Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Amon Nuwahereza
ID: UNCST-2022-R011428
 Ride and Arrive Safe (RAS). A Case study of Mbarara Municipality
REFNo: HS577ES

i. To explore the feasibility of the community facilitation and engagement approach in equipping the Boda-boda cyclists with safety riding knowledge and skills.
ii. To develop a Boda-boda safety user check the mobile application for passengers using Boda-boda a means of transport
iii. To evaluate the effect of Boda-boda cyclist training and community engagement in reducing the number of Boda-boda road traffic accident-related admissions at Mbarara Regional Referral Hospital.

 Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Denis  Bwayo
ID:
Program Assessment and Implementation Learning for the University Research Co., LLC - Department of Defense HIV Prevention Program – Uganda
REFNo: HS959ES

1.To determine compliance to program set targets for the URC-DHAPP program between October 2018 and September 2021
2.To assess the quality of HIV services delivered at 28 UPDF HIV clinics
3.To determine program outcomes across key program implementation strands in line with 95:95:95 frameworks
4.To share implementation experiences across key program implementation strands including HIV testing, ART services, TB diagnosis and management, PMTCT, OVC and systems strengthening.

 Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Kamya Moses
ID: UNCST-2020-R014203
 ENHANCED ENTOMOLOGICAL SURVEILLANCE(EES) TO INFORM MALARIA CONTROL IN UGANDA
REFNo: HS1059ES

1. To examine the impact of current vector control interventions on malaria vector densities, vector behaviour, and species composition.
2. To monitor the status and intensity of insecticide resistance.
3. To establish the entomological inoculation rates in the selected districts.
4. To build the capacity of districts to conduct routine entomological surveillance

 Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Philippa Musoke
ID: UNCST-2021-R013523
 Manifestations and Outcomes of Hospitalized African children and Adolescents with SARS-CoV-2 Infection: Insights from the Democratic Republic of the Congo, Ghana, Kenya, Nigeria, South Africa and Uganda (AFRE-Ped-CoV-19) protocol Version November 06 2020. Grant No. 1R25TW011217-01
REFNo: HS1168ES

Study Aims

a) To describe the socio-demographic features; clinical WHO COVID-19 staging at admission, clinical characteristics, laboratory features including inflammatory and
cardiac markers; imaging investigations and associated abnormalities, treatments applied; and comparisons within and across participating African countries.
b) To estimate the prevalence of comorbidities at presentation and recent/current treatment with immunosuppressive drugs and comparisons within and across
participating African countries.
c) To estimate the prevalence of associated tuberculosis (past, current), HIV status (HIV-exposed uninfected or HIV-infected, and type of treatment if HIV-infected), malaria, bacterial infections influenza and other viral infections and comparisons within and
across participating African countries.
d) To assess overall mortality and independent factors associated with mortality and comparisons within and across participating African countries.

 Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Grace Ndeezi
ID: UNCST-2019-R001802
 A Phase 2b Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease IMR-SCD-301
REFNo: HS1130ES

Primary Objectives
To evaluate the HbF response to IMR-687 versus placebo
To evaluate the safety of IMR-687 versus placebo
Secondary Efficacy Objectives
To evaluate the effect of IMR-687 versus placebo on HbF-associated biomarkers
To evaluate the effect of IMR-687 versus placebo on indices of red cell hemolysis
To evaluate the effect of IMR-687 versus placebo on indices of WBC adhesion
To evaluate the effect of IMR-687 versus placebo on the incidence of VOCs
To evaluate the effect of IMR-687 versus placebo on quality of life (QoL) measures

Pharmacokinetic Objectives
To evaluate the PK of IMR-687 and any major circulating metabolites
Exploratory Efficacy Objectives
To evaluate the effect of IMR-687 versus placebo on changes in RBC characteristics and total Hb
To evaluate the effect of IMR-687 versus placebo on renal function
To evaluate the effect of IMR-687 versus placebo on indices associated with cardiovascular pathophysiology and ischemic stroke risk

Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
FRED SEMITALA COLLINS
ID: UNCST-2020-R014096
 Strengthening Integrated Screening for TB and COVID19 in Kampala, Uganda
REFNo: HS1152ES

The overall goal is to establish the acceptability, feasibility and potential for scaling up the use of COVID19-TB Screening algorithm at Kiruddu National Referral Hospital.
Specific objectives

(1) To explore the perspectives of healthcare providers on the integration of COVID19 and TB screening at Kiruddu National referral Hospital.
(2) To determine the effect of the COVID19-TB algorithm on the proportion of patients screened for TB at Kiruddu National Referral Hospital over a 4-month period.

