Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Deo Wabwire Ogema
ID: UNCST-2021-R013932
 COVPN 3008: Multi-Center, Randomized, Efficacy Study of COVID-19 mRNA Vaccine in Regions with SARS-CoV-2 Variants of Concern. Version 1.0 16 May 2021
REFNo: HS1659ES

The primary objectives are:
•To assess vaccine efficacy (VE) of COVID-19 mRNA vaccine to prevent virologically-confirmed symptomatic COVID-19 starting 14 days after dose 2 in adults who are at risk of severe COVID-19
•To assess vaccine efficacy (VE) of COVID-19 mRNA vaccine to prevent severe COVID-19 starting 14 days after dose 2 in adults who are at risk for severe COVID-19
•To assess safety and tolerability of COVID-19 mRNA vaccine in adults who are at risk of severe COVID-19

Secondary objectives are to evaluate the following:
•Durability of VE of COVID-19 mRNA vaccine against COVID-19 and against severe COVID-19 through the final study visit (Month 12 post-dose 1) in volunteers with no previous COVID-19
•VE of COVID-19 mRNA vaccine against COVID-19 and against severe COVID-19 by neutralization phenotype and Spike sequence features of acquired SARS-CoV-2 viruses (sieve analysis), including VE against the B.1.351/501Y.V2 variant and VE against all other variants combined in volunteers with no previous COVID-19
•VE of COVID-19 mRNA vaccine against SARS-CoV-2 infection defined by nucleocapsid protein seroconversion regardless of symptomology in volunteers with no previous COVID-19
•VE of COVID-19 mRNA vaccine against asymptomatic SARS-CoV-2 infection defined by nucleocapsid protein seroconversion without prior occurrence of the symptomatic COVID-19 primary endpoint in volunteers with no previous COVID-19
•Post -vaccination immune response markers as correlates of risk of COVID-19 and as correlates protection against COVID-19
•VE of COVID-19 mRNA vaccine against COVID-19 and severe COVID-19 in all participants regardless of baseline SARS-CoV-2 status
gestational age)
The exploratory objectives are to evaluate:
•VE of COVID-19 mRNA vaccine against COVID-19 and severe COVID-19 by baseline HIV infection status in volunteers with no previous COVID-19 and in all volunteers regardless of previous COVID-19 status
•VE of COVID-19 mRNA vaccine against COVID-19 and against severe COVID-19 by neutralization phenotype and Spike sequence features of acquired SARS-CoV-2 viruses (sieve analysis), including VE against the B.1.351/501Y.V2 variant and VE against all other variants combined in volunteers with no previous COVID-19 and in all volunteers regardless previous COVID-19 status
•VE of COVID-19 mRNA vaccine against COVID-19 and severe COVID-19 in volunteers with previous COVID-19
•Relative rate of COVID-19 and severe COVID-19 in placebo recipients with previous COVID-19 compared to vaccine recipients with no previous COVID-19
•Assess T-cell responses in placebo recipients who develop COVID-19 compared to vaccine recipients who develop symptomatic COVID-19
•Assess incidence of adverse birth outcomes among pregnant persons enrolled in the trial

 Uganda 2021-08-20 2024-08-20 Medical and Health Sciences Clinical Trial Non-degree Award
Edwin Nuwagira
ID: UNCST-2021-R013488
 Improving Pulmonary function after Tuberculosis (IMPACT) at Mbarara Regional Referral Hospital. The incidence, clinical characteristics and factors associated with post-tuberculosis obstructive pulmonary disease at Mbarara Regional Referral Hospital (MRRH)
REFNo: HS1579ES

To determine the incidence, clinical characteristics and factors associated with post-tuberculosis obstructive pulmonary disease at Mbarara Regional Referral Hospital ,
 Uganda 2021-08-20 2024-08-20 Medical and Health Sciences Non-Clinical Trial Degree Award
Umaru Ssekabira Byansansa
ID:
Assessing COVID-19 sero-prevalence from routine antenatal care visits in Moyo and Adjumani Districts, Uganda, 2021-2022
REFNo: HS1628ES

