Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Janet Lewis I
ID:
Reducing Prejudice Against Refugees Pilot
REFNo: SS662ES

The vast majority (85%) of the world’s political refugees live in developing countries, according to UNHCR. As of early 2019, Uganda was home to over one million refugees from South Sudan, and had the largest refugee/asylum-seeker population in Africa (ACCORD 2019). Uganda has a strong national commitment to hosting refugees that is reflected in its immigration policies, leading some to call it a “melting pot” of regional nationalities. Still, its population faces challenges absorbing these refugees that are common to host countries. Relations are often strained between the refugee population and Ugandans, some of who perceive refugees as unwelcome competition for local resources and services (World Vision 2018; UNHCR 2018; ACCORD 2019).
This study will allow us to better understand the perceptions of Ugandans towards South Sudanese refugees, and measure both the extent of anti-refugee prejudice there and whether a perspective-taking intervention is effective at reducing prejudice. This knowledge will be crucial for understanding how best to design a later, larger study, which could substantially advance knowledge about prejudice reduction towards refugees in Uganda.
Furthermore, this study will provide a useful indication about whether our full version of this study will be able to measure spillover of the treatment through social networks; we will ask respondents in our endline survey about whether and with whom respondents discussed the intervention. Prejudicial attitudes are socially reinforced; changing one person’s mind may be difficult if that person’s peers still hold prejudicial beliefs. Likewise, if many of one’s peers have begun to reconsider their own prejudices, one may be encouraged to do so as well. Our prior work leads us to expect the information to spread widely, and some change in attitudes and behavior, but only for those connected to a treatment recipient via certain kinds of social ties (Larson and Lewis 2017, 2018). Practitioners often assume that interventions spread from a subset of individuals to their broader community through felicitous spillovers. If this pilot is successful, our full study will be among the first to measure whether and how this occurs for prejudice reduction through networks. This knowledge could, among other things, lead to more efficient designs of community prejudice-reduction projects. Moreover, even if spillover effects are not present, the full study will be able to detect how news of the intervention spreads through local networks. Doing so will provide rare, direct evidence of information dissemination through word-of-mouth networks, which is useful for the design of programs aimed at seeding any type of public service message – from news intended to diffuse conflicts, to information about a new technology that promises to better hold politicians accountable or improve public health.

Our pilot study therefore addresses four questions:
(1) What is the extent of anti-refugee prejudice among Ugandans living in villages in West Nile?
(2) Do positions towards refugees correlate with their positions in village social networks?
(3) Can a brief conversation oriented towards taking the perspective of South Sudanese refugees reduce Ugandans’ prejudice toward them? If so, does the effect persist after 2-3 weeks?
(4) To what extent does news spread about this perspective-taking exercise, and through which types of contacts?
USA 2021-02-12 2024-02-12 Social Science and Humanities Non-degree Award
AGGREY DHABANGI
ID:
Hemolytic Disease of the Newborn in Uganda: Burden and Clinical Characteristics (Short title: HDN in Uganda)
REFNo: HS1089ES

To determine the prevalence of HDN due to RhD among newborn infants with jaundice admitted to Kawempe National Referral hospital in Uganda.
Uganda 2021-02-12 2024-02-12 Medical and Health Sciences Non-degree Award
Peter Elyanu James
ID: UNCST-2021-R013210
PREVALENCE AND RISKS ASSOCIATED WITH METABOLIC SYNDROME IN CHILDREN AND ADOLESCENTS LIVING WITH HIV IN UGANDA. A PILOT STUDY
REFNo: HS1128ES

i To determine the prevalence of MetS among children and adolescents living with HIV in Uganda.
ii To identify risks factors for the development of MetS in children and adolescents living with HIV.

Uganda 2021-02-12 2024-02-12 Medical and Health Sciences Non-degree Award
Abner Tagoola
ID:
A phase 2b study to Evaluate the safety and efficacy of IMR-687 in subjects with sickle cell disease.
REFNo: HS1092ES

1. To evaluate the fetal Hb (Hbf) response to IMR-687 versus placable.

2. To evaluate of IMR-687 versus placable
Uganda 2021-02-11 2024-02-11 Medical and Health Sciences Non-degree Award
Afiz Kibuuka Kibuuka
ID: UNCST-2021-R012755
A Phase 2b Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease
REFNo: HS1150ES

