Christine Wiltshire Sekaggya
ID: UNCST-2019-R000578
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A phase II trial to describe the pharmacokinetics, safety and efficacy of pharmacogenetics-guided dosing of isoniazid in patients with HIV-associated TB
REFNo: HS1159ES
• To describe the pharmacokinetics of isoniazid, given at a higher dose (10mg/kg) among patients with fast or intermediate NAT2 acetylator status and a standard dose (5mg/kg) among patients with slow NAT2 acetylator status, among patients with HIV and drug sensitive TB.
• To investigate the safety of pharmacogenetically-determined isoniazid dosing among TB-HIV co-infected patients with drug sensitive TB.
• To explore the efficacy of isoniazid among TB-HIV co-infected patients with drug sensitive TB receiving pharmacogenetically-determined dosing, using pharmacokinetic – pharmacodynamic (PK-PD) models.
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Uganda |
2021-02-24 |
2024-02-24 |
Medical and Health Sciences |
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Non-degree Award |
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Olive Kobusingye Chifefe
ID:
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Observational Studies on Helmet Use, Speeding, Seat-Belt and Child Restraint in Kampala, Uganda
REFNo: HS1178ES
Main objective:
To establish the prevalence of road traffic crash severity risk factors in Kampala city namely speed, use of helmet use, seat-belt use, and drink- driving to generate evidence that can be used to inform policy and implementation strategies to promote road safety.
Specific objectives:
1. To assess the prevalence of seat-belt use and child restraint use among car occupants in Kampala.
2. To determine the prevalence of helmet use among motorcyclists in Kampala
3. To establish the prevalence and extent of speeding in Kampala
4. To determine the level of drink-driving in Kampala
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Uganda |
2021-02-24 |
2024-02-24 |
Medical and Health Sciences |
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Non-degree Award |
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Karugahe Wilber
ID:
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Identifying psychosocial impact of COVID-19 and promising practices for meeting the mental health and protection needs to SGBV of vulnerable populations during a protracted crisis in Kampala Slums
REFNo: SS721ES
1. Identification of psychosocial and mental health issues/problems for potential SGBV victims as a result of COVID-19 pandemic.
2. To examine the relationship that exists between psychosocial and mental health issues, Sexual Gender based violence and Coping strategies among potential SGBV victims.
3. Identify the coping strategies to help potential SGBV victims to improve their mental health, avoid prevent its occurrence or re-occurrence.
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Uganda |
2021-02-24 |
2024-02-24 |
Social Science and Humanities |
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Non-degree Award |
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Mohammed Lamorde
ID: UNCST-2019-R001293
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COVID-19 in people living with HIV: Evaluation of risk factors and outcomes in resource-limited settings
REFNo: HS1192ES
To characterize the clinical features and course of symptomatic COVID-19 in PLWH, described overall and by HIV and comorbid disease factors including pregnancy status
|
Nigeria |
2021-02-24 |
2024-02-24 |
Medical and Health Sciences |
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Non-degree Award |
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Dorothy Nalweyiso Irene
ID:
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Enhancing Ugandan undergraduate healthcare students’ application of evidence into practice through the development and evaluation of an Evidence-Based Practice Education Package
REFNo: HS1246ES
The main objective of the study is to determine the impact of an Evidence Based Practice (EBP) educational Package on the knowledge, skills, attitudes and behavior among undergraduate healthcare students in Uganda.
Specific objectives of the study:
i) To assess of the current literature regarding the present approaches for teaching EBP among undergraduate healthcare students.
ii) To explore the views and experiences of lecturers regarding the training and use of EBP in health practice.
iii) To assess the perceived knowledge, skills, attitudes and behaviour of EBP among undergraduate healthcare students before implementation the educational package.
iv) To develop an Evidence Based Practice (EBP) educational package for Ugandan undergraduate health care professionals.