The aim of this activity is to determine COVID-19 sero-prevalence from women attending antenatal clinics for their first ANC visit in Moyo and Adjumani Districts from April 2021 to September 2022.
The specific objectives of this sero-prevalence assessment shall be to:
•Measure the sero-prevalence of antibodies to COVID-19 in the population of pregnant women attending first ANC by age group, in order to ascertain the cumulative population immunity
•Monitor trends and detect emerging hotspots of COVID-19 in selected geographic areas

 Uganda 2021-08-20 2024-08-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Doreen Chemutai
ID:
Pathways, Perceptions and Performance: A comparative Analysis of Women on Open and Reserved Seats in Uganda’s 10th Parliament
REFNo: SS971ES

i. To comparatively analyze the motives of women MPs on the reserved and open seats for seeking parliamentary seats in Uganda’s 10th parliament.
ii. To document the experiences of women members of parliament on the reserved and open seats of their journey to parliamentary seats.
iii. To explain voter’s perceptions of performance of women members of parliament on reserved and open seats.
iv. To evaluate the performance differences of women MPs on the reserved and opens seats of representation and legislation

 Uganda 2021-08-20 2024-08-20 Social Science and Humanities Non-Clinical Trial Degree Award
Annet Nanvubya
ID: UNCST-2025-R015525
 Randomized, Efficacy Study of COVID-19 mRNA Vaccine in Regions with SARS-CoV-2 Variants of Concern version 1.0 16-05-2021.
REFNo: HS1677ES

Primary Objectives
The primary objectives of this study are to determine the following:
• To assess vaccine efficacy (VE) of COVID-19 mRNA vaccine to prevent virologically-confirmed symptomatic COVID-19 starting 14 days after dose 2 in adults who are at risk of severe COVID-19
• To assess vaccine efficacy (VE) of COVID-19 mRNA vaccine to prevent severe COVID-19 starting 14 days after dose 2 in adults who are at risk for severe COVID-19
• To assess safety and tolerability of COVID-19 mRNA vaccine in adults who are at risk of severe COVID-19

Secondary Objectives

The secondary objectives of this study are to evaluate the following:
• Durability of VE of COVID-19 mRNA vaccine against COVID-19 and against severe COVID-19 through the final study visit (Month 12 post-dose 1) in volunteers with no previous COVID-19
• VE of COVID-19 mRNA vaccine against COVID-19 and against severe COVID-19 by neutralization phenotype and Spike sequence features of acquired SARS-CoV-2 viruses (sieve analysis), including VE against the B.1.351/501Y.V2 variant and VE against all other variants combined in volunteers with no previous COVID-19
• VE of COVID-19 mRNA vaccine against SARS-CoV-2 infection defined by nucleocapsid protein seroconversion regardless of symptomology in volunteers with no previous COVID-19
• VE of COVID-19 mRNA vaccine against asymptomatic SARS-CoV-2 infection defined by nucleocapsid protein seroconversion without prior occurrence of the symptomatic COVID-19 primary endpoint in volunteers with no previous COVID-19
• Post -vaccination immune response markers as correlates of risk of COVID-19 and as correlates protection against COVID-19
• VE of COVID-19 mRNA vaccine against COVID-19 and severe COVID-19 in all participants regardless of baseline SARS-CoV-2 status
gestational age)

Exploratory Objectives
The exploratory objectives of this study are to:
• VE of COVID-19 mRNA vaccine against COVID-19 and severe COVID-19 by baseline HIV infection status in volunteers with no previous COVID-19 and in all volunteers regardless of previous COVID-19 status
• VE of COVID-19 mRNA vaccine against COVID-19 and against severe COVID-19 by neutralization phenotype and Spike sequence features of acquired SARS-CoV-2 viruses (sieve analysis), including VE against the B.1.351/501Y.V2 variant and VE against all other variants combined in volunteers with no previous COVID-19 and in all volunteers regardless previous COVID-19 status
• VE of COVID-19 mRNA vaccine against COVID-19 and severe COVID-19 in volunteers with previous COVID-19
• Relative rate of COVID-19 and severe COVID-19 in placebo recipients with previous COVID-19 compared to vaccine recipients with no previous COVID-19
• Assess T-cell responses in placebo recipients who develop COVID-19 compared to vaccine recipients who develop symptomatic COVID-19
• Assess incidence of adverse birth outcomes among pregnant persons enrolled in the trial


