Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
KYOMUGISHA AGATHA agathakyomugisha3@gmail.com
ID: UNCST-2025-R017288
 TEACHING METHODS, PERSONALITY TRAITS MONITORING AND EVALUATION AND STUDENTS’ ACADEMIC PERFORMANCE AT NATIONAL TEACHERS COLLEGES IN UGANDA.
REFNo: SS4279ES

To examine how monitoring and evaluation practices mediate the relationship between personality traits and academic performance,To explore the mediating role of monitoring and evaluation practices in the relationship between teaching methods and academic performance,To evaluate the combined effect of monitoring and evaluation practices, personality traits, and teaching methods on academic performance in Uganda’s National Teacher Colleges.,To assess the impact of teaching methods on academic performance in Uganda’s National Teacher Colleges.,To investigate how personality traits influence academic performance in Uganda’s National Teacher Colleges.,To analyze the relationship between monitoring and evaluation practices and academic performance in Uganda’s National Teacher Colleges.,
 Uganda 2025-09-17 15:43:55 2028-09-17 Social Science and Humanities Degree Award
Allan Kalungi
ID: UNCST-2022-R009843
 Harnessing DNA Methylation Variation Between Populations to Understand Disease Discordance Across Ancestries
REFNo: HS6352ES

i. Create a comprehensive mQTL resource: We aim to expand the diversity of methylation quantitative trait loci (mQTL) resources by incorporating genetic data from underrepresented populations, including Africa. The study will compare genetic architecture and selection signatures across populations and use mQTLs as instruments to identify causal relationships between DNA methylation (DNAm), genome-wide association studies (GWAS), and epigenome-wide association studies (EWAS) signals.

ii. Conduct multi-ancestry epigenetic analyses: We aim to explore disease discordance mechanisms between populations by conducting multi-ancestry EWAS with a focus on cardiometabolic and blood cell phenotypes. This will include cell-type-specific EWAS and variance EWAS analyses to understand differences across global populations.

iii. Improve disease and exposure prediction models: We will refine existing predictors of disease risk or exposure (such as smoking and alcohol use) by including data from multi-ancestry participants. This approach will help develop predictive models that are either generalizable across populations or optimized for specific ancestries.

iv. Form equitable partnerships: The study will foster global collaboration through co-developed training resources and shared analytical tools, ensuring that the research benefits a wide range of stakeholders across various regions

 Uganda 2025-09-17 15:40:49 2028-09-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
AKANKWASA ALEX
ID: UNCST-2025-R018808
 INTERNAL CONTROL SYSTEMS AND LOCAL GOVERNMENTS’ PERFORMANCE IN UGANDA; RUBANDA DISTRICT LOCAL GOVERNMENT
REFNo: SS4182ES

To examine the effect of financial controls on financial performance of Rubanda District Local Government.
(ii) To determine the influence of human resource controls on the staff satisfaction in Rubanda District Local Government.
(iii) To explore the relationship between systems control on the levels of customer satisfaction in Rubanda District Local Government.
(iv) To evaluate the moderating effect of staff retention on internal control systems and Performance of Rubanda District Local Government.

 Uganda 2025-09-17 15:37:56 2028-09-17 Social Science and Humanities Non-Clinical Trial Degree Award
LYDIA NAKIGANDA
ID: UNCST-2025-R016917
 A Qualitative Study Exploring the Role of Peer Navigators in Supporting PrEP Adherence and Retention Among Female Sex Workers in South-Western Uganda.
REFNo: HS6339ES

i. To examine the roles, characteristics, and relationship-building qualities of peer navigators in supporting FSW and integrating into health systems.
ii. To investigate the mechanisms and activities of peer navigation in community and healthcare settings that enhance retention and adherence to PrEP care among FSW.
iii. To explore the lived experiences of peer navigators as they balance community-based and professional identities in delivering healthcare services.
iv. To understand the socio-ecological factors that facilitate or hinder the success of peer navigation programs in supporting PrEP care for FSW.

