Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Lydia Nakiyingi
ID:
Impact of TB and HIV co-infection on host and microbial gene expression in the upper airway
REFNo: HS502ES

Objectives of the research project: Aim 1: Compare the differences in the microbiota and host gene expression in the upper airway of TB/HIV cases versus HIV only individuals. We will use RNA-seq to profile host gene expression and microbial abundance in TB/HIV and HIV only individuals and identify differences between these two groups.

Aim 2: Develop candidate diagnostic biomarkers for identifying TB/HIV co-infection. We will develop a preliminary nasal biomarker for differentiating TB/HIV from HIV only (controls) using host gene expression, the microbiome, or a combination.

Uganda 2019-12-27 2022-12-27 Medical and Health Sciences Non-degree Award
Gorrette Nalwadda Kayondo
ID:
Analysis of Quality of Child Immunization Delivery in Rural and Urban Health Care Settings in Uganda
REFNo: HS505ES

a) Design short formatted and de-identified video footage for education, communication and research purpose on immunization delivery in low income settings, based on video footage previously collected under the “Child Immunization Delivery Project, Pathway/Landscape Analysis in Rural and Urban Health Care Settings in Uganda” (Protocol 258).
b)Design and develop a website/web portal to make available video, artefacts, field observation notes and other research data (de-identified data) for non-restricted use, and restricted use (raw data) to people working in public health, innovators, programmers, policy makers.
c) Explore and analyze the quality of child immunization service delivery and compliance with immunization guidelines in rural and urban health care settings, and possible solutions
d) Engaging policy makers in the use of the research findings from the child immunization delivery project for sound development of policies and programs
e) Utilize the de-identified ethno videography data for capacity building, communication and charitable global health activities in maternal newborn and child health policy development and program implementation.

 Uganda 2019-12-27 2022-12-27 Medical and Health Sciences Non-degree Award
Cara Ebert
ID:
Impact evaluation of two youth skill development interventions as part of the Employment for Development (E4D) program of the German Corporation for International Cooperation (GIZ)
REFNo: SS397ES

The objective of the investigation is to identify interventions implemented by the German Development Corporation program E4D/SOGA that work and have the potential to be scaled up. The E4D/SOGA funds and implements a large portfolio of interventions in Uganda – comprising a total budget of EUR 10,700,000. In this light, we intend to evaluate the effectiveness of two E4D/SOGA programs. The investigation will give guidance on policy decisions by highlighting the relevance of short-course technical skills trainings, work readiness skills and labor market attachment via internship placement.
 Germany 2019-12-27 2022-12-27 Social Science and Humanities Non-degree Award
Shevin  Jacob Thomas
ID:
THE AFRICAN RESEARCH COLLABORATION ON SEPSIS IN UGANDA (ARCS-UGANDA) COHORT STUDY: AN OBSERVATIONAL STUDY TO IMPROVE UNDERSTANDING OF SEPSIS EPIDEMIOLOGY, DEFINITIONS, HOST IMMUNE RESPONSE AND COSTS OF HOSPITAL CARE IN UGANDAN ADULTS
REFNo: HS511ES

General Objective:
To describe adult sepsis prevalence and incidence, validate sepsis definitions, characterize AMR, describe short- and long- term morbidity and mortality, identify host response to sepsis and quantify hospital costs using a cohort of adult patients with suspected sepsis admitted to hospitals in Uganda

Specific objectives:
1. Determine the epidemiologic characteristics, AMR characteristics, clinical outcomes (including morbidity, mortality and frequency of readmission after discharge from the hospital) and attributable costs from suspected sepsis in Ugandan hospitals
2. Evaluate performance characteristics of extant sepsis definitions/criteria when applied to a cohort of adult patients who fulfil study eligibility criteria for sepsis in Uganda
3. Characterize pathways of sepsis pathogenesis through exemplar pro-inflammatory (through neutrophil respiratory burst activity) and immunosuppressive (through HLA-DR) markers and agnostic transcriptomic analysis in a Ugandan sepsis cohort with a high prevalence of HIV infection.

