Abner Tagoola
ID:
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A phase 2b study to Evaluate the safety and efficacy of IMR-687 in subjects with sickle cell disease.
REFNo: HS1092ES
1. To evaluate the fetal Hb (Hbf) response to IMR-687 versus placable.
2. To evaluate of IMR-687 versus placable
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Uganda |
2021-02-11 |
2024-02-11 |
Medical and Health Sciences |
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Non-degree Award |
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Afiz Kibuuka Kibuuka
ID: UNCST-2021-R012755
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A Phase 2b Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease
REFNo: HS1150ES
Objectives:
Primary Objectives
• To evaluate the fetal hemoglobin (HbF) response to IMR-687 versus placebo
• To evaluate the safety of IMR-687 versus placebo Seconduy Efficacy Objectives
• To evaluate the effect of IMR-687 versus placebo on HbF-associated biomarkers
• To evaluate the effect ofIMR-687 versus placebo on indices of red cell hemolysis
• To evaluate the effect ofIMR-687 versus placebo on indices of white blood cell (WBC) adhesion
To evaluate the effect of IMR-687 versus placebo on the incidence of vaso-occlusive crises (vocs)
• To evaluate the effect of IMR-687 versus placebo on quality of life measures Pharmacokinetic•Óbjectives
• To evaluate the PK ofIMR-687 and any major circulating metabolites
Exploratory Efficacy Objectives
To evaluate the effect of IMR-687 versus placebo on changes in red blood cell (RBC) characteristics and total Hb e To evaluate the effect of IMR-687 versus placebo on renal function
• To evaluate the effect of IMR-687 versus placebo on indices associated with cardiovascular pathophysiology and ischemic stroke risk
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Uganda |
2021-02-11 |
2024-02-11 |
Medical and Health Sciences |
|
Non-degree Award |
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Casim Tolo Umba
ID: UNCST-2021-R012658
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Action Towards Reducing Aquatic snail-borne Parasitic diseases (ATRAP)
REFNo: NS128ES
The main objective of the project is to improve Health through the prevention and mitigation of risks that originate at the interface between humans, animals and the environment. In this project we want to increase the capacity to prevent infections by snail-borne diseases in western Uganda. The strategic objectives are as follows:
1. To strengthen scientific research capacity.
2. To strengthen physical and virtual diffusion of scientific research
results to the larger scientific community
3. To raise awareness about snail borne diseases to the general public.
4. To support good governance, based on the scientific results.
5. To develop synergies and complementary activities among partners through multi-partner governance and coordination
|
Uganda |
2021-02-10 |
2024-02-10 |
Natural Sciences |
|
Degree Award |
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MIRIAM NAKALEMBE
ID: UNCST-2019-R000824
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Designing and Piloting of a Mobile-based Transport Technology linking Mothers to Health Facilities to Reduce Maternal and New-born Deaths in Uganda during the COVID-19 Pandemic.
REFNo: HS1148ES
1. To identify the existing automated maternal services apps and assess the extent to which they provide near real-time information and communication between mothers and the transporters at community level.
2. To develop a mobile-based transport technology that improves two-way communication between mothers and the transporters at community levels
3. To pilot the mobile-based transport technology for its usability and acceptability
|
Uganda |
2021-02-10 |
2024-02-10 |
Medical and Health Sciences |
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Non-degree Award |
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Anthony Nuwa
ID:
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Evaluating the feasibility, acceptability and protective efficacy of seasonal malaria chemoprevention in two districts in Karamoja, Uganda
REFNo: HS1182ES
Objective 1: To document the adaptation of SMC in Karamoja region in Uganda
Objective 2: To Assess the process of implementing SMC in Uganda, with regards to coverage and quality of implementation
Objective 3: To assess the acceptability of SMC among policy makers, implementers, and beneficiaries.
Objective 4: To determine the impact of SMC on malaria incidence and prevalence among children under 5 years in the Karamoja region and assess the protective efficacy of SPAQ
Objective 5: To analyse cost of SMC delivery to children 3-59 months in Karamoja region
Objective 6: Monitor the safety of sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) when used in SMC among children 3-59 months in Karamoja region.
|
Uganda |
2021-02-10 |
2024-02-10 |
Medical and Health Sciences |
|
Non-degree Award |
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Noah Kiwanuka
ID: UNCST-2021-R010125
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Capturing spatial patterns of new M. tuberculosis infection in Kampala, Uganda
REFNo: HS1230ES
To map the geo-spatial incidence of Mtb infections in a prospective community cohort study of HIV+ and HIV- adults in Kampala Uganda. GPS tracking technology will be used to trace and map subjects to locate areas of high Mtb transmission, or hotspots. Study participants without tuberculous infection will be followed for IGRA/TST conversion for up to 2 years with serial plasma samples taken quarterly.