Objectives:
Primary Objectives
• To evaluate the fetal hemoglobin (HbF) response to IMR-687 versus placebo
• To evaluate the safety of IMR-687 versus placebo Seconduy Efficacy Objectives
• To evaluate the effect of IMR-687 versus placebo on HbF-associated biomarkers
• To evaluate the effect ofIMR-687 versus placebo on indices of red cell hemolysis
• To evaluate the effect ofIMR-687 versus placebo on indices of white blood cell (WBC) adhesion
To evaluate the effect of IMR-687 versus placebo on the incidence of vaso-occlusive crises (vocs)
• To evaluate the effect of IMR-687 versus placebo on quality of life measures Pharmacokinetic•Óbjectives
• To evaluate the PK ofIMR-687 and any major circulating metabolites
Exploratory Efficacy Objectives
To evaluate the effect of IMR-687 versus placebo on changes in red blood cell (RBC) characteristics and total Hb e To evaluate the effect of IMR-687 versus placebo on renal function
• To evaluate the effect of IMR-687 versus placebo on indices associated with cardiovascular pathophysiology and ischemic stroke risk

Uganda 2021-02-11 2024-02-11 Medical and Health Sciences Non-degree Award
Casim Tolo Umba
ID: UNCST-2021-R012658
Action Towards Reducing Aquatic snail-borne Parasitic diseases (ATRAP)
REFNo: NS128ES

The main objective of the project is to improve Health through the prevention and mitigation of risks that originate at the interface between humans, animals and the environment. In this project we want to increase the capacity to prevent infections by snail-borne diseases in western Uganda. The strategic objectives are as follows:
1. To strengthen scientific research capacity.
2. To strengthen physical and virtual diffusion of scientific research
results to the larger scientific community
3. To raise awareness about snail borne diseases to the general public.
4. To support good governance, based on the scientific results.
5. To develop synergies and complementary activities among partners through multi-partner governance and coordination


Uganda 2021-02-10 2024-02-10 Natural Sciences Degree Award
MIRIAM NAKALEMBE
ID: UNCST-2019-R000824
Designing and Piloting of a Mobile-based Transport Technology linking Mothers to Health Facilities to Reduce Maternal and New-born Deaths in Uganda during the COVID-19 Pandemic.
REFNo: HS1148ES

1. To identify the existing automated maternal services apps and assess the extent to which they provide near real-time information and communication between mothers and the transporters at community level.
2. To develop a mobile-based transport technology that improves two-way communication between mothers and the transporters at community levels
3. To pilot the mobile-based transport technology for its usability and acceptability

Uganda 2021-02-10 2024-02-10 Medical and Health Sciences Non-degree Award
Anthony Nuwa
ID:
Evaluating the feasibility, acceptability and protective efficacy of seasonal malaria chemoprevention in two districts in Karamoja, Uganda
REFNo: HS1182ES

Objective 1: To document the adaptation of SMC in Karamoja region in Uganda
Objective 2: To Assess the process of implementing SMC in Uganda, with regards to coverage and quality of implementation
Objective 3: To assess the acceptability of SMC among policy makers, implementers, and beneficiaries.
Objective 4: To determine the impact of SMC on malaria incidence and prevalence among children under 5 years in the Karamoja region and assess the protective efficacy of SPAQ
Objective 5: To analyse cost of SMC delivery to children 3-59 months in Karamoja region
Objective 6: Monitor the safety of sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) when used in SMC among children 3-59 months in Karamoja region.

Uganda 2021-02-10 2024-02-10 Medical and Health Sciences Non-degree Award
Noah Kiwanuka
ID: UNCST-2021-R010125
Capturing spatial patterns of new M. tuberculosis infection in Kampala, Uganda
REFNo: HS1230ES

To map the geo-spatial incidence of Mtb infections in a prospective community cohort study of HIV+ and HIV- adults in Kampala Uganda. GPS tracking technology will be used to trace and map subjects to locate areas of high Mtb transmission, or hotspots. Study participants without tuberculous infection will be followed for IGRA/TST conversion for up to 2 years with serial plasma samples taken quarterly.
To determine and validate whether a defined plasma signature found in other studies can identify recent Mtb infection in persons who developed LTBI. Using a paired analysis, we will evaluate baseline and follow-up samples within individuals to determine whether changes associated with new Mtb infection in the community can be detected in plasma with published and newly developed biomarkers. Using a nested case control design, we will compare incident infections with randomly selected controls from the cohort who did not convert

Uganda 2021-02-10 2024-02-10 Medical and Health Sciences Non-degree Award
Daphine Namara Arinaitwe Namara
ID:
The Risk of Diabetes and pre-Diabetes associated with use of Dolutegravir based Antiretroviral Therapy among adult persons living with HIV: A Case-control study at Mulago ISS clinic, Kampala, Uganda
REFNo: HS1077ES

Primary objective: To determine the risk of DM and pre-DM associated with the use of DTG-based ART among adult PLHIV at Mulago ISS Clinic.
Secondary objective; To determine other risk factors for DM and pre-DM among PLHIV adult PLHIV at Mulago ISS Clinic.

