Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
MISAKI WAYENGERA
ID:
Prevalence of Polymorphic genes of Alzheimer disease in Nodding disease Tauopathy.
REFNo: HS726ES

To determine if polymorphisms in the eight common genes associated with Alzheimer Disease (APP, MAPT, PREN-1, PREN-2, BACE-1, BACE-2, IDE, and APOE-ε4) are present in DNA of Nodding Disease patients
 Uganda 2021-05-18 2024-05-18 Medical and Health Sciences Degree Award
Obondo Sande James
ID: UNCST-2019-R000241
 Selecting Single Component Adjuvants for Vaccine Formulations
REFNo: HS821ES

1. To determine if adjuvants induce maturation of dendritic cells from healthy donors, LTBI and asymptomatic VL
2. To determine if adjuvants induce antigen-independent proliferation of different lymphocyte populations from healthy donors, LTBI and asymptmatic VL.
3. To measure levels of cytokine production induced by the different adjuvants
4. To determine if adjuvants induce cytotoxicity (as measured by annexin V).

 Uganda 2021-05-18 2024-05-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Richard Idro
ID: UNCST-2021-R013599
 Neurodevelopmental, Behavioural and Physical Growth Outcomes of Children born to Mothers with Nodding Syndrome in Northern Uganda.
REFNo: HS852ES

Primary Objective
To determine the neurodevelopmental and behavioural outcomes of children born to mothers suffering from nodding syndrome compared to children of healthy mothers.

Secondary Objectives
1.To describe adverse medical conditions children of mothers of nodding syndrome have experienced from birth
2.To determine physical growth outcomes among children born to NS patients.
3.To determine the effect of seizure burden (frequency and duration) during pregnancy on child neurodevelopmental outcomes.
4.To determine the effect of caregiver emotional wellbeing on child neurodevelopmental outcomes.

 Uganda 2021-05-18 2024-05-18 Medical and Health Sciences Non-degree Award
Wilson  Tumuhimbise
ID:
A mobile health framework for public private mix in Tuberculosis prevention and care in Uganda
REFNo: HS963ES

1). To explore the barriers and motivators to private hospital engagement in TB care among private healthcare workers with particular focus on understanding the current Public Private Mix frameworks utilized.
2). To develop a mobile phone based framework for enhancing the tracking of TB patients referred from private to public hospitals and assess its initial acceptability and feasibility
3). To assess the preliminary impact of the mobile phone based framework on TB patients’ adherence to referrals for TB diagnosis and treatment in public hospitals.

Uganda 2021-05-18 2024-05-18 Medical and Health Sciences Degree Award
Janet Nakigudde
ID: UNCST-2019-R000444
 Catalyzing Change in Education through a Transformative Learning Collaborative: Scaling-Up of a Social Emotional Learning Curriculum in Uganda A Phase III Randomized Control Trial
REFNo: HS1189ES

Specific Objectives
1. To identify effective strategies to integrate the PD-SEL curriculum into Nakaseke Core Primary Teachers College by applying a learning collaborative approach
2. To carry out additional Professional development adaption of a behavioral management program (PARENT-CORPS) enhancement by integrating teacher/adult SEL training and gender equity. (the PARENT-CORPS program is being adapted at Kibuli CPTC and Bulera CPTC in Hoima but without the SEL component)
3. To evaluate the effectiveness of PD-Enhanced on teachers’ and students’ SEL/SEC when implemented using a task-shifting model with PTC tutors and incorporating a gender-sensitive approach

 Uganda 2021-05-18 2024-05-18 Medical and Health Sciences Non-degree Award
Josephine  Ndagire
ID:
Assessment of Justice Delivery for Children Victims of Defilement
REFNo: SS744ES

The main objective of the research is to assess the response of the justice sector in Uganda to the issue of defilement throughout the justice chain in the last decade and the role that the legal framework particularly the law on defilement (as amended in 2007) has played in facilitating or impeding the actions by the sector and ultimately make recommendations on policy and institutional reforms to address the high defilement rates in the face of strong legal guarantees.
Uganda 2021-05-18 2024-05-18 Social Science and Humanities Non-Clinical Trial Non-degree Award
Steven Ndugwa Kabwama
ID:
Risk Factors for Non-Communicable Diseases among Adults in a District with a High Prevalence of Schistosomiasis
REFNo: HS1289ES