To determine and validate whether a defined plasma signature found in other studies can identify recent Mtb infection in persons who developed LTBI. Using a paired analysis, we will evaluate baseline and follow-up samples within individuals to determine whether changes associated with new Mtb infection in the community can be detected in plasma with published and newly developed biomarkers. Using a nested case control design, we will compare incident infections with randomly selected controls from the cohort who did not convert
|
Uganda |
2021-02-10 |
2024-02-10 |
Medical and Health Sciences |
|
Non-degree Award |
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Daphine Namara Arinaitwe Namara
ID:
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The Risk of Diabetes and pre-Diabetes associated with use of Dolutegravir based Antiretroviral Therapy among adult persons living with HIV: A Case-control study at Mulago ISS clinic, Kampala, Uganda
REFNo: HS1077ES
Primary objective: To determine the risk of DM and pre-DM associated with the use of DTG-based ART among adult PLHIV at Mulago ISS Clinic.
Secondary objective; To determine other risk factors for DM and pre-DM among PLHIV adult PLHIV at Mulago ISS Clinic.
|
Uganda |
2021-02-09 |
2024-02-09 |
Medical and Health Sciences |
|
Non-degree Award |
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Christine Nalwadda Kayemba
ID: UNCST-2020-R014220
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A BASELINE ASSESMENT FOR THE ADVANCING SEXUAL REPRODUCTIVE HEALTH AND RIGHTS (ANSWER) PROGRAM IN THE WEST NILE AND ACHOLI SUBREGIONS IN UGANDA
REFNo: HS1079ES
General objective
To analyse the situation of sexual and reproductive health and rights (SRHR) aspects as well as GBV in the intervention districts of UNFPA’s programme targeting to advance SRHR in the Acholi and West Nile sub regions in Uganda, in order to generate scientific evidence that will inform evidence based planning, implementation and form a basis for monitoring and evaluation of the program interventions.
Specific objectives
1.To conduct Health facility assessment at targeted health facilities in West-Nile and Acholi sub regions in regards to offering quality equitable SRHR services (FP/Maternal health/Post abortion Care, HIV testing and Post GBV) that is responsive to the needs of women, girls, boys and men, refugees, and people with disabilities
2.To undertake an assessment of SRHR Knowledge, Attitudes and Practices (KAP) of adolescents and youth in school including refugees and people with disabilities from a sample of 1,800 targeted schools (primary & secondary) in the study districts on GBV and SRHR.
3.To conduct an assessment of SRHR Knowledge, Attitudes and Practices (KAP) of adolescents and youth out of school including refugees and people with disabilities in the study districts on GBV and SRHR.
4.To conduct a budget and expenditure analysis of key sectors at national level and the district local governments focusing on implementation of and accountability towards the demographic dividend priorities.
|
Uganda |
2021-02-09 |
2024-02-09 |
Medical and Health Sciences |
|
Non-degree Award |
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RUTH NAKATO
ID:
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A model for assessing the Banking Sector Employees’ Ethical Behavior towards Cyber security.
REFNo: SIR34ES
1. To examine the extent to which cardinal virtue constructs can influence the cyber security behavioral intention of employees towards cyber security ethical behavior in commercial banks in Uganda.
2. To analyze the moderation effect of ethical climate on the virtue constructs in connection with the behavioral intention of employees towards cyber security ethical behavior in commercial banks in Uganda.
3. To examine the mediation effect of behavior intention on the influence of virtue ethics towards cyber security ethical behavior in commercial banks in Uganda.
4. To develop a model for assessing the Employees’ Ethical Commitment and Behavior towards Cyber security in commercial banks in Uganda.
5. To test and validate the developed model.
|
Uganda |
2021-02-08 |
2024-02-08 |
Engineering and Technology |
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Degree Award |
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Tadele Yadesa Mekuriya
ID: UNCST-2022-R010338
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Incidence, predictors and risk prediction of adverse drug reactions among inpatients 60 years and older at Mbarara Regional Referral Hospital, Mbarara, Uganda
REFNo: HS992ES
1. To determine the incidence and prevalence of ADRs among elderly inpatients at MRRH
2. To characterize (types, severity and preventability) the ADRs detected among elderly inpatients at MRRH
3. To determine the risk factors of ADRs among elderly inpatients at MRRH
4. To develop and validate an ADR risk score tool (to be named as PADR-HE) for elderly inpatients at MRRH
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Ethiopia |
2021-02-08 |
2024-02-08 |
Medical and Health Sciences |
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Degree Award |
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Angua Amis Mao
ID:
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Energy access as a dividend for designing just transition pathways (EAJT)
REFNo: SIR48ES
1. To assess the effectiveness of different renewable energy technologies in accelerating green jobs creation and a low carbon trajectory;
2. To analyse the equity and distributional implications of energy transition in vulnerable communities across gender, age, and income groups;
3. To develop potential financial and business models to deliver a just transition pathway; and
4. To explore appropriate policy and regulatory frameworks required to support a just transition at multiple levels from grassroots to the national and regional level.
