Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Lwanga  Jonathan
ID:
Prediction modelling for Infectious Diseases and Outbreak prevention
REFNo: HS473ES

To determine patterns of flow of outbreaks
 Uganda 2019-09-26 2022-09-26 Medical and Health Sciences Non-degree Award
Serawit Chorito Deyno
ID:
ANTIBACTERIAL EFFECT AND SAFETY OF ESSENTIAL OIL FROM ECHINOPS KEBERICHO
REFNo: HS398ES

1.3. Objective of the study
Major objective
• To evaluate the antibacterial effect and safety of EO from E. Kebericho
Specific objectives
1. To identify and isolate main components of the EO from E. kebericho
2. To determine antibacterial activity of EO and its combined effect with existing antibiotics against S. aureus and P. aeruginosa
3. To determine antibacterial activity of main constituent of EO and its combined effect with existing antibiotics against S. aureus and P. aeruginosa
4. To examine acute and sub-acute toxicity of the EO from E. kebericho

 Ethiopia 2019-09-19 2022-09-19 Medical and Health Sciences Degree Award
Heather Brown
ID:
Evaluating the Impact of a Layperson EMS System on Morbidity and Mortality of Injured Patients in Masindi, Uganda
REFNo: HS414ES

The purpose of this study is to evaluate the effectiveness of a pilot layperson EMS system for commercial boda drivers and the feasibility of using a pre-existing trauma registry to evaluate the outcomes of these patients.

Primary Objective:

Evaluate the impact of a boda driver EMS system on time to presentation for ill and injured patients.

Secondary Objectives:

1. Evaluate the purpose and rate of utilization for a lay person EMS system in Masindi, Uganda.

2. Evaluate the impact of a lay person EMS system on patient morbidity and mortality at MKMC.

USA 2019-09-19 2022-09-19 Medical and Health Sciences Non-degree Award
Sona Shah
ID:
Validation of the safety and performance of a clinical vital signs monitor on infants and neonates: A pilot study
REFNo: HS420ES

1. To assess the safety of the Neopenda wearable vital signs monitor (neoGuard) in healthy infants (aged 8 to 16 weeks) and stable neonates (aged 0-28 days)
2. To determine the performance accuracy of neoGuard device in comparison to a gold standard monitor comparable to the Edan M3A Vital Signs Monitor

USA 2019-09-19 2022-09-19 Medical and Health Sciences Non-degree Award
Mary Namubiru
ID:
Meet Your Future Job Search Effort and Aspirations of Young Jobseekers
REFNo: SS338ES

Jobseekers in developing contexts face a number of search barriers to quality employment. The most recurring ones in the literature range from liquidity constraints for travel costs (Abebe et al. 2017a) to high opportunity cost of search-time due to job availability in the informal sector (Franklin, 2017). In addition to these, young jobseekers often do not know how or where to search for jobs, might not understand their skills in relation to what employers want and are likely to have distorted expectations of wage levels and working conditions (Babcock et al. 2012). Importantly, these barriers are magnified right in the most vulnerable phase of a career: the transition into the labor market (Becker 1994, Pissarides 1994). This study seeks to investigate (i) how barriers in access to information affect search efforts, labor outcomes and aspirations of young jobseekers taking their first step in the job market, (ii) how can career-coaching and job search assistance from “the future you” help influencing their expectations and labor market trajectories and (iii) how does the trainees’ degree of identification with “the future you” affect the way in which they interpret somebody else’s experience with respect to their own future. The experimental setting is that of Vocational Training Institutes (VTIs) in Uganda and “the future you” is an alumnus of the VTI, who successfully entered the labor market after receiving the training.
 Uganda 2019-09-19 2022-09-19 Social Science and Humanities Non-degree Award
Wyatt Brooks James
ID:
Community Lending and Outside Capital (CLOC)
REFNo: SS339ES

To measure the impact of community lending and outside capital on SILC members’ returns and default rate behavior, levels of liquid savings, and change in livelihood.
USA 2019-09-19 2022-09-19 Social Science and Humanities Non-degree Award
Fabien Schultz
ID: UNCST-2023-R008622
 Self-medication in wild chimpanzees and mountain gorillas
REFNo: NS104ES

Observation of novel medicinal plants used for self-medication by wild chimpanzees and mountain gorillas:
The fieldwork at the field stations in Bulindi, Kibale Forest National Park, Budongo Forest Reserve, and Bwindi Impenetrable National Park will result in the documentation of potentially novel medicinal plant species used by great apes in Uganda, which will be reported in our publications.

