Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
Search By Approval Date:
Clear Filter Total: 5,902
Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Jennifer Serwanga
ID: UNCST-2024-R002056
 Preparation of an Inactivated covid-19 vaccine at UVRI for pre-clinical evaluations at COVAB and an Outsourced primate centre
REFNo: HS1018ES

Collect nasopharyngeal swab of circulating virus strains b. Isolate local and globally representative wildtype SARS-CoV2 stocks c. Generate inactivated SARS-CoV-2 products (The Vaccine). d. Generate SARS-CoV-2 and other b-CoVs pseudovirus stocks
e. Develop assays to distinguish SARS-CoV-2 binding antibodies
f. Develop assays to distinguish SARS-CoV-2 functional neutralizing antibodies
g. Assess inactivated vaccine in Humanized ACE2 mice challenge models
h. Challenge Macaque models to assess safety, immunogenicity and protectiveness
i. Assess immunized mice for vaccine-induced antibody responses
j. Assess immunized mice for vaccine induced cellular responses
k. Assess immunized mice plasma for inflammatory responses
l. Immuno/histopathology of immunized mice organs/tissues
m. Train and develop capacity for skill transfer
The research questions are;
• Will the inactivated vaccine protect challenged mice against developing COVID-19
disease?
• Will the vaccine elicit potent neutralizing antibodies against diverse SARS-CoV-2
strains and how potent are these antibodies?
• Will the vaccine protect the challenged mice against severe inflammatory responses
and organ pathology?
• Will the inactivated vaccine elicit potent and protective effector T -Cell responses?
 Uganda 2021-02-05 2024-02-05 Medical and Health Sciences Non-degree Award
Athanansio Bashaija
ID:
Occupational Stress, Hope, and Alcohol Use among Secondary School Teachers in Greater Bushenyi, Uganda
REFNo: SS671ES

To examine the level of occupational stress among secondary school teachers in Greater Bushenyi.
To assess the level of alcohol use among secondary school teachers in Greater Bushenyi.
To examine the level of hope among secondary school teachers in Greater Bushenyi.
To determine the relationship between occupational stress and alcohol use among secondary school teachers in Greater Bushenyi.
To establish the moderation effect of hope on the relationship between occupational stress and alcohol use among secondary school teachers in Greater Bushenyi.

 Uganda 2021-02-05 2024-02-05 Social Science and Humanities Degree Award
Victor Musiime
ID: UNCST-2021-R013794
 A Phase 2b Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease (IMR-SCD-301)
REFNo: HS1119ES

Primary Objectives:
1. To evaluate the HbF response to IMR-687 versus placebo
2. To evaluate the safety of IMR-687 versus placebo

Secondary Efficacy Objectives:
1. To evaluate the effect of IMR-687 versus placebo on HbF-associated biomarkers
2. To evaluate the effect of IMR-687 versus placebo on indices of red cell hemolysis
3. To evaluate the effect of IMR-687 versus placebo on indices of RBC adhesion
4. To evaluate the effect of IMR-687 versus placebo on the incidence of VOCs
5. To evaluate the effect of IMR-687 versus placebo on quality of life (QoL) measures

Pharmacokinetic Objectives:
To evaluate the PK of IMR-687 and any major circulating metabolites

Exploratory Efficacy Objectives:
1. To evaluate the effect of IMR-687 versus placebo on changes in RBC characteristics and total Hb
2. To evaluate the effect of IMR-687 versus placebo on renal function
3. To evaluate the effect of IMR-687 versus placebo on indices associated with cardiovascular pathophysiology and ischemic stroke risk

Uganda 2021-02-05 2024-02-05 Medical and Health Sciences Non-degree Award
Sheila Balinda Nina
ID: UNCST-2021-R013804
 Novel Adenovirus-based Vaccine for Uganda SARS COV-2 viruses
REFNo: HS1153ES

