Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Samson Okello
ID: UNCST-2019-R001580
Impact of HIV-infection on Geriatric Health among Older-Age People in Southwestern Uganda.
REFNo: HS97ES

Our main objective for this study is to provide data to help answer the following question: How does the prevalence of and risk factors for frailty, decreased physical functioning, visual/auditory impairment, and neurocognitive disorders differ between HIV-infected people versus HIV-uninfected controls in Uganda.
Uganda 2017-11-08 2020-11-08 Medical and Health Sciences Non-degree Award
Nakueira Sophie
ID:
Group Identification and resource conflict amongst South Sudanese and Somali Refugees in Southwestern Uganda
REFNo: SS118ES

a) To unpack the dispute resolution mechanisms used by refugees in dealing with resource conflict. b) To investigate how processes of inclusion and exclusion take place amongst specific groups within two distinct refugee groups. c) To understand the interactions between state and non-state actors in Nakivale Refugee Settlement and how their activities and interactions intertwine with the specific refugee groups that are the subject of this study. d) To examine if and to what extent refugee resettlement programs such as the Self Reliance Strategy play a role in ongoing conflicts in Nakivale Refugee Settlement.
Uganda 2017-11-08 2020-11-08 Social Science and Humanities Non-degree Award
Hang ZHOU
ID:
Bring African Bureaucracies back in: Negotiations and Implementation of Chinese Development Engagement in Uganda
REFNo: SS125ES

This project seeks to take African bureaucracies seriously, an actor that has largely neglected in the existent literature. Taking an empirically grounded approach, this project aims to study the real governance of African bureaucracies and investigating what they actually do without classifying them into pre-determined ideal-typical categories. More specifically, using China-Uganda development engagement in road construction and agriculture sectors as a case study, this project conceives this development engagement as ‘processes of negotiation, contestation and bricolage’ through which Ugandan bureaucrats together with local, national and Chinese actors seek to articulate their preferred positions and fulfil the mandates of their organisations.
China 2017-11-08 2020-11-08 Social Science and Humanities Degree Award
Stephanie Grand
ID:
Volcanic inputs in soils of the Albertine Rift Valley: implication for modern soil biogeochemistry
REFNo: NS33ES

1. Identify the geochemical signature of recent volcanic eruptions products in the area based on the literature and lab analyses of grab samples of volcanic rocks. 2. Look for evidence of volcanic influence in modern soils using geochemical and mineralogical analyses of soil samples collected at different locations and different landscape positions 3. Analyze the link between inferred volcanic inputs and soil fertility 4. Formulate recommendations for integrating pedologic and geochemical information into agricultural sustainability studies
France 2017-11-08 2020-11-08 Natural Sciences Non-degree Award
Kate Scow
ID:
Innovations  in Dry Season Horticulture for Women and Smallholders in East Africa -Production and Marketing for income, nutrition, and climate resilience
REFNo: A14ES

Dry season vegetable production has been identified as a high priority in the largely rainfed (>97%) agricultural systems of Uganda. Off season vegetable supplies are currently inadequate to meet human nutritional needs. As rainfall patterns become increasingly unpredictable and rapid population expansion places more pressure on food systems, demand for vegetables will further outstrip supplies. This spin-off project builds on the team’s previous participatory work in Uganda to convene stakeholders from public and private sectors and develop innovations in small scale dry season vegetable production for women farmers in East Africa. We will develop a research and development approach resulting in release of horticulture irrigation innovations tested at five ‘innovation sites’ over three field seasons in Eastern Uganda and create a framework for local public and private sector organizations to develop small scale irrigation systems. We will work closely with smallholder women farmers who are often excluded from irrigation and marketing developments. We will: i) work at five locations over three dry seasons to test dry season vegetable production systems with farmers, research partners, district staff, NGO partners, and university students, ii) assess agronomic, economic, market, nutrition, and gender impacts of the innovations; and iii) develop scale-out options for the most promising technologies. Ugandan partners include two regional NGOs, three institutes of the National Agricultural Research Organization, and one university. Development of a co-innovation systematic approach for assessing and supporting innovations in dry season vegetable production will strengthen small scale farmer enterprises targeted to local markets and family consumption.
USA 2017-10-31 2020-10-31 Agricultural Sciences Non-degree Award
Aleksander Braczkowski Ryszard
ID: UNCST-2019-R001345
Assessing the densities and conflict of large carnivores within and on the boundaries of Queen Elizabeth National Park
REFNo: NS25ES