|
Uganda |
2021-02-08 |
2024-02-08 |
Engineering and Technology |
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Non-degree Award |
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David Musoke
ID:
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Distribution of antibiotic profiles and antibiotic resistance associated with tuberculosis treatment regimens from wastewater treatment plants in Africa
REFNo: HS1017ES
Specific objectives
1. To determine the profile and concentration of antibiotics used in TB treatment in raw and treated sewage.
2. To investigate the efficiency of the WWTP treatment process in relation to removal of antibiotics post chlorination.
3. To determine the prevalence of antibiotic resistant bacteria (ARB) in raw and treated wastewater in these WWTPs.
4. To evaluate the prevalence of antibiotic resistance genes (ARGs) in raw and treated wastewater.
|
Uganda |
2021-02-08 |
2024-02-08 |
Medical and Health Sciences |
|
Non-degree Award |
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Francis Ssali
ID: UNCST-2021-R012134
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An open-label, roll-over study with rilpivirine in combination with a background regimen containing other antiretrovirals (ARVs) in human immunodeficiency virus type 1 (HIV-1) infected subjects who participated in rilpivirine pediatric studies
REFNo: HS1083ES
In view of the primary objective of the study to provide continued access to RPV, no primary endpoint is defined for this study.Secondary Endpoint
The secondary endpoints are applicable for all subjects until data collection is terminated, as indicated.
Major Secondary Endpoints
The proportion of subjects experiencing adverse events (AEs) considered to be at least possibly related to RPV, AEs leading to discontinuation, serious adverse events (SAEs), pregnancies, and grade 3/4 rash regardless of causality throughout the study. Results of routine safety laboratory tests will only be collected if related to these types of AEs.
Other Secondary Endpoint
The proportion of subjects maintaining viral suppression (ie, <50 HIV-1 RNA copies/mL) based on available viral load data throughout the study. In case of virologic failure, emergence of resistance will also be evaluated based on available genotype/phenotype data.
|
Uganda |
2021-02-08 |
2024-02-08 |
Medical and Health Sciences |
|
Non-degree Award |
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Jonathan Mwiindi Thuranira
ID:
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EMERGENCY CESAREAN SECTION AND LENGTH OF STAY IN HOSPITALS IN UGANDA
REFNo: HS1093ES
1. To determine if payer-type (SAFE vs. self-pay) is associated with the decision to delivery interval (DDI) for rural Uganda women undergoing an emergency C-section in Nyakibale Hospital and Rushoroza Hospital. The DDI is the first phase of the aggregated LOS.
2. To determine if payer-type (SAFE vs. self-pay) is associated with the aggregate LOS for rural Uganda women undergoing an emergency C-section in Nyakibale Hospital and Rushoroza Hospital in rural Uganda while adjusting for the Decision to Delivery Interval (DDI).
3. To describe the experience of eight young mothers (aged 18-25) having their second (or more) C-Section delivered by emergency C-section in Southwest Uganda under the SAFE program during April 2020.
|
Kenya |
2021-02-08 |
2024-02-08 |
Medical and Health Sciences |
|
Degree Award |
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Bonaventure Ssebyanzi Wasswa
ID:
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PRIMARY SCHOOL SUPPORT SYSTEMS TO DEAF CHILDREN LEADING TO THEIR TRANSITION TO POST-PRIMARY EDUCATION IN UGANDA
REFNo: SS590ES
(i) To investigate the support systems for deaf children at the completion of primary school studies.
(ii) To examine the situation of deaf children at the completion of primary studies.
(iii) To explore the self of deaf children at the completion of primary studies.
(iv) To establish the strategies for transition to post-primary level of deaf children at the completion of primary studies.
|
Uganda |
2021-02-05 |
2024-02-05 |
Social Science and Humanities |
|
Degree Award |
|
Alex Taremwa Taremwa
ID: UNCST-2020-R014302
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VIABILITY OF DIGITAL SUBSCRIPTION IN EAST AFRICA – AN ANALYSIS OF VIUSASA AND CHIMPREPORTS’ PAYWALLS
REFNo: SS629ES
1. To identify critical success factors for subscription-based models in digital media platforms.
2. To establish the barriers to subscription uptake among digital media in East Africa.
3. To assess the critical success factors against the ChimpReports and Viusasa’s strategies.
4. To analyse the consumption habits of audiences in line with payment for digital content on Viusasa and Chimp.
|
Uganda |
2021-02-05 |
2024-02-05 |
Social Science and Humanities |
|
Degree Award |
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Joseph Lutaakome
ID: UNCST-2020-R008323
|
An open-label, roll-over study with rilpivirine in combination with a background regimen containing other antiretrovirals (ARVs) in human immunodeficiency virus type 1 (HIV-1) infected subjects who participated in rilpivirine pediatric studies
REFNo: HS1013ES
Primary Endpoint
The primary objective of the study is to provide continued access to RPV, however there is no primary endpoint defined for this study.