To develop a Novel SARS-Cov-2 Adeno-Vectored Vaccine against COVID-19. Briefly, we propose two adenovirus vector constructs using both S1 and S2 SARS-CoV-2 glycoproteins previously generated for the subunit vaccine design at CoVAB. Alternatively, these genes can also be amplified directly from the genome at the UVRI laboratories. Although most of the world is focused on SARS-CoV-2 Spike as an antigen, there are additional viral capsid proteins that should also be considered including the Envelope and N proteins.
 Uganda 2021-02-05 2024-02-05 Medical and Health Sciences Non-degree Award
Kinyaa Rufina Ayia
ID:
Teachers use of formative assessment in teaching reading comprehension in transition class, Moyo Sub County, Moyo district.
REFNo: SS582ES

To investigate teachers’, use of formative assessment in teaching reading comprehension in the transition class.
> To examine the strategies teachers’, use for formative assessment in reading comprehension in the transition class.
> To establish the challenges teachers’ encounter when administering formative assessment in reading comprehension in the transition class

 Uganda 2021-02-04 2024-02-04 Social Science and Humanities Degree Award
AGNES NAGGIRINYA BWANIKA
ID: UNCST-2019-R001126
 DETERMINATION OF CROSS-SPECIES TRANSMISSION OF COVID-19 AT ANIMAL-HUMAN INTERFACE USING A ONE HEALTH APPROACH FOR IMPROVED DISEASE SURVEILLANCE AND CONTROL
REFNo: HS905ES

General Objectives
To assess existence of SARS-CoV-2 in domestic and wild animals (in Amuru/ Greater Rakai and UWEC) and corona virus antibody in humans (Amuru/ Greater Rakai) with no history of infection, using a one health approach.
Specific Objectives
• Assess prevalence of SARS-CoV-2 in wild, livestock and companion animals, which may act as reservoirs of the causative agent in areas with confirmed cases of COVID-19 in Uganda
• Assess prevalence of the virus-specific antibodies in humans with no known history of contact with confirmed COVID-19 cases
• To determine the genetic relatedness between the human virus isolates with those obtained from the animals in order to confirm cross-host species transmission in Amuru and Greater Rakai districts.

 Uganda 2021-02-04 2024-02-04 Medical and Health Sciences Non-degree Award
Caroline Delaire
ID:
Evaluating the potential of point-of-collection chlorination and village savings and loans associations to improve water safety management in rural Uganda
REFNo: SIR47ES

1. To evaluate the effectiveness of an inline handpump chlorinator (PurAll 50H) at improving water safety.
2. To understand the contexts that are favorable for bundling maintenance and chlorination, and the contexts where bundling is not appropriate.
3. To understand the contexts where VSLA-managed “water funds” are successful at increasing financial resources available for handpump maintenance, and the contexts where this strategy is less effective.

 France 2021-02-04 2024-02-04 Engineering and Technology Non-degree Award
Eve  Namisango
ID: UNCST-2021-R014038
 Health Systems Strengthening through person-centred care: development of a feasible and acceptable theory-based workforce approach to improve quality
REFNo: HS1000ES

i) To adapt the conceptual framework of person-centred care for serious illness (MONTHS 1-10).
ii) To determine professional views on the feasibility, acceptability and necessary requirements for health systems change to deliver person-centred and values-based care (MONTHS 11-12).
iii) To design a systems-oriented strategy to enhance the person-centredness of care based on evidence from objectives i+ii (MONTHS 13-16).
iv) To refine and determine psychometric properties of a brief measure of person-centredness for subsequent evaluation of the health systems strengthening strategy (MONTHS 17-24).

Uganda 2021-02-04 2024-02-04 Medical and Health Sciences Non-degree Award
Nathan Fiala
ID: UNCST-2022-R009060
 “An exploration of groundnut Seed Quality Along the distribution chain in Uganda.”
REFNo: A109ES

The general objective of this study is to conduct an analysis of seed quality along the supply chain of groundnuts in Uganda. The selected crop for this study is important and the seed system is largely informal. Groundnuts is nearly 100% self-pollinating (98-99%) and farmers keep the seeds often beyond the recommended replacement period.
 USA 2021-02-04 2024-02-04 Agricultural Sciences Non-degree Award
Aloysius Ssennyonjo Ssennyonjo
ID: UNCST-2021-R013504
 COVID-19 Lockdown in Slums Informal Urban Settlements: Social and- Health Effects, Coping Strategies and Lessons for Improving the Livelihood of the Urban Poor in Kisenyi, Kampala, Uganda
REFNo: HS887ES

General Objective
To explore the social and health effects of COVID-19 lockdown, coping strategies and lessons for improving the livelihood of the urban poor in Kisenyi, Kampala, Uganda
Specific Objectives

1. To assess the immediate health effects of COVID 19 lockdown among the urban poor in Kampala
2. To assess the immediate social effects of COVID 19 lockdown among the urban poor in Kampala
3. To explore how the urban poor households coped with selected effects of the COVID-19 lockdown
4. To explore lessons for mitigating the effects of COVID 19 lockdown in the immediate recovery phase and consider implications for long term programming for urban poor.

