Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Isaac Ssewanyana
ID: UNCST-2020-R014336
 Integration of SARS-CoV-2 surveillance in the active and reactive screening activities of the Intensified Sleeping Sickness Elimination Program (ISSEP) in West Nile districts, Uganda
REFNo: HS2104ES

3. To demonstrate the feasibility of using a new tool to digitalize data capture and facilitate real-time data reporting of the HAT reactive and active community screening campaigns.,2. To conduct a serosurvey for antibodies against the SARS CoV-2 spike and nucleocapsid proteins to estimate the prevalence of community exposure.,1. To demonstrate the feasibility of integrating SARS-CoV-2 in the HAT reactive and active community screening campaigns to detect active symptomatic SARS-CoV-2 infection.,
 Uganda 2022-03-16 2025-03-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 Uganda Gender and Tuberculosis Key Populations Assessment
REFNo: HS1864ES

1. To establish the gender differences evident in TB care cascade (diagnosis through treatment) records in Uganda. 2. To determine the gender barriers and facilitators to TB prevention, diagnosis, treatment and treatment completion in Uganda. 3. To generate information to guide the listing of TB KVPs relevant to Uganda context, and for designing interventions for addressing the gaps among prioritized KVPs. 4. To determine to what extent the National TB response (NSP and policies/guidelines) addresses gender and KVP issues in Uganda.
 Uganda 2022-03-14 2025-03-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
 Exposure-Response Evaluation of IV Artesunate in Children with Severe Malaria
REFNo: HS2027ES

Primary:
• To determine the relationship between dihydroartemisinin (DHA) exposures following intravenous dosing and markers of physiologic dysfunction associated with severe malaria
Secondary:
• To determine the relationship between DHA exposures and time to hospital discharge
• To determine the relationship between DHA exposures and parasite clearance associated with treatment of severe malaria.
Exploratory:
• To determine the relationship between DHA exposures and neurodevelopmental outcomes associated with treatment of severe malaria outcomes and explore predictors that may affect this relationship
• To evaluate the role of parasite clearance as a mediator of the relationship between DHA exposures and markers of physiologic dysfunction associated with severe malaria
• To develop a score comprised of markers of physiologic dysfunction and describe its relationship to clinical outcomes
• To assess P. falciparum infections for artemisinin resistance

Uganda 2022-03-14 2025-03-14 Medical and Health Sciences Clinical Trial Non-degree Award
Danielle Falk
ID:
Educators in Emergencies: The Lived Experiences and Professional Identities of Refugee and National Primary School Teachers in Uganda and South Sudan
REFNo: SS1213ES

To determine in what ways teachers conceptualize their professional identities,To understand how protracted conflict, forced displacement, and recurrent migration influences teachers’ lived experiences in their classrooms, schools, and communities in refugee-producing and receiving countries,To explore the lived experiences and professional identities of refugee and National Primary School Teachers in Uganda and South Sudan,
 USA 2022-03-14 2025-03-14 Social Science and Humanities Non-Clinical Trial Degree Award
Mathias Wambuzi
ID:
Community Engagement Strengthening for future HIV Vaccice trial participation in fishing communities around Entebbe,Uganda( CEVAC)
REFNo: SS1201ES

1. To assess knowledge on HIV vaccine trials among people living in FCs around Entebbe, Uganda.
2. To assess willingness to participate in future HIV vaccine trials among people living in FCs around Entebbe, Uganda.
3. To understand HIV vaccine trials experiences and motivators to participation among former participants.
4. To explore communities’ experiences, perceptions and preferences for community engagement among FCs around Entebbe, Uganda.

 Uganda 2022-03-11 2025-03-11 Social Science and Humanities Non-Clinical Trial Non-degree Award
Ambrose Oruni
ID:
Impact of escalating insecticide resistance on malaria control tools and parasite transmission in An. funestus from Uganda
REFNo: HS2063ES


i. Temporal monitoring of super-resistance every 6 months for 3 years. The frequency of the known resistance markers, changes in transcription profiles of resistance genes and variations in the genome will be monitored.

ii. Assess the impact of super-resistance on the effectiveness of the current and novel bednets against An. funestus.

iii. Assess the impact of super-resistance on malaria entomological transmission indices.

