Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Paul Mukasa
ID: UNCST-2021-R013464
 Antirabies compounds in Selected Medicinal Plants used in the Treatment of Rabies in Uganda
REFNo: NS290ES

Mian objective: To explore the medicinal plants used in the treatment of rabies for bioactive potential and phytochemical compounds as possible leads to antirabies agents in Uganda. Specific objectives: 1. To carry out an ethnobotatical survey on plant species used to treat rabies in Uganda. 2. To determine the cytotoxicity of the crude extracts of the selected plants used to treat rabies. 3. To determine the antirabies potency of the crude extracts of selected plants against rabies virus. 4. To elucidate the structure of the antirabies compound(s) isolated from the most bioactive portion(s).
 Uganda 2021-10-27 2024-10-27 Natural Sciences Non-Clinical Trial Degree Award
Kenneth Odur
ID:
Youth Public Health Ambassadors Community Health Assessment 2021
REFNo: SS1025ES

Collect information on sanitation and hygiene, nutrition, health and safety, and preventive health services present at primary and secondary schools located in participating communities surrounding Lira, Uganda.,Collect information on existing health care services and infrastructure present at health facilities in participating communities surrounding Lira, Uganda.,Collect data on health behaviors, knowledge and attitudes among adolescents living in participating communities surrounding Lira, Uganda.,Collect demographic information, baseline knowledge and beliefs about disease, and health-related behaviors from households in participating communities surrounding Lira, Uganda,To Asses a comprehensive Community health behaviours and practices in the Rural comminities in Lira District Northern Uganda. ,
 Uganda 2021-10-27 2024-10-27 Social Science and Humanities Non-Clinical Trial Non-degree Award
Peter Olds
ID: UNCST-2023-R006240
 The impact of the COVID-19 pandemic on NCD care in Mbarara, Uganda
REFNo: HS1535ES

1. Patients differentially sought medical care during the COVID-19 pandemic, resulting in different utilization of NCD care at health centers and a regional referral hospital.
2. We hope to understand both patient and provider perspectives on NCD care during COVID-19 pandemic, and discuss their outlook on more mobile versions of care.
 USA 2021-10-26 2024-10-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Urs KALBITZER
ID:
Aerial Imagery Data for the Construction of Primate Nutritional Landscapes
REFNo: NS303ES

To develop a methodological framework and create high-resolution models of the temporal and spatial distribution of nutrients for primates and other animals, so called ‘nutritional landscapes’
 Germany 2021-10-26 2024-10-26 Natural Sciences Non-Clinical Trial Non-degree Award
Kenia Martinez Raquel
ID:
PREVALENCE AND FACTORS ASSOCIATED WITH PRIMARY POSTPARTUM HEMORRHAGE AMONG WOMEN WITH PRE-ECLAMPSIA/ ECLAMPSIA DELIVERING AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS1564ES

General Objective
To determine the prevalence and factors associated with primary postpartum hemorrhage among women with pre-eclampsia/eclampsia delivering at Mbarara Regional Referral Hospital

Specific Objectives
1. To determine the prevalence of primary postpartum hemorrhage in women with pre-eclampsia/ eclampsia at Mbarara Regional Referral Hospital.

2. To determine the factors associated with primary postpartum hemorrhage in women with pre-eclampsia/ eclampsia at Mbarara Regional Referral Hospital.

 Eswatini 2021-10-25 2024-10-25 Medical and Health Sciences Non-Clinical Trial Degree Award
Julian Adong
ID: UNCST-2021-R013487
 A social media intervention to promote antiretroviral therapy adherence among adolescents and young adults living with HIV in Uganda
REFNo: HS1824ES

Determine the feasibility, acceptability, and preliminary effectiveness of the U-SMART intervention among AYAWH in Uganda.,Adapt the social media to improve ART outcomes (SMART) Connections platform to create Uganda-SMART (U-SMART), a novel WhatsApp-based social media intervention to improve antiretroviral therapy (ART) adherence among adolescents and young adults with HIV (AYAWH) in Uganda.,
 Uganda 2021-10-25 2024-10-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Frank Mwiine Norbert
ID:
Epidemiological investigation of brucellosis in livestock in selected agro-pastoralist districts of Eastern Uganda
REFNo: A153ES

1. To determine the sero-prevalence of brucellosis in various livestock raised under the agro-pastoralist system in Eastern Uganda.
2. To establish the status and the factors behind the dynamics and perpetuation of livestock brucellosis in selected districts of Eastern Uganda.
3. To determine knowledge, attitudes and practices (KAPs) vital for brucellosis control among livestock farmers in the agro-pastoralist system in Eastern Uganda.
4. To isolate and molecularly characterize causative bacterial agents of brucellosis infecting livestock in Eastern Uganda.
5. To determine and raise awareness, biosecurity and biosafety on brucellosis and work with stakeholders to participatorily develop sustainable disease reduction protocols.

