Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
John Rek
ID: UNCST-2024-R004373
Bednet use across a spectrum of malaria transmission risk in Tororo and Busia Uganda
REFNo: SS769ES

1. Determine household- and individual-level characteristics that correlate with poor bednet use using novel metrics from an electronic adherence monitor.
2. Relate bednet use to malaria-related outcomes such as mosquito density, malaria infection and clinical malaria episodes.
3. Develop a theoretical behavioral model of bednet adherence using qualitative interviews.
4. Compare methods for objective bednet adherence monitoring using the SmartNet platform.

Uganda 2021-03-18 2024-03-18 Social Science and Humanities Non-degree Award
Aubryn Sidle Allyn
ID:
Barriers to Returning Girls to School After COVID-19 Related School Closures in East Africa
REFNo: SS750ES

1. Identify and disseminate information about the barriers that adolescent girls in Uganda are facing that may prevent school resumption once directives to resume are given.

2. Identify and disseminate information about promising best practice programming in distance education and returning formerly school-going adolescent girls to school, once schools

USA 2021-03-18 2024-03-18 Social Science and Humanities Non-degree Award
Agnes Kiragga
ID:
Piloting a HIV Risk assessment application to increase awareness and uptake of HIV prevention services among young adults in Uganda. (SIDARISK)
REFNo: HS1293ES

• To assess the extent of high-risk sexual behavior and related practices among young adults using a web-based individualized HIV risk platform (SIDARISK)
• To establish the feasibility of using an existing telehealth platform for the referral and linkage to HIV/STI testing and prevention services following risk assessment by the SIDARISK application.
• To understand acceptability of the SIDARISK application for HIV risk assessment among young adults in Uganda
• To establish the feasibility of using a telehealth platform for provision of information on HIV risk reduction and linkage to HIV and PrEP services following using of the SIDARISK application

Uganda 2021-03-18 2024-03-18 Medical and Health Sciences Non-degree Award
Catriona  Waitt John
ID: UNCST-2019-R001068
Pilot feasibility study for uptake and implementation of a clinical algorithm for warfarin dosing in sub-Saharan African patients in the War-PATH Ugandan and South African clinical study sites.
REFNo: HS721ES

To evaluate whether the clinical algorithm improves anticoagulation control compared with local standards of care.
To determine the feasibility and acceptability of implementation of a clinical algorithm developed from the observational phase (phase 2) of the War-PATH study
UK 2021-03-17 2024-03-17 Medical and Health Sciences Non-degree Award
Ben Jones
ID:
Challenging categories: educated unemployed youth as institutional innovators in rural Uganda
REFNo: SS599ES

The objective of the study is to examine participation in local institutions to challenge understandings of youth, education and
unemployment. The outputs involve academic publications and advocacy work. The target population are educated unemployed youth and actors working with local institutions, including churches and courts. By “educated unemployed youth” we mean youth who are educated up to a minimum of S4.
UK 2021-03-17 2024-03-17 Social Science and Humanities Non-degree Award
Cissy  Kityo
ID: UNCST-2021-R013663
Gut Integrity and Metabolic Complications in Youth Living with HIV in Uganda.
REFNo: HS1036ES

The overall objective is to use surrogate markers to investigate the interplay between intestinal integrity, microbial translocation, immune activation, systemic inflammation and metabolic comorbidities in YLPHIV residing in urban and rural settings in Uganda.
Specific Aim 1: Assess differences in gut integrity, microbial and fungal translocation markers, as well as inflammation in YLPHIV compared to HIV-uninfected controls in Kampala (urban), and Gulu (rural), Uganda.
Specific Aim 2: Assess whether markers of gut integrity, translocation and inflammation are associated with adiposity, measured by dual-energy X-ray absorptiometry (DXA) and levels of the homeostatic assessment of insulin resistance (HOMA) in YLPHIV and HIV-uninfected participants in Kampala and Gulu.
Specific Aim 3: Assess the relationship between gut and inflammatory biomarkers and diet, physical activity, socioeconomic status and air pollution.
Uganda 2021-03-17 2024-03-17 Medical and Health Sciences Non-degree Award
Christine Kiconco
ID:
Management of Agricultural Indigenous Knowledge in Agricultural Research Organizations in Uganda.
REFNo: SS739ES

1. To establish the efforts of AR4D organizations towards AIK management
2. To examine how AR4D researchers’ perceptions of AIK influence their attitudes towards AIK management
3. To assess how facilitating conditions influence AIK management efforts in AR4Ds
4. To explore strategies that can enhance AIK management in AR4Ds to prevent continued AIK loss and increase possibilities for its access and utilization in agricultural development.
Uganda 2021-03-17 2024-03-17 Social Science and Humanities Degree Award
Shevin  Jacob Thomas
ID:
Understanding Drivers of Antimicrobial Resistance Among Mothers and Children in Uganda (DRUM+)
REFNo: HS1185ES