 Uganda 2022-03-11 2025-03-11 Medical and Health Sciences Non-Clinical Trial Degree Award
Rahel Nkola
ID:
Depression, Suicidality and associated factors among people with Diabetes and/or Hypertension at a Tertiary Hospital in South Western Uganda.
REFNo: HS1818ES

To determine the prevalence and factors associated with Depression and Suicidality among individuals with DM and/or HTN at Mbarara Regional Referral Hospital, southwestern Uganda.
 Tanzania 2022-03-10 2025-03-10 Medical and Health Sciences Non-Clinical Trial Degree Award
Cissy  Kityo
ID: UNCST-2021-R013663
 Rapid Proof-of-Principle Study: Diversity in the Spike gene of Sars Cov-2 and duration of SARS-Co-2 infection in immunologically compromised People Living with HIV-1
REFNo: HS2006ES

1.To characterize the SARS-CoV-2 virus found in HIV positive patients
2.To assess the impact of HIV immunosuppression on SARS-CoV-2 diversity
3.Determining the duration of SARS-CoV-2 infection in HIV infection
Uganda 2022-03-10 2025-03-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Alison Kinengyere Annet
ID:
Communication of research findings: a case study of medical researchers at the College of Health sciences, Makerere University
REFNo: HS2030ES

To assess the facilitators and barriers of medical research communication by researchers at MAKCHS.,To develop video documentaries, cartoons, podcasts, webinars and research briefs to communicate research findings of selected research studies at the college of health Sciences, Makerere University,To assess the factors associated with communication of medical research findings by researchers at the college of health sciences, Makerere University,To determine communication channels used by Makerere University College of Health sciences (MAKCHS) researchers in disseminating their research findings ,To investigate communication of medical research findings to different stakeholders by researchers at the college of health sciences, Makerere University,
 Uganda 2022-03-10 2025-03-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ruth Nanyonga
ID:
The Impact of Health Cooperative Membership on Health Agency and Economic Status of Women in Uganda’ Study
REFNo: SS1121ES

The main objective of the study is to quantify the impact of health cooperative membership on women’s health agency and economic status. The specific objectives include:

1. The health care access
• Safe delivery/pre-natal care
• Access to health trainings/education
• Access to regular primary care/check-ups

2. The health knowledge level
• Knowledge about health care resources (location of nearest clinic, where to get information regarding health)
• Knowledge about health itself (self-efficacy)
• Knowledge about insurance

3. The ability to set goals
• Preference to have a role in making the decisions about family planning?
• Preference to make the decision about when to seek health care for yourself?
• Preference to have a role in making the decisions about seeking health care for your family members/children?

4. Perceived ability and control
a. Ability to make decisions about family planning
b. Ability to make the decision to seek health care without delay
c. Ability to make decisions to seek health care for family members/children without delay

5. Action taken
a. Demonstrated decision-making power to seek health care without delay
b. Demonstrated decision-making power about family planning
c. Demonstrated decision-making power in seeking health care for family/children

 Uganda 2022-03-09 2025-03-09 Social Science and Humanities Non-Clinical Trial Non-degree Award
Dianah Aharimpisya
ID: UNCST-2021-R012528
 Elder Abuse and Welfare Status: Interrogating the deterrent gerontological mechanisms. A case of selected districts in south-western Uganda.
REFNo: SS1015ES

