Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
NICHOLAS KULABA
ID:
Blood Pressure Variability and Early Clinical Outcomes Amongst Stroke Patients Admitted to Mbarara Regional Referral Hospital
REFNo: HS1973ES

2. To determine the association between blood pressure variability and poor clinical outcome measured by modified Rankin score at fourteen days after a stroke onset.,1. To determine variability in systolic blood pressure and diastolic blood pressure that occurs over seven days in both hemorrhagic and ischemic stroke patients after hospitalization,To determine blood pressure variability and its association with early clinical outcome amongst acute and subacute stroke patients admitted within 7 days onset at MRRH.,
 Uganda 2021-12-21 2024-12-21 Medical and Health Sciences Non-Clinical Trial Degree Award
David Musoke
ID:
A Health Systems Approach to Strengthening Community Health in Wakiso District, Uganda
REFNo: HS1965ES

The project is aimed at strengthening community health using a health systems approach with a focus on: (a) enhancing the capacity of CHWs (locally known as village health teams (VHTs)), their coordinators and supervisors; (b) supporting the completeness and timely submission of data from VHTs; (c) enhancing timely delivery of drugs and other commodities to CHWs; (e) improving performance of CHWs in relation to quality of care, respective care, and timely referral of patients; and (f) supporting the supervision and coordination of community health.
Uganda 2021-12-21 2024-12-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Victoria Nankabirwa
ID: UNCST-2021-R011871
 Effectiveness of mobile money payments to vaccination campaign health care workers on polio vaccination campaign coverage and quality: a cluster randomized controlled trial
REFNo: HS1932ES

Primary Objectives:
1) To compare vaccination coverage in areas where campaign health care workers are paid using mobile money versus in cash.
2) To compare the motivation, satisfaction and performance of vaccination health care workers in areas where they are paid using mobile money versus in cash

Secondary objectives:
1) To compare vaccination campaign quality in areas where health care workers are paid using mobile money versus in cash
2) To estimate the incremental cost of the intervention.

 Uganda 2021-12-20 2024-12-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
SSEMBATYA RENNY
ID:
COVID/COPE Study: An Interdisciplinary Empirical Approach to Understanding Unequal Economic and Health Consequences of COVID-19 Measures among Pregnant Women in Uganda
REFNo: SS936ES

Objective 1: To analyze the effects of Covid-19 measures among pregnant women in Uganda of varying size, socio-economic, health and poverty indexes.
Objective 2: To assess the proportion of pregnant women with symptoms, rates of social interactions; financial and non-financial costs; how pregnant women have recently responded to the Covid-19 measures, especially in relation to their personal circumstances and expectations.
Objective 3: To provide recommendations how to improve access to care for these vulnerable populations and prevent unnecessary, delayed care while safeguarding public health concerns.

Uganda 2021-12-17 2024-12-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
Obondo Sande James
ID: UNCST-2019-R000241
 Capacity Building towards Primary Immunodeficiency Disorders Research, Diagnosis, and Clinical Management in Uganda
REFNo: HS1867ES

3. To strengthen local laboratory screening and research capacity in the management of PIDs. ,2. To increase knowledge on PIDs among clinicians, pediatricians, laboratory technologists, immunologists through training focused on detection of potential PIDs cases. ,1. To map and create profiles of the current PIDs knowledge and diagnostic capacity in Uganda,To evaluate clinical and laboratory diagnostic knowledge about PIDs, and undertake PIDs-focused training in Uganda,
 Uganda 2021-12-17 2024-12-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Claudia Ringler
ID:
Endline Evaluation for Reaching Smallholder Women with Information Services and Resilience Strategies to Respond to Climate Change
REFNo: SS1127ES

3) At the endline (The subject of this application, to be undertaken in January of 2022), the study will establish the impact of the strategies used to disseminate the climate-smart technologies and approaches and whether these translate into closing gendered yield gaps, enhanced equity and inclusion.
 Germany 2021-12-17 2024-12-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
Victoria Ndyanabangi
ID: UNCST-2021-R012645
 Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs during Pregnancy and Postpartum,DAIDS Study ID #38609, IND #146262
REFNo: HS1023ES