USA 2019-12-27 2022-12-27 Medical and Health Sciences Non-degree Award
Lydia Nakiyingi
ID:
Prospective Multicentre Evaluation of the Accuracy and Diagnostic Yield of the Fujifilm SILVAMP TB LAM Test for the Diagnosis of Tuberculosis in People Living with HIV
REFNo: HS513ES

ï‚· To determine the diagnostic accuracy of FujiLAM for TB detection among PLHIV using an eMRS
ï‚· To determine the diagnostic accuracy of FujiLAM for TB detection among PLHIV using a CRS ï‚· To determine the diagnostic yield of FujiLAM among all patients identified as having TB by
eMRS and compare to AlereLAM, Smear and Xpert/Ultra (sputum, urine) as comparators
(on Day 1 specimens).

Secondary,
ï‚· To determine the diagnostic accuracy of FujiLAM for TB detection among PLHIV using a MRS.
ï‚· To determine the diagnostic yield of FujiLAM among all patients identified by MRS and compare to AlereLAM, Smear and Xpert/Ultra (sputum, urine) as comparators (on Day 1 specimens).
ï‚· To determine the diagnostic accuracy of FujiLAM across predefined subgroups using a MRS, eMRS and CRS separately.
ï‚· To determine the diagnostic accuracy of FujiLAM of Day 2 early morning urine using a MRS, eMRS and CRS separately.
ï‚· To determine the diagnostic accuracy of FujiLAM of Day 2 early morning urine across subgroups using a MRS, eMRS and CRS separately.
ï‚· To determine the diagnostic accuracy of AlereLAM in the same way as described in objectives 1.1, 1.2 and 2.1, 2.3 and compare it to that of FujiLAM.
ï‚· To determine the yield of FujiLAM over (incremental yield) or in combination with (combined yield) Smear and Xpert/Ultra (sputum) among eMRS-positive patients.
 To determine the diagnostic accuracy of Omega VISITECT® CD4 test for detection of a CD4 count ≤200 cells/µl, using WHO pre-qualified cytometers as the reference standard.  To collect and store high quality and well-characterized urine specimen from PLHIV
Uganda 2019-12-27 2022-12-27 Medical and Health Sciences Non-degree Award
Joseph Baluku B
ID: UNCST-2019-R000612
 Prevalence of Sputum Positive Tuberculosis and associated Factors among Individuals found at Bars in Kampala Slums
REFNo: HS459ES

Primary Objective: To determine the prevalence of sputum positive TB among individuals found at bars in Kampala slums
Secondary Objectives:
1. To evaluate factors associated with sputum positive TB individuals found at bars in Kampala slums.
2. To determine the prevalence of HIV infection among individuals found at bars in Kampala slums
3. To determine the prevalence of TB/HIV co-infection among individuals at bars in Kampala Slums

 Uganda 2019-12-13 2022-12-13 Medical and Health Sciences Non-degree Award
Jayne Webster
ID:
Process Evaluation of Integrated Immunisation & Family Planning Projects in Benin, Kenya, Malawi and Uganda
REFNo: SS367ES

1. Assess FP method acceptance and continuation in women who access immunisation and/or family planning services 2. Test associations between FP method acceptance and continuation and integration attributes 3. Assess the quality and responsiveness of integrated immunisation and FP delivery 4. Determine implementation fidelity, causal mechanisms and context in integrated immunisation and family planning 5. Develop an overall programme theory of what works, for who, how and in what circumstances the integrated delivery of immunisation and family planning
 UK 2019-12-13 2022-12-13 Social Science and Humanities Non-degree Award
Namara  Khadija Asiimwe
ID:
INFORMATION TECHNOLOGY ALIGNMENT AND ORGANIZATIONAL PERFORMANCE IN THE SERVICE SECTOR IN UGANDA. A CASE STUDY OF UMEME (U) LIMITED
REFNo: SS378ES

i.To establish the relationship between IT governance and organizational performance in Umeme Limited
ii.To establish the relationship between IT investment and organizational performance at Umeme Limited.
iii.Assess the effect IT implementation has on organizational performance at Umeme Limited.