 Uganda 2021-10-25 2024-10-25 Agricultural Sciences Non-Clinical Trial Non-degree Award
Brenda Nakimuli Luswata
ID: UNCST-2021-R013228
 Refining the programme theory for realist inquiry on adolescent SRH accountability in disadvantaged urban areas: macro and meso-contextual drivers and social mechanisms. Case studies Uganda and Benin
REFNo: SS1032ES

(4) To develop guidance on accountability for adolescent girls living in urban slums and methodological guidance for realist evaluation of complex problems. (Work package 4),To develop an overarching programme theory (Work package 3),To test and refine the initial programme theory grounded in case studies conducted in two urban poor neighborhoods in Delhi and Mumbai, India ; Kampala, Uganda and Cotonou, Benin (Work package 2),To develop the initial programme theory on accountability towards adolescent girls living in urban slum, based on the MRT and existing imperical literature on accountability in sexual and reproductive health in an urban and rural health system (Van Belle, 2014, Van Belle & Mayhew, 2016; Van Belle et al. 2018),To contribute to a better understanding of the causal chain underlying accountability in sexual and reproductive health towards adolescents living in urban slums in LMIC. The,
 Uganda 2021-10-25 2024-10-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Joseph Erume
ID:
Antimicrobial resistance in zoonotic pathogens – a challenge for urban small holder livestock production system
REFNo: A156ES

1. To determine the burden of campylobacter infections in small holder, commercial broiler farms and food markets in and around Kampala, Uganda.
2. To determine management and risk factors which underlie the dynamics and perpetuation of in small holder, commercial broiler farms and food markets in and around Kampala, Uganda.
3. To establish the poultry farmers and traders’ knowledge, attitudes and practices related to AMR campylobacter strains and antibiotic usage at poultry farms.
4. To establish the AMR of campylobacters strains from the poultry phenotypically and molecularly including whole genome sequencing (WGS).

 Uganda 2021-10-25 2024-10-25 Agricultural Sciences Non-Clinical Trial Non-degree Award
Steven Odongo
ID: UNCST-2021-R013336
 DEVELOPMENT AND VALIDATION OF MULTIPLEXED LATERAL FLOW ASSAY FOR DETECTION AND DIFFERENTIATION OF SARS COV-2 FROM OTHER HUMAN CORONAVIRUSES
REFNo: HS1706ES

(1) Track levels of conservation of SARS CoV-2 structural proteins based on nucleotide sequences published in the Global Initiative on Sharing All Influenza Data (GISAID) database by sequencing laboratories in Uganda, (2) Identification and production of specific but conserved SARS-CoV-2 marker protein (s) capable of distinguishing SARS-CoV-2 from other hCoVs, (3) Develop a Nanobody (Nb) based multiplex LFA device targeting the marker proteins, and (4) Validate the performance characteristics of the LFA in a laboratory setting on archived sera.
 Uganda 2021-10-22 2024-10-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Mark Jordans
ID: UNCST-2020-R014861
 Evaluating the effectiveness of Can’t Wait to Learn in formal education in Uganda
REFNo: SS1024ES

1)To assess the feasibility of the intervention and study (cRCT) methods, 2)To evaluate the effectiveness of CWTL in improving reading and numeracy outcomes of children in Primary 3 (P3), 3)To assess the value for money of CWTL and other factors for EdTech programme scale-up.
Netherlands 2021-10-22 2024-10-22 Social Science and Humanities Non-Clinical Trial Non-degree Award
Juliet Nattabi Kigongo
ID:
Vanishing Glaciers of the Rwenzori Mountains National Park (Uganda)
REFNo: NS291ES

Vanishing Glaciers project aims for the first
time to explore the streams of mountain
biogeochemistry, and the living
microorganisms of these remote
ecosystems, now strongly impacted by
climate change.
The project’s main goals are:
• To establish the census of microbial
life of the world’s glacier-fed
streams.
• To predict the future changes of the
glacier-fed streams biogeochemistry
as the world’s glaciers recede

1. Study the microbial life from glacier-fed streams
2.Study the biogeochemistry of glacier-fed streams
3.Study the environment of glacier-fed streams, including glaciological parameters
 Uganda 2021-10-22 2024-10-22 Natural Sciences Non-Clinical Trial Non-degree Award
Andrew Katumba
ID:
Performance of a novel, rapid AI-driven screening tool for improved COVID-19 patient care and management in Uganda
REFNo: SIR74ES

General Objective
To develop and deploy AI-driven screening tools for improved care and management of COVID-19 patients. This will be achieved through the following specific objectives:
Specific Objectives
1. To collect, curate and label Lung Ultrasound (LUS) images from COVID-19 patients and patients with related pulmonary pathologies such as non-COVID-19 derived pneumonia, yielding a generalizable and representative image/video dataset.
2. To develop robust image-driven machine learning (ML) models for detection and screening of COVID-19 using the data from objective 1.
3. To build mobile and web-based applications that integrate the ML models, for online (real-time) and offline COVID-19 screening.
4. To pilot the developed applications and evaluate their clinical efficacy in COVID-19 screening.