v) To implement an Evidence Based Practice educational package among undergraduate healthcare students at Makerere university college of health sciences
vi) To compare the perceived knowledge, skills, attitudes and behaviour of EBP among undergraduate healthcare professional students before and after implementation of the educational package
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Uganda |
2021-02-24 |
2024-02-24 |
Medical and Health Sciences |
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Degree Award |
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Cissy Kityo
ID: UNCST-2021-R013663
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Ankle-Brachial Index Screening for Peripheral Artery Disease in Uganda: Building a Training Model and Exploring the Feasibility and Acceptability of Implementation Strategies, Version Date: September 30, 2020
REFNo: HS1028ES
General Objective;
The long-term goal of the project will be to provide insights into the barriers and facilitators of implementing PAD screening interventions in resource-poor settings. Early detection of subclinical cardiovascular disease—including PAD—may be a personalized and cost-effective way to reduce cardiovascular disease burden in low- and middle-income countries worldwide.
Specific aims;
-Assess knowledge of cardiovascular risk and subclinical disease
-Estimate the percentage of participants achieving competency in ABI screening techniques after receiving basic training
-Determine the perceived acceptability and feasibility of a PAD screening implementation strategy within the community
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Uganda |
2021-02-22 |
2024-02-22 |
Medical and Health Sciences |
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Non-degree Award |
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Obed Mugisha
ID:
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USING REDUCED DOSES OF INTRAVENOUS NEOSTIGMINE/GLYCOPYRROLATE TO REDUCE ITS SIDE EFFECTS IN THE MANAGEMENT OF POST-DURAL PUNCTURE HEADACHE AT MBARARA REGIONAL REFERRAL HOSPITAL: A SINGLE-BLIND RANDOMIZED DOSE-FINDING STUDY
REFNo: HS1075ES
General Objective
To assess the role of Neostigmine/Glycopyrrolate combination dose reduction on the incidence of its associated side effects in the management of PDPH in obstetric post-operative patients at Mbarara Regional Referral Hospital.
Specific Objectives
1. To compare pain scores for PDPH in the three Neostigmine treatment groups (20, 10, and 5mcg/kg).
2. To compare the incidence of Neostigmine/Glycopyrrolate side effects in the standard dose group (20mcg/kg) with the reduced dose groups(10mcg/kg and 5mcg/kg).
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Uganda |
2021-02-22 |
2024-02-22 |
Medical and Health Sciences |
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Degree Award |
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Immaculate Atukunda
ID: UNCST-2021-R013573
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WULIRA APP – OCCUPATIONAL HEARING LOSS AMONG INDUSTRIAL WORKERS IN KAMPALA, UGANDA.
REFNo: HS1237ES
1. To determine the prevalence of occupational hearing loss among workers in a steel and iron manufacturing industry in Kampala.
2. To assess the acceptability of using the Wulira App for hearing loss screening among workers in a steel and iron manufacturing industry.
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Uganda |
2021-02-22 |
2024-02-22 |
Medical and Health Sciences |
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Non-degree Award |
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Joweria Nambooze
ID: UNCST-2019-R001118
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BASELINE ASSESSMENT FOR NUTRITION INTERVENTIONS IN PALORINYA REFUGEE SETTLEMENT, OBONGI DISTRICT
REFNo: HS1241ES
The overall aim of this baseline study will be to assess the current status of nutrition outcomes, infant and young child feeding (IYCF) and livelihoods indicators among children and WRA, household food security and selected livelihood indicators among refugee households in Palorinya Refugee Settlement.
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Uganda |
2021-02-22 |
2024-02-22 |
Medical and Health Sciences |
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Non-degree Award |
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Tim Colbourn
ID:
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How does a multi-country, multilateral network focused on specific health care improvements evolve and what shapes its ability to achieve its goals?
REFNo: SS659ES
1. To characterise how the QCN initiative was conceptualized and brought together, explore its aims and ethos and understand the global context in which QED arose
2. To explore how the QCN is enacted as a strategy for linking global and national actors
3. To explore case study countries’ contexts and capacities, their interactions with the global QCN and the effects this has on the emergence of the national QCN programme
4. To characterise strategies adopted in countries, their scale, scope and focus, mechanisms of action, the evolution of programmes and what influences them
5. To map the activities of the national programmes at district level and examine the approach to intervention
6. To examine which key data are collected to evaluate the effect of the QCN and assess any effects of network activities
|
UK |
2021-02-18 |
2024-02-18 |
Social Science and Humanities |
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Non-degree Award |
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Charles Drago Kato Drago
ID: UNCST-2021-R012897
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Establishment of a Biomarker research facility to first track the development of COVID19 novel diagnostics and treatment alternatives in Uganda
REFNo: HS1096ES
1. To establish a biomarker research facility at Makerere University. (Here we shall add more equipment capacity to the existing BSL3 lab at COVAB to execute COVID19 research).