Primary Objectives
Component 1:
• To describe the PK parameters during pregnancy of selected ARV drugs administered to WLHIV who are not receiving TB drugs, and to compare these parameters to (a) historical PK data from non-pregnant women and (b) each participant’s own postpartum PK data.
Component 2:
• To describe the kinetics of (a) placental and breast milk transfer of CAB LA from mother to fetus/infant and (b) infant elimination of CAB LA acquired across the placenta after maternal dosing during pregnancy.
Component 3:
• To describe the PK parameters during pregnancy and postpartum of selected ARV drugs and first-line TB treatment drugs co-administered to WLHIV.
Component 4:
• To describe the PK parameters during pregnancy and postpartum of second-line TB treatment drugs administered to WLHIV and HIV-uninfected women.
Component 5:
• To describe the kinetics of drug transfer of selected ARVs from mother to infant via breast milk.
Secondary Objectives
All Components:
• To describe maternal and infant safety and clinical outcomes.
Components 1, 3 and 4:
• To compare drug concentrations in plasma from cord blood with concentrations in maternal plasma at delivery for selected ARV and/or TB treatment drugs.
• To describe the neonatal elimination of selected ARV and/or TB treatment drugs acquired across the placenta after maternal dosing during pregnancy.
Components 3 and 4:
• To describe the kinetics of drug transfer of selected ARVs and/or TB treatment drugs from mother to infant via breast milk
Component 4:
• To describe the PK parameters of selected ARVs when co-administered with selected second-line TB treatment drugs to WLHIV during pregnancy and postpartum.
Other Objectives
• To assess plasma protein binding of highly bound ARVs and/or TB treatment drugs during pregnancy and postpartum.
• To explore genetic sources for variability in drug exposure in pregnant and postpartum women and their infants for selected ARV and/or TB treatment drugs.

 Uganda 2021-12-16 2024-12-16 Medical and Health Sciences Non-degree Award
Katrina  Fernandez
ID:
Determining distribution, ecology and threats of otter species in Uganda
REFNo: NS245ES

1)To confirm the presence of otter species in and around specific wetlands in Uganda.
2)Determine the ecology, habitat, behaviour and threats to otter species in Uganda.
3)Generate awareness and education to create stewardship and foster positivity towards wildlife and habitats.
4)Identifying conflict issues and threats and developing mitigation measures where necessary.

India 2021-12-16 2024-12-16 Natural Sciences Non-Clinical Trial Non-degree Award
BOSCO AGABA BEKIITA
ID: UNCST-2019-R000549
 Protocol for Regional Estimation of pfhrp2/3 gene deletion in P. falciparum parasites in Uganda (Prep)
REFNo: HS1911ES

1. Estimate the proportion of P. falciparum pfhrp2/3 gene deletions among false-negative HRP2 RDTs in the regions
2. Detect the parasite density and frequency of non-P. falciparum species in the samples
3. Identify regions in which the prevalence of pfhrp2/3 gene deletions causing false negative P. falciparum RDTs is at or above 5%, warranting a change in RDTs.
4. Assess the diagnostic field performance of the HRP2 and pan-pLDH RDTs compared to PCR as gold standard

Uganda 2021-12-16 2024-12-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Christine Semambo Sempebwa
ID: UNCST-2021-R011977
 A Situation Analysis Of Refugees And Migrant Families Of Children Ages 3 To 8 In Uganda
REFNo: SS1126ES