Comparison between self-medication behavior in chimpanzees at different locations:
The study will generate a comparison between plants and self-medication techniques used by Bulindi chimpanzees (a highly disturbed habitat shared with humans) and Kibale/Budongo chimpanzees (less disturbed habitats).

Impact on modern medicine:
Through this study, we seek to integrate behavioral data with novel pharmacological screenings of plants. Without doubt, the evolution of self-medicative habits from the great apes to early hominids and modern humans has important implications for modern medicine. This project would significantly advance previous research on zoopharmacognosy (or “ape-pharmacognosy”).

Discovery of new plant and insect species and first-time pharmacological investigation of medicinal natural remedies:
I estimate that around 60% of all plant and insect species in the dense rainforests of Western Uganda and Eastern Democratic Republic of Congo remain undiscovered. As such, this project could result in the discovery of novel species, but most likely in the documentation and evaluation of novel medicinal uses in known plants. The majority of plant species used in self-medication by wild chimpanzees and mountain gorillas in the tropical rainforests of Uganda have never been screened for pharmacological activity in a lab or investigated with regard to their chemical composition.

Conservation of biodiversity:
Wild mountain gorillas are classified as Critically Endangered and chimpanzees as Endangered by the International Union for Conservation of Nature. Both great apes are highly threatened by human encroachment, forest degradation, regional political instability and disease. Through our workshop within local communities, we aim to raise awareness of the importance of protecting these creatures as well as local medicinal plants.


Germany 2019-09-19 2022-09-19 Natural Sciences Non-degree Award
Christine  Wiltshire Sekaggya
ID: UNCST-2019-R000578
 The utility of urine Lipoarabinomannan as a Tuberculosis treatment monitoring tool.
REFNo: HS432ES

To describe the temporal changes of urine LAM during the first 2 months TB treatment of TB-HIV co-infected patients.
To determine the correlation between urine LAM and microbiological response measured by sputum culture among TB-HIV co-infected patients receiving anti-TB treatment.

 Uganda 2019-09-10 2022-09-10 Medical and Health Sciences Non-degree Award
Richard Muwanika
ID:
DEFINING DIAGNOSTIC PERFORMANCE, ANALYTICAL AND OPERATIONAL SUITABILITY FOR POINT OF CARE DEVICES FOR HEMOGLOBIN ESTIMATION DEVICES IN ROUTINE HIV AND MATERNITY CARE IN UGANDA
REFNo: HS437ES

1) To evaluate the analytical performance (accuracy and precision/repeatability) of the available non-investigational Hb POC devices in use in Uganda
2) To evaluate the diagnostic performance (sensitivity, specificity, Positive and Negative Predictive values) of the available Hb POC devices in Uganda
3) To evaluate the operational suitability of the available Hb POC devices in Uganda using a standardized scorecard
4) To determine the operational cost and cost-effectiveness of the available Hb POC devices in Uganda

 Uganda 2019-09-10 2022-09-10 Medical and Health Sciences Non-degree Award
Dunstan Kalanzi
ID:
EXPLORING THE ASSOCIATION BETWEEN PERIODONTAL DISEASE AND THE RISK OF ALZHEIMER’S DISEASE AND RELATED DEMENTIAS: A COMPARATIVE STUDY
REFNo: HS438ES

To determine the periodontal health status of a community-based cohort of elderly persons and factors associated with Alzheimer’s disease and related dementias in Uganda
 Uganda 2019-09-10 2022-09-10 Medical and Health Sciences Non-degree Award
EDITH  NAKKU-JOLOBA NAKKU
ID: UNCST-2021-R013931
 Performance of a novel, rapid Neisseria gonorrhoeae genotypic and phenotypic test and estimation of prevalence of 4 STI in a gonococcal surveillance program in Uganda
REFNo: HS455ES

Primary:
• To determine the accuracy (correlation, sensitivity, specificity) of a new mobile, dual purpose gonorrhea point-of-care (POC) STI test device [the Mobile NAAT (MobiNAAT)] against reference laboratory methods for diagnosis (Gram stain and/or culture).

