Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Sudi Mohamed Ali
ID:
Cervical Cancer: Late presentation and associated factors at Mbarara Regional Referral Hospital.
REFNo: HS485ES

1. To determine the proportion of women with cervical cancer that presents late at Mbarara Regional Referral Hospital. 2. To determine the factors associated with late presentation among women with cervical cancer at Mbarara Regional Referral Hospital. 3. To explore the factors associated with health care seeking from onset of symptoms to diagnosis among women with cervical cancer at Mbarara Regional Referral Hospital.
Kenya 2020-03-11 2023-03-11 Medical and Health Sciences Degree Award
Richard  Muhumuza
ID:
INTEGRATED PREVALENCE MAPPING OF SCHISTOSOMIASIS AND SOIL TRANSMITTED HELMINTHIASIS AMONG COMMUNITIES IN MAYUGE DISTRICT: IMPLICATIONS FOR NTD ELIMINATION PROJECT 2019-2021
REFNo: HS434ES

2. Study objectives
2.1 General objective/Goal
The establish the prevalence of Schistosomiasis and STH infections among school going children and surrounding communities in Mayuge district

Specific objectives
1. To build capacity of Laboratory assistants and technicians on sample (Stool) collection and microscopic analysis
2.To collect sample (Stool) collect from the selected schools
3. To conduct Microscopic analysis for collected samples


Uganda 2020-03-09 2023-03-09 Medical and Health Sciences Non-degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
Assessment of Public Knowledge, Attitudes, and Practices Related to Ebola Virus Disease Prevention and Treatment in Uganda
REFNo: HS531ES

1. Measure district-level estimates in six districts in Uganda of the public’s knowledge, beliefs, attitudes, and practices related to Ebola Virus Disease (EVD) risks due to the ongoing and widespread EVD outbreak in DRC; and
2. Identify socio-behavioral and health system barriers that may hinder the containment of an EVD outbreak in Uganda given the complex socio-political and security context of the protracted outbreak in neighboring DRC.

Nigeria 2020-03-09 2023-03-09 Medical and Health Sciences Non-degree Award
REBECCA NANTANDA
ID: UNCST-2019-R001533
Improving neonatal outcomes through early detection and management of hypoxaemia: The role of routine pulse oximetry
REFNo: HS132ES

1.To evaluate the effect of routine pulse oximetry on neonatal outcomes in the first 24 hours of life. 2.To determine the utility of pulse oximetry compared to clinical signs in detection of hypoxaemia in neonates with possible serious bacterial infections at lower level facilities 3.To assess the feasibility and acceptability of routine pulse oximetry by healthcare workers and caretakers of newborn babies. 4.To determine the cost-effectiveness of routine pulse oximetry in identifying neonates with hypoxaemia. 5.To describe the maternal factors that predict hypoxaemia in the newborn babies
Uganda 2020-03-06 2023-03-06 Medical and Health Sciences Non-degree Award
Moses Joloba Lutaakome
ID: UNCST-2022-R011558
Advancing Tissue and Organ Biobanking in Uganda
REFNo: HS572ES

General objective: To establish a tissue and organ biobank at Makerere University to serve as a catalyst for research in organ collection, biobanking and transplantation in Uganda.
Specific Objective :
1. To train personnel and develop standard operating procedures for collection, processing and storage of human ova, sperm and umbilical cord blood.
2. To collect, process and store human ova, sperms and umbilical cord blood.
3. To develop a publicly accessible catalog of HLA typed viable human tissue and organs.
4. To explore the ethical, legal and societal issues (ELSI) in human tissue and organ biobanking

Uganda 2020-03-03 2023-03-03 Medical and Health Sciences Non-degree Award
ROSE ATIM
ID:
Law, Culture and Reality: Women Navigating Post Conflict Marital Relations in Northern Uganda
REFNo: SS423ES

1. Investigate the legal implication of the institution of marriage on women born in internally displaced peoples camps and victims of sexual violence of the LRA conflict;
2. Interrogate if cohabitation as an alternative to ‘legal’ marriage is becoming institutionalized among women born in internally displaced peoples camps and victims of sexual violence of the LRA Conflict;
3. Analyse the effectiveness of legal and informal marital protection mechanisms in a post conflict society;
4. Interrogate the future of the law in customary marital unions.

Uganda 2020-03-03 2023-03-03 Social Science and Humanities Degree Award
Jackson Mukonzo
ID: UNCST-2021-R013916
SAFETY AND EFFICAY OF DOLUTEGRAVIR AND EFV 400 FOR PREGNANT AND BREAST FEEDING WOMEN; A RANDOMISED NON INFERIORITY CLINICAL TRIAL ACRONYM: PREGART
REFNo: HS515ES

PRIMARY OBJECTIVE; to identify safer and more effective ART regimen for pregnant and breast feeding women by comparing three alternative first line ART regimens for their safety and efficacy using randomized clinical trial.

SECONDARY OBJECTIVE; To provide evidence based recommendations for safe and effective first line ART regimens for prevention of mothers to child transmission and treatment of HIV infected pregnant and breast feeding women living in resource limited setting.

