the percentage of FP clients at WISH service delivery points reporting exposure to WISH social and behavioral change communication (SBCC) activities
9. Estimate the percentage of users of FP services by WISH service delivery points who have a disability.
10. Understand why FP users changed methods
11. Explore the predictors of FP adopters
12. Explore the predictors of being likely to promote FP services
13. Determine effect of Social and Behavior Change Communication (SBCC) campaign on outcomes of interest

Uganda 2020-06-01 2023-06-01 Medical and Health Sciences Non-degree Award
Pontiano Kaleebu
ID: UNCST-2021-R013577
Uganda Virus Research Institute Performance Evaluation for COVID-19 Diagnostic tests
REFNo: HS637ES

Overall objectives
The overall objectives of this performance evaluation are:
- To verify the performance characteristics of new on-the-market NAATs,
- To evaluate the performance characteristics of new, on-the-market, EIAs and RDTS (IgA, IgG and IgM),
- To train laboratory and POC staff in the country in biosecurity and the required technical skills to perform COVID-19 diagnostic testing,
- To establish serum/plasma panels of well-characterized COVID-19 sera/plasma to support evaluation efforts.

Specific Objectives:
- To confirm whether or not a new NAAT complies with the manufacturer’s specifications,
- To determine the performance equivalence of new on-the-market NAATs using the Berlin protocol NAAT as the gold standard,
- To determine the sensitivity and specificity of new on-the-market diagnostic EIAs and RDTs against a gold-standard method,
- To evaluate the operational characteristics of new on-the-market immunoassays. Operational utility characteristics that may be considered include;
o ease of performance
o specimen type utility
o inter-reader variability
o reaction endpoint stability
o suitability for use in facilities with limited infrastructure (no/limited electricity, no/limited clean water, inadequate means of biosafety disposal)
- To document Standard Operating Procedures (SOPs) and train laboratory staff in the country in performing COVID-19 diagnostic testing using recommended EIAs and RDTs,
- To establish serum panels of well characterized COVID-19 sera/plasma to support future validation and evaluation of immunoassays.


Uganda 2020-05-20 2023-05-20 Medical and Health Sciences Non-degree Award
Badru Bukenya
ID:
Displaced communities, environmental degradation and sustainable livelihoods in Uganda

REFNo: SS310ES

(i) understand the various ways in which refugees and nationals living in or around new and long-term refugee settlements interact with the environment and ecosystem services.
(ii) explore the variety of knowledges (indigenous; cultural, social and economic) and needs (shelter, food, water, sanitation) of refugee and local households for understanding how the environment is used.
(iii) examine the nature and extent of environmental degradation (loss of forests/fragmentation and soil degradation) in different camp settlements. And,
(iv) offer recommendations for the management of increasing pressure on land resources within sustainable livelihood practices for development and policy programming.

Uganda 2020-05-08 2023-05-08 Social Science and Humanities Non-degree Award
Hussein Kafeero Mukasa
ID:
HEPATITIS B GENOTYPES AND IL-2, 4, 10, INF-γ, TNF-α, PROMOTER GENE POLYMORPHISMS IN A HIGH AND LOW ENDEMIC REGION OF UGANDA
REFNo: HS575ES

1. To determine the circulating hepatitis B virus genotypes in regions of high and low endemicity in Uganda.
2. To characterize Th1/Th2 cytokine gene promoter polymorphisms among HBV unexposed and exposed individuals in low and high endemicity regions.
3. To investigate the relationship between hepatitis B virus genotype and the observed Th1/Th2 cytokine gene promoter polymorphisms
4. To determine the expression levels of the cytokines and correlate them with the infecting genotypes and the single nucleotide polymorphisms in the Th1/Th2 cytokine gene promoter.


Uganda 2020-04-30 2023-04-30 Medical and Health Sciences Degree Award
ERIC WOBUDEYA
ID: UNCST-2019-R001047
A randomised trial of 6 months intensified anti-tuberculosis and 2 months anti-inflammatory treatment for HIV-infected and HIV-uninfected African and Asian children with tuberculous meningitis
REFNo: HS593ES

Main objectives of the SURE trial

a) To determine whether the standard 12 month ATT regimen for treating paediatric TBM can be reduced to 6 months with similar efficacy and safety, with an intensified regimen of anti-TB drugs in children aged under 15 years with TBM AND b) To determine whether adjunctive aspirin for the first 60 days of treatment reduces TBM-related neuro-disability with minimal or no toxicity in children with TBM.

Other objectives

(a) To determine whether the doses of anti-TB drugs, prescribed according to weight bands, result in appropriate drug exposures when compared with historical paediatric and adult PK data.