PURPOSE: To analyze the overall refugees and the host community dynamics, highlighting issues surrounding inclusion/non-discrimination, diversity, and the influence of these issues on ECCE service provision and uptake. SPECIFIC OBJECTIVES: 1) Analyze the overall refugees and the host community dynamics, highlighting issues surrounding inclusion/non-discrimination, diversity, and the influence of these issues on ECCE service provision and uptake. 2) Assess the context and the most salient needs of 3 to 8 year old refugee and host community children and their families. 3) Investigate the factors affecting ECCE service provision and uptake of ECCE among refugee and host community populations. 4) Provide an evidence base that will inform the best ECCE programming for 3 to 8-year-olds affected by migration, along with those from the host communities. 5) Document lessons and best practices from the already existing ECCE service provision interventions that will inform Sesame Workshop’s programming.
 Uganda 2021-12-16 2024-12-16 Social Science and Humanities Non-Clinical Trial Non-degree Award
Andrea Felde Kronstad
ID:
Student Politics and mobilization in a Hybrid Regime: the Case of Makerere University, Uganda
REFNo: SS1122ES

The prime outcome of the study is to explain under which conditions the political system and system linkages affecting the organization, activity and substance of institutionalized and non-institutionalized student politics at Makerere University. The study aims to compare the effects on institutionalized student politics at Makerere University. Institutionalized student politics is operationalized as the Students Guild and non-institutionalized student politics is operationalized as Student Activism. The findings will be presented in 4 articles through an article based PhD dissertation.
Norway 2021-12-16 2024-12-16 Social Science and Humanities Non-Clinical Trial Degree Award
Mwebaze Nicholas
ID:
IMPLICATIONS OF AEROBIC EXERCISE ON CLINICAL OUTCOMES OF HIV POSITIVE CLIENTS IN UGANDA; A CASE OF GENERAL MILITARY HOSPITAL-BOMBO
REFNo: HS1276ES

1. To assess the effect of aerobic exercise on immunological measures of HIV positive clients on ART at GMH-Bombo.
2. To measure the effect of aerobic exercise on functional work capacity of HIV positive clients on ART at GMH-Bombo.
3. To determine the contribution of aerobic exercise on psychological markers of HIV positive clients on ART at GMH-Bombo.

Uganda 2021-12-15 2024-12-15 Medical and Health Sciences Degree Award
Lillian Ayebale
ID:
Fertility desires, dilemmas and coping responses among adolescents in Kabira county Kyotera district.
REFNo: SS901ES

1. To review and examine the available evidence on fertility desires among adolescents in sub-Saharan Africa
2. To assess adolescents’ fertility dilemmas in relation to their fertility desires.
3. To explore adolescent coping responses relating to their fertility desires and HIV risk behavior
4. To examine the influence of parent-child communication on sexual matters on adolescents’ coping responses
5. To develop and conceptualizeand conceptualize a parent-child communication model for better ASRH outcomes

 Uganda 2021-12-15 2024-12-15 Social Science and Humanities Non-Clinical Trial Degree Award
Peter OReilly
ID:
Regionalism in East Africa c. 1900 to present
REFNo: SS923ES

This project aims to undertake the first comprehensive historical study of regionalism in East Africa across the 20th and 21st centuries. Attempts at formal economic and political integration in East Africa has been a common feature of the region’s history over the last century. This is evident today with East African Community’s (EAC) regional integration and cooperation agenda. However, there has been remarkably little historical and contemporary research on this theme that has sought unpack the continuities and disjunctures of regional integration in East Africa across this period. This reflects both an ingrained methodological nationalism in the field, and a tendency to assume the weakness of regional integration in Africa as compared to the supposed European ‘ideal type’. This project will therefore address fundamental questions relevant to the topic relating to the intellectual, political and economic drivers and obstacles to integration in East Africa in historical and contemporary perspective, and from a range of levels of analysis: national, regional and global. Research for this project will be conducted across the EAC’s founding members-states (Kenya, Tanzania and Uganda) and in important international and regional bureaucratic centres (Addis Ababa, Ethiopia; Abidjan, Côte d’Ivoire; Washington DC, United States; Brussels, Belgium).
 Ireland 2021-12-15 2024-12-15 Social Science and Humanities Non-Clinical Trial Non-degree Award
ANGELLA MUSIIMENTA
ID: UNCST-2021-R013297
 Using Mobile Technologies to prevent Vulnerable Mothers from COVID-19 in Rural Southwestern Uganda
REFNo: HS1693ES