Uganda 2020-02-25 2023-02-25 Medical and Health Sciences Non-degree Award
Coleen Sabatini
ID: UNCST-2019-R001321
Outcomes Following Surgical Release of Gluteal Fibrosis in Children of Eastern Uganda
REFNo: HS561ES

This study is a longitudinal case series to evaluate if surgical release of gluteal fibrosis in Ugandan children has a sustained benefit. We will examine the two-year outcomes after surgical release of gluteal fibrosis in children undergoing surgical intervention for gluteal fibrosis.

USA 2020-02-25 2023-02-25 Medical and Health Sciences Non-degree Award
NAASSON TUYIRINGIRE
ID:
Metabolomics Approaches to Elucidate the Mechanisms of Action of Antimycobacterial Medicinal Plants
REFNo: HS422ES

The main objective is to elucidate the mechanisms of action of antimycobacterial medicinal plants using metabolomics. The specific objectives are:
1. To determine the metabolome of M.tb subjected to medicinal plant extracts with antimycobacterial activity as compared to control culture
2. To optimize an analytical metabolomics workflow to facilitate reproducible measurements of bacterial metabolome with extract treatment or without the treatment
3. To elucidate the metabolic pathways affected by plant extracts
4. To identify the macromolecule targets of plant extracts

Rwanda 2020-02-21 2023-02-21 Medical and Health Sciences Degree Award
Jean Damascene Niyonsenga
ID:
Exercise and well-being: NCD risks and constraints to Physical Activity and sports participation among Ugandan rural and urban secondary school students
REFNo: HS490ES

1. To examine the correlation between NCDs risk factors and level of physical activity/sports participation, type of eaten food, and lung function among both rural and urban secondary school students in Mbarara, uganda
2. To establish constraints to PA/sports participation of secondary school students in rural and urban schools in Mbarara, Uganda.
3. To examine the relationship between internal motivation and external support for PA/sports participation for secondary school students in rural and urban schools of Mbarara, Uganda.
4. To determine the commonest sustained injuries and to establish the proportion attributable to PA/sports among rural and urban secondary school students in Mbarara, Uganda.
5. To compare constraints and injuries identified by secondary school students from rural and urban schools in Mbarara, Uganda.

Rwanda 2020-02-21 2023-02-21 Medical and Health Sciences Non-degree Award
Robert Kairania
ID:
Exploration of psychological distress and cross-cultural adaptation of a mental health measure for people living with HIV in Rakai, Uganda
REFNo: SS408ES

Aim 1: To characterize local manifestations of psychological distress among people living with HIV in rural communities in Rakai, Uganda

Aim 2: To identify and cross-culturally adapt appropriate mental health measurement instruments based on findings from Aim 1.

Aim 3: To validate the adapted mental health measurement instrument within the rural Rakai population.

Uganda 2020-02-21 2023-02-21 Social Science and Humanities Non-degree Award
Vincentina Achora
ID:
Postpartum haemorrhage in Northern Uganda: Community perspectives; burden and associated factors; Health Facilities preparedness for its management; and outcomes
REFNo: HS518ES

1. To explore the community perspectives of PPH in Lira district.
2. To assess the level of health facilities preparedness for management of labour, delivery and postnatal care in prevention of PPH in Lira district.
3. To describe the burden and factors associated with PPH among mothers delivering in Lira district and Lacor Referral hospital.
4. To describe the factors associated with outcomes of PPH among mothers delivering in Lira district and Lacor Referral hospital.

Uganda 2020-02-21 2023-02-21 Medical and Health Sciences Degree Award
Maria Nakku Elizabeth Mirembe
ID:
Women in Higher Education: An Ethnographic Case Study of Women Lecturers and Administrator Experience in Selected Universities in Uganda
REFNo: SS410ES

1. To investigate how women lecturers and administrators advance the institutional mission of teaching, scholarship, and service in selected universities in Uganda
2. To explore how the culture of higher education shape and affect women leadership
3. To examine the obstacles and challenges do women experience as lecturers and administrators in higher education
4. To assess common attributes and strategies support women’s success in higher education teaching and administration in Uganda


Uganda 2020-02-21 2023-02-21 Social Science and Humanities Degree Award
Lawrence Mugisha
ID:
Developing Monitoring System for Quantifying and Mapping Antimicrobials used in Livestock Farming Systems in Uganda
REFNo: HS538ES

1. To determine the proportions of different types of antimicrobials imported into Uganda for use in livestock production systems.
2. To determine the volumes of antimicrobial medicines imported into Uganda for use in livestock production systems.
3. To map and create an inventory of manufacturers, importers, distributors and medicine stockists of antimicrobials used in livestock production systems in Kampala, Wakiso and Mukono districts.
4. To develop an information technology (IT) monitoring system for monitoring importation, distribution and consumption of antimicrobials used in livestock production systems