 Uganda 2021-01-21 2024-01-21 Medical and Health Sciences Non-degree Award
Kirsten Beyer M
ID: UNCST-2021-R013472
 Assessing Health Professionals’ Knowledge, Perspectives and Practices Regarding HPV and Cervical Cancer Prevention and Control among Women Living with Human Immunodeficiency Virus Infection in Uganda
REFNo: HS782ES

General Objective The proposed study seeks to examine the role that health professionals play in influencing WHIVs’ perceptions of HPV and cervical cancer and their associated health behaviors in Uganda.

Specific Objective
Interview public health and health care professionals (including clinicians, nurses, counselors, other/public health professionals, and community health workers/village health teams) to examine the following:
1. Knowledge regarding how HPV or cervical cancer impacts WHIV, which populations are impacted most, and frequency of HPV vaccination, screening and treatment. 2. Perspectives regarding barriers/facilitators of cervical cancer and HPV prevention and treatment among WHIV. 3. Practices regarding HIV professionals’ work in cervical cancer and HPV.
USA 2021-01-20 2024-01-20 Medical and Health Sciences Non-degree Award
Emmanuel Sendaula
ID: UNCST-2020-R014767
 Clinical profile of HIV-infected patients receiving a holistic approach of care model attending Reach Out Mbuya facilities in Kampala district
REFNo: HS903ES

Main Objective

To describe the clinical profile and the factors associated with viral suppression status among HIV-infected patients receiving a holistic approach of care model in Kampala District.
Specific objectives

1. To describe the clinical profile of HIV-infected patients receiving a holistic model of care in Kampala District.
2. To determine the socio-demographic factors associated with viral suppression status among HIV-infected patients receiving a holistic model of care in Kampala District.
3. To determine the clinical factors associated with viral suppression status among HIV-infected patients receiving a holistic model of care in Kampala District.

 Uganda 2021-01-20 2024-01-20 Medical and Health Sciences Non-degree Award
FRANK MULINDWA
ID:
Glucose metabolism changes in HIV patients starting dolutegravir based antiretroviral treatment in Uganda
REFNo: HS1032ES

1) To determine the incidence and predictors of diabetes at week 48 in Ugandan HIV patients initiating dolutegravir.
2) To describe temporal changes in insulin resistance, pancreatic beta cell function, body mass index and blood glucose in Ugandan HIV patients on dolutegravir for 48 weeks.
3) To determine the effect of DTG on intracellular magnesium levels in Ugandan HIV patients on dolutegravir for 48 weeks.
4) To compare insulin kinetics in patients who develop diabetes while on dolutegravir and those that don’t in Ugandan HIV patients.
5) To determine the difference in DTG pharmacokinetics in HIV positive patients with incident hyperglycemia and those without in Ugandan HIV patients.

 Uganda 2021-01-20 2024-01-20 Medical and Health Sciences Non-degree Award
Proscovia Nabunya
ID: UNCST-2019-R000970
 SAY NO TO STIGMA”: Making Mental Health Visible Among School-Going Children in Rural Uganda
REFNo: SS637ES

The objective of this proposed study is to develop a set of new age-appropriate, culturally relevant signage and messaging around mental health and stigma for this study. The visual solutions will be developed through a set of extensive hands-on creative workshops and focus groups with children as well as school administrators and teachers working in one primary school in the Masaka region of Uganda. After visual and message development, the visuals will be presented to a different group of students within the school to gather feedback on their effectiveness and clarity in portraying mental health and stigma.
 Uganda 2021-01-20 2024-01-20 Social Science and Humanities Non-degree Award
Polycarp Komakech
ID:
Incentivizing Action to Reduce Air Pollution and Susceptibility to COVID-19
REFNo: SS667ES

The main objective is to investigate a number of practical and scalable strategies to reduce waste burning through voluntary behavioral change and thereby reduce the exposure of residents to harmful air pollution. The specific objectives are (a) to investigate whether the provision of information about the link between air pollution and the chances of contracting and dying from COVID-19 can spur action to stop waste burning, (b) to test the efficacy of a novel design where social competition that is not imposed top-down but is organized horizontally can help leaders to organize communities for positive action towards reducing waste burning.
Uganda 2021-01-20 2024-01-20 Social Science and Humanities Non-degree Award
SHAFIC MAKUMBI
ID:
Voluntary Consent to Research on Children: A sub-study of the CHAPAS-4 and ODYSSEY Trial
REFNo: SS677ES

1.2 Overall objective
The aim of this study is to assess parental perception of voluntariness of consent in Paediatric HIV clinical trials and associated factors.