Uganda 2021-02-09 2024-02-09 Medical and Health Sciences Non-degree Award
Christine Nalwadda Kayemba
ID: UNCST-2020-R014220
A BASELINE ASSESMENT FOR THE ADVANCING SEXUAL REPRODUCTIVE HEALTH AND RIGHTS (ANSWER) PROGRAM IN THE WEST NILE AND ACHOLI SUBREGIONS IN UGANDA
REFNo: HS1079ES

General objective

To analyse the situation of sexual and reproductive health and rights (SRHR) aspects as well as GBV in the intervention districts of UNFPA’s programme targeting to advance SRHR in the Acholi and West Nile sub regions in Uganda, in order to generate scientific evidence that will inform evidence based planning, implementation and form a basis for monitoring and evaluation of the program interventions.

Specific objectives

1.To conduct Health facility assessment at targeted health facilities in West-Nile and Acholi sub regions in regards to offering quality equitable SRHR services (FP/Maternal health/Post abortion Care, HIV testing and Post GBV) that is responsive to the needs of women, girls, boys and men, refugees, and people with disabilities

2.To undertake an assessment of SRHR Knowledge, Attitudes and Practices (KAP) of adolescents and youth in school including refugees and people with disabilities from a sample of 1,800 targeted schools (primary & secondary) in the study districts on GBV and SRHR.

3.To conduct an assessment of SRHR Knowledge, Attitudes and Practices (KAP) of adolescents and youth out of school including refugees and people with disabilities in the study districts on GBV and SRHR.

4.To conduct a budget and expenditure analysis of key sectors at national level and the district local governments focusing on implementation of and accountability towards the demographic dividend priorities.
Uganda 2021-02-09 2024-02-09 Medical and Health Sciences Non-degree Award
RUTH NAKATO
ID:
A model for assessing the Banking Sector Employees’ Ethical Behavior towards Cyber security.
REFNo: SIR34ES

1. To examine the extent to which cardinal virtue constructs can influence the cyber security behavioral intention of employees towards cyber security ethical behavior in commercial banks in Uganda. 2. To analyze the moderation effect of ethical climate on the virtue constructs in connection with the behavioral intention of employees towards cyber security ethical behavior in commercial banks in Uganda. 3. To examine the mediation effect of behavior intention on the influence of virtue ethics towards cyber security ethical behavior in commercial banks in Uganda. 4. To develop a model for assessing the Employees’ Ethical Commitment and Behavior towards Cyber security in commercial banks in Uganda. 5. To test and validate the developed model.
Uganda 2021-02-08 2024-02-08 Engineering and Technology Degree Award
Tadele Yadesa Mekuriya
ID: UNCST-2022-R010338
Incidence, predictors and risk prediction of adverse drug reactions among inpatients 60 years and older at Mbarara Regional Referral Hospital, Mbarara, Uganda
REFNo: HS992ES

1. To determine the incidence and prevalence of ADRs among elderly inpatients at MRRH
2. To characterize (types, severity and preventability) the ADRs detected among elderly inpatients at MRRH
3. To determine the risk factors of ADRs among elderly inpatients at MRRH
4. To develop and validate an ADR risk score tool (to be named as PADR-HE) for elderly inpatients at MRRH
Ethiopia 2021-02-08 2024-02-08 Medical and Health Sciences Degree Award
Angua Amis Mao
ID:
Energy access as a dividend for designing just transition pathways (EAJT)
REFNo: SIR48ES

1. To assess the effectiveness of different renewable energy technologies in accelerating green jobs creation and a low carbon trajectory; 2. To analyse the equity and distributional implications of energy transition in vulnerable communities across gender, age, and income groups;

3. To develop potential financial and business models to deliver a just transition pathway; and

4. To explore appropriate policy and regulatory frameworks required to support a just transition at multiple levels from grassroots to the national and regional level.

Uganda 2021-02-08 2024-02-08 Engineering and Technology Non-degree Award
David Musoke
ID:
Distribution of antibiotic profiles and antibiotic resistance associated with tuberculosis treatment regimens from wastewater treatment plants in Africa
REFNo: HS1017ES

Specific objectives
1. To determine the profile and concentration of antibiotics used in TB treatment in raw and treated sewage.
2. To investigate the efficiency of the WWTP treatment process in relation to removal of antibiotics post chlorination.
3. To determine the prevalence of antibiotic resistant bacteria (ARB) in raw and treated wastewater in these WWTPs.
4. To evaluate the prevalence of antibiotic resistance genes (ARGs) in raw and treated wastewater.