Implement the MobileMomCare app and carry out an endline assessment to evaluate its preliminary impact on prevention knowledge, risk perception, and adoption of COVID-19 prevention practices, coping mechanism, and system usability among 72 illiterate mothers,Develop scripts and multimedia videos/audios for COVID-19- prevention as well as information on preventing/coping with COVID-19-induced challenges such as domestic violence and HIV/AIDS.,Carry out a baseline study to quantitatively assess the COVID-19 prevention knowledge, risk perception, adoption of COVID-19 prevention practices, among 72 illiterate mothers,Assess the factors constraining the adoption of COVID-19 prevention practices utilized by rural illiterate mothers. ,To support the prevention of COVID-19 among rural illiterate, poor, and vulnerable mothers using a mobile phone-based multimedia application—MobileMomCare application,
 Uganda 2021-12-15 2024-12-15 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JUDE MULOWOOZA THADDEUS
ID:
QUALITY IMPROVEMENT PROCESS METRICS FOR CAESAREAN SECTION IN UGANDA, A LOWER-RESOURCE SETTING: DEVELOPMENT AND FEASIBILITY ASSESSMENT
REFNo: HS1768ES

Löfgren, J., Kadobera, D., Forsberg, B. C., Mulowooza, J., Wladis, A., & Nordin, P. (2015a). District-level surgery in Uganda: Indications, interventions and perioperative mortality. Surgery, 158(1), 7-16. https://doi.org/10.1016/j.surg.2015.03.022
Löfgren, J., Kadobera, D., Forsberg, B. C., Mulowooza, J., Wladis, A., & Nordin, P. (2015b). Surgery in district hospitals in rural Uganda-indications, interventions, and outcomes. Lancet, 385 Suppl 2, S18. https://doi.org/10.1016/s0140-6736(15)60813-3
Löfgren, J., Mulowooza, J., Nordin, P., Wladis, A., & Forsberg, B. C. (2015). Cost of surgery in a low-income setting in eastern Uganda. Surgery, 157(6), 983-991. https://doi.org/10.1016/j.surg.2015.01.026
Mulowooza, J., Santos, N., Isabirye, N., Inhensiko, I., Sloan, N. L., Shah, S., Butrick, E., Waiswa, P., & Walker, D. (2021). Midwife-performed checklist and ultrasound to identify obstetric conditions at labour triage in Uganda: A quasi-experimental study. Midwifery, 96, 102949. https://doi.org/10.1016/j.midw.2021.102949
Santos, N., Mulowooza, J., Isabirye, N., Inhensiko, I., Sloan, N. L., Shah, S., Butrick, E., Waiswa, P., & Walker, D. (2021). Effect of a labor triage checklist and ultrasound on obstetric referral at three primary health centers in Eastern Uganda. Int J Gynaecol Obstet, 153(1), 130-137. https://doi.org/10.1002/ijgo.13420
Shah, S., Santos, N., Kisa, R., Mike Maxwell, O., Mulowooza, J., Walker, D., & Muruganandan, K. M. (2020). Efficacy of an ultrasound training program for nurse midwives to assess high-risk conditions at labor triage in rural Uganda. PLoS One, 15(6), e0235269. https://doi.org/10.1371/journal.pone.0235269
Waiswa, P., Wanduru, P., Okuga, M., Kajjo, D., Kwesiga, D., Kalungi, J., Nambuya, H., Mulowooza, J., Tagoola, A., & Peterson, S. (2021). Institutionalizing a Regional Model for Improving Quality of Newborn Care at Birth Across Hospitals in Eastern Uganda: A 4-Year Story. Glob Health Sci Pract, 9(2), 365-378. https://doi.org/10.9745/ghsp-d-20-00156