1.4 Specific objectives
1.4.1. To describe the process in which parents and guardians consent for their children to be enrolled in two pediatric HIV Clinical Trials.
1.4.2. To measure the level of perceived voluntariness of consent using the voluntariness ladder
1.4.3. To identify the social demographic, situational and external control factors that influence parental perception of the voluntariness of their consent

 Uganda 2021-01-20 2024-01-20 Social Science and Humanities Degree Award
Rhoda Wanyenze
ID: UNCST-2021-R013352
 Impact of Masks on Community Spread of COVID-19: Evidence from Uganda
REFNo: HS1124ES

2.1 General Objective

The aim of this study is to provide policy makers with the first population-based estimate of the extent to which face coverings reduce the spread of SARS-CoV-2. We also intend to provide evidence to the Ministry of Health in Uganda (and public health officials more generally) with evidence about effective communication and education tools for increasing the proper use of masks in the general population.


2.2 Specific Aims

The specific objectives of our study are as follows:

Aim 1: To test whether free mask distribution increases the proper use of masks in intervention communities
Aim 2: To test whether combining free mask distribution with education and communication about masks and COVID-19 increases the proper use of masks in intervention communities Aim 3: To evaluate whether increased mask use affects seroprevalence of SARS-CoV-2
Aim 4: To evaluate potential spillovers, or whether higher mask use in intervention communities affect mask use and probability of infection in neighboring non-intervention communities

 Uganda 2021-01-20 2024-01-20 Medical and Health Sciences Non-degree Award
Kamya Moses
ID: UNCST-2020-R014203
 COVID-19 sydromic and sero-surveillance using established Uganda malaria surveillance sites.
REFNo: HS1125ES

To establish COVID-19 syndromic surveillance through existing Uganda Malaria Surveillance sites by collecting additional data on COVID-19 specific symptoms.

To perform enhanced surveillance for COVID-19 and assess for serological evidence of past infection with SARS-CoV-2 in patients, in order to estimate disease burden and map the geographic spread of the epidemic.

 Uganda 2021-01-20 2024-01-20 Medical and Health Sciences Non-degree Award
Edgar Agaba
ID:
One Nutrition in Complex Environments (ONCE), a cluster-randomized trial of nutrition education and access to simple supportive technologies in improving agricultural practices and water quality management
REFNo: HS492ES

Aim 1: Implement and test a social and behavior change (NIPP) program alone (free-standing) and in combination with a “value-added” approach (NIPP+). The latter includes access to innovative low-cost tools and technologies relating to WASH and agriculture.

Aim 2: Identify best-practices emerging from the implementation of both approaches through process and program monitoring for effective integration, implementation, scale-up, and uptake of multi-sectoral and multi-level packages in complex environments to ascertain potential for scale up.

Aim 3: Study the sustained impact of the NIPP approach and the “value added” package (NIPP+) on knowledge and practices by gender within participating households, environmental risk factors, child health and nutritional status through a rigorous impact evaluation and longitudinal monitoring system.
 Uganda 2021-01-12 2024-01-12 Medical and Health Sciences Non-degree Award
Henry Ddungu
ID: UNCST-2019-R000966
 A Phase 2b Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease.
REFNo: HS1078ES

Primary Objectives:
(a)To evaluate the fetal hemoglobin (HbF) response to IMR-687 versus placebo
(b)To evaluate the safety of IMR-687 versus placebo.
Secondary Efficacy Objectives
(a)To evaluate the effect of IMR-687 versus placebo on HbF-associated biomarkers
(b)To evaluate the effect of IMR-687 versus placebo on indices of red cell hemolysis
(c)To evaluate the effect of IMR-687 versus placebo on indices of white blood cell (WBC)
adhesion
(d)To evaluate the effect of IMR-687 versus placebo on the incidence of vaso-occlusive crises(VOCs)
(e)To evaluate the effect of IMR-687 versus placebo on quality of life measures

Pharmacokinetic Objectives
(i)To evaluate the PK of IMR-687 and any major circulating metabolites