 Uganda 2021-08-20 2024-08-20 Medical and Health Sciences Clinical Trial Non-degree Award
Judith Kobusinge
ID:
Effect of selected soil moisture conservation practices on water budgeting in Robusta coffee in Uganda
REFNo: A117ES

1) To predict the effect of soil moisture on Robusta coffee production and productivity in Uganda. 2) To estimate the water use efficiency (WUE) of Robusta coffee at various phenological stages under Albizia coriaria and Open sun 3) To determine the effect of selected soil moisture conservation practices on soil-water relations in Robusta coffee agro-systems.
Uganda 2021-08-19 2024-08-19 Agricultural Sciences Non-Clinical Trial Degree Award
Patrick OJOK
ID:
Teachers’ Perceived Preparedness to Implement the Competency-Based Lower Secondary Curriculum
REFNo: SS810ES

Purpose of the Study The primary purpose of this study is to determine the perceptions of preparedness of lower secondary teachers and explore the factors hindering and/or facilitating the implementation of the new LS curriculum in Uganda. Research Objectives 1) Determine the perceived preparedness of lower secondary school teachers to implement the new lower secondary curriculum. 2) Explore the school and teacher-factors that facilitate/hinder the implementation of the new lower secondary curriculum. 3) Identify the support that lower secondary teachers need to improve their capacity to implement the new LS curriculum.
Uganda 2021-08-19 2024-08-19 Social Science and Humanities Non-Clinical Trial Non-degree Award
Christopher Dolan Gerald
ID:
"changing gender norms and gender-responsive humanitarian action in Uganda”
REFNo: SS858ES

 To examine gendered norms, roles and power relations changed during and after forced displacement;
 To explore how existing knowledge on gender issues informed design of the current refugee response; and
 To find out implications for humanitarian agencies of observed changes in gender roles, norms and power relations

 UK 2021-08-17 2024-08-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
Elizabeth Najjingo
ID:
Factors that influence false tooth extraction among children below two years in Isingiro, Southwestern Uganda.
REFNo: SS952ES

To explore alternatives that can be used instead of false tooth extraction,To explore outcomes of the practice false tooth extraction,To identify methods used for false tooth extraction in Isingiro district.,To explore factors responsible for false tooth extraction within Isingiro district.,To explore factors responsible for the practice of false tooth extraction and methods used in Isingiro district in South Western Uganda.,
 Uganda 2021-08-17 2024-08-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
Munshi Sulaiman
ID:
Mobile money, privacy, security and women’s empowerment: Exploring the impact pathways of digital finance for women’s empowerment
REFNo: SS907ES

This research aims to assess the mechanisms (e.g. security and privacy) through which digital transfers may increase women’s agency and economic empowerment. The study will answer a number of research questions including:
• Are digital transfers more adequate instruments compared to cash transfers for improving women’s economic empowerment?
• Do digital transfers increase women’s privacy over financial information?
• Does privacy of information enhance the women’s enactment of choices?
• Does the secure nature of mobile money transfers significantly impact WEE outcomes?
• Which DFS pathways play a greater role in enhancing women’s agency and enactment of choices; security of money or privacy of information?
Bangladesh 2021-08-17 2024-08-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
Laura Sirabella
ID:
Translating sustainable development goals to address poor reproductive health: exploring the role of civil society organisations
REFNo: SS949ES

The objectives of this study are to:
- explore the role of CSOs in translating the SDGs in the context of reproductive health in effective policies;
- explore how CSOs implement such policies;
- investigate how CSOs advocate for the implementation of policies aimed at addressing reproductive health;
- elaborate the role of CSOs in promoting individual and community’s agency to advocate for reproductive justice.
 Italy 2021-08-17 2024-08-17 Social Science and Humanities Non-Clinical Trial Degree Award
Akulia Agnes
ID:
UNDERSTANDING ACCESS TO SCHOOL LEADERSHIP: A CASE OF WOMEN IN PUBLIC PRIMARY SCHOOLS IN KOBOKO DISTRICT, UGANDA
REFNo: SS623ES