(b) To further understand the pathophysiology of TBM in children and the effects of intensified antibacterial and anti-inflammatory treatment on intra-cerebral inflammation and the macroscopic complications of TBM (infarcts, tuberculomas, hydrocephalus).
Uganda 2020-04-30 2023-04-30 Medical and Health Sciences Non-degree Award
Annette Schuh Hildegard
ID: UNCST-2024-R003745
Evaluation and Transfer of mobile whole slide tissue scanners and liquid biopsies to deliver fast and precise diagnosis for improved outcomes of children and young adults with EBV-driven lymphoma: a joint Tanzanian and Ugandan Paediatric Oncology Network Initiative
REFNo: HS529ES

We have four objectives: to 1. Assess the diagnostic accuracy of liquid biopsy testing 2. Asses the diagnostic accuracy of digital pathology 3. Development of a digital pathology machine learning algorithm 4. Transfer of above novel tests and associated expertise to local laboratories
UK 2020-04-24 2023-04-24 Medical and Health Sciences Non-degree Award
Peter Nkurunziza Munya
ID:
'Evaluation of The Bio-Rad Geenius HIV-1/2 Confirmatory Assay as Part of Confirmatory and Differentiation of HIV infection at Uganda Virus Research Institute-HIV Reference Laboratory'
REFNo: HS612ES

Primary objective
• To conduct an in-country evaluation of the performance of Geenius™ HIV-1/2 Confirmatory Assay for confirmation of HIV infection using DBS and Plasma specimens, as compared to Murex HIV Ag/Ab Combination and/or Genscreen Ultra HIV Ag/Ab Combo.
Specific objectives
• To determine the sensitivity of Geenius™ HIV-1/2 Confirmatory Assay as compared to Murex HIV Ag/Ab Combination and/or Genscreen Ultra HIV Ag/Ab Combo
• To determine the specificity of the Geenius™ HIV-1/2 Confirmatory Assay as compared to Murex HIV Ag/Ab Combination and/or Genscreen Ultra HIV Ag/Ab Combo
• To determine the positive predictive value and negative predictive value of Geenius™ HIV-1/2 Confirmatory Assay as compared to Murex HIV Ag/Ab Combination and/or Genscreen Ultra HIV Ag/Ab Combo.

Uganda 2020-04-24 2023-04-24 Medical and Health Sciences Non-degree Award
PROSPER BEHUMBIIZE
ID:
Implementation Research on Education Management Information Systems (EMIS) Data Use Innovations in Uganda
REFNo: SIR33ES

1. To assess the existing management information systems for the Education Sector
2. To understand how innovations including DHIS2 can be used to improve EMIS data quality, management and use at all levels of the education sector
3. To ascertain the best practices that will inform scale up of Dhis2-for Education within and across countries

Uganda 2020-04-17 2023-04-17 Engineering and Technology Non-degree Award
Peter Olupot-Olupot
ID:
Coronavirus Disease 2019 Open Cohort (COC) Study
REFNo: HS611ES

The specific objectives:
1. Through a cross sectional survey describe risk factors and enlist study participants for the cohort study.
2. To characterize the clinical spectrum of COVID-19.
3. To refine case definitions of COVID-19 using data from different population groups.
4. To explore in detail, the epidemiology of COVID-19.
5. To document outcomes associated with COVID-19 in various age groups, populations and concomitant conditions.
6. To generate data to inform clinical research on COVID-19.
7. To generate population specific data for evidence based public health education as a control measure.
8. Provide a decision tree that has automated feedback that has standard of care including quarantine, call help-line, seek medical attention and avoid spread of the disease.

Uganda 2020-04-03 2023-04-03 Medical and Health Sciences Non-degree Award
AGNES NAGGIRINYA BWANIKA
ID: UNCST-2019-R001126
Acceptability, effect and cost of mobile-health on art adherence among youths: a mixed methods sequential study in Kiryandongo
REFNo: HS576ES

General objective: To assess the acceptability, effect and cost of the Call For Life Uganda mHealth tool on ART adherence among youth initiating ART at Kiryandongo Hospital.

Specific objectives:
Objective 1a: To assess barriers, enablers of ART adherence among youth living with HIV in Kiryandongo Hospital at baseline & study end.
Objective 1b: To assess acceptability of mHealth for HIV adherence among youth living with HIV in Kiryandongo Hospital at baseline & study end.
Objective 2: To assess effect of the CFLU mHealth tool on ART adherence among youths initiating ART at 6 and 12 months.
Objective 3: To evaluate the cost of the CFLU mHealth adherence tool in comparison to Standard of Care.

Uganda 2020-03-28 2023-03-28 Medical and Health Sciences Degree Award
Anthony Matovu
ID:
G - Therapy: Classical Mechanical Resonance Tool For HIV Cure
REFNo: SIR26ES

Main Objective
To design and implement an effective, safe, “isolate – and – kill” Classical Mechanical resonance tool for HIV – riddance from HIV – positive patients.