Secondary:
• To determine agreement between self-collected meatal swabs and urine samples for the diagnosis of STI using a gold standard NAATs in Ugandan men (a population with high NG positivity).
• To assess acceptability of self-collected tests in men with UDS in Uganda.
• To validate MobiNAAT for gonorrhoea ciprofloxacin AMR in symptomatic men compared with gold standard (culture & disk diffusion).
• To estimate the prevalence of the following 4 STIs in a population of men with UDS: Chlamydia trachomatis (CT), Neisseria gonorrhoea (NG), Trichomonas vaginalis (TV), and Mycoplasma genitalium (MG) using NAATs.
• To compare sensitivity and specificity of GC NAAT with microscopy and culture in Ugandan samples.
• To assess the prevalence of HIV, syphilis and viral hepatitis, and compare HIV result to self-reported HIV status.
• To explore socio-demographic, behavioural and clinical factors associated with positive STI diagnosis (including NG NAAT-positive and NG culture-negative status).
• Determine the proportion of non-reportable results (unresolved, indeterminate and incomplete).
• Test other STI diagnostics in future on available samples.

Uganda 2019-09-10 2022-09-10 Medical and Health Sciences Non-degree Award
David Meya Bisagaya
ID: UNCST-2019-R000837
 High Dose Oral Rifampicin to Improve Survival from Adult Tuberculous Meningitis: A Double-blinded Randomised Controlled Phase III Trial. HARVEST trial
REFNo: HS428ES

Our primary objective is: To determine if high dose rifampicin, delivered orally at ~35 mg/kg/day for 8 weeks, is safe and improves 6-month survival compared to standard of care (rifampicin 10 mg/kg/day) for patients with TBM.
Secondary objectives are to compare the high dose rifampicin regimen to the standard of care regimen for:
1. 12-month survival
2. Neurological disability and functional outcomes from TBM
3. Safety and tolerability
4. Hospital outcomes related to TBM
5. Subsequent neurologic deterioration
6. Management of drug-induced liver injury
Tertiary objectives are to:
1. To describe the pharmacokinetics (PK) of high dose rifampicin in plasma and CSF, assess predictors of exposure to rifampicin in plasma and CSF, assess PK-PD relationships also considering exposures to the other first-line TB drugs and ART in HIV-infected patients, and determine the minimally desired rifampicin exposure for optimal treatment of TBM.
2. To determine the cost-effectiveness of the intervention.
3. To determine appropriate TBM diagnostic algorithms

Uganda 2019-09-05 2022-09-05 Medical and Health Sciences Non-degree Award
Kevin Hunt Dean
ID:
DRY HABITAT CHIMPANZEE ECOLOGY: IMPLICATIONS FOR HUMAN EVOLUTION
REFNo: NS101ES

Document feeding, social and locomotor behavior using 1-minute focal observations. Record food items, ranging behavior, canopy use, feeding rate and habitat use. Collect hairs for trace element analysis. Collect skeletal material from any deceased individuals. Analyze skeletal material for distinctive characteristics. Analyse hormone profiles to determine if lower levels of aggression are due to low T levels. Look for poisons in Muguri River to find source of sex organ abnormalities. Examine dental micro wear and trace elements in hair to determine diet. Look at genetic variations
 USA 2019-09-05 2022-09-05 Natural Sciences Non-degree Award
Sangjin Kang
ID:
Establishment of libraries of indigenous medicinal plants in Mount Elgon area
REFNo: NS86ES

To conserve knowledge and resources about indigenous medicinal plants in Mt. Elgon area through activities such as;

 Republic of Korea Reunion 2019-08-27 2022-08-27 Natural Sciences Non-degree Award
Mushagalusa Kasali Félicien Kasali
ID:
Phytochemical and Pharmacological Study of Chenopodium ambrosioides L. and Physalis peruviana L., herbs used to treat diabetes in Congolese Traditional Medicine
REFNo: HS440ES

1. To test the activity of the bioguided fractions of the extracts obtained in-vivo, on acute, sub-acute and chronic hyperglycemia in experimental rats.
2. To determine the zootechnical, biochemical and histopathological markers of the extracts obtained in experimental rats.
3. To isolate and elucidate the structure of the bioactive components of the extracts obtained.