 Uganda 2019-12-13 2022-12-13 Social Science and Humanities Degree Award
Shevin  Jacob Thomas
ID:
STUDY OF WASH AND ANTIMICROBIAL RESISTANCE IN UGANDA (SWAR-U)
REFNo: HS489ES

Primary objective: To describe the transmission dynamics and ecological niches of ESBL-E and ESBL-K within selected households from Kampala and Hoima

Secondary objectives:
To evaluate the drivers of Water, Sanitation, and Hygiene (WASH) practices and their relation to the faecal-oral transmission of extended spectrum beta-lactamase producing Eschericia coli and Klebsiella pneumoniae

To create a dynamic agent-based model to evaluate the drivers of antimicrobial resistance transmission in Uganda, through the incorporation of microbiological resistance data (ESBL-E and ESBL-K) and WASH observational data obtained from all households included in the SWAR-U study

 USA 2019-12-13 2022-12-13 Medical and Health Sciences Non-degree Award
Innocent Ssemanda
ID:
IMPLEMENTATION FIDELITY OF TRICHIASIS SURGERY PROGRAME IN NORTHEASTERN UGANDA
REFNo: HS497ES

To assess and describe implementation fidelity of Trichiasis surgery programme and associated factors, to outcomes in Northeastern Uganda.
 Uganda 2019-12-13 2022-12-13 Medical and Health Sciences Degree Award
Simon L'Allier
ID:
Behavioral endocrinology of male dispersal in vervet monkeys (Chlorocebus pygerythrus) at Lake Nabugabo, Uganda
REFNo: NS84ES

Evolutionary causes and consequences (or the “why”) of dispersal are fairly well established, bein respectively inbreeding avoidance and increased reproductive success (Bowler & Benton, 2005). However, the environmental, social, individual, and physiological proximate mechanisms underlying individual dispersal decisions, and their consequences, are still poorly understood. Previous studies have mainly focused on the individual’s physiological response to
8

dispersal events (before and after) and looked at the social outcome (e.g., dominance rank) rather than the processes leading to that outcome. For this research, my objectives are to examine how the numerous potential costs of dispersal drive individual dispersal decisions as to when, where, and how they transfer (lone or parallel). I will assess the environmental, social, and physiological causes and consequences of dispersal in vervet monkeys at Lake Nabugabo. My hypotheses and predictions are summarized in Table 2. Dominance rank is often established once a male immigrates into another group. The males’ ability to take over a group and the attainment of a high dominance rank might be dependent on when, where, and how they disperse. My research contributes to a broader understanding of how the immediate environmental, social, and individual factors affect the way they transfer.
Canada 2019-12-12 2022-12-12 Natural Sciences Degree Award
Eliab Kweyunga Horub
ID:
Mathematical Models for the dynamics of banana xanthomonas wilt and the banana weevil, Cosmopolites Sordidus, (Germar) and control Interventions
REFNo: A58ES

1. to quantify the role of symptomless but infectious plants in the persistence of banana xanthomonas wilt;

2. evaluate the effectiveness of existing control options against the banana weevil;

3. use optimal control theories to originate a combination of controls that will ensure management of the pest and disease at minimal cost in terms of time, funds and environmental damage;
 Uganda 2019-12-09 2022-12-09 Agricultural Sciences Degree Award
Sarah Lofgren
ID: UNCST-2019-R001647
 The Growth Study- Group Therapy In HIV For Depression In Uganda
REFNo: HS493ES

Determine if depression, which persists after depression treatment at 26 weeks, is associated with increased innate inflammation in a prospective cohort of HIV-infected Ugandans receiving SSRIs in which group psychotherapy is initiated.
 USA 2019-12-09 2022-12-09 Medical and Health Sciences Non-degree Award
David Lawrence S
ID:
THE LIVED EXPERIENCE OF PARTICIPANTS IN AN AFRICAN RANDOMISED TRIAL (LEOPARD)
REFNo: SS386ES

AIM: To document the AMBITION participant experience in order to build an understanding of how to improve trial delivery for future participants in the trial. OBJECTIVES From the perspective of the participant: 1. To build an understanding of the factors that enhance or diminish a clinical trial experience. From the perspective of the next-of-kin of a participant: 2. To build an understanding of the factors that enhance or diminish a clinical trial experience. From the perspective of the researcher: 3. To build an understanding of the factors that are perceived to enhance or diminish a trial participant’s experience of a clinical trial. 4. To compare the individual researcher’s experience of the conceptualisation, development, initiation and implementation of a multi-centred clinical trial in Africa.
 UK 2019-12-09 2022-12-09 Social Science and Humanities Degree Award
SIMON BYONANUWE
ID:
“Prevalence, bacterial pathogens and factors associated with premature rupture of membranes at Kampala International University Teaching Hospital”.
REFNo: HS503ES

Main objective: To determine the prevalence, bacterial pathogens and factors associated with premature rupture of membranes at Kampala International University Teaching Hospital.