Understanding Drivers of Antimicrobial Resistance Among Mothers and Children in Uganda (DRUM+)
Specific Objectives:
Determine the prevalence of ESBL-E and ESBL-K bloodstream infections (BSI) and colonization among peripartum women and neonates/children < 5yo hospitalized with suspected sepsis.
2. Among peripartum women and neonates/children < 5yo hospitalized for suspected sepsis, determine the clinical outcomes, including morbidity (e.g., incidence of chronic kidney disease), mortality percentage (in-hospital and up to 4 months after the date of hospitalization) and frequency of readmission up to 4 months after the date of hospitalization.
3. Determine whether there is a molecular epidemiologic linkage between household carriage (including humans, associated domestic animals, and environment) of ESBL-E and ESBL-K AND patients (peripartum women or neonates/children < 5yo) hospitalized with sepsis who have ESBL-E and ESBL-K BSI or colonization.
4. Among patients (peripartum women or neonates/children < 5yo) hospitalized with sepsis who have ESBL-E and ESBL-K BSI or colonization, evaluate drivers of AMR transmission in Uganda (e.g., directionality of transmission and independent risk factors for transmission) using a dynamic agent-based model incorporating their microbiologic resistance data AND the data from linked households describing microbiological resistance and WASH observations.
USA 2021-03-17 2024-03-17 Medical and Health Sciences Non-degree Award
Coleen Sabatini
ID: UNCST-2019-R001321
Outcomes of Vascularised Fibula Flaps for Reconstruction of Segmental Bone Defects at CoRSU Rehabilitation Hospital
REFNo: HS1203ES

General Objectives To assess if vascularised fibula flap surgery for long segmental bone defects results in good outcomes for patients with an acceptable complication profile. Specific objectives 1.To determine the functional and aesthetic outcomes of vascularised fibula flaps for treatment segmental bone defects from osteomyelitis. 2.To determine outcomes of use of vascularized fibula flap in reconstruction for pseudarthrosis of the tibia, benign tumor, trauma and infection 3.To determine the complications related to the use of vascularized fibula flap in the patient populations of infection, trauma, tumour, and pseudarthrosis.
USA 2021-03-17 2024-03-17 Medical and Health Sciences Non-degree Award
Jakob Svensson
ID: UNCST-2021-R013843
The impact of value chain participation for smallholder farmers: evidence from the coffee sector in Uganda
REFNo: SS754ES

This proposal builds on our earlier work by trying to answer a logical follow-up question. Given what we know, namely: (i) supply side interventions tend to raise adoption rates (although the effect sizes are typically modest) but at best tend to have a marginal effect on farmer income, (ii) improved market access (a demand intervention) resulted in upgrading and large positive effect on both farm profit and productivity, but quantitatively small effects on adoption rates, there may be important complementarities between the supply and demand side.

The main objective of this study is to study the impact on productivity (yield) and income (farm profit) of relaxing both supply constraints and a demand constraint (access to a market for quality produce). Or in other words, what is the impact on productivity and income of farmers gaining access to a market where quality produce is paid a premium (i.e. participates in a high-value chain) and at the same time get access to subsidized inputs? By studying such complementarities between demand and supply factors, our proposed study is unique.
Sweden 2021-03-17 2024-03-17 Social Science and Humanities Non-degree Award
Janet SEELEY
ID:
Rapid assessment of secondary school physical and social environments for menstraul health in Uganda
REFNo: HS1270ES

1)To describe the current status of schools and menstrual health programmes being implemented
2)To describe the social and physical school environment, access and type of basic WASH facilities and school facilities for illness management.
3)To develop an understanding of the interactions between school staff, students and parents and the social and physical school environment relating to menstraul health.
UK 2021-03-17 2024-03-17 Medical and Health Sciences Non-degree Award
Herve Monka Lekuya Monka
ID:
Depressed Skull fractures: Timing of surgery, systemic inflammatory response, intraoperative blood loss, surgical site infection, and post-traumatic seizures - (DESTINE study)
REFNo: HS1284ES

5) To compare the risk of developing a delayed PTE up to 6 months of postoperative period between early and delayed surgery of DSFs ,4) To compare the risk of SSI within 3 months of postoperative period between early and delayed surgery of DSFs ,3) To compare the volume of intraoperative blood loss during the elevation of the DSFs between early and delayed surgery ,2) To compare the changes of serum levels of inflammatory cytokines among TBI patients regarding the timing of the elevation of DSFs ,1) To describe the epidemiology, clinical and radiological presentations of patients with DSFs ,This study aims to determine whether the timing of surgery of DSFs has a relationship with the changes of the biological markers of SIR, the risk of excessive intraoperative blood loss, the occurrence of SSI, and the incidence of PTE; this could optimize the clinical management of patients with head trauma in LMIC settings.,
Democratic Republic of Congo 2021-03-17 2024-03-17 Medical and Health Sciences Degree Award
VINCENT KIBERU MICHEAL
ID:
Implementing and evaluation of a low-resource digital infrastructure in Uganda: Visualization and Interpretation of Radiographic Images (VIoRI) to improve access to imaging services at Mulago and Kayunga regional referral hospitals.
REFNo: HS1287ES

a) To determine the diagnostic accuracy (specificity and sensitivity) of ordinary core i3 PC based display systems when compared to the dedicated PACS Workstations.
b) To determine the quality of JPEG images on ordinary core i3 PC’s compared to the DICOM images generated by the PACS workstations.
c) To determine the turnaround time of patient’s diagnosis processes using ordinary core i3 PC based digital display systems relative to the PACS workstations.
d) To strengthen research capacity and collaborations with the Ministry of Health so as to allow continuity of innovative digital health research that informs improved service provision.