1) Provide the most accurate estimates of carnivore numbers in Queen Elizabeth using spatially-explicit statistics 2) Assess human-carnivore conflict hotspots within and on the boundaries of Queen Elizabeth National Park to ensure effective targeting of mitigation interventions
South Africa 2017-10-31 2020-10-31 Natural Sciences Degree Award
Christine Namata
ID:
KETAMINE-MIDAZOLAM VERSUS MORPHINE-MIDAZOLAM FOR CONTINOUS PATIENT SEDATION IN INTENSIVE CARE UNITS IN UGANDA. A RANDOMISED CONTROLLED TRIAL.
REFNo: HS76ES

Specific objectives i. To compare duration of mechanical ventilation among patients sedated with ketamine-midazolam versus morphine-midazolam. ii. To compare incidence of hypotension necessitating vasopressor support among patients under ketamine-midazolam versus morphine-midazolam. iii. To compare incidence of delirium among patients under ketamine-midazolam versus morphine- midazolam.
Uganda 2017-10-31 2020-10-31 Medical and Health Sciences Degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
Global Excellence in Chronic Obstructive Pulmonary Disease Outcomes (GECO): Implementation of COPD case finding and self-management action plans in low and middle income countries.
REFNo: HS110ES

1. To determine whether case-finding for COPD can be facilitated using a modified 5-item questionnaire. 2. To determine whether a self-directed COPD Action Plan for the management of COPD exacerbations can be implemented with CHWs and local health care centers. 3. To determine whether a self-directed COPD Action Plan is cost-effective
Uganda 2017-10-31 2020-10-31 Medical and Health Sciences Non-degree Award
Benjamin Hounsell
ID:
Innovating Mobile Solutions for Refugees in East Africa
REFNo: SS120ES

Much literature on the use of mobile technology for migration focuses on migration into Europe, with little research conducted to assess the technology uses and needs of refugees traveling too, from and within East Africa. This study will explore how refugees in Kenya and Uganda use mobile technology to support migration, during their journey and at arrival, and to what extent current solutions meet their needs. The results will open the way for innovative solutions, uniquely tailored for refugees across the region and in Uganda particularly. 
UK 2017-10-31 2020-10-31 Social Science and Humanities Non-degree Award
Pavel Reppo Aleksandrovich
ID:
Implementing the MANAS trial in Uganda (MAN U) - The Pilot Phase
REFNo: HS134ES

Research Question & Specific Objectives Question: How will implementing a trained Community Health Worker (CHW)-led Collaborative Stepped Care Intervention (CSCI) lead to an improvement in recovery from depression among patients within general outpatient attending public primary care facilities in Uganda? Aim 1: To determine whether treatment from trained CHWs leads to 1) patient recovery from MDD as defined by the DSM-IV at 6 months, and 2) the proportion of patients with above threshold scores (PHQ-9 score of ≥10). Hypothesis: Constituents of collaborative care interventions predicted a favorable outcome. Aim 2: To increase awareness of CHW-led, collaborative stepped care as a viable option of treatment for depression among trainees, study participants, the community and stakeholders. Relevance: Community views and input are essential to inform the development of a culturally appropriate training curriculum for CHWs. Aim 3: To determine the outcome of the CHW training on retention of knowledge and skills in competencies required to deliver the stepped care intervention among trainees after the training. Hypothesis: Trained CHWs will demonstrate increased level of knowledge and skills in competencies required to deliver collaborative stepped care after the training. Aim 4: To determine the perceptions of CHWs, study participants, the community and stakeholders towards the process of integrating CHW-led, collaborative stepped care into community based mental healthcare. Relevance: There is a need to understand the views of participants and stakeholders pre and post to determine project efficacy.
USA 2017-10-31 2020-10-31 Medical and Health Sciences Non-degree Award
Anaclet Namanya Mutiba
ID:
Teachers' Understanding and Classroom Practices of Quality Education in Ugandan Primary Education: A Case of Bushenyi District
REFNo: SS124ES