Specific Objectives
a) To outline a velocity, frequency and wavelength generating system based on scalable vibratory/circulatory dynamics pertinent with the vibratory characteristics of the HIV particles (H – 1 atom system is earmarked).
b) To identify the HIV virus by morphology (physical structure) differentiation using light optical nanoscopy – observation procedures (use flue virus for comparison).
c) To characterize the projected mechanical resonance – based fight between HIV and human defense system cells (realizable by articulating and relating factors implicated).
d) To design and implement a counter resonance tool against HIV’s own mechanical resonance combat weapon against human defense cells (achievable through determining rupture-prone resonant frequency-amplitude factors leading to an effective, safe body- penetrative capacity; as well as the functional body/specimen exposure period).

Uganda 2020-03-20 2023-03-20 Engineering and Technology Degree Award
Doreen Nakku
ID:
Assessment of knowledge and attitudes towards hearing loss and community utilisation of hearing screening services at a Health Centre IV in Mbarara District
REFNo: HS549ES

1. To assess knowledge on hearing loss and attitudes towards hearing loss of communities served by Bwizibwera HC IVs in Mbarara District
2. To assess the utilisation of hearing screening services at Bwizibwera HC IVs in Mbarara District.
Uganda 2020-03-20 2023-03-20 Medical and Health Sciences Non-degree Award
KAHUNZIRE EVANGELIST
ID:
Evaluation of parental involvement on primary pupils educational academic performance in public day primary schools of Ndorwa County,Kabale District-Uganda.
REFNo: SS426ES

To establish the relationship between parental involvement on primary pupils educational academic performance in selected public day primary schools of Ndorwa County,Kabale District-Uganda.
To examine the utilization of educational domains on primary pupils'educational academic performance in selected public day primary schools of Ndorwa County ,Kabale District-Uganda.
To formulate a parenting involvement model that enhances primary pupils'educational academic performance in selected public day primary schools of Ndorwa Ounty,Kabale District-Uganda.
Uganda 2020-03-20 2023-03-20 Social Science and Humanities Degree Award
Paddy Tukamuhebwa Mutungi
ID: UNCST-2020-R014201
Barriers and facilitators of investigation coverage among index tuberculosis case contacts in rural Mbarara district, Uganda.
REFNo: HS569ES

1. To identify the barriers of TB contact investigation coverage among contacts of TB index clients in three rural primary health facilities in Mbarara district in Uganda. 2. To identify the facilitators of TB contact investigation coverage among contacts of TB index clients in three rural primary health facilities in Mbarara district, Uganda.
Uganda 2020-03-20 2023-03-20 Medical and Health Sciences Degree Award
Charles Batte
ID: UNCST-2021-R013587
Hypertension and cardiovascular diseases comorbidities among people living with HIV: A health outcomes and cost study.
REFNo: HS581ES

• To determine and compare Health Related Quality of Life (HRQoL) of People living with HIV (PLWH) with or without hypertension and/or CVD comorbidities that have been on ART for more than 10 years in Uganda using both generic and disease specific HRQoL tools.
• To determine and compare health care utilization costs of patients with HIV & HTN/CVD and those with HIV alone.

Uganda 2020-03-20 2023-03-20 Medical and Health Sciences Non-degree Award
Peter MUSINGUZI
ID:
Social Enterprises and sustainable rural development: performance and impacts on beneficiaries’ livelihood
REFNo: SS434ES

General objective To guide the design and operation of Social Enterprises in rural development Specific objectives 1.To analyse what CSFs determine the performance of SEs 2.To understand how the presence and influence of CSFs in SEs varies across contexts. 3.To determine and describe how SE management and performance influence impact on stakeholders.
Uganda 2020-03-20 2023-03-20 Social Science and Humanities Degree Award
Obbo Aggrey
ID:
Algorithms for detection and management people crowds using wireless sensor networks
REFNo: SIR31ES

Design develop and analyze algorithms for people crowds detection and management using wireless sensor networks.
Uganda 2020-03-20 2023-03-20 Engineering and Technology Degree Award
Nathan Kenya-Mugisha
ID: UNCST-2021-R013752
Influencing Sepsis policy in Uganda
REFNo: HS517ES

The main objective of this study is to generate evidence on how researchers’ stakeholder engagement influences Uganda’s health policy agenda. The study will be guided by the following specific objectives.
1. Assess changes in Uganda’s health policy agenda around sepsis as a result of ARCS policy stakeholder engagement activities.
2. Reflectively review the process stakeholder engagement strategies (Informing and translating, Linking, Matchmaking, and Capacity strengthening) designed to influence key stakeholders to recognise sepsis as a priority health issue and put it on Uganda’s policy agenda.

Uganda 2020-03-18 2023-03-18 Medical and Health Sciences Non-degree Award
View Sort By:

"A prosperous Science and Technology Led Ugandan Society."