Uganda 2021-03-17 2024-03-17 Medical and Health Sciences Non-degree Award
Freddy Kitutu Eric
ID: UNCST-2020-R014751
Availability and use of essential medicines and health supplies
REFNo: HS1122ES

4. Explore the effect of centralized funding mechanism on the availability of essential medicines in private not for profit facilities,3. Assess the impact of SPARS on the quality of HMIS health facility logistics data.,2. Determine the effect of SPARS on the availability of essential medicines and health supplies in public and private not for profit health facilities,1. Determine the effect SPARS has had on medicines management practices within health facilities during the scale-up period beyond one year,
Uganda 2021-03-16 2024-03-16 Medical and Health Sciences Non-degree Award
Achilles Katamba
ID: UNCST-2019-R000540
Understanding the trajectories of individuals in Uganda with trace M. tuberculosis nucleic acid in sputum- The TURN-TB study (Trace Ultra Result iNsight in TB screening)
REFNo: HS1177ES

1.To characterize baseline evidence for current or past TB disease and infection among individuals with Ultra-trace-positive sputum.
2.To longitudinally evaluate the incidence of TB and the dynamics of molecular, imaging, and immunological findings among individuals with trace-positive Ultra but no active TB at study entry.
3.To quantitatively and qualitatively explore the implications of trace-positive results and associated patient trajectories for active TB case finding strategies.

Uganda 2021-03-16 2024-03-16 Medical and Health Sciences Non-degree Award
Stephen  Ojiambo Wandera
ID: UNCST-2021-R012147
Parent-Child Communication on Sexual and Reproductive Health in border districts of Eastern Uganda
REFNo: SS748ES

The aim of the study is to assess parents’ knowledge, attitudes, and practices (KAP) and preferred approaches to PCC on sexual and reproductive health in eastern Uganda. Specific objectives are:
1. To assess parents’ knowledge, attitudes, and practices about parent-child communication about sexual and reproductive health in eastern Uganda.
2. To determine the prevalence and determinants of PCC on SRH in eastern Uganda using survey data.
3. To examine the facilitators and barriers of PCC on SRH using qualitative data among parents in eastern Uganda.
4. To identify parents’ and children’s preferred approaches to PCC on SRH in eastern Uganda.

Uganda 2021-03-16 2024-03-16 Social Science and Humanities Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
Strategies for resolving the gap in Adolescent TB care in Uganda: A pilot cluster randomized-controlled trial
REFNo: HS1042ES

1.To develop an adolescent friendly TB screening package in Ugandan health facilities.
2.To evaluate the effectiveness of an adolescent friendly screening package for TB in Ugandan health facilities
3.To ascertain the cost effectiveness of rolling out an adolescent friendly TB screening intervention in Ugandan health facilities

Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
Immaculate  Nankya Lillian
ID: UNCST-2020-R014784
Validation of an Antigen ELISA based assay for the detection of SARS-CoV-2 RNA: A COVID-19 rapid diagnostic test method
REFNo: HS1103ES

• Demonstrate the ability of the AirJump ESP Platform, a simplified RNA isolation method to extract SARS COV-2 RNA from patient samples
• Evaluate an ELISA based assay to detect RNA converted to cDNA and bound to biotin labeled primers
• Assess accuracy of the ELISA assay in detecting SARS-CoV-2 from paired Nasal Pharyngeal swabs and saliva samples collected from COVID-19 positive and negative participants.
• Determine the Reproducibility of the Antigen ELISA Assay

Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
JOSEPH SSUUNA
ID: UNCST-2024-R016102
Epidemiology and impact of HIV, NCD and urbanization syndemic in Africa.
REFNo: HS1188ES

Aim 1: Characterize HIV-related and -unrelated risk factors for cardiopulmonary non-communicable diseases (CP-NCDs) in a novel Rural-to-Urban (R2U) African cohort.

Aim 2: Characterize the impact of air pollution and moderating effects of HIV on cardiopulmonary clinical outcomes among R2U migrants.

Aim 3: Assess HIV and CP-NCDs health services utilization patterns among R2U migrants and design an integrated HIV/CP-NCD intervention.

Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
CHRISTOPHER  OPIO KENNETH
ID:
Knowledge, Attitudes and Practice of doctors in Uganda regarding screening, diagnosis and management of colorectal cancer.
REFNo: HS1198ES

To improve early detection, screening and the management of colorectal cancer in Uganda,
Uganda 2021-03-15 2024-03-15 Medical and Health Sciences Non-degree Award
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