Uganda 2020-02-21 2023-02-21 Medical and Health Sciences Non-degree Award
Herbert Muyinda
ID: UNCST-2019-R000373
Cango Lyec (Healing the Elephant) Study: Determining HIV Vulnerabilities and Designing Targeted Interventions to Improve Clinical outcomes among conflict affected Adolescent girls and young women under 25 in Northern Uganda
REFNo: HS521ES

1. Estimate prevalence and incidence of HIV, Hepatitis B, and syphilis, and identify associated risk factors among conflict-affected young women in Northern Uganda

2. Investigate associations between posttraumatic stress, resilience, and depression with HIV incidence among conflict-affected young women in Northern Uganda

3. Pilot feasibility and acceptability of comprehensive mHealth package to support engagement in HIV care among conflict-affected young women living with HIV in Northern Uganda

Uganda 2020-02-19 2023-02-19 Medical and Health Sciences Non-degree Award
Dathan  Byonanebye Mirembe
ID:
Impact of Mobile Health Interactive Software on Tuberculosis Treatment Outcomes: The Call for Life (CFLU-TB) Project
REFNo: HS524ES

To determine the effect of CFLU-TB on TB treatment success (treatment completion and cure rates) in patients with TB receiving care at three public health facilities in Uganda.
1. To compare TB cure rates (six months) in patients with microbiologically diagnosed TB in the intervention and control arms.
2. To compare treatment completion (six months) in patients clinically diagnosed with TB in the intervention and control arms.
3. To determine the effect of enhanced TB treatment support with CFLU-TB on retention at 2 and 6 months in patients receiving TB treatment at Kisenyi Health Center IV.
4. To assess perception of patients’ care providers (treatment buddies) and other stakeholders towards the CFLU-TB.
5. To determine the cost-effectiveness of the CFLU-TB intervention.
6. To compare adherence rates between patients in the intervention arm and control arms.
7. To determine the effect of CFLU-TB on adherence to clinic appointments.
8. To compare knowledge about TB/HIV in patients enrolled in the intervention and control arms.
9. To determine Drug-resistant TB rates in the intervention and control arms.
10. To determine the uptake of the CFLU-TB tool in patients and their care providers (treatment buddies).


Uganda 2020-02-19 2023-02-19 Medical and Health Sciences Non-degree Award
Fredrick Mutungi
ID:
CONTEXT-FITTING MOBILE SERVICES FOR MONITORING THE DELIVERY OF PUBLIC HEALTH SERVICES
REFNo: SIR20ES

1. To identify the performance indicators of mobile services for monitoring the delivery of public health services.
2. To establish the performance of existing mobile services used for monitoring the delivery of public health services.
3. To find out the contextual factors affecting the performance of mobile services for monitoring the delivery of public health services.
4. To design a model for guiding development of context-fitting mobile services for monitoring delivery of public health services.
5. To establish performance improvements anticipated with the use of context-fitting mobile services when monitoring the delivery of public health services.

Uganda 2020-02-19 2023-02-19 Engineering and Technology Degree Award
John Mark Bwanika
ID:
Utilization Of Telehealth (Tele-care) To Improve Post-Clinic Therapy For Youths with HIV and Depression- A Feasibility Study.
REFNo: HS539ES

-Design and develop mobile/web content for post-clinic telecare for young adult HIV patients with depression.

-Assess feasibility and acceptability of the telehealth intervention Package (Telecare) for depression among HIV young adult patients as well as their post-intervention self-efficacy.

Uganda 2020-02-19 2023-02-19 Medical and Health Sciences Non-degree Award
Sara Weschler Weschler
ID:
Deep Roots and Bitter Greens: Legacies of Colonial-Era Forced Displacement in Western Acholiland
REFNo: SS419ES

For my Master’s thesis research I studied the way British colonial officials used Sleeping Sickness control measures to justify the forced relocation of the entire population of western Acholiland between 1911 and 1920. For my PhD dissertation research, I will use qualitative interview methods to explore how the history of this early colonial-era forced displacement is remembered and understood in Acholiland today. I intend to examine what sorts of socio-cultural changes colonial-era displacement precipitated in Acholiland. At the same time, though, I hope to trace examples of cultural resilience and examine how Acholi culture and society recovered from these upheavals over the course of the intervening century.
USA 2020-02-19 2023-02-19 Social Science and Humanities Degree Award
Ian Munabi G
ID:
Birth related brain injury in Ugandan full term neonates
REFNo: HS551ES

Objective 1: To determine the association between foetal head moulding and hypoxic ischemic encephalopathy following spontaneous vaginal delivery.

Secondary objective:
Objective 2a: To determine the foetal factors (including foetal weight, infections, head circumference and birth order), associated with hypoxic ischemic encephalopathy following spontaneous vaginal delivery with foetal head moulding

Objective 2b: To determine the maternal factors (including maternal body mass, dietary patterns, gut microbiome, parity, social economic status and birth experience), associated with hypoxic ischemic encephalopathy following spontaneous vaginal delivery with foetal head moulding
Uganda 2020-02-19 2023-02-19 Medical and Health Sciences Non-degree Award
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