1. To examine the effect of elder abuse on welfare status in 5 selected districts of south-western Uganda. 2. To examine the mediating role of quality relationships on the association between elder abuse and welfare status in 5 selected districts of south-western Uganda. 3. To analyse the mediating effect of gerontological services access on the relationship between elder abuse and welfare status in 5 selected districts of western Uganda.
Uganda 2022-03-07 2025-03-07 Social Science and Humanities Non-Clinical Trial Degree Award
Divya Rayamajhi
ID:
Child and Adolescent mental health services in Uganda
REFNo: HS1786ES

i. To explore the availability of child and adolescent mental health services (CAMHS) in health facilities of Mbale district. ii. To identify barriers that may prevent people from accessing child and adolescent mental health services in Mbale from the perspective of health care providers. iii. To identify possible solutions to those barriers which may encourage or improve people`s access to child and adolescent`s mental health services in Mbale from the perspective of health care providers.
 Nepal 2022-03-07 2025-03-07 Medical and Health Sciences Non-Clinical Trial Degree Award
Agnes Rwashana Semwanga
ID:
A WEB-BASED HISTOPATHOLOGY REPOSITORY SYSTEM FOR BREAST CANCER MANAGEMENT
REFNo: HS2002ES

To validate the slides to establish the intra and inter observer agreement in morphological assessment of breast core cancer cases using glass slides and digital slides.,To establish the requirements and develop a web-based Histopathology Repository System (NHRS) for breast cancer case,To digitize core breast cancer glass slides for morphological assessment of core breast cancer cases.,To develop a national digital histopathology reporting system storing digitized slides for assessment of morphological characteristics of core breast cancer.,
 Uganda 2022-03-07 2025-03-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Phillip Wanduru
ID: UNCST-2019-R000381
 Determining short and medium-term sequelae, their predicting factors, and experiences of caring for newborns with intrapartum hypoxic-ischemic insults: Studies in Eastern rural Uganda
REFNo: HS2057ES

To understand caregivers’ experiences of caring for newborns with encephalopathy.,To determine the risk, and predicting factors of NDD at 6 and 12 months of age among infants who survived hypoxic-ischemic insults at birth.,To understand the interaction between healthcare providers and caregivers in the Newborn Care Units (NCU) when caring for newborns with hypoxic-ischemic insults at two high-volume hospitals in Eastern Central Uganda,To determine the predicting factors of hypoxic-ischemic insults and encephalopathy among newborns at two high-volume hospitals in Eastern Central Uganda,
 Uganda 2022-03-07 2025-03-07 Medical and Health Sciences Non-Clinical Trial Degree Award
Sarah Kiguli
ID: UNCST-2021-R013020
 Sickle Pan-African Research Consortium (SPARCO) Uganda: Strengthening Capacity for Clinical Care, Research and Training in Sickle Cell Disease - SCRT Project.
REFNo: HS2012ES

The overall goal of the project is to join and become one of the sites of the Collaborative Consortium of the SCD in Sub-Saharan Africa Network (SPARCO) with a goal of strengthening capacity for clinical care research and training in sickle cell disease in Uganda through implementation of evidence-based interventions. We shall do this by: Aim 1: Developing a centralized, electronic, patient consented, sickle hemoglobinopathy registry for Uganda. AIM 2: To improve SCD patient outcomes in Uganda by establishing regional SCD standards of care. AIM 3. To advance SCD related research by conducting cohort studies and implementation science studies on patients enrolled in the SCD registry, and an additional study on transition from pediatric to adult care by SCD adolescents.
 Uganda 2022-03-07 2025-03-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Emma Riley-Green
ID:
Financial Diaries Uganda
REFNo: SS1178ES

Test if taking women through a report on their business highlighting areas of improvement and a comparison to similar businesses results in additional improvements in business outcomes,Test if the act of frequently asking the women about aspects of their businesses makes these dimensions more salient and results in improvements in business outcomes,Understand more about female-owned microenterprises using high-frequency data collected in the form of diaries.,To examine the impact of financial diaries for female entrepreneurs, with and without reports and comparisons to similar businesses, on a range of business outcomes.,
 UK 2022-03-07 2025-03-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
Mwangi Fridah Gakii
ID:
PREVALENCE OF DYSLIPIDEMIA AMONG WOMEN WITH PRECANCEROUS AND CANCEROUS LESIONS ATTENDING CERVICAL CANCER CLINIC AT UGANDA CANCER INSTITUTE
REFNo: HS2087ES

