Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
twinamasiko nelson
ID: UNCST-2021-R013346
 MULTIDRUG RESISTANT BACTERIA CONTAMINATION OF CLINICAL ATTIRE OF MEDICAL DOCTORS IN MULAGO NATIONAL REFERRAL HOSPITAL.
REFNo: HS2177ES

Primary objective
1. To determine the prevalence of pathogenic bacteria on clinical attires of medical doctors in Mulago National referral hospital.
Secondary Objectives
1. To determine the prevalence of multidrug resistant bacteria on clinical attires of medical doctors in Mulago National referral hospital.
2. To determine the level of knowledge and attitudes on IPC among medical doctors in Mulago National referral hospital.
3. To determine the level of practice of IPC measures among medical doctors in Mulago National referral hospital.

 Uganda 2022-04-04 2025-04-04 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Damian Kajunguri
ID:
Assessing the effectiveness of alternative science education teaching methods during and after COVID-19 lockdown in Kigezi region, Western Uganda
REFNo: SS928ES

The main objective of the research is to determine how the different learning approaches impacted science education during and after COVID-19 induced lockdown. The specific objectives are to: i) Establish the type and extent of coverage of the science-based learning that took place during and after lockdown. ii) Determine how practical aspects were handled in the alternative learning processes that were provided during and after lockdown. iii) Ascertain the uniformity of syllabus coverage of science subjects before-during- and after lockdown. iv) Assess students’ responses towards the various science-based learning processes during and after lockdown in respect of gender, age groups and school status.
 Uganda 2022-04-02 2025-04-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Andrew Michael Mutyaba
ID:
The Politics of Uganda's Refugee Policy
REFNo: SS1066ES

To investigate the political economy of the relationship between Uganda's refugee policy and its political system
To understand the needs, incentives and logics behind Uganda's liberal refugee policy
To examine how liberal Uganda's refugee policy is, compared with her neighbours Rwanda, Tanzania and Kenya
To explore the constraints that politic imposes upon the implementation of Uganda's refugee policy in the context of decentralisation
 Uganda 2022-04-02 2025-04-02 Social Science and Humanities Non-Clinical Trial Degree Award
Miriam Nakalembe
ID: UNCST-2021-R014040
 Simplified Treatment for Eclampsia Prevention using Magnesium sulfate: A phase III, randomized, open label, active controlled, multicountry, multicentre, non-inferiority trial of simplified magnesium sulfate regimen for eclampsia prophylaxis (The STEP-Mag Trial).
REFNo: HS2076ES

The primary objective of this trial is to evaluate non-inferiority of magnesium sulfate 10g IM administered 12 hourly x 2 doses compared with a standard IV (Zuspan) or IM (Pritchard) magnesium sulfate regimen1 in the prevention of maternal eclamptic seizure.

The secondary objective of this trial is to evaluate superiority of magnesium sulfate 10g IM administered 12 hourly x 2 doses compared with a standard IV (Zuspan) or IM (Pritchard) magnesium sulfate regimen in the proportion of women experiencing adverse events indicative of magnesium toxicity.
 Uganda 2022-04-02 2025-04-02 Medical and Health Sciences Clinical Trial Non-degree Award
Patrick OJOK
ID:
Exploratory study on the implementation Status of inclusive education policies in Uganda
REFNo: SS1202ES

4. Identify and document best practices and lessons that can be up-scaled to improve the implementation of inclusive education in Uganda and at the sub-regional level (EAC). ,3. Explore the perceptions of education stakeholders in Uganda towards inclusive education and the appropriate model for implementing inclusive education.,2. Explore the facilitators and barriers to implementing inclusive education policies in Uganda.,1. Determine the implementation status of existing inclusive education policies in Uganda.,The purpose of the proposed study is to ascertain the implementation status of inclusive education policies in Uganda, explore the factors that influence their implementation and document best practices and lessons to reinvigorate inclusive education at a sub-regional level.,
 Uganda 2022-04-02 2025-04-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Lydia Nakiyingi
ID:
Exploring immune mechanisms among persons with MTB infection or TB disease, compared to no MTB infection in an endemic setting
REFNo: HS2125ES

