Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Christine Nalwadda Kayemba
ID: UNCST-2020-R014220
 Understanding Leadership and Accountability mechanisms in delivering a responsive Maternal and Newborn care in a decentralized health system, Uganda: Lessons for SRHS improvement
REFNo: HS1024ES

Broad objective:

The main objective of this study is to assess leadership and accountability mechanisms for maternal and newborn health in decentralized health systems in Uganda in order to formulate a theory of change for delivering an efficient health services for maternal and newborn health


Specific Objective:

1.Review existing health systems policies in order to highlight leadership and accountability guidelines/policies for maternal and newborn health
2.Explore health systems managers’ understanding and interpretation of leadership and accountability guidelines/policy directives for maternal and newborn health
3.Describe how decentralized health systems managers adapt and implement leadership and accountability policies in maternal and newborn health

 Uganda 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
Warren Phipps
ID:
Attitudes and Practices of Antimicrobial Resistance and Stewardship at the Uganda Cancer Institute
REFNo: HS871ES

We will investigate the knowledge, attitudes, and practices about antimicrobial use and antimicrobial resistance among the doctors (including medical officers, fellows, oncologists, and surgeons), nurses, and pharmacists at the Uganda Cancer Institute (UCI).

The aims of the study are;
Aim 1: To examine the current knowledge and attitudes of UCI healthcare providers towards antimicrobial resistance.
Aim 2: To determine the current knowledge and attitudes of UCI healthcare providers towards antimicrobial stewardship.
Aim 3: To understand perceived barriers to the diagnosis and management of infections in patients at UCI

USA 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
Jennifer Serwanga
ID: UNCST-2024-R002056
 Characterising the Global Immune Response to SARS-CoV-2 in COVID-19 Acutely Infected and Recovered Ugandans
REFNo: HS997ES

To describe the frequencies and phenotypes of SARS-CoV2 induced immune
responses in qrt-PCR COVID-19 confirmed Ugandan cases.
b) To describe the evolution and durability of the induced responses.
c) To describe factors associated with COVID-19 disease outcome.
d) To isolate and clone SARS-CoV-2 spike specific human monoclonal antibodies with
potent virus neutralising capabilities
 Uganda 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
David Musoke
ID:
A feasibility study for a randomised controlled trial on integrated malaria prevention in Wakiso district, Uganda
REFNo: HS999ES

1. To explore community willingness to participate in an RCT on integrated malaria prevention.
2. To assess stakeholder perspectives on the RCT on integrated malaria prevention.

Uganda 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
David Musoke
ID:
Use of Photovoice to explore community members perspectives on health and healthcare challenges in Mukono District, Uganda
REFNo: HS1058ES

To use photovoice as a community-based participatory research method to explore healthcare delivery including barriers and challenges in Mukono district so as to provide information to inform future research and interventions to improve health of the community.
Uganda 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
ALEX NDYABAKIRA
ID:
Durability monitoring of Long Lasting Insecticidal Nets in Uganda, distributed during the 2020 mass campaign
REFNo: HS1109ES

Primary objective
1.To assess the physical durability of 5 different brands of nets over a three-year period, estimate median LLIN survival and identify major determinants of field performance
Secondary objectives
1. To describe major behavioral aspects of net care and repair and their impact on physical durability
2. To assess the insecticidal effectiveness (bio-efficacy) and chemical residue of 5 ITN brands during three years of field use

 Uganda 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
Philippa Musoke
ID: UNCST-2021-R013523
 Clinical manifestations and Outcomes of SARS-CoV-2 Infection in pregnancy in Africa: Novel Insights from the Democratic Republic of the Congo, Ghana, Kenya, Nigeria, South Africa and Uganda (AFRE-Mom-CoV-19) protocol
REFNo: HS1164ES

To retrospectively investigate the socio-demographic and clinical characteristics and maternal/infant outcomes of pregnant patients with RT-PCR-confirmed SARS‐CoV‐2 infection in six west, east, central and southern African countries: DRC, Ghana, Kenya, Nigeria, South Africa and Uganda.
Uganda 2021-01-22 2024-01-22 Medical and Health Sciences Non-degree Award
Amon Nuwahereza
ID: UNCST-2022-R011428
 Ride and Arrive Safe (RAS). A Case study of Mbarara Municipality
REFNo: HS577ES

i. To explore the feasibility of the community facilitation and engagement approach in equipping the Boda-boda cyclists with safety riding knowledge and skills.
ii. To develop a Boda-boda safety user check the mobile application for passengers using Boda-boda a means of transport
iii. To evaluate the effect of Boda-boda cyclist training and community engagement in reducing the number of Boda-boda road traffic accident-related admissions at Mbarara Regional Referral Hospital.

 Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Denis  Bwayo
ID:
Program Assessment and Implementation Learning for the University Research Co., LLC - Department of Defense HIV Prevention Program – Uganda
REFNo: HS959ES

1.To determine compliance to program set targets for the URC-DHAPP program between October 2018 and September 2021
2.To assess the quality of HIV services delivered at 28 UPDF HIV clinics
3.To determine program outcomes across key program implementation strands in line with 95:95:95 frameworks
4.To share implementation experiences across key program implementation strands including HIV testing, ART services, TB diagnosis and management, PMTCT, OVC and systems strengthening.

 Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Kamya Moses
ID: UNCST-2020-R014203
 ENHANCED ENTOMOLOGICAL SURVEILLANCE(EES) TO INFORM MALARIA CONTROL IN UGANDA
REFNo: HS1059ES

1. To examine the impact of current vector control interventions on malaria vector densities, vector behaviour, and species composition.
2. To monitor the status and intensity of insecticide resistance.
3. To establish the entomological inoculation rates in the selected districts.
4. To build the capacity of districts to conduct routine entomological surveillance

 Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Philippa Musoke
ID: UNCST-2021-R013523
 Manifestations and Outcomes of Hospitalized African children and Adolescents with SARS-CoV-2 Infection: Insights from the Democratic Republic of the Congo, Ghana, Kenya, Nigeria, South Africa and Uganda (AFRE-Ped-CoV-19) protocol Version November 06 2020. Grant No. 1R25TW011217-01
REFNo: HS1168ES

Study Aims

a) To describe the socio-demographic features; clinical WHO COVID-19 staging at admission, clinical characteristics, laboratory features including inflammatory and
cardiac markers; imaging investigations and associated abnormalities, treatments applied; and comparisons within and across participating African countries.
b) To estimate the prevalence of comorbidities at presentation and recent/current treatment with immunosuppressive drugs and comparisons within and across
participating African countries.
c) To estimate the prevalence of associated tuberculosis (past, current), HIV status (HIV-exposed uninfected or HIV-infected, and type of treatment if HIV-infected), malaria, bacterial infections influenza and other viral infections and comparisons within and
across participating African countries.
d) To assess overall mortality and independent factors associated with mortality and comparisons within and across participating African countries.

 Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Grace Ndeezi
ID: UNCST-2019-R001802
 A Phase 2b Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease IMR-SCD-301
REFNo: HS1130ES

Primary Objectives
To evaluate the HbF response to IMR-687 versus placebo
To evaluate the safety of IMR-687 versus placebo
Secondary Efficacy Objectives
To evaluate the effect of IMR-687 versus placebo on HbF-associated biomarkers
To evaluate the effect of IMR-687 versus placebo on indices of red cell hemolysis
To evaluate the effect of IMR-687 versus placebo on indices of WBC adhesion
To evaluate the effect of IMR-687 versus placebo on the incidence of VOCs
To evaluate the effect of IMR-687 versus placebo on quality of life (QoL) measures

Pharmacokinetic Objectives
To evaluate the PK of IMR-687 and any major circulating metabolites
Exploratory Efficacy Objectives
To evaluate the effect of IMR-687 versus placebo on changes in RBC characteristics and total Hb
To evaluate the effect of IMR-687 versus placebo on renal function
To evaluate the effect of IMR-687 versus placebo on indices associated with cardiovascular pathophysiology and ischemic stroke risk

Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
FRED SEMITALA COLLINS
ID: UNCST-2020-R014096
 Strengthening Integrated Screening for TB and COVID19 in Kampala, Uganda
REFNo: HS1152ES

The overall goal is to establish the acceptability, feasibility and potential for scaling up the use of COVID19-TB Screening algorithm at Kiruddu National Referral Hospital.
Specific objectives

(1) To explore the perspectives of healthcare providers on the integration of COVID19 and TB screening at Kiruddu National referral Hospital.
(2) To determine the effect of the COVID19-TB algorithm on the proportion of patients screened for TB at Kiruddu National Referral Hospital over a 4-month period.

 Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Kirsten Beyer M
ID: UNCST-2021-R013472
 Assessing Health Professionals’ Knowledge, Perspectives and Practices Regarding HPV and Cervical Cancer Prevention and Control among Women Living with Human Immunodeficiency Virus Infection in Uganda
REFNo: HS782ES

General Objective The proposed study seeks to examine the role that health professionals play in influencing WHIVs’ perceptions of HPV and cervical cancer and their associated health behaviors in Uganda.