Uganda 2021-10-22 2024-10-22 Engineering and Technology Non-Clinical Trial Non-degree Award
Moffat  Nyirenda Joha
ID: UNCST-2020-R019333
 Identification and characterization of Diabetes in low-resource Populations
REFNo: HS1791ES

The secondary study objectives are:
1. To establish a base-line cohort of well-characterised people with diabetes to understand disease progression of the different phenotypes, including uptake and response to treatment.
2. To identify and recruit a cohort of non-diabetic volunteers (including prediabetes i.e., at high risk of developing diabetes) for longitudinal follow-up.
i. To identify a cohort of non-diabetic people in order to measure the incidence of disease in the future estimate incidence of diabetes.
ii. To assess the burden and rates of progression of vascular complications associated with the different phenotypes of dysglycaemia.
Malawi 2021-10-22 2024-10-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Frederick Mubiru Edward
ID:
Market Research on User Perspectives for a 4-month Depot Medroxyprogesterone Acetate Subcutaneous (DMPA-SC) Product
REFNo: HS1792ES

1. To solicit input from potential and current contraceptive injectable users, as well as males/partners, on acceptability and implications for having multiple injectable products of different durations in the market, with an emphasis on a 4-month DMPA-SC product as well as a potential 6-month injectable
2. To co-create marketing strategies/messages with current and potential users for the introduction and differentiation of new injectable products

 Uganda 2021-10-22 2024-10-22 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Josef Bryja
ID:
Evolutionary diversity of small mammals in isolated mountains in north-eastern Uganda - stepping stones for colonization of the Albertine Rift and Kenyan Highlands from Ethiopia?
REFNo: NS301ES

Overall goal: To analyse genetic diversity of small mammals and their pathogens to test alternative hypotheses of colonization of Eastern Afromontane Biodiversity Hotspot (EAMBH)
Objective: Description of biodiversity patterns in EAMBH using integrative approach

Output 1: List of small mammals of isolated sky islands of north-eastern Uganda
Activity 1: Field sampling, species identification (using integrative approach)

Output 2: Phylogeographic scenarios for the colonization of EAMBH, identification of "refugia within refugia", biogeographical regionalization
Activity 2: Combination of obtained (genetic) data with other datasets from Ethiopia, Kenya, Tanzania, etc. Testing of phylogeographic hypotheses.

 Czech Republic 2021-10-22 2024-10-22 Natural Sciences Non-Clinical Trial Non-degree Award
Eddy Walakira Joshua
ID: UNCST-2022-R009077
 Strengthening the Effectiveness of National Children’s Care Systems: A Political Analysis of Uganda
REFNo: SS1064ES

This study will examine the effectiveness of the National Children’s Care System in Uganda focusing on the political, bureaucratic and economic forces as well as the strategies that augment the effectiveness of this system.

The study aims to use the collected data to develop an adaptable framework to achieve effective national care systems for children in Low-Income Countries (LICs).

In specific terms, the research will:
1. Examine the political, bureaucratic and economic forces shaping the effectiveness of Uganda’s national children’s care systems

2. Delineate the strategies to improve the capacity of these systems to protect children

3. Develop an adaptable framework for Uganda to analyze factors shaping children’s care systems in LICs?
 Uganda 2021-10-22 2024-10-22 Social Science and Humanities Non-Clinical Trial Non-degree Award
Gorretti Nassali
ID:
Trends of Breast Cancer among patients younger than 40 years at St. Francis Hospital Nsambya: A cross section descriptive study
REFNo: HS1758ES

This study aims to describe prevalence by age, stage at diagnosis, cancer type and grade, and hormone receptor status, among women younger than 40 years at St. Francis Hospital Nsambya between 2010 and 2020.
 Uganda 2021-10-21 2024-10-21 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Anna Ritah  Namuganga
ID:
Mycobacterium tuberculosis associated immune activation and exhaustion profiles for prediction of active pulmonary tuberculosis
REFNo: HS1201ES

Main Objectives
Determine the differential expression of immune activation and exhaustion markers to predict active TB disease among presumptive TB cases.
Primary Specific Objectives
i. To determine the levels of soluble markers of immune activation and exhaustion in serum of active PTB cases, LTBI and those with ORDs and response to treatment.
ii. To determine levels of immune activation and exhaustion associated cytokines/chemokines in serum among active PTB, LTBI and ORDs and response to treatment.
iii. Perform a phenotypic profiling of expression of markers immune activation and exhaustion in PBMCs and determine their association with active PTB, LTBI states or other respiratory diseases (ORDs).
iv. To determine the activation and exhaustion genes expression profiles in QFT Gold plus cell pellets and compare levels in active PTB cases and LTBI.

 Uganda 2021-10-20 2024-10-20 Medical and Health Sciences Degree Award
Andrew Okwi Livex
ID: UNCST-2021-R013180
 Unlocking the potential of thiocyanate in cassava root for management of painful crisis in sickle cell disease patients in Uganda
REFNo: HS1486ES

1. To determine the frequency of cassava consumption in the districts of Uganda with high prevalence of sickle cell disease
2. To assess the frequency of painful crisis among SCD patients in these districts.
3. To determine the levels of thiocyanate in patients with SCD in these districts
4. To determine the optimum concentration of thiocyanate that causes antisickling (in vitro studies)

 Uganda 2021-10-20 2024-10-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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