General objective:
•To understand the immune mechanisms that underlie TB infection and TB disease compared to those with neither state in an MTB endemic setting using samples collected from individuals with either latent or active TB infection and those without-MTB infection for comparison.
Specific objectives:
• To define the immunological mechanism(s) in MTB using samples from individuals with latent infection, active TB or no MTB infection.
•To identify correlates of immune protection against TB infection and disease in adults in high TB endemic settings; an important pre-requisite in responses to newer TB vaccines
•To compare genetic sequences between adults with active TB, latent TB and no MTB infection in order to delineate genetic mechanisms of protection or disease

 Uganda 2022-04-02 2025-04-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Teddy Nakubulwa
ID:
Sexual and Reproductive Health and Economic Empowerment –Supporting Out-of-school Adolescent girls’ Rights and Skills (SHE SOARS) Program
REFNo: SS1225ES

4) Identify programmatic priorities and approaches through key informant interviews with stakeholders such as government staff, community leaders, health care providers and staff from other sexual reproductive health rights projects.,3) Contribute to the evidence base surrounding Gender Equality and Sexual Reproductive Health outcomes for adolescent s through documenting evidences of how the project is rendering effective, relevant, efficient and sustainable solutions to target project participants. ,2) Examine the current knowledge, attitudes and practices related to sexual reproductive health and gender equality among adolescents, particularly out-of-school adolescents, to inform project implementation ,1) Establish baseline, mid term and endline values for all indicators for the SHE SOARS project.,
 Uganda 2022-04-02 2025-04-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Ninsheka  Leonard
ID:
Analysis of the Effects of the Forms and Drivers of Urban Agriculture on the socio-Economic Status of Farmers in Kampala and Mbarara Cities, Uganda
REFNo: A172ES

1) Examine the forms of urban agriculture on the socio-economic status of the urban farmers
in Kampala and Mbarara Cities.
2) Examine the Drivers of urban agriculture on the socio-economic status of the urban farmers
in Kampala and Mbarara Cities.
3) Establish appropriate policy directions of urban agriculture on the socio-economic status
of urban farmers in Kampala and Mbarara Cities.
4) To establish the influence of socio-demographic characteristics on the socio-economic
status of urban farmers in Kampala and Mbarara Cities

 Uganda 2022-04-01 2025-04-01 Agricultural Sciences Non-Clinical Trial Degree Award
Alinda  Fred
ID:
ADVANCING AGRICULTURAL INSURANCE IN UGANDA’S CLIMATE CHANGE ADAPTATION: DETERMINANTS AND STRATEGIES FOR INSURANCE UPTAKE
REFNo: A181ES

1. To assess the agricultural insurance positioned in the climate change adaptation framework for Uganda and what are the critical gaps
2. To assess the demand and supply side constraints to adoption of agricultural insurance in Uganda borrowing insights from empirical literature in other countries
3. To identify the existing strategies to promoting agricultural insurance as an overarching climate change adaptation strategy.
4. To identify strategies that Uganda can adapt to effectively promote agricultural insurance as a climate change adaptation strategy.

Uganda 2022-04-01 2025-04-01 Agricultural Sciences Non-Clinical Trial Degree Award
Alfred Jatho
ID: UNCST-2021-R011710
 Barriers to and Facilitators of Prostate Cancer Screening among Men in Uganda Prisons
REFNo: HS2128ES

The goal of this study is to examine the perceptions, attitudes and beliefs of men in Uganda Prisons regarding barriers to and facilitators of PCa screening. This will enable the research team to identify potential interventional strategies to promote PCa screening among men in Uganda prisons.,
 Uganda 2022-04-01 2025-04-01 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joaniter Nankabirwa Immaculate
ID: UNCST-2021-R012896
 Optimizing the use of SARS-Cov-2 antigen rapid diagnostic tests (Ag-RDT) for timely detection and effective response to COVID-19 in key border communities in Uganda
REFNo: HS2050ES

To evaluate the feasibility of active surveillance using the SARS-CoV-2 Ag-RDT in high-risk populations in border districts of Tororo and Busia.