2. To identify and evaluate key SARS-CoV-2 biomarkers in saliva, urine and blood with diagnostic/prognostic or therapeutic potential.
3. To develop biomarker panels (single or multiple analytes) with diagnostic/prognostic or therapeutic potential.
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Uganda |
2021-02-18 |
2024-02-18 |
Medical and Health Sciences |
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Non-degree Award |
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Robert Ssekitoleko
ID: UNCST-2019-R001716
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Mobile Phone enabled Diagnostics for Infectious Disease Diagnosis: Low Cost Tools for Digital Health in Uganda
REFNo: SIR50ES
I. Understanding Digital Health for Infectious Disease in Low Resource Settings
II. Understanding Data Integrity and Security in Digital Health in Africa;
III. Exploring the Relationship between Data and Healthcare Policy;
IV. ICT Devices for Data Acquisition and Communication in East Africa with a focus on Uganda;
V. Capacity Strengthening - Educational Training underpinning Mobile Health.
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Uganda |
2021-02-18 |
2024-02-18 |
Engineering and Technology |
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Non-degree Award |
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Christine Aanyu
ID:
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Alarm and response systems for addressing maternal and perinatal deaths in Eastern Uganda. A case of re-activation of MPDSR
REFNo: HS635ES
1) To explore the factors that facilitate or constrain the implementation of the MPDSR protocols
2) To develop a collaborative innovation to address the constraints of implementing MPDSR protocols
3) To enhance system wide learning through documenting and sharing of best practices for implementing MPDSR protocols
|
Uganda |
2021-02-17 |
2024-02-17 |
Medical and Health Sciences |
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Non-degree Award |
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Peter Olupot-Olupot
ID:
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Paracetamol for Acute Renal Injury in Severe Malaria Trial (PARIST)
REFNo: HS965ES
1. To conduct pharmacokinetic studies of paracetamol in patients with acute kidney injury in severe malaria.
2. To assess the feasibility of conducting AKI in severe malaria in Eastern Uganda.
3. To conduct safety and preliminary effectiveness study for use of paracetamol in ameliorating AKI in severe malaria.
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Uganda |
2021-02-17 |
2024-02-17 |
Medical and Health Sciences |
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Non-degree Award |
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Elizabeth Ekong Namukombe
ID:
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Work-Based Learning for Baccalaureate Nurses in Uganda: Perception and Current Practice
REFNo: HS810ES
1. Explore the perception of baccalaureate nurses in Uganda on the ease of engaging in Work-based learning.
2. Explore the perception of baccalaureate nurses in Uganda on the usefulness of work-based learning.
3. Describe the current practice of Work-Based Learning among baccalaureate nurses in Uganda.
4. Determine any existing relationship between perceived usefulness and current practice of work-based learning among baccalaureate nurses in Uganda.
|
Uganda |
2021-02-15 |
2024-02-15 |
Medical and Health Sciences |
|
Degree Award |
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Jane Namagga Kasozi
ID:
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HIV-Associated Neurocognitive Burden: Feasibility of Implementing International HIV Dementia Scale into a Nurse-led HIV Model at TASO centres in southwestern Uganda
REFNo: HS814ES
1.To determine the prevalence of HIV- associated neurocognitive disorders using IHDS among PLWH attending TASO centres in rural Southwestern Uganda.
2.To identify the risk factors associated with HIV- associated neurocognitive disorders among PLWH attending TASO centres in rural Southwestern Uganda.