Specific objectives:
1. To determine the prevalence of premature rupture of membranes at Kampala International University Teaching Hospital.
2. To determine the obstetric and gynaecologic factors associated with premature rupture of membranes at Kampala International University Teaching Hospital.
3. To identify bacterial pathogens commonly associated with premature rupture of membranes at Kampala International University Teaching Hospital.
4. To assess antibacterial susceptibility patterns of the isolated bacterial pathogens.


 Uganda 2019-12-09 2022-12-09 Medical and Health Sciences Degree Award
PETER SPENCER SIMNER
ID:
Etiology of Nodding Syndrome: an Epileptic Disorder of East African Children
REFNo: HS410ES

Increase understanding of the role of environmental exposures, notably to specific neurotropic viruses, as risk factors for Nodding syndrome.
 USA 2019-12-04 2022-12-04 Medical and Health Sciences Non-degree Award
Willy Ssengooba
ID: UNCST-2022-R001801
 PERFORMANCE OF ALTERNATIVE MEASURES OF RESPONSE TO THERAPY DURING THE INITIAL 12 WEEKS OF MDR-TB TREATMENT
REFNo: HS471ES

1. To examine the correlations of FDA smear microscopy, PMA-Xpert Ct value &16s rRNA (MBLA) with MGIT-TTP as a reference standard.
2. To evaluate the ability of FDA smear microscopy, PMA-Xpert Ct value, MBLA in predicting 12-weeks MGIT culture conversion (outcome).
3. To evaluate the influence of patient clinical characteristics, baseline resistance profiles, adherence and HIV-status to the performance of the alternative measures of response.

 Uganda 2019-12-04 2022-12-04 Medical and Health Sciences Degree Award
Jimmy Otim
ID:
Bridewealth and the Future of Customary Marriages in postwar Acholi society
REFNo: SS377ES

To examine the cultural relevance of bride wealth practices in shaping customary marriages across generations in Acholi society
To find out the changes which have occurred overtime to bride wealth practices in shaping customary marriages
To investigate how marriages are contracted in the face of scarcity of cattle and increasing bride wealth payments in postwar Acholi society
To explore perceptions and attitudes of men and women towards bridewealth practices, cohabitation, and children born out of wedlock
 Uganda 2019-12-04 2022-12-04 Social Science and Humanities Degree Award
Gerardo Zarazua de Rubens
ID:
Cleaning the air through cooking: providing alternative energy solutions for cooking practices in the Bidibidi Refugee Settlement in Yumbe district in Uganda
REFNo: SS390ES

The project focuses on investigating emissions and respiratory impact between traditional fuel burning cooking methods (solid biomass/ charcoal/ firewood) and solar voltaic clean cooking methods within the Bidibidi Refugee Settlement in northern Uganda. The aim is to evaluate the type and level of impact of each technology, in particular the effects on the environment in the form of air pollution and impacts such as deforestation, wellbeing (health and economic creation) and safeguarding.
Mexico 2019-12-04 2022-12-04 Social Science and Humanities Non-degree Award
Peter Kirabira Simon
ID: UNCST-2020-R014690
 Active Reporting of Adverse drug reactions of antiretroviral drugs among adults living with HIV in East Africa: a pilot study on using SMS
REFNo: HS431ES

2. Objectives 2.1 Main objective: To test the feasibility and acceptability of Mhealth system to create awareness on importance of reporting adverse drug reactions of antiretroviral therapy among adults living with HIV in Tanzania and Uganda
2.2 Specific objectives
1. To investigate feasibility of the SMS system among health care workers by measuring practicality, actual fit, utility, trialability,
2. To investigate acceptability of the system among health care workers by measuring and comfort, relative advantage and credibility
3. To investigate feasibility of the system among PLHIV by measuring practicality, actual fit utility, trialability.
4. To investigate acceptability of the system among PLHIV by measuring comfort, relative advantage and credibility.
5. To describe the perceptions/attitudes of HCWs towards the use of m-health to improve ADR reporting.
6. To investigate the technical feasibility of the system by measuring sent, received and replied messages.
7. To give an overview of reported ADRs among adults living with HIV in KCMC and Majengo in Moshi and Nsambya in Kampala

 Uganda 2019-11-27 2022-11-27 Medical and Health Sciences Non-degree Award
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