 Democratic Republic of Congo 2019-08-27 2022-08-27 Medical and Health Sciences Degree Award
Zubair Lukyamuzi
ID: UNCST-2021-R013107
 THE ROLE OF COMMUNITY HEALTH WORKERS IN FACILITATING DISCLOSURE AMONG HIV AFFECTED COUPLES IN GREATER LUWEERO DISTRICT, UGANDA.
REFNo: HS443ES

1. To determine the predictors of non-disclosure among HIV affected couples
2. To document perceptions of HIV affected couples on using CHWs to facilitate their HIV status disclosure
3. To explore CHW’s general and attitudes about HIV status disclosure among HIV affected couples
4. To explore CHW’s experience in facilitating disclosure among HIV affected couples.
5. To determine the proportion of HIV status disclosure among HIV affected couples that can be achieved using CHWs

 Uganda 2019-08-26 2022-08-26 Medical and Health Sciences Degree Award
Christa Kuntzelman Marie
ID:
Refugee Perceptions of their Rights in Uganda
REFNo: SS305ES

The purpose of this study is to learn (a) learn what rights refugees believe they have in Uganda; (b) learn how refugees understand the roles and responsibilities of the Ugandan Government, UNHCR, InterAid, and other NGOs (non-governmental organizations) to provide for refugees in the cities and in the settlements, (c) gain understanding of to whom refugees turn when they need assistance, and (d) understand the role of refugee-led organizations to support other refugees for learning rights or gaining assistance.
 USA 2019-08-20 2022-08-20 Social Science and Humanities Degree Award
Teddy  Kyomuhangi
ID:
Using Digital Stories for Knowledge Translation in Rural South Western Uganda
REFNo: SS318ES

The main objectives of the study are to document evidence-based digital storytelling methods and enhance local capacity to create and disseminate digital stories for knowledge translation in rural southwest Uganda by: 1.Documenting the DST training process so as to contribute towards establishing a model-site offering ongoing mentorship in DST research methodology. 2.Describing experiences of trainees in using DST as a means of disseminating research findings.
 Uganda 2019-08-20 2022-08-20 Social Science and Humanities Non-degree Award
Andrew Mujugira
ID: UNCST-2019-R000871
 Understanding barriers and motivators to HIV self-testing uptake and clinic linkage among male partners of pregnant women in Uganda
REFNo: HS391ES

Aim 1: To qualitatively elucidate men and women’s personal narratives explaining beliefs, motivations, barriers and experiences influencing clinic HIV testing and linkage to HIV services.

Aim 2: To qualitatively identify attributes of a successful HIVST intervention to increase men’s HIVST uptake and clinic attendance after HIV self-testing. We will assess men and women’s knowledge/perceptions of HIVST and acceptability of strategies to optimize secondary distribution of HIVST from female partners.

Aim 3: To assess healthcare workers perspectives regarding the feasibility and acceptability of potential strategies of secondary distribution of HIVST from pregnant women to their male partners.
Uganda 2019-08-20 2022-08-20 Medical and Health Sciences Non-degree Award
Jorem Awadu Emmillian
ID:
Validation of autism screening assessments: Comparison of the Social Communication Questionnaire, Social Responsiveness Scale and 23-Q with DSM- 5 in assessing for autism spectrum disorder (ASD) in Uganda
REFNo: HS423ES

The study seeks to answer the questions below.
1) In the Ugandan context, do total scores for the three ASD measures (i.e., SCQ, SRS-2, and 23-Q) yield adequate internal consistency relative to values reported in the test manual or available studies for those with ASD?
2) In the Ugandan context, do total scores for the three ASD measures (i.e., SCQ, SRS-2, and 23-Q) yield adequate internal consistency relative to values reported in the test manual or available studies for non-ASD cases?
3) In the Ugandan context, do total scores from the three measures (i.e., SCQ, SRS-2, and 23-Q) yield substantial mean differences consistent with construct-related (i.e., ASD construct) differentiation between ASD and typically-developing groups?
4) In the Ugandan context, will use of the recommended screening cut scores for each of the three measures (i.e., SCQ, SRS-2, and 23-Q) result in adequate sensitivity and specificity using DSM-5 ASD diagnosis vs. typically developing cases as the outcome variable?
5) Beyond the recommended cut scores for screening reported in each test manual, are there more optimal cut scores for each of the three measures (i.e., SCQ, SRS-2, and 23-Q) in the Ugandan context?
6) Are there significant convergent relationships among the total scores of the three measures (i.e., SCQ, SRS-2, and 23-Q) in the Ugandan context?

 Uganda 2019-08-20 2022-08-20 Medical and Health Sciences Degree Award
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