3.To assess the impact of an education intervention on nurses’ knowledge and skills regarding the use of IHDS in screening and managing HIV- associated neurocognitive disorders
4.To explore nurses' perceptions towards screening and managing HIV- associated neurocognitive disorders using IHDS among HIV positive clients attending TASO centres in rural Southwestern Uganda.
5.To determine the feasibility of implementing IHDS into a nurse-led model of HIV care.
|
Uganda |
2021-02-15 |
2024-02-15 |
Medical and Health Sciences |
|
Degree Award |
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Andrew Ssemata
ID: UNCST-2023-R008259
|
Exploring and understanding the life skills, sexual, reproductive and mental health needs among adolescents and young people with Spina bifida and Hydrocephalus disability in Sub Saharan Africa; a mixed methods study. (REMHAND)
REFNo: SS703ES
To explore and understand the life skills, sexual, reproductive and mental health needs among adolescents and young people with Spina bifida and Hydrocephalus disability and their significant others (siblings and parents) in Uganda.
Specific objectives
1. Explore and understand the life skills, sexual, reproductive and mental health needs among children and adolescents with disability.
2. Explore the SRH vulnerabilities, and experience (barriers and facilitators) to accessing SRH and mental health services.
3. Explore caregiver (parents and siblings) experiences and perspectives of the health implications of long‐term informal caregiving for children with SBH and disability.
4. Investigate the health, wellbeing and factors affecting the mental health of parents and siblings caring for children with disabilities.
|
Uganda |
2021-02-15 |
2024-02-15 |
Social Science and Humanities |
|
Non-degree Award |
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Bas van Boekholt
ID:
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Turn-taking interactions in chimpanzees (Pan troglodytes schweinfurthii) in the wild
REFNo: NS153ES
To shed light on the evolution of language by providing the first systematic insights into the development of turn-taking in chimpanzees
|
Netherlands |
2021-02-15 |
2024-02-15 |
Natural Sciences |
|
Non-degree Award |
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Geoffrey Babughirana Babughirana
ID:
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Effect of implementing the timed and targeted counselling (ttC) model on pregnancy outcome and Newborn survival in rural Uganda. A Quaisi experimental study in Hoima and Mansidi district
REFNo: HS574ES
To determine the effect of ttC on pregnancy outcomes and Newborn survival in Rural Uganda
1. To ascertain the extent to which ttC improves uptake of timely Goal Oriented ANC with a focus on the recommended 4 visits
2. To determine whether ttC contributes to the recommended hygienic birthing practices
3. To establish the extent to which ttC improves essential new-born care practices (ENC) during the new born period
4. To ascertain the extent to which ttC fosters positive male involvement in Pregnancy and New Born care
5. To ascertain the relationship between ttC implementation and appropriate pregnancy weight gain by end of Pregnancy.
6. To ascertain the relationship between ttC implementation and appropriate birth weight
|
Uganda |
2021-02-12 |
2024-02-12 |
Medical and Health Sciences |
|
Non-degree Award |
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Francis Ssali
ID: UNCST-2021-R012134
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A5379: B-ENHANCEMENT OF HBV VACCINATION IN PERSONS LIVING WITH HIV (BEe-HIVe): Evaluation of HEPLISAV-B
REFNo: HS622ES
• To compare the week 12 seroprotection response (SPR) of a two-dose regimen of HEPLISAV-B (Group A, Arm 1) versus the week 28 SPR of a standard three-dose regimen of ENGERIX-B (Group A, Arm 3) in Hepatitis B virus (HBV) vaccine-experienced participants living with HIV (Group A).
• To compare the week 28 SPR of a three-dose regimen of HEPLISAV-B (Group A, Arm 2) versus a standard three-dose regimen of ENGERIX-B (Group A, Arm 3) in HBV vaccine-experienced participants living with HIV (Group A).
• To determine the week 28 SPR of a three-dose regimen of HEPLISAV-B in HBV vaccine-naïve participants living with HIV (Group B).
• To describe adverse events (AEs) reported in each study arm (Groups A and B, separately) over the duration of the study.
|
Uganda |
2021-02-12 |
2024-02-12 |
Medical and Health Sciences |
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Non-degree Award |
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