Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Gilbert Sendugwa Sendugwa
ID:
Towards Gender Balance: Understanding the Barriers and Solutions to Include Women-Led Businesses in East Africa
REFNo: SS712ES

This research will document policies and practices that exclude and include women-led businesses in Ethiopia, Kenya, Rwanda, Tanzania, and Uganda. Specifically, it aims to: - Understand the participation of and challenges facing women-led businesses and sole proprietorships in the five countries and regionally. - Identify measures being implemented or tested to improve fairness and inclusion of women in public procurement in the selected countries. - Assess the effectiveness of the measures put in place by specific governments to improve fairness and inclusion. - Recommend actionable changes to improve the current situation, based on the findings of the research and international best practice.
 Uganda 2021-05-21 2024-05-21 Social Science and Humanities Non-degree Award
Joannah Nalwoga
ID: UNCST-2024-R002651
 GROUP B STREPTOCOCCUS GENITAL COLONIZATION PATTERNS AMONG NON- PREGNANT WOMEN OF REPRODUCTIVE AGE AT KAWEMPE NATIONAL REFERRAL HOSPITAL
REFNo: HS728ES

General objective
To determine how colonization with GBS changes over time among non-pregnant women of reproductive age and how the changes correlate with the host immunity
Specific objectives
1. To describe how the GBS colonization status changes over a three months period among non-pregnant women who were uncolonized at baseline
2. To describe how the GBS colonization status changes over a three months period among non-pregnant women who were colonized at baseline

3. To determine whether the concentration of GBS IgG in serum correlates with the concentration of GBS IgG at the vaginal mucosa
4. To determine whether we can predict colonization from GBS IgG concentration in blood
5. To determine whether we can predict colonization from GBS IgG concentration in the vaginal mucosa

Uganda 2021-05-20 2024-05-20 Medical and Health Sciences Non-Clinical Trial Degree Award
Hellen Kinyi Wambui
ID:
“Effect of varying ratios of dietary macronutrients on immune system function of Swiss albino mice”
REFNo: NS159ES

i. To assess the effects of varying macronutrient ratios on the nutrition status of Swiss albino mice
ii. To evaluate the effects of varying macronutrients ratios on leucocyte count, neutrophil adhesion and cytokine production of Swiss albino mice
iii. To determine the effects varying ratios of macronutrients on the production of pro-inflammatory (TNF-α, IFN-γ, IL-6) and anti-inflammatory (IL-10) cytokines in Swiss Albino mice challenged with lipopolysaccharide
iv. To evaluate the effects of varying macronutrients ratios on delayed -type hypersensitivity and antibody titers of Swiss albino mice challenged with cow red blood cells (CRBC)

 Kenya 2021-05-20 2024-05-20 Natural Sciences Degree Award
Enock Matovu
ID:
Development and Evaluation of Recombinant SARS-CoV-2 Spike and Membrane Protein-Based Sub-Unit Vaccines
REFNo: NS146ES

(i) To express recombinant subunits of the RBD region of the spike protein and the M protein
(ii) To characterize the humoral and cell mediated immune response generated by the RBD region and the M protein in mouse models
(iii) To determine the safety of the vaccine candidates in mouse models
(iv) To determine the efficacy of the potential candidate vaccine in mice

 Uganda 2021-05-20 2024-05-20 Natural Sciences Non-degree Award
Lena Mpalampa
ID:
FACTORS ASSOCIATED WITH PROVISION OF PHYSICAL ACTIVITY IN PRIMARY SCHOOLS IN MAKINDYE DIVISION IN KAMPALA
REFNo: SS768ES

5. To establish the school related factors associated with insufficient physical activity offered by the primary schools in Kampala during the school term?,4. To establish the class related factors associated with insufficient physical activity offered by the primary schools in Kampala during the school term?,3. To ascertain the teacher related factors associated with insufficient physical activity offered by the primary schools in Kampala during the school term?,2. To describe the various types of physical activity offered in primary schools in Kampala during the school term,1. To determine the proportion of schools offering sufficient time for PA among primary schools in Kampala during the school term,To analyse the factors associated with insufficient physical activity offered in primary schools in Makindye Division in Kampala during the school term.,
 Uganda 2021-05-20 2024-05-20 Social Science and Humanities Degree Award
Katelin Wilton
ID:
Supporting Families through Community Health Workers during COVID: A feasibility and acceptability study
REFNo: SS752ES

Main objective/ purpose
The main objective of this study is to better understand coping strategies of frontline health workers, feasibility and acceptability indicators of messaging success.
Specific Objectives
The specific objectives of this study are to:
• Understand frontline health workers perspective on their stress and psychosocial wellbeing
• Understand the feasibility and acceptability of behaviorally-informed SEL and MHPSS messaging targeted at adult and child clients delivered through frontline health workers
• Determine whether such messaging targeted at clients may also improve frontline health worker coping strategies

USA 2021-05-20 2024-05-20 Social Science and Humanities Non-degree Award
Paul Atherton
ID:
Girls’ Education Challenge Phase II: Continued Access and Learning during Covid-19 in GEC-II PEAS treatment and control schools in Uganda
REFNo: SS764ES

The final research questions for the proposed study are listed below:

a) How have PEAS sought to provide continued access to learning opportunities during school closures?
b) How are the PEAS supporting girls to return to school, and with what effects on girls’ access to learning opportunities?
c) How are PEAS identifying which girls are most at risk of not returning to school? Can a scorecard approach help projects identify those most at risk within projects in a cost-effective way?
d) How have girls’ learning levels changed during the COVID-19 period?