Specific Objective
Interview public health and health care professionals (including clinicians, nurses, counselors, other/public health professionals, and community health workers/village health teams) to examine the following:
1. Knowledge regarding how HPV or cervical cancer impacts WHIV, which populations are impacted most, and frequency of HPV vaccination, screening and treatment. 2. Perspectives regarding barriers/facilitators of cervical cancer and HPV prevention and treatment among WHIV. 3. Practices regarding HIV professionals’ work in cervical cancer and HPV.
USA 2021-01-20 2024-01-20 Medical and Health Sciences Non-degree Award
Emmanuel Sendaula
ID: UNCST-2020-R014767
 Clinical profile of HIV-infected patients receiving a holistic approach of care model attending Reach Out Mbuya facilities in Kampala district
REFNo: HS903ES

Main Objective

To describe the clinical profile and the factors associated with viral suppression status among HIV-infected patients receiving a holistic approach of care model in Kampala District.
Specific objectives

1. To describe the clinical profile of HIV-infected patients receiving a holistic model of care in Kampala District.
2. To determine the socio-demographic factors associated with viral suppression status among HIV-infected patients receiving a holistic model of care in Kampala District.
3. To determine the clinical factors associated with viral suppression status among HIV-infected patients receiving a holistic model of care in Kampala District.

 Uganda 2021-01-20 2024-01-20 Medical and Health Sciences Non-degree Award
FRANK MULINDWA
ID:
Glucose metabolism changes in HIV patients starting dolutegravir based antiretroviral treatment in Uganda
REFNo: HS1032ES

1) To determine the incidence and predictors of diabetes at week 48 in Ugandan HIV patients initiating dolutegravir.
2) To describe temporal changes in insulin resistance, pancreatic beta cell function, body mass index and blood glucose in Ugandan HIV patients on dolutegravir for 48 weeks.
3) To determine the effect of DTG on intracellular magnesium levels in Ugandan HIV patients on dolutegravir for 48 weeks.
4) To compare insulin kinetics in patients who develop diabetes while on dolutegravir and those that don’t in Ugandan HIV patients.
5) To determine the difference in DTG pharmacokinetics in HIV positive patients with incident hyperglycemia and those without in Ugandan HIV patients.

 Uganda 2021-01-20 2024-01-20 Medical and Health Sciences Non-degree Award
Proscovia Nabunya
ID: UNCST-2019-R000970
 SAY NO TO STIGMA”: Making Mental Health Visible Among School-Going Children in Rural Uganda
REFNo: SS637ES

The objective of this proposed study is to develop a set of new age-appropriate, culturally relevant signage and messaging around mental health and stigma for this study. The visual solutions will be developed through a set of extensive hands-on creative workshops and focus groups with children as well as school administrators and teachers working in one primary school in the Masaka region of Uganda. After visual and message development, the visuals will be presented to a different group of students within the school to gather feedback on their effectiveness and clarity in portraying mental health and stigma.
 Uganda 2021-01-20 2024-01-20 Social Science and Humanities Non-degree Award
Polycarp Komakech
ID:
Incentivizing Action to Reduce Air Pollution and Susceptibility to COVID-19
REFNo: SS667ES

The main objective is to investigate a number of practical and scalable strategies to reduce waste burning through voluntary behavioral change and thereby reduce the exposure of residents to harmful air pollution. The specific objectives are (a) to investigate whether the provision of information about the link between air pollution and the chances of contracting and dying from COVID-19 can spur action to stop waste burning, (b) to test the efficacy of a novel design where social competition that is not imposed top-down but is organized horizontally can help leaders to organize communities for positive action towards reducing waste burning.
Uganda 2021-01-20 2024-01-20 Social Science and Humanities Non-degree Award
SHAFIC MAKUMBI
ID:
Voluntary Consent to Research on Children: A sub-study of the CHAPAS-4 and ODYSSEY Trial
REFNo: SS677ES

1.2 Overall objective
The aim of this study is to assess parental perception of voluntariness of consent in Paediatric HIV clinical trials and associated factors.

1.4 Specific objectives
1.4.1. To describe the process in which parents and guardians consent for their children to be enrolled in two pediatric HIV Clinical Trials.
1.4.2. To measure the level of perceived voluntariness of consent using the voluntariness ladder
1.4.3. To identify the social demographic, situational and external control factors that influence parental perception of the voluntariness of their consent

 Uganda 2021-01-20 2024-01-20 Social Science and Humanities Degree Award
Rhoda Wanyenze
ID: UNCST-2021-R013352
 Impact of Masks on Community Spread of COVID-19: Evidence from Uganda
REFNo: HS1124ES

2.1 General Objective

The aim of this study is to provide policy makers with the first population-based estimate of the extent to which face coverings reduce the spread of SARS-CoV-2. We also intend to provide evidence to the Ministry of Health in Uganda (and public health officials more generally) with evidence about effective communication and education tools for increasing the proper use of masks in the general population.


2.2 Specific Aims

The specific objectives of our study are as follows:

Aim 1: To test whether free mask distribution increases the proper use of masks in intervention communities
Aim 2: To test whether combining free mask distribution with education and communication about masks and COVID-19 increases the proper use of masks in intervention communities Aim 3: To evaluate whether increased mask use affects seroprevalence of SARS-CoV-2
Aim 4: To evaluate potential spillovers, or whether higher mask use in intervention communities affect mask use and probability of infection in neighboring non-intervention communities

 Uganda 2021-01-20 2024-01-20 Medical and Health Sciences Non-degree Award
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