To determine the yield of active surveillance using the SARS-CoV-2 Ag-RDT in high-risk populations in the border districts of Tororo and Busia districts

To assess the acceptability of active surveillance using the SARS-CoV-2 Ag-RDT in high-risk populations in border districts of Tororo and Busia.

 Uganda 2022-04-01 2025-04-01 Medical and Health Sciences Non-Clinical Trial Non-degree Award
helen harrison
ID:
A grounded theory epistemological exploration of wellbeing for women with lived experience of conflict-affected trauma, based in Uganda
REFNo: HS2148ES

- To use thematic-induced analysis to develop a theory relating to the epistemology of wellbeing that is grounded in the interview data,- To conduct semi-structured interviews with six – eight female participants from each of the communities.,- To explore the epistemology of wellbeing for women from three specific Uganda-based communities, each of whom has lived experience of conflict-affected trauma, and who are linked through trauma counselling,
 UK 2022-04-01 2025-04-01 Medical and Health Sciences Non-Clinical Trial Degree Award
Thereza Piloya Were
ID: UNCST-2019-R000491
 Diabetes in African Youth: Improving Glucose Time-In-Range (DAY Time) Randomized Clinical Trial.
REFNo: HS2129ES

Primary Study Objectives
1. To determine if patient ability to continuously observe plasma glucose levels for 6 months using a flash intermittently scanned CGM improves glucose TIR compared to baseline. The change in glucose TIR while wearing the unblinded CGM will be compared to change in TIR in patients performing 3x/day SMBG (wearing a blinded CGM for endpoint measurement).
2. To perform a cost analysis on flash glucose monitoring compared to 3x/day SMBG, to determine whether this technology is cost effective in the setting of a low-resource nation.
Secondary Objectives: To assess the change-from-baseline impact of unblinded CGM on:
1. Percent time-in-range at 12 months
2. Percent time with glucose 180-250, >250, <70, and <54 mg/dl at 6 and 12 months
3. HbA1c at 6 and 12 months
4. Patient satisfaction and quality of life at 6 and 12 months
5. Glucose variability (coefficient of variation, CV) at 6 and 12 months

 Uganda 2022-04-01 2025-04-01 Medical and Health Sciences Clinical Trial Non-degree Award
Pontiano  Kaleebu
ID: UNCST-2020-R019901
 Performance evaluation of the CheckNOW™ HIV Self-Test study
REFNo: HS2170ES

1. To evaluate the performance (Sensitivity and specificity) of the CheckNOW™ HIV SELF TEST when compared to the Genscreen ULTRA HIV1/2 Ag/Ab EIA followed by the Murex diasorin HIV1/2 Ag/Ab combination (reference testing) in the laboratory and the national testing algorithm.

2. To describe the clinical performance (sensitivity and specificity) of the CheckNOW™ HIV SELF TEST, as obtained by the professional users, when compared to the reference testing and the national testing algorithm.

3. To describe the clinical performance (sensitivity and specificity) of the CheckNOW™ HIV SELF TEST, as obtained by the lay users, when compared to the reference testing and the national testing algorithm.

4. To assess the accuracy of the lay user interpretation of the HIVST result. This will be compared with the interpretation by the RA.
5. To assess the usability of the CheckNOW™ HIV SELF TEST. The usability of the test will be evaluated by questionnaires completed by the study staff observers and by the lay users.



Uganda 2022-04-01 2025-04-01 Medical and Health Sciences Clinical Trial Non-degree Award
Samson Okello
ID: UNCST-2019-R001580
 Epidemiology of cardiac dysfunction in sub-Saharan Africa: Heart Failure Registry of HIV-infected and HIV-uninfected persons in Uganda and Zambia
REFNo: HS788ES

1. To describe the clinical characteristics, treatment outcomes, and predictors of all-cause and CV mortality among HIV-infected and HIV-uninfected heart failure adults hospitalized at Mbarara Regional Referral Hospital (Mbarara, Uganda) and University of Zambia Hospital (Lusaka, Zambia).
2. To describe echocardiographic etiology of heart failure among HIV-infected and uninfected adults hospitalized at Mbarara Regional Referral Hospital (Mbarara, Uganda) and University of Zambia Hospital (Lusaka, Zambia).
3. To determine the differences in the serum markers of cardiac fibrosis, cardiac injury, oxidative stress, and hypercoagulability in HIV-infected and HIV-uninfected individuals hospitalized with heart failure at Mbarara Regional Referral Hospital and the University of Zambia Hospital.