UK 2021-05-20 2024-05-20 Social Science and Humanities Non-Clinical Trial Non-degree Award
WINNIE NAMBATYA
ID:
Evaluation of the complexity of medicine regimens and drug therapy problems among children with sickle cell anemia in Jinja Regional Referral Hospital: A prescription audit
REFNo: HS1299ES

• To determine the complexity of medication regimens prescribed to the patients with SCA.
• To determine the incidence of DTPs among medications prescribed to children with SCA.

 Uganda 2021-05-20 2024-05-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Waiswa Peter
ID: UNCST-2020-R014921
 ALERT – ACTION LEVERAGING EVIDENCE TO REDUCE PERINATAL MORTALITY AND MORBIDITY IN SUB-SAHARAN AFRICA
REFNo: HS1324ES

To develop and evaluate a multifaceted intervention to i) strengthen the implementation of evidence-based interventions and responsive care and ii) reduce in-facility perinatal mortality and morbidity through a multidisciplinary approach in Benin, Malawi, Tanzania and Uganda.
 Uganda 2021-05-20 2024-05-20 Medical and Health Sciences Non-degree Award
Mark Okwir
ID: UNCST-2021-R013417
 Spectrum, Outcomes, and Factors Associated with the Liver disease in a Tertiary Care Hospital, Northern Uganda: a 5 Year Retrospective Study.
REFNo: HS1333ES

General Objectives
To determine the spectrum, outcome, and factors associated with liver disease in patients admitted at Lira hospital in northern Uganda over the last five years.

Specific Objectives:
1. To describe the spectrum of liver disease among patients admitted to Medical wards in Lira Regional Referral Hospital over the last five years.
2. To determine the factors associated with liver disease among patients admitted with liver disease at Lira Hospital in the last five years.
3. Determine the admission outcomes (mortality and survival) of liver diseases among patients admitted at Lira Reginal Referral Hospital in the last five years.
4. To determine the factors associated with the admission outcomes (mortality and survival) of patients admitted with liver disease at LRRH in the last five years.

Uganda 2021-05-20 2024-05-20 Medical and Health Sciences Non-degree Award
SHAMIM NAMUKASA
ID:
Prevalence of Sickle Cell Trait and Needs Assessment for Up-Take of Sickle Cell Screening Among Secondary School Students in Kampala City
REFNo: SS818ES

To explore the stakeholders' perceptions regarding the uptake of sickle cell screening among secondary school students in Kampala City,To Assess the factors influencing uptake of sickle cell screening services among secondary school students in Central Uganda.,To determine the prevalence of sickle cell trait among secondary school students in Kampala City,Determine the prevalence of sickle cell trait among secondary school students and identify student-related and stakeholders' factors influencing up-take of sickle trait screening,3. To Explore the stakeholders' perspectives regarding the uptake of sickle cell screening services among secondary school students in Central Uganda.,2. To Assess the factors influencing uptake of sickle cell screening services among secondary school students in Central Uganda.,1. To determine the proportion of sickle cell among secondary school students in Central Uganda.,
 Uganda 2021-05-20 2024-05-20 Social Science and Humanities Non-Clinical Trial Non-degree Award
Grace Lubega Biyinzika
ID: UNCST-2020-R014149
 Perceptions and adherence to preventive measures for Coronavirus Disease 2019 among rural community households in Wakiso district, Uganda.
REFNo: SS819ES

3. To explore community barriers and facilitators of adherence to COVID-19 preventive measures among rural community households.,2. To assess adherence to COVID-19 preventive measures as issued by the Government of Uganda among rural community households.,1. To assess perceptions towards COVID-19 preventive measures among rural community households. ,To assess community perceptions and adherence to COVID-19 preventive measures in rural community households of Wakiso district, Uganda in order to provide essential information needed by public health officials and other stakeholders to make an informed decision on the most effective strategy for reduced community transmission.,
 Uganda 2021-05-20 2024-05-20 Social Science and Humanities Non-Clinical Trial Non-degree Award
MISAKI WAYENGERA
ID:
Prevalence of Polymorphic genes of Alzheimer disease in Nodding disease Tauopathy.
REFNo: HS726ES

To determine if polymorphisms in the eight common genes associated with Alzheimer Disease (APP, MAPT, PREN-1, PREN-2, BACE-1, BACE-2, IDE, and APOE-ε4) are present in DNA of Nodding Disease patients
 Uganda 2021-05-18 2024-05-18 Medical and Health Sciences Degree Award
Obondo Sande James
ID: UNCST-2019-R000241
 Selecting Single Component Adjuvants for Vaccine Formulations
REFNo: HS821ES

1. To determine if adjuvants induce maturation of dendritic cells from healthy donors, LTBI and asymptomatic VL
2. To determine if adjuvants induce antigen-independent proliferation of different lymphocyte populations from healthy donors, LTBI and asymptmatic VL.
3. To measure levels of cytokine production induced by the different adjuvants
4. To determine if adjuvants induce cytotoxicity (as measured by annexin V).