The main study objective is to find out how teachers understand and practice quality education in Ugandan primary education. The specific objectives are: (i) To find out how teachers understand neoliberal policies in relation to quality education. (ii) To establish how teaching and instruction processes reflect quality education. (iii) To find out factors that influence teaching and instructional processes and methodology.
Uganda 2017-10-31 2020-10-31 Social Science and Humanities Degree Award
KOHJUN HORI
ID:
Land use and Soil erosion in high populated region in southwestern Uganda
REFNo: A21ES

The area of southwestern Uganda lies along the border with Rwanda and is characterized by high population density, despite the fact that it is a rural area. The area is a highland ranging in altitude from 1,200 to 2,350 m. People have been forced to use limited areas of farmland because of the population increase. In the slope areas of this Area, the shapes of the crop fields are irregular depending on the landform. This feature exacerbates soil loss and agricultural production. There is a high risk of collapse of embankment due to heavy rain. In the previous study, it is pointed out using questionnaire survey as a measure to prevent soil erosion carried out by local residents, but it is not clear by investigate scientifically that the usefulness to prevent soil erosion possessed by terrace farming. It is suggested that soil degradation is accelerating due to short fallow and sudden heavy rain due to climate change. It is expected that the population increase will continue in the future, and it will be necessary to prepare the environment that can sustain livelihood even in the situation of decreasing the per capita area of farm land. Therefore, I will clarify in detail the natural environment aspects that have a big influence on the livelihood activities of the local residents and verify the land use form of the local residents. In discussing soil erosion in mountainous regions of Africa, it is essential to verify sustainable land use that can withstand the effects of climate change. In this study, scientific verification of soil erosion possessed by terrace farming will be carried out in the mountainous area in southwestern Uganda, where land shortage and soil deterioration become serious. Finally I devise a method of land use to prevent soil degradation and aim to improve residents' livelihoods. This research is composed of three main research.
Japan 2017-10-31 2020-10-31 Agricultural Sciences Degree Award
Adrian Muwonge
ID:
The dynamics of antimicrobial resistance (AMR) genes in the pig and human gut microbiome in Uganda
REFNo: HS103ES

The hypothesis to be tested is that people in contact with pigs in peri-urban settings are at higher risk of acquiring AMR genes across this interface than people in rural settings. The specific objectives are: 1. To identify significant changes in taxonomic and AMR genes in gut microbiomes of people and their pigs in peri urban and rural settings over a one-year period using 16SrRNA, AMR gene probes and real time PCR. 2. To conduct forensic investigations of the significant changes detected in objective 1 using sequence based metagenomics on the corresponding gut microbiomes in parallel with whole genome sequencing and phenotypic AMR testing of sentinel bacteria to understand the underlying dynamics. 3. To predict, estimate and make inferences on AMR gene occurrence, taxa-linked within and between host exchange and their potential phenotypic effects using bioinformatic, statistical and support vector machine approaches on the data generated in 1&2.
Uganda 2017-10-11 2020-10-11 Medical and Health Sciences Non-degree Award
Gladys Tugume T
ID:
Predictors and Outcomes of patients lost to follow-up from HIV care and treatment in Uganda
REFNo: HS130ES

1. To describe outcomes (HIV-related &other death, self-transfers and disengaged from care) of PLHIV LTFU from HIV care and treatment. 2. To describe the change in cumulative incidence of mortality, retention and ART initiation of HIV-infected patients in Pre-ART care after incorporating outcomes of LTFU patients. 3. To describe the change in cumulative incidence of mortality and retention of HIV-infected patients on ART after incorporating outcomes of LTFU patients. 4. To determine predictors of loss to follow-up among PLHIV in HIV care and treatment at Jinja, Lira, Mubende RRH’s. 5. To determine reasons for engagement or disengagement from HIV care and treatment
Uganda 2017-10-11 2020-10-11 Medical and Health Sciences Non-degree Award
Sylvester Onzivua
ID:
Postmortem study on patients with neuropsychiatric manifestations of unknown etiology, nodding syndrome, and other forms of epilepsy who died in Gulu, Kitgum, Lamwo and Pader
REFNo: HS64ES