 Uganda 2021-02-02 2024-02-02 Medical and Health Sciences Non-degree Award
Julius Tumusiime
ID:
Dynamics of Snail Species and Interventions to Reduce associated Schistosoma and Fasciola Parasitic Infections: A Citizen Scientists’ approach in Western Uganda
REFNo: NS148ES

1. determining the diversity and spatial-temporal distribution of freshwater snail intermediate hosts of Schistosoma/Fasciola parasites.
2. evaluating the diversity of Schistosoma/Fasciola trematodes shed per snail host: comparison of traditional and molecular methods.
3. examining the biotic (macrophyte, vertebrate hosts) and abiotic (rainfall, pH, DO, EC, temperature, inorganic ions) factors that influence the occurrence of Schistosoma/Fasciola snail hosts.
4. assessing the dependability/reliability of citizen researchers’ malacological survey, snail species identification and disease risk hotspot identification.

Uganda 2021-01-29 2024-01-29 Natural Sciences Degree Award
Alex Saturday
ID: UNCST-2023-R007459
 INVESTIGATION OF SPATIO-TEMPORAL VARIATION IN BIOLOGICAL AND PHYSICO-CHEMICAL WATER QUALITY PARAMETERS IN LAKE BUNYONYI, SOUTH-WESTERN UGANDA
REFNo: NS149ES

i. To determine the Spatio-temporal variations of bacterial fecal indicators of water in Lake Bunyonyi.
ii. To assess the Spatio-temporal variations in phytoplankton composition and biomass in the water of Lake Bunyonyi.
iii. To determine the Spatio-temporal variations of physicochemical quality of water in Lake Bunyonyi.
iv. To examine the seasonal variations of the trophic state conditions of Lake Bunyonyi ecosystem
v. To investigate the processes that governs nutrient dynamics in Lake Bunyonyi ecosystem.

Uganda 2021-01-28 2024-01-28 Natural Sciences Degree Award
Emily Otali
ID:
A study of health and forage patterns of wild African honeybees (Apis mellifera scutellata) and their impact on the survival of Kibale National Park, its threatened chimpanzees and elephants.
REFNo: A82ES

The general objective for this study is to engage farmers and students living around Kibale National Park, Uganda, in an accessible and culturally relevant participatory science project that collects and analyzes data measuring colony health and foraging plants of wild African honeybees for a period of two years. This will be achieved through:
• Developing participatory science project appropriate for rural Ugandan farmers and partnering students.
• Establishing baseline colony health and forage patterns for the wild African honey bee in the Kibale National Park ecosystem.
• Determining if colony health and forage patterns for the wild African honey bee knowledge will help achieve maximum honey yields and increased forage diversity.

 Uganda 2021-01-28 2024-01-28 Agricultural Sciences Non-degree Award
Jackson Mukonzo
ID: UNCST-2021-R013916
 IDENTIFICATION, VALIDATION AND OPTIMIZATION OF AVAILABLE DRUG MOLECULES FOR CLINICAL TREATMENT OF COVID-19.-IVCOM
REFNo: HS1065ES