Exploratory Efficacy Objectives
(ii)To evaluate the effect of IMR-687 versus placebo on changes in red blood cell (RBC)
characteristics and total Hb
(iii)To evaluate the effect of IMR-687 versus placebo on renal function
(iv)To evaluate the effect of IMR-687 versus placebo on indices associated with
cardiovascular pathophysiology and ischemic stroke risk.
 Uganda 2021-01-12 2024-01-12 Medical and Health Sciences Non-degree Award
Kamya Moses
ID: UNCST-2020-R014203
 Impact of long-lasting insecticidal nets (LLINs) treated with pyrethroid plus pyriproxyfen vs LLINs treated with pyrethroid plus piperonyl butoxide on malaria incidence in Uganda: a cluster-randomised trial
REFNo: HS1097ES

Primary Objective:
To evaluate the impact of LLINs treated with a pyrethroid insecticide plus pyriproxyfen (PPF LLINs), as compared to LLINs treated with a pyrethroid plus piperonyl butoxide (PBO LLINs), on malaria incidence in Uganda. We will test the hypothesis that malaria incidence will be lower in intervention clusters (randomised to receive PPF LLINs) than in control clusters (randomised to receive PBO LLINs).

Secondary Objectives:
To evaluate the impact of PPF LLINs vs PBO LLINs on parasite prevalence, anaemia, and vector density.
To estimate the cost-effectiveness of delivering PPF LLINs, as compared to PBO LLINs
To assess net durability, survivorship and use of PPF LLINs vs PBO LLINs.

Uganda 2021-01-11 2024-01-11 Medical and Health Sciences Non-degree Award
Robert Opika Opoka
ID: UNCST-2021-R014036
 The Influence of Comprehensive Follow-Up in Pediatric Sickle Cell Disease in an African Setting: a retrospective cohort Study
REFNo: HS636ES

General Objectives: To compare a set of sickle cell-related outcomes (mortality, stroke, blood transfusions, and hospitalizations) between children with SCA on a comprehensive follow up schedule under clinical trials setting and that of a cohort of children with SCA receiving routine care at a specialized sickle cell clinic.


Primary Objective: To compare sickle cell-related outcomes in the NOHARM children who were on the placebo arm to those of children of similar age group from the MHSCC who fulfilled the inclusion criteria for the NOHARM study at the time the study was recruiting patients but who were not enrolled.

Secondary Objectives: To assess the added effect of hydroxyurea therapy (in addition to comprehensive follow up schedule) on sickle cell-related outcomes. This shall be done by comparing sickle cell related outcomes in
1) NOHARM children randomized to hydroxyurea arm and that of the cohort of non-study MHSCC children with SCA over the time period of the NOHARM study (calendar years 2015-17).
2) NOHARM children on the MTD dose of hydroxyurea to that of the cohort of non-study MHSCC children with SCA over the time period of the MTD study (calendar years 2018-19).

 Uganda 2021-01-08 2024-01-08 Medical and Health Sciences Non-degree Award
JANE  BWIRUKA FRIDA
ID:
Student teachers Narratives on Pedagogical Practices that inform their Competences at Makerere University, Uganda
REFNo: SS518ES

1)Explore the narratives of student teachers on teaching practices that inform their competences at Makerere University.
2)Explore the narratives of student teachers on mentoring practices that inform their competences at Makerere University.
3)Explore the narratives of student teachers on supervision practices that inform their competences at Makerere University.
 Uganda 2021-01-08 2024-01-08 Social Science and Humanities Degree Award
ANNETTEE NAKIMULI OLIVIA
ID: UNCST-2022-R011194
 Using new genomic approaches to investigate causes of maternal sepsis among women delivering in sub-Saharan Africa
REFNo: HS969ES

Primary objectives
1)To compare the pathogen profiles using routine microbiology (blood cultures, urinalysis, malaria tests, complete blood count) among women with fever at delivery and those without fever at KNRH
2)To compare the prevalence of Streptococcus agalactiae in placental samples using qPCR among women with fever at delivery and those without fever at KNRH

Secondary objectives
1)To compare the composition and diversity of the nasal and ano-vaginal microbiota among women with fever at delivery and those without fever at KNRH
2)To compare the composition and diversity of the nasal and ano-vaginal microbiota among newborns of women with fever at delivery and the newborns of those without fever at KNRH
3)To compare the single-cell RNA-seq transcriptome of the placentae of women with placental malaria and those without placental malaria at Kawempe National Referral Hospital (KNRH).


 Uganda 2021-01-08 2024-01-08 Medical and Health Sciences Non-degree Award
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