• Use postmortem examination to determine cause of death in a selected study population. • Use histopathology to describe the post-mortem findings of individuals who die of neuropsychiatric manifestations of unknown origin, NS and other forms of epilepsy in villages with high epilepsy prevalence in Gulu, Kitgum, Lamwo and Pader. • Use histopathology to investigate whether Ov microfilariae are able to penetrate the brain by evaluating histologic tissue for the products of Ov microfilariae
Uganda 2017-10-03 2020-10-03 Medical and Health Sciences Non-degree Award
othiniel musana mambya
ID:
Prospective, Single Arm, Pivotal Clinical Trial Designed to Assess the Safety and Effectiveness of the InPress Device In Treating Primary Postpartum Hemorrhage
REFNo: HS92ES

Evaluate the safety and effectiveness of the InPress Device in the control and reduction of primary postpartum hemorrhage.
Uganda 2017-10-03 2020-10-03 Medical and Health Sciences Non-degree Award
Christopher Mayanja Samuel
ID:
Leadership and Gender: Exploring female students’ lived experiences in leadership in Ugandan public University Councils
REFNo: SS117ES

The main research question of the study is: What are the lived leadership experiences of female student leaders who are members of public university councils in Uganda? 1. Who are female student leaders participating in public university councils in Uganda? 2. How do female student leaders who participate in public university councils in Uganda experience their relations with other council members? 3. What challenges (if any) do female student leaders face on public university councils in Uganda? 4. What lessons can be drawn about gender and leadership from the experiences of female student leaders participating in public university councils in Uganda?
Uganda 2017-10-03 2020-10-03 Social Science and Humanities Degree Award
Moses Kamya R
ID:
Cohort and entomology studies to estimate longitudinal changes in malaria metrics in Nagongera, Uganda
REFNo: HS119ES

Objectives of epidemiology studies 1. To estimate the incidence of malaria, parasite prevalence, and the molecular force of infection among cohort study participants. 2. To characterize factors determining the malarial force of infection. 3. To determine factors affecting the duration, density, and clinical consequences of blood stage malaria infection. 4. To assess the associations between overnight travel and the risk of malaria infection. 5. To estimate measures of transmission intensity including the human biting rate, sporozoite rate, and the entomological inoculation rate at the household level. 6. To characterize the species composition of mosquito vectors and the host source of mosquito blood meals. Objectives of transmission studies 7. To characterize factors associated with gametocyte production. 8. To evaluate the impacts of human, parasite, and mosquito factors on parasite infectivity to mosquito vectors. 9. To characterize the human infectious reservoir for malaria. Objectives of immunology studies 10. To measure antibody responses to malaria antigens and associations between antibodies responses and protection from /exposure to infection with malaria parasites. 11. To characterize malaria specific cellular immune responses in naturally exposed children and adults. Objectives of resistance studies 12. To assess the impact of genotypic markers of antimalarial drug resistance on malaria transmission. 13. To assess the impact of genotypic markers of insecticide resistance on malaria transmission.
Uganda 2017-09-29 2020-09-29 Medical and Health Sciences Non-degree Award
Irene Andia Biraro Rebecca
ID: UNCST-2019-R001475
The Link Between Tuberculosis Infection and Type-2 Diabetes Mellitus: Contribution of Innate Lymphoid Cells
REFNo: HS66ES

Primary objective: To investigate the exposure prevalence of latent and active tuberculosis among newly diagnosed type 2 diabetes mellitus (T2DM) patients attending the diabetic clinic at Mulago National Referral Hospital (MNRH)-Kiruddu, compared to healthy non diabetic community controls in Kampala, Uganda Nested Secondary objective: To assess the frequency of innate lymphoid cells (ILCs), T-helper (Th)17, Th1 cells, and immune responses among T2DM patients.
Uganda 2017-09-26 2020-09-26 Medical and Health Sciences Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
Reducing exposure to household air pollution
REFNo: HS71ES

To evaluate the feasibility, acceptability and effectiveness of proven household air pollution reduction interventions in households using traditional way of cooking and heating methods in selected communities in four countries of Uganda, Vietnam, the Kyrgyz Republic and Greece. Research questions will be: 1. What is the feasibility and acceptability of clean cooking and heating interventions compared to traditional cooking and heating? 2. What is the effectiveness of a clean cooking intervention on health outcomes? 3. What is the effectiveness of household air pollution reduction on health outcomes?
Uganda 2017-09-26 2020-09-26 Medical and Health Sciences Non-degree Award
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