GENERAL OBJECTIVE: To understand perspectives on caesarean patient care coordination and quality, develop a caesarean process quality assessment instrument, and assess feasibility, usability, and acceptability of the instrument through a pilot study in Iganga District Hospital in Eastern Uganda and its referring health centres.
SPECIFIC OBJECTIVES
1. To understand key stakeholders’ perspectives on patient flow through caesarean care pathways, including key transition and decision points, and opportunities for improving care efficiency and safety.
2. To understand providers’ views on currently employed and alternative caesarean process quality metrics.
3. To understand patient experiences of caesarean decision making and flow through caesarean care.
4. To develop a set of caesarean quality process metrics reflecting the importance of transdisciplinary high-quality care for improving CS-related outcomes
5. To understand the feasibility of assessment of the proposed caesarean process indicators.
6. To understand the usability of the proposed caesarean process indicators.
7. To test the validity of the proposed caesarean process indicators.
8. To compare the strengths and weaknesses of each indicator and approach.

 Uganda 2021-12-15 2024-12-15 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Winnie  Muyindike R
ID: UNCST-2021-R013558
 TB Risk by Alcohol Consumption
REFNo: HS1962ES

To determine the incidence of active TB disease among PLWH with prior LTBI, who received TPT, by level of alcohol use. To estimate the incidence rate of new TB infection among PLWH with prior negative TST results by level of alcohol use. To examine the risk of acquiring TB infection and of incident active TB disease among PLWH with heavy alcohol use after receipt of TPT in PLWH in Uganda.
 Uganda 2021-12-15 2024-12-15 Medical and Health Sciences Non-Clinical Trial Non-degree Award
FREDDIE SSENGOOBA Peter
ID: UNCST-2021-R011834
 Landscape Analysis of Health Technology Assessment (HTA) Ecosystem in Uganda.
REFNo: HS1935ES

The main objective of the landscape assessment is to understand the current decision-making environment in Uganda’s health sector relevant to priority setting, including the identification of key stakeholders and interests, to support the development of a strategy to institutionalise HTA as an essential process for priority setting and evidence-informed decision making in Uganda’s quest for UHC.
Uganda 2021-12-15 2024-12-15 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Christopher Tumwine
ID:
A QUALITATIVE STUDY OF THE AGRICULTURAL LIVELIHOOD SUPPORT PROGRAMME TO PERSONS LIVING WITH HIV IN UGANDA
REFNo: HS1954ES

To assess whether HIV programmes in Uganda still need to provide livelihoods’ support to persons living with HIV in the era-of test and treat. To examine clients’ perspectives on changes/benefits experienced as a result of participating in the agricultural livelihood support programme. To examine challenges which have been experienced by clients as result of participating in the agricultural livelihood support programme. To examine key stakeholders’ perspectives on the process, benefits and challenges of the agricultural livelihood support programme to HIV clients.
Uganda 2021-12-15 2024-12-15 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Stephen Okoboi
ID: UNCST-2019-R001356
 Anti-Retroviral Therapy Adherence Measurement Methods and Virological Failure in HIV infected Ugandans on long-term ART
REFNo: HS1949ES

1a. To describe incidence of virological failure in patients enrolled in the long-term ART cohort and assess the relationship between adherence to antiretroviral therapy (ART) measured either by patient self-report, appointment keeping and pill count and having virologic failure among HIV-infected Ugandan adults receiving long-term first line.
1b. To examine overall adherence measurement methods as a predictive test for VF among long term ART patients using a case control design taking patients confirmed with VF as cases and use incidence density sampling to sample for controls matched with time and age.
2. Determine the barriers and facilitators of ART adherence among patients on long-term ART at adult Infectious Diseases Institute (IDI) ART clinic using the Theoretical-Domains-Framework with 16 semi-structured, in-depth interviews with both people experiencing VF and those without VF, and ART providers (Medical Officers, Nurses, and counsellors)

 Uganda 2021-12-15 2024-12-15 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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