Uganda 2021-02-08 2024-02-08 Medical and Health Sciences Non-degree Award
Francis Ssali
ID: UNCST-2021-R012134
An open-label, roll-over study with rilpivirine in combination with a background regimen containing other antiretrovirals (ARVs) in human immunodeficiency virus type 1 (HIV-1) infected subjects who participated in rilpivirine pediatric studies
REFNo: HS1083ES

In view of the primary objective of the study to provide continued access to RPV, no primary endpoint is defined for this study.Secondary Endpoint
The secondary endpoints are applicable for all subjects until data collection is terminated, as indicated.
Major Secondary Endpoints
The proportion of subjects experiencing adverse events (AEs) considered to be at least possibly related to RPV, AEs leading to discontinuation, serious adverse events (SAEs), pregnancies, and grade 3/4 rash regardless of causality throughout the study. Results of routine safety laboratory tests will only be collected if related to these types of AEs.
Other Secondary Endpoint
The proportion of subjects maintaining viral suppression (ie, <50 HIV-1 RNA copies/mL) based on available viral load data throughout the study. In case of virologic failure, emergence of resistance will also be evaluated based on available genotype/phenotype data.


Uganda 2021-02-08 2024-02-08 Medical and Health Sciences Non-degree Award
Jonathan Mwiindi Thuranira
ID:
EMERGENCY CESAREAN SECTION AND LENGTH OF STAY IN HOSPITALS IN UGANDA
REFNo: HS1093ES

1. To determine if payer-type (SAFE vs. self-pay) is associated with the decision to delivery interval (DDI) for rural Uganda women undergoing an emergency C-section in Nyakibale Hospital and Rushoroza Hospital. The DDI is the first phase of the aggregated LOS. 2. To determine if payer-type (SAFE vs. self-pay) is associated with the aggregate LOS for rural Uganda women undergoing an emergency C-section in Nyakibale Hospital and Rushoroza Hospital in rural Uganda while adjusting for the Decision to Delivery Interval (DDI). 3. To describe the experience of eight young mothers (aged 18-25) having their second (or more) C-Section delivered by emergency C-section in Southwest Uganda under the SAFE program during April 2020.
Kenya 2021-02-08 2024-02-08 Medical and Health Sciences Degree Award
Bonaventure Ssebyanzi Wasswa
ID:
PRIMARY SCHOOL SUPPORT SYSTEMS TO DEAF CHILDREN LEADING TO THEIR TRANSITION TO POST-PRIMARY EDUCATION IN UGANDA
REFNo: SS590ES

(i) To investigate the support systems for deaf children at the completion of primary school studies.
(ii) To examine the situation of deaf children at the completion of primary studies.
(iii) To explore the self of deaf children at the completion of primary studies.
(iv) To establish the strategies for transition to post-primary level of deaf children at the completion of primary studies.

Uganda 2021-02-05 2024-02-05 Social Science and Humanities Degree Award
Alex Taremwa Taremwa
ID: UNCST-2020-R014302
VIABILITY OF DIGITAL SUBSCRIPTION IN EAST AFRICA – AN ANALYSIS OF VIUSASA AND CHIMPREPORTS’ PAYWALLS
REFNo: SS629ES

1. To identify critical success factors for subscription-based models in digital media platforms.
2. To establish the barriers to subscription uptake among digital media in East Africa.
3. To assess the critical success factors against the ChimpReports and Viusasa’s strategies.
4. To analyse the consumption habits of audiences in line with payment for digital content on Viusasa and Chimp.

Uganda 2021-02-05 2024-02-05 Social Science and Humanities Degree Award
Joseph Lutaakome
ID: UNCST-2020-R008323
An open-label, roll-over study with rilpivirine in combination with a background regimen containing other antiretrovirals (ARVs) in human immunodeficiency virus type 1 (HIV-1) infected subjects who participated in rilpivirine pediatric studies
REFNo: HS1013ES

Primary Endpoint
The primary objective of the study is to provide continued access to RPV, however there is no primary endpoint defined for this study.
Secondary Endpoint
The secondary endpoints are applicable for all subjects until data collection is terminated, as indicated.
Major Secondary Endpoints
The proportion of subjects experiencing adverse events (AEs) considered to be at least possibly related to RPV, AEs leading to discontinuation, serious adverse events (SAEs), pregnancies, and grade 3/4 rash regardless of causality throughout the study. Results of routine safety laboratory tests will only be collected if related to these types of AEs.
Other Secondary Endpoint
The proportion of subjects maintaining viral suppression (ie, <50 HIV-1 RNA copies/mL) based on available viral load data throughout the study. In case of virologic failure, emergence of resistance will also be evaluated based on available genotype/phenotype data.
Uganda 2021-02-05 2024-02-05 Medical and Health Sciences Non-degree Award
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