 Uganda 2022-03-30 2025-03-30 Medical and Health Sciences Non-degree Award
Jennifer Ross
ID:
Modeling Approaches to Prioritize TB Prevention in Uganda
REFNo: HS1981ES

1. Estimate national, regional- or district-level patterns in prevalence, incidence, and mortality of TB and TBHIV using a geospatial model to identify geographic areas with higher versus lower infection burden.

2. Quantify the potential impact in disease burden and cost for PT scale-up in regionalized versus uniform implementation.

3. Engage stakeholders to inform model development and evaluate strategies to improve the acceptability and feasibility of modeled strategies for TB prevention.

 USA 2022-03-30 2025-03-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bernard Kikaire
ID:
Utility of using C - reactive protein (CRP) in identifying bacteremia in children below five years presenting with fever at the Kawempe National Referral hospital.
REFNo: HS2038ES

1. To assess the performance of CRP in identifying bacterial infection among children less than 5 five years presenting with fever Kawempe National Referral Hospital
2. To assess the performance of Neutrophilia in identifying bacterial infection among children less than 5 five years presenting with fever Kawempe National Referral Hospital
3. To compare the two diagnostic criteria in identifying children with bacteremia at Kawempe National Referral Hospital

 Uganda 2022-03-30 2025-03-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
HARRIET NANKYA
ID:
Toward effective community engagement for genomics research in Uganda
REFNo: SS1172ES

1. To assess Genomics Researchers’ perspectives and practices on CE for genomics research in Uganda.
2. To explore Community Stakeholders’ experiences and perspectives on CE for genomics research in Uganda.
3. To assess research regulators’ perspectives on what constitutes effective community engagement for genomics research in Uganda.
4. To develop a framework for effective community engagement for genomics research in Uganda.

 Uganda 2022-03-30 2025-03-30 Social Science and Humanities Non-Clinical Trial Degree Award
Raymond Tweheyo
ID: UNCST-2020-R014507
 Development and validation of a Medical Internship Experience Scale (MIES) for low- and middle-income countries.
REFNo: HS2062ES

4.2 General Objective
To develop and validate the Medical Internship Experiences Scale in Uganda, so as to contribute to the understanding of internship experiences for the health workforce in low- and middle-income countries.
4.3 Specific Objectives
1) To draft a Medical Internship Experiences Scale (MIES) for testing in Uganda alongside other LMICs.
2) To develop and test the Medical Internship Experiences Scale (MIES) among intern doctors in Uganda.
3) To evaluate the experiences of intern doctors and 3-year post internship doctors with their medical internship, using the MIES in Uganda.
4) To explore the perceptions of intern doctors, and intern doctor supervisors regarding the wellbeing of intern doctors during the medical internship training in Uganda.

UK 2022-03-30 2025-03-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
ANITA ARINDA
ID: UNCST-2020-R014158
 AN EDUCATION PROGRAM FOR IMPROVEMENT IN HIV KNOWLEDGE FOR ADOLESCENTS WITH INTELLECTUAL DISABILITY IN ENTEBBE, UGANDA
REFNo: HS2159ES

To estimate the retention of HIV knowledge and change in attitudes to HIV of adolescents with mild-to-moderate ID at 3 months following an HIV education program.,To estimate the change in HIV knowledge and attitudes of adolescents with mild-to-moderate ID following an HIV education program education intervention.,To determine the feasibility and acceptability of the HIV education program for adolescents with mild-to-moderate intellectual disability in Entebbe.,To conduct a pilot study of an HIV education intervention program for adolescents with mild-to-moderate intellectual disability (ID) and to assess its feasibility, acceptability and ability to increase HIV knowledge at baseline and 3 months.,
 Uganda 2022-03-30 2025-03-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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