The main objective of this study is to establish how women in school leadership been able to navigate their way into leadership positions. Specifically the study will establish factors that motivate women to pursue school leadership positions, the barriers women have to navigate to access positions of school leadership and the strategies women use to enhance them access school leadership positions.
 Uganda 2021-08-16 2024-08-16 Social Science and Humanities Degree Award
Joseph  Olobo Okao Olobo
ID:
A multicentre observational study to assess immune response status in patients before and after treatment for visceral leishmaniasis
REFNo: HS1266ES

Primary Objective To assess systemic and skin immune responses and parasite load in patients before, and at end of treatment for visceral leishmaniasis
Secondary Objectives
1. To identify systemic and local immune correlates of treatment outcome.
2. To evaluate parasite genotype in relation to immune response characteristics
3. To compare immunology and parasitological data across each site and determine possible correlates of progression to PKDL


 Uganda 2021-08-16 2024-08-16 Medical and Health Sciences Non-degree Award
Joseph  Matovu KB
ID: UNCST-2020-R014654
 Formative research to inform the design of a youth-led self-care intervention to increase uptake of voluntary family planning and reproductive health care services among adolescent girls (10-19 years) in Uganda
REFNo: HS1294ES

The overall objective of the study will be to explore adolescent girls perceptions towards provision of self-care FP services and stakeholders’ perceptions towards provision of voluntary FP and RHC information and services to adolescent girls aged 10-19 years by fellow adolescents in order to inform the design of a youth-led self-care intervention to improve uptake of voluntary FP and RHC services to adolescent girls aged 10-19 years in Uganda. Specifically, this study will aim to:
1. Determine differentials in teenage pregnancy rates and contraceptive use by socio-demographic and behavioural characteristics
2. Assess the association between modern contraceptive use and teenage pregnancy rates among adolescents (15-19 years) across the different demographic and health surveys.
3. Explore the FP and RHC information and service needs of the very young adolescent girls (10-14 years) and older adolescents (15-19 years).
4. Explore mechanisms through which adolescent girls (10-19 years) can be involved in the design and delivery of voluntary FP and RHC interventions for fellow adolescents.
5. Explore adolescent girls’ perceptions about self-care FP methods and whether or not self-care FP methods can help to reduce the barriers that adolescents face in accessing and utilizing FP services.
6. Explore key stakeholders’ perceptions towards: a) provision of self-care FP information and services to adolescents; and b) provision of voluntary FP and RHC information and services to adolescent girls aged 10-19 years by fellow adolescents.
7. Explore key stakeholders’ perceptions on the acceptability of an intervention that entails provision of FP and RHC information and services to adolescent girls (10-19 years) by fellow adolescent girls.
8. Explore the barriers to and facilitators of interventions that provide FP and RHC information and services to adolescent girls by adolescent girls in the target districts and how provision of such information and services to adolescent girls by fellow adolescent girls can be improved.
 Uganda 2021-08-16 2024-08-16 Medical and Health Sciences Non-degree Award
Elizeus Rutebemberwa
ID: UNCST-2022-R009070
 Advancing the health of rural communities in Uganda through strong community health programs
REFNo: SS872ES

4.3 General Objective
To evaluate non-monetary incentive packages required for strengthening the community health workforce, which provides critical health services to the rural poor in Masindi District.

Specific objectives
i. To identify the priorities of the national government regarding compensation packages for the VHTs in Masindi District.
ii. To assess how the national government compensation packages align with the priorities of the VHTs in Masindi District.
iii. To identify the structure and group of incentives best suited to motivate VHTs, improve their performance in the delivery of services, and increase their retention in the health workforce in Masindi District.
iv. To identify the behavioural mechanism through which the new incentives may work or fail to work in Masindi District
v. To understand how changes in the national VHT program impact utilization of maternal and child health services, sanitary practices and perception of quality of health services at the community-level