 Uganda 2021-05-18 2024-05-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Richard Idro
ID: UNCST-2021-R013599
 Neurodevelopmental, Behavioural and Physical Growth Outcomes of Children born to Mothers with Nodding Syndrome in Northern Uganda.
REFNo: HS852ES

Primary Objective
To determine the neurodevelopmental and behavioural outcomes of children born to mothers suffering from nodding syndrome compared to children of healthy mothers.

Secondary Objectives
1.To describe adverse medical conditions children of mothers of nodding syndrome have experienced from birth
2.To determine physical growth outcomes among children born to NS patients.
3.To determine the effect of seizure burden (frequency and duration) during pregnancy on child neurodevelopmental outcomes.
4.To determine the effect of caregiver emotional wellbeing on child neurodevelopmental outcomes.

 Uganda 2021-05-18 2024-05-18 Medical and Health Sciences Non-degree Award
Wilson  Tumuhimbise
ID:
A mobile health framework for public private mix in Tuberculosis prevention and care in Uganda
REFNo: HS963ES

1). To explore the barriers and motivators to private hospital engagement in TB care among private healthcare workers with particular focus on understanding the current Public Private Mix frameworks utilized.
2). To develop a mobile phone based framework for enhancing the tracking of TB patients referred from private to public hospitals and assess its initial acceptability and feasibility
3). To assess the preliminary impact of the mobile phone based framework on TB patients’ adherence to referrals for TB diagnosis and treatment in public hospitals.

Uganda 2021-05-18 2024-05-18 Medical and Health Sciences Degree Award
Janet Nakigudde
ID: UNCST-2019-R000444
 Catalyzing Change in Education through a Transformative Learning Collaborative: Scaling-Up of a Social Emotional Learning Curriculum in Uganda A Phase III Randomized Control Trial
REFNo: HS1189ES

Specific Objectives
1. To identify effective strategies to integrate the PD-SEL curriculum into Nakaseke Core Primary Teachers College by applying a learning collaborative approach
2. To carry out additional Professional development adaption of a behavioral management program (PARENT-CORPS) enhancement by integrating teacher/adult SEL training and gender equity. (the PARENT-CORPS program is being adapted at Kibuli CPTC and Bulera CPTC in Hoima but without the SEL component)
3. To evaluate the effectiveness of PD-Enhanced on teachers’ and students’ SEL/SEC when implemented using a task-shifting model with PTC tutors and incorporating a gender-sensitive approach

 Uganda 2021-05-18 2024-05-18 Medical and Health Sciences Non-degree Award
Josephine  Ndagire
ID:
Assessment of Justice Delivery for Children Victims of Defilement
REFNo: SS744ES

The main objective of the research is to assess the response of the justice sector in Uganda to the issue of defilement throughout the justice chain in the last decade and the role that the legal framework particularly the law on defilement (as amended in 2007) has played in facilitating or impeding the actions by the sector and ultimately make recommendations on policy and institutional reforms to address the high defilement rates in the face of strong legal guarantees.
Uganda 2021-05-18 2024-05-18 Social Science and Humanities Non-Clinical Trial Non-degree Award
Steven Ndugwa Kabwama
ID:
Risk Factors for Non-Communicable Diseases among Adults in a District with a High Prevalence of Schistosomiasis
REFNo: HS1289ES

1. To estimate the prevalence of risk factors for NCDs such as alcohol intake, tobacco use, fruit and vegetable intake, obesity and physical activity among adults in Buyende District.
2. To determine the prevalence of schistosomiasis infection among adults in Buyende District.
3. To assess the factors associated with the risk factors for non-communicable diseases (alcohol use, tobacco use, fruit and vegetable intake, obesity) among persons presenting with or without schistosomiasis infection.

 Uganda 2021-05-18 2024-05-18 Medical and Health Sciences Non-degree Award
Johnbosco Turyasingura
ID:
Community participation and sustainability of donar funded potato projects in Kabale district
REFNo: SS758ES

i. To examine effect of project design and implementation of donor funded potato projects in Kabale District.
ii. To determine the effect of project resourcing on sustainability of donor funded potato projects in Kabale District.
iii. To determine the effect of project monitoring and evaluation on the implementation of donor funded potato projects in Kabale District

 Uganda 2021-05-18 2024-05-18 Social Science and Humanities Degree Award
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