General objectives
1. To determine the prevalence of dyslipidemia and its association with precancerous and cancerous lesions among women attending cervical cancer clinic at Uganda Cancer Institute for screening
Specific objectives
1. To determine the prevalence of dyslipidemia among women with precancerous and cancerous
lesions attending cervical cancer clinic at Uganda Cancer Institute for screening.
2. To determine the association between dyslipidemia, and grades of precancerous lesions among women attending cervical cancer clinic at Uganda Cancer Institute for screening.
3. To determine the association between dyslipidemia and grades of cancerous lesions among women attending cervical cancer clinic at Uganda Cancer Institute for screening
 Kenya 2022-03-07 2025-03-07 Medical and Health Sciences Non-Clinical Trial Degree Award
Michael  Ediau
ID:
Stakeholders’ perspectives on early infant male circumcision for HIV prevention in a traditionally non-circumcising community in Northeastern Uganda
REFNo: HS2109ES

To explore the stakeholders’ perspectives on the feasibility of introducing and scaling up EIMC in Katakwi and Soroti districts, traditionally non-circumcising communities – northeastern Uganda,To assess the health system-related facilitators and barriers for introduction and scale-up of EIMC for HIV prevention in Katakwi and Soroti districts, traditionally non-circumcising communities – northeastern Uganda,To explore the health workers individual-level and parents’ related perspectives regarding EIMC for HIV prevention in Katakwi and Soroti districts,To explore the knowledge, attitudes, norms, behavior control, intention and experiences on EIMC for HIV prevention among parents of male children in Katakwi and Soroti districts, traditionally non-circumcising communities – northeastern Uganda,To explore stakeholders’ perspectives on early infant male circumcision for HIV prevention in Katakwi and Soroti districts, traditionally non-circumcising communities – northeastern Uganda,
 Uganda 2022-03-07 2025-03-07 Medical and Health Sciences Non-Clinical Trial Degree Award
Florence Ndagire
ID:
Access to Maternal, sexual and reproductive health for persons with disabilities in Uganda
REFNo: SS1062ES

The aim of this study is to conduct empirical research on access to maternal, sexual and reproductive health services for persons with disabilities in Uganda to ascertain whether the services, programmes and policies are inclusive of persons with disabilities.
Specific objectives
1. To analyse the legal and policy framework on access to maternal, sexual and reproductive health services to ascertain whether they mainstream reproductive health needs of persons with disabilities in Uganda.
2. To assess the barriers faced by persons with disabilities in accessing MSRH services.
3. To examine the lived experiences of persons with disabilities in accessing MSRH services.
4. To assess the effects of COVID 19 on access to maternal, sexual and reproductive health services by persons with disabilities in Uganda.

 Uganda 2022-03-04 2025-03-04 Social Science and Humanities Non-Clinical Trial Degree Award
Justus Atwijukire
ID:
Understanding the context in which it is profitable for various vanilla agricultural market actors to invest in stronger relationships and adopt product quality standards to meet the needs of higher-value markets
REFNo: A185ES

Identify the context in which it is profitable for agricultural actors, particularly producers and processors, to comply with and invest in higher product quality standards.,Assess the types of market linkages that best enable multinationals to collaborate with emerging agricultural markets to increase efficiency and effectiveness along the value chain in a mutually beneficial manner.,Evaluate the extent to which strengthening linkages and relationships between supply chain actors increasing horizontal and vertical market linkages among agricultural actors at various levels (companies, SMEs, smallholders, and intermediaries) promote economic benefits for the different actors and market expansion. ,To understand how existing vanilla supply chains in Uganda and targeted interventions designed to strengthen relationships between market actors affect production, quality, market access, profits and investment within supply chains. ,
 Uganda 2022-03-03 2025-03-03 Agricultural Sciences Non-Clinical Trial Non-degree Award
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