 Uganda 2025-09-17 15:35:04 2028-09-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Obadia Mugabirwe
ID: UNCST-2024-R002359
 CREATIVITY, INNOVATION, SKILLS DEVELOPMENT, AND YOUTH EMPLOYABILITY AMONG VOCATIONAL TRAINEES. A CASE OF VOCATIONAL AND SKILLS TRAINING INITIATIVES IN UGANDA (WESTERN REGION)
REFNo: SS3587ES

The main objective of this study is to assess the impact of creativity, innovation, and skills development on youth employability in Western Uganda, focusing on how vocational training programs can enhance employability outcomes by enhancing technical and soft skills, promoting career adaptability, and aligning training with labor market demands to improve job readiness and long-term career success. Specific Objectives 1. To assess the role of vocational training in enhancing the creativity of youth in Western Uganda and its contribution to employability. 2. To examine how vocational training influences the innovation capabilities of youth and their ability to adapt to evolving job market demands. 3. To evaluate the effectiveness of vocational training in equipping youth with both technical skills and essential soft skills such as communication, teamwork, and problem-solving. 4. To analyze how skills development mediates the relationship between creativity, innovation, and youth employability in Western Uganda. 5. To identify and measure key employability indicators—such as career adaptability, job search skills, career identity, and career proactivity—among vocational training graduates in Western Uganda. 6. To investigate barriers faced by vocational training graduates in transitioning to meaningful employment and propose strategies to enhance job placement and employability outcomes.
Uganda 2025-09-17 15:28:06 2028-09-17 Social Science and Humanities Non-Clinical Trial Degree Award
Laban Musinguzi Kashaija
ID: UNCST-2020-R014407
 Endline evaluation of the Rights, Autonomy and Choice project (INTPA) in Kamuli & Buyende districts
REFNo: SS4170ES

1. To assess the extent to which the project\'s objectives were achieved, using the OECD DAC criteria and measuring the status of the project\'s outcome and output indicators, providing contextualized analysis of the progress achieved against the expected results, through a gender transformative and inclusive lens.
2. To foster learning from experience, capturing project challenges, lessons learnt and best practices to inform future programming in similar intervention area.
3. To assess project performance on the project indicators as indicated in the Monitoring and Evaluation Framework
 Uganda 2025-09-17 14:28:07 2028-09-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
Daudi Hasahya-Mulongo
ID: UNCST-2025-R017131
 Predictors of Retirement Readiness, and Planned Coping Strategies among Headteachers of Public Secondary Schools in Uganda
REFNo: SS4330ES

1. To assess the level of retirement readiness among headteachers of public secondary schools in Uganda.
2. To examine the predictors of retirement readiness among pre-retiring headteachers of public secondary schools in Uganda.
3. To explore the planned retirement coping strategies among pre-retiring headteachers of public secondary schools in Uganda, in managing transition into mandatory retirement.

 Uganda 2025-09-17 14:00:17 2028-09-17 Social Science and Humanities Non-Clinical Trial Degree Award
ARTHUR KICONCO
ID: UNCST-2025-R018937
 Type 2 diabetes self-management in resource limited settings: family support, self-efficacy, self-management practices, and readiness to implement Diabetes Self-Management Education and Support in informal settlements in Kampala, Uganda
REFNo: HS6253ES

i. To validate the diabetes management self-efficacy scale in Uganda Hypotheses
ii. To assess the joint association between diabetes knowledge and family support, and diabetes self-management among people with type 2 diabetes in informal settlements in Kampala Uganda
iii. To evaluate the causal effect of family support on self-efficacy among people with type 2 diabetes in informal settlements in Kampala Uganda.
iv. To explore the perceived readiness to implement DSMES for patients with type 2 diabetes in informal settlements in Kampala, Uganda using the Consolidated Framework for Implementation Research (CFIR).
Uganda 2025-09-17 13:59:03 2028-09-17 Medical and Health Sciences Non-Clinical Trial Degree Award
ASINAI LILIAN
ID: UNCST-2024-R016497
 STRATEGIC FINANCIAL MANAGEMENT PRACTICES AND SERVICE DELIVERY IN NATIONAL WATER AND SEWERAGE CORPORATION: THE CASE OF KAMPALA METRO-POLITAN REGION
REFNo: SS4102ES

Main objective: The study's general objective is to examine the effect of strategic financial management practices on service delivery at National Water and Sewerage Corporation, Kampala Metropolitan Region. Specific objectives i. To determine the significant effect of strategic planning on service delivery at National Water and Sewerage Corporation, Kampala Metropolitan Region. ii. To identify the significant effect of strategic budgeting on service delivery at National Water and Sewerage Corporation, Kampala Metropolitan Region. iii. To investigate the significant effect of strategic managing of risks and service delivery at National Water and Sewerage Corporation, Kampala Metropolitan Region. iv. To assess the significant effect of strategic ongoing procedures on service delivery at National Water and Sewerage Corporation, Kampala Metropolitan Region. v. To examine the moderating role of staff commitment on strategic financial management practices and service delivery at National Water and Sewerage Corporation, Kampala Metropolitan Region.
Uganda 2025-09-17 13:30:37 2028-09-17 Social Science and Humanities Non-Clinical Trial Degree Award
MARILYN BAKO ARUMADRI
ID: UNCST-2024-R002256
 IMPLEMENTATION OF THE UNITED NATIONS SECURITY COUNCIL RESOLUTION 1325 AND REPRESENTATION OF WOMEN IN LEADERSHIP POSITIONS IN SECURITY INSTITUTIONS IN UGANDA
REFNo: SS4324ES