 Uganda 2021-08-16 2024-08-16 Social Science and Humanities Non-Clinical Trial Non-degree Award
Manjari Quintanar-Solares
ID:
MICROARRAY PATCH FOR PEDIATRIC ANTIRRETROVIRAL TREATMENT STAKEHOLDER INTERVIEWS IN UGANDA
REFNo: HS1359ES

To define the target product profile (TPP) and preferred user characteristics, identify stakeholder needs, and evaluate potential acceptability of a pediatric ARV MAP
 Mexico 2021-08-16 2024-08-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eun Seok Kim
ID:
Cross-sectional prevalence study of schistosomiasis and soil-transmitted helminthiasis with nested open-label randomised controlled study of evaluating the impact of fatty meal co-administration and double-dosing on albendazole effectiveness against hookworm infection among school-aged children in Mayuge district: Implications for Mayuge NTDs Elimination (MANE) Project
REFNo: HS1411ES

Objective 1: To determine the effect of albendazole administration with a fatty meal such as avocado, versus albendazole administration without a fatty meal, on hookworm cure rate and egg reduction rate.

Objective 2: To determine the effectiveness of dual-dose (400mg/day, two consecutive days) versus single-dose (400mg) albendazole treatment regimens on hookworm cure rate and egg reduction rate.

Objective 3: To identify and evaluate environmental, social and cultural variables affecting hookworm infection, and cure rate and egg reduction rate of albendazole against hookworm.

 South Korea 2021-08-16 2024-08-16 Medical and Health Sciences Clinical Trial Degree Award
Carmen  Logie
ID: UNCST-2021-R013185
 Kuwawezesha Vijana (Empowering Youth): An HIV Self-Testing and Comic Intervention with Refugee Adolescents and Youth in a Refugee Settlement in Northern Uganda
REFNo: SS884ES

The primary study aim is to compare the effectiveness of adding HIV self-testing, education- comics, or both to the standard of care approaches of HIV testing among refugee youth in Bidi Bidi in increasing HIV status knowledge.
The primary outcome is HIV testing uptake (HIV status knowledge, verified through asking HIV serostatus and verifying with voluntary point of care testing).
The secondary outcomes include HIV knowledge, HIV-related stigma, use of SRH services (e.g., condoms, contraception), and linkage to a clinic for confirmatory testing.
 Canada 2021-08-16 2024-08-16 Social Science and Humanities Non-Clinical Trial Non-degree Award
Doris Kakuru
ID:
Representation of Young Motherhood: Performing young womanhood, subjectivities and agency in Sexual and Reproductive Health in Uganda
REFNo: SS960ES

To find out the implications of representations of young motherhood on reproductive justice,To establish alternatives of young parenthood which are made available through motherhood performances by young mothers in Uganda (Including their lived experiences, identity formation and agency to adhere, comply or resist dominant subjectivities). ,To examine how dominant notions about young motherhood affect SRHR rights of young mothers in Uganda.,To ascertain how dominant assumptions of young motherhood by different SRHR actors position young mothers in urban poor locales in Uganda. ,
 Uganda 2021-08-16 2024-08-16 Social Science and Humanities Non-Clinical Trial Degree Award
Rosalind  Parkes-Ratanshi Parkes
ID: UNCST-2019-R000717
 Acceptability and feasibility of mhealth technology for sensitization and contact follow up for high-risk communities for infectious disease outbreaks; Call for Life-COVID (CFL-C) and Call for Life Ebola (CFL-E)
REFNo: SS865ES

1.To document experiences of using an IVR service to support COVID positive patients and for those in COVID quarantine.
2.To evaluate the acceptability of using an IVR service for post COVID-19 mental health screening in Uganda.
3.To assess feasibility of using an IVR service for outbreak response, through documentation of the experience and lessons learned of using CFL-C by health care workers, policy makers, developers and implementing actors
4.To explore barriers and enablers to health seeking behaviour and vaccinations, perceptions/ stigma/ fears/concerns of COVID and other epidemic outbreaks including EVD and mitigation measures (e.g. cancelling funerals – Ebola, school and business closures – COVID, including comparisons of the two) within at risk and hard to reach communities.

UK 2021-08-16 2024-08-16 Social Science and Humanities Non-Clinical Trial Non-degree Award
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