Secondary Endpoint
The secondary endpoints are applicable for all subjects until data collection is terminated, as indicated.
Major Secondary Endpoints
The proportion of subjects experiencing adverse events (AEs) considered to be at least possibly related to RPV, AEs leading to discontinuation, serious adverse events (SAEs), pregnancies, and grade 3/4 rash regardless of causality throughout the study. Results of routine safety laboratory tests will only be collected if related to these types of AEs.
Other Secondary Endpoint
The proportion of subjects maintaining viral suppression (ie, <50 HIV-1 RNA copies/mL) based on available viral load data throughout the study. In case of virologic failure, emergence of resistance will also be evaluated based on available genotype/phenotype data.
|
Uganda |
2021-02-05 |
2024-02-05 |
Medical and Health Sciences |
|
Non-degree Award |
|
Jennifer Serwanga
ID: UNCST-2024-R002056
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Preparation of an Inactivated covid-19 vaccine at UVRI for pre-clinical evaluations at COVAB and an Outsourced primate centre
REFNo: HS1018ES
Collect nasopharyngeal swab of circulating virus strains
b. Isolate local and globally representative wildtype SARS-CoV2 stocks
c. Generate inactivated SARS-CoV-2 products (The Vaccine).
d. Generate SARS-CoV-2 and other b-CoVs pseudovirus stocks
e. Develop assays to distinguish SARS-CoV-2 binding antibodies
f. Develop assays to distinguish SARS-CoV-2 functional neutralizing antibodies
g. Assess inactivated vaccine in Humanized ACE2 mice challenge models
h. Challenge Macaque models to assess safety, immunogenicity and protectiveness
i. Assess immunized mice for vaccine-induced antibody responses
j. Assess immunized mice for vaccine induced cellular responses
k. Assess immunized mice plasma for inflammatory responses
l. Immuno/histopathology of immunized mice organs/tissues
m. Train and develop capacity for skill transfer
The research questions are;
• Will the inactivated vaccine protect challenged mice against developing COVID-19
disease?
• Will the vaccine elicit potent neutralizing antibodies against diverse SARS-CoV-2
strains and how potent are these antibodies?
• Will the vaccine protect the challenged mice against severe inflammatory responses
and organ pathology?
• Will the inactivated vaccine elicit potent and protective effector T -Cell responses?
|
Uganda |
2021-02-05 |
2024-02-05 |
Medical and Health Sciences |
|
Non-degree Award |
|
Athanansio Bashaija
ID:
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Occupational Stress, Hope, and Alcohol Use among Secondary School Teachers in Greater Bushenyi, Uganda
REFNo: SS671ES
To examine the level of occupational stress among secondary school teachers in Greater Bushenyi.
To assess the level of alcohol use among secondary school teachers in Greater Bushenyi.
To examine the level of hope among secondary school teachers in Greater Bushenyi.
To determine the relationship between occupational stress and alcohol use among secondary school teachers in Greater Bushenyi.
To establish the moderation effect of hope on the relationship between occupational stress and alcohol use among secondary school teachers in Greater Bushenyi.
|
Uganda |
2021-02-05 |
2024-02-05 |
Social Science and Humanities |
|
Degree Award |
|
Victor Musiime
ID: UNCST-2021-R013794
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A Phase 2b Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease (IMR-SCD-301)
REFNo: HS1119ES
Primary Objectives:
1. To evaluate the HbF response to IMR-687 versus placebo
2. To evaluate the safety of IMR-687 versus placebo
Secondary Efficacy Objectives:
1. To evaluate the effect of IMR-687 versus placebo on HbF-associated biomarkers
2. To evaluate the effect of IMR-687 versus placebo on indices of red cell hemolysis
3. To evaluate the effect of IMR-687 versus placebo on indices of RBC adhesion
4. To evaluate the effect of IMR-687 versus placebo on the incidence of VOCs
5. To evaluate the effect of IMR-687 versus placebo on quality of life (QoL) measures
Pharmacokinetic Objectives:
To evaluate the PK of IMR-687 and any major circulating metabolites
Exploratory Efficacy Objectives:
1. To evaluate the effect of IMR-687 versus placebo on changes in RBC characteristics and total Hb
2. To evaluate the effect of IMR-687 versus placebo on renal function
3. To evaluate the effect of IMR-687 versus placebo on indices associated with cardiovascular pathophysiology and ischemic stroke risk
|
Uganda |
2021-02-05 |
2024-02-05 |
Medical and Health Sciences |
|
Non-degree Award |
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