3. Identify challenges perceived and related to women involvement in decision-making leadership positions in security institutions in Uganda.,2. Examine the impact of the implementation of UNSCR 1325 on women’s representation in the security institutions in Uganda; and,1. Examine the adoption and implementation of UNSCR 1325 in the security institutions in Uganda;,The broad aim of the study is to examine the implementation of UNSCR 1325 and representation of women in decision-making leadership positions in the security institutions of Uganda.,
 Uganda 2025-09-17 13:29:27 2028-09-17 Social Science and Humanities Non-Clinical Trial Degree Award
Joseph Ngonzi
ID: UNCST-2019-R001579
 PACO Heart Evaluation and Risk Tracking (PACO-HEART)
REFNo: HS5985ES

Main objective: 1. Determine whether women with HIV taking DTG during pregnancy are more likely to experience hypertension, have elevated cardiovascular disease risk factors, and demonstrate vascular dysfunction postpartum.

Sub-Objectives:
1. Prospectively assess postpartum cardiovascular disease risk factors in women with HIV on DTG versus women with HIV on efavirenz (EFV), women who took PrEP in pregnancy, and women without HIV participating in the PACO cohort.
2. Assess vascular function in women with HIV on DTG versus women with HIV on efavirenz (EFV), women who took PrEP in pregnancy, and women without HIV participating in the PACO cohort.
3. Quantify and compare biomarkers of cardiovascular disease in peripheral plasma in women with HIV on DTG versus women with HIV on efavirenz (EFV), women who took PrEP in pregnancy, and women without HIV participating in the PACO cohort.
4. Examine association between placenta pathological features (already measured in PACO cohort participants) and postpartum hypertension, vascular function, and biomarkers of cardiovascular disease


 Uganda 2025-09-17 13:26:00 2028-09-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Stella Kyohairwe Baketuraki
ID: UNCST-2024-R004001
 The Cost of Doing Politics: Gender Aspects of Political Violence
REFNo: SS3887ES

Aim/Overall objective: This project aims to better understand how gender shapes the scope, form, and consequences of political violence targeted at politicians, as well as to develop response strategies to reduce the problem.
RQ 1: How does gender shape the scope and form of political violence? What are the gendered dimensions of violence in political parties’ election campaigns and in the parliamentary arena?
RQ2: What are the gendered consequences of political violence on political representation in political party recruitment – and at parliamentary arenas?
RQ 3: What are the most effective and gender-sensitive responses to different forms of political violence in political party recruitment -and in the parliamentary sphere?
 Uganda 2025-09-17 13:24:26 2028-09-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
NORBERT BYARUHANGA MUSISI
ID: UNCST-2024-R002079
 PREVALENCE AND FACTORS ASSOCIATED WITH ADVERSE PERINATAL OUTCOMES AMONG WOMEN WITH LATE ANTENATAL CARE BOOKING AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS5772ES

1. To determine the prevalence of adverse perinatal outcomes among women with late ANC booking at Mbarara regional referral hospital.
2. To determine the factors associated with adverse perinatal outcomes among women with late ANC booking at Mbarara regional referral hospital

 Uganda 2025-09-17 13:22:53 2028-09-17 Medical and Health Sciences Non-Clinical Trial Degree Award
Catriona  Waitt John
ID: UNCST-2019-R001068
 Drug Optimisation for LMICs in Pregnant HIV mothers and their INfants: temporary switch to CAB/RPV long acting injections in postpartum period
REFNo: HS5982ES

To characterise drug exposure in breast milk, and drug transfer to infants through breastfeeding, as well as infant drug elimination. To characterise the elimination of CAB/RPV by describing PK profiles of IM CAB/RPV LA after last injection between 48 and 96 weeks. To establish strategies on how to safely re-establish oral ART after discontinuation of IM CAB/RPV LA at 48 weeks and switch back to daily oral ART. To explore early postpartum PK of CAB/RPV in maternal plasma and breastmilk. To demonstrate antiviral activity and impact on retention in HIV care of temporarily switching to CAB/RPV LA compared with continuation of daily oral ART over 48 weeks.,
 UK 2025-09-17 13:21:16 2028-09-17 Medical and Health Sciences Clinical Trial Non-degree Award
Catriona  Waitt John
ID: UNCST-2019-R001068
 Acceptability and feasibility of long-acting injectable antiretroviral therapy (LAI-ART) as a bridging strategy for postpartum mothers living with HIV in South Africa and Uganda
REFNo: HS5944ES