1. Explore the clinical use of combination anticoagulant: lower dose aspirin and ivermectin, an FDA-approved anti-parasitic drug therapy in treatment of COVID-19 patients in an exploratory randomized trial.
2. To identify target molecules through testing and screening for SARS-CoV-2 activity of existing substances, molecules or formulations on basis of registered activity claims or scientific evidence for anti- SARS-CoV-2 activity including herbal preparations, quinolone derivatives (chloroquine and hydroxyquinoline) in combination with zinc, HIV entry and protease inhibitors, HCV protease inhibitors and entry inhibitors as well as agents with inhibitory and down regulatory effect on ACE2 and those that might be identified thorough literature search.
3. Use bioinformatics tools to perform structural optimization of molecules identified in objective 2 above for efficacy and safety of COVID-19 patents and conduct early phase clinical trials on the resulting molecules.
Uganda 2021-01-28 2024-01-28 Medical and Health Sciences Non-degree Award
Alex Mabirizi
ID:
ASSESING THE EFFECT OF CONCURRENT VACCINE ADMINISTRATION FOR PESTE DES PETITS RUMINANTS, CAPRIPOX AND CONTAGIOUS CAPRINE PLEUROPNEUMONIA ON IMMUNITY OF SHEEP AND GOATS IN UGANDA
REFNo: A106ES

1. To determine antibody titres against PPR, CCPP and Capripox Virus following single and concurrent administration of two or three vaccines.
2. To determine cytokine responses to PPR, CCPP and Capripox Virus following single and concurrent administration of two or three vaccines.

Uganda 2021-01-28 2024-01-28 Agricultural Sciences Degree Award
faith mbabazi musinguzi
ID:
Role conflict and Burnout among university administrators in selected universities in Uganda
REFNo: SS552ES

4. To assess the influence of role conflict on burnout for administrators across universities.,3. To establish the administrators’ experience with role conflict and burnout among administrators.,2. 2. To examine the degree to which role conflict constructs predict burnout among non-academic administrators.,1.To establish the extent to which role conflict constructs predict burnout among academic administrators.,
 Uganda 2021-01-27 2024-01-27 Social Science and Humanities Degree Award
Ponsiano Ocama
ID: UNCST-2019-R000440
 Clinical and immunological impact of Schistosoma mansoni infection and treatment on the course of chronic hepatitis B virus (HBV) infection in HIVuninfected patients in Uganda
REFNo: HS1002ES

To determine Clinical and immunological impact of Schistosoma mansoni (Sm) infection and treatment on the course of chronic hepatitis B virus (HBV) infection in Uganda. This will be done through the following aims: Aim 1: To define and quantify Sm infection, treatment response, and reinfection rates within a cohort of chronic HBV patients Aim 2: To determine the impact of Sm infection and treatment on HBV virological markers, disease stage, and longer-term progression among urban Ugandans Aim3: To determine if HBV-specific immunological responses in the periphery and within the liver are altered in response to Sm infection and treatment

Uganda 2021-01-27 2024-01-27 Medical and Health Sciences Non-degree Award
Miriam Nakalembe
ID: UNCST-2021-R014040
 Understanding CIN2+ among HIV infected women after LEEP: An epidemiological and immunohistochemical study
REFNo: HS1154ES

1. To assess the incidence and risk factors for “recurrent” CIN2/3 after LEEP among HIV- infected women.
2. To determine baseline HR-HPV types (in tissue) among HIV-infected women with CIN2/3 undergoing LEEP compared to the HR-HPV types with “recurrent” cervical lesions after a second LEEP.
3. To determine the immunohistochemical differences between the initial and repeat LEEP specimens among HIV-infected women with “recurrent” CIN2/3

 Uganda 2021-01-27 2024-01-27 Medical and Health Sciences Non-degree Award
Edward Nsubuga
ID:
Work place violence and interventions used at mental health units in uganda
REFNo: HS435ES

Identifying the patterns of workplace violence,contributing factors ,and remedial interventions available in place for such victims.
 Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Non-degree Award
Joseph Kagaayi
ID: UNCST-2024-R015946
 Hard to reach populations in Uganda; An observational cohort study
REFNo: HS607ES

Aim 1-We will first determine CHP coverage and HIV incidence among hard-to-reach persons using enhanced surveillance techniques.

Aim 2-We will then characterize ongoing sources of incident HIV infection through partner tracing of newly HIV-infected participants and matched HIV-negative controls, viral phylogenetics, and sexual network analyses.

Aim 3-Finally, we will determine if state-of-the-art CHP can engage hard-to-reach populations and reduce population-level HIV incidence to a level sufficient for HIV elimination by 2030.



Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Non-degree Award
View Sort By:

"A prosperous Science and Technology Led Ugandan Society."

NRIMS