3. To assess the feasibility of adopting LAI-ART into national ART programmes and healthcare facilities, identifying programmatic considerations for optimal LAI-ART deployment.,2. To explore patient acceptability of LAI-ART during breastfeeding and as a postpartum bridging strategy to enhance adherence.,1. To develop and validate a tool for identifying and supporting women at risk of poor ART adherence postpartum.,
 UK 2025-09-17 13:19:23 2028-09-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Wenceslaus Sseguya
ID: UNCST-2019-R000877
 Feasibility of clinical nuance implemented using value-based community financing for the management of diabetes and hypertension in primary health care in rural South-Western Uganda
REFNo: HS6153ES

3. To assess the willingness of the community to contribute to risk pooling towards clinically nuanced VBID,2. To understand the perspectives of health workers in implementing clinically nuanced care for diabetes and hypertension in the community.,1. To explore the community’s perception of clinically nuanced VBID in the prevention and management of diabetes and hypertension.,To investigate the potential of a community-level, value-based insurance design (VBID) in enhancing clinical management and prevention of hypertension and diabetes within primary health care,
 Uganda 2025-09-17 13:17:21 2028-09-17 Medical and Health Sciences Non-Clinical Trial Degree Award
Mercy Wanyana Wendy
ID: UNCST-2025-R016999
 Barriers and facilitators to implementing one health approach for visceral leishmaniasis control in the Karamoja Region.
REFNo: HS6125ES

To examine barriers and facilitators to implementing one health approach for visceral leishmaniasis control in the Karamoja,2025.
 Uganda 2025-09-17 13:05:50 2028-09-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Lillian Mugisha
ID: UNCST-2025-R018187
 Impact of a Co-designed School-Based Intervention on 24-Hour Movement Behaviour and Selected Health Indicators Amongst Female Adolescents in Wakiso District, Uganda
REFNo: SS3966ES

1. Determine the level of adherence to 24-HMB guidelines among adolescent girls aged 15-18 years in mixed-boarding secondary schools in Wakiso district, Uganda.
2. Explore the determinants of adherence to 24-HMB guidelines among adolescent girls aged 15-18 years in mixed-boarding secondary schools in Wakiso district, Uganda.
3. Co-design a SBMB intervention with adolescent girls and teachers, targeted to enhance 24-HMB among adolescent girls aged 15-18 years in secondary schools in Wakiso District, Uganda.
4. Determine the association between accelerometer-measured 24-HMB and selected health indicators (CRF, BMI, WHtR, and BP) among adolescent girls aged 15-18 years in secondary schools in Wakiso District, Uganda.
5. Determine the impact of a co-designed SBMB intervention program on 24-HMB, and selected health indicators (CRF, BMI, WHtR and BP) among adolescent girls aged 15-18 years in mixed-boarding secondary schools in Wakiso district, Uganda

 Uganda 2025-09-17 13:03:31 2028-09-17 Social Science and Humanities Non-Clinical Trial Degree Award
Mugumya  Kabaja Lawrence Kabaja
ID: UNCST-2024-R002956
 Evaluating the effect of Caregiver DOTs on viral re-suppression among children in Kigezi region
REFNo: HS6505ES

1. To establish the viral re-suppression rates among children on the CAGDOTS strategy in Kigezi Region. 2. To find out the factors associated with viral load re-suppression among the CALHIV) in Kigezi region.
Uganda 2025-09-17 12:36:18 2028-09-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Timothy Makumbi Kabanda
ID: UNCST-2021-R011760
 MICRO RNAS PROFILING: BIOPATHOLOGIC CHARACTERIZATION AND SURVIVAL OF EARLY ONSET BREAST CANCER AMONG UGANDAN Ref No. Mak-SOMREC-2021-272
REFNo: HS3699ES

iii) To correlate aberrantly expressed miRNAs profiles with associated survival among women with EOBC.,ii) To determine the association between MicroRNAs dysregulation and the clinical pathological characteristics among women with EOBC. ,i) To determine the prevalence of dysregulated MicroRNAs expression profiles among women with EOBC.,To determine the prevalent profiles of aberrantly expressed(dysregulated) miRNAs and how they influence the specific pathological characteristics, and survival after mastectomy breast surgery for early onset breast cancer (EOBC),
 Uganda 2025-09-17 12:32:26 2028-09-17 Medical and Health Sciences Non-Clinical Trial Degree Award
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