1. To estimate the prevalence of risk factors for NCDs such as alcohol intake, tobacco use, fruit and vegetable intake, obesity and physical activity among adults in Buyende District.
2. To determine the prevalence of schistosomiasis infection among adults in Buyende District.
3. To assess the factors associated with the risk factors for non-communicable diseases (alcohol use, tobacco use, fruit and vegetable intake, obesity) among persons presenting with or without schistosomiasis infection.

 Uganda 2021-05-18 2024-05-18 Medical and Health Sciences Non-degree Award
Johnbosco Turyasingura
ID:
Community participation and sustainability of donar funded potato projects in Kabale district
REFNo: SS758ES

i. To examine effect of project design and implementation of donor funded potato projects in Kabale District.
ii. To determine the effect of project resourcing on sustainability of donor funded potato projects in Kabale District.
iii. To determine the effect of project monitoring and evaluation on the implementation of donor funded potato projects in Kabale District

 Uganda 2021-05-18 2024-05-18 Social Science and Humanities Degree Award
Adeodata Rukyalekere Kekitiinwa Kekitiinwa
ID: UNCST-2019-R000799
 Novel and Optimized Diagnostics in Pediatric Tuberculosis in Kampala, Uganda(NOD)
REFNo: HS1341ES

The study has the following objectives:
Objective 1: Evaluate and develop novel assays that diagnose TB by detecting Mycobacterium tuberculosis (MTB) bacterial products in non-sputum body fluids. Objective 2: Evaluate and develop novel assays that diagnose TB by detecting host biomarkers in non-sputum body fluids.
Objective 3: Identify combinations of assays that applied together could be used to diagnose TB among children with unconfirmed.

 Uganda 2021-05-18 2024-05-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Edith Wakida K
ID: UNCST-2019-R001225
 Impact and process Evaluation of the Health-Professional Education Partnership Initiative – Transforming Ugandan Institutions Training Against HIV/AIDS
REFNo: HS1351ES

1. To evaluate the acceptability, appropriateness, feasibility, and implementation process of the HIV curriculum
2. To evaluate the acceptability, appropriateness, feasibility, and implementation process of building capacity of primary health care (PHC) providers to provide comprehensive HIV services and strengthen bidirectional linkages between health facilities and communities
3. To evaluate the acceptability, appropriateness, feasibility, and implementation process of the micro-research program

Uganda 2021-05-18 2024-05-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Pontiano Kaleebu
ID: UNCST-2021-R013577
 A phase I study to determine the safety and immunogenicity of the candidate Rift Valley Fever Virus (RVFV) vaccine ChAdOx1 RVF among healthy adult volunteers in Uganda.
REFNo: HS793ES

The primary objective of this study is to assess the safety profile of the candidate vaccine ChAdOx1 RVF in healthy adult volunteers in Uganda. This will be assessed through comparing the frequency of solicited, unsolicited and serious adverse events and changes from the baseline of laboratory safety measures between participants who will receive the active vaccine and those who will receive the placebo.
The Secondary objective is to assess the immunogenicity of the candidate vaccine ChAdOx1 RVF in healthy adult volunteers in Uganda. This will be assessed through quantification of antibodies to the GnGc proteins using ELISA, RVFV neutralising antibody titres and Ex vivo ELISpot and flow cytometry responses to GnGc.
 Uganda 2021-05-17 2024-05-17 Medical and Health Sciences Non-degree Award
Allen Kabagenyi
ID:
Impoverishing and Catastrophic health expenditure on cancer care among persons affected by cancer in Uganda
REFNo: SS851ES

1. To determine the out of pocket expenditure associated with cancer care for persons affected by cancer, by type and stage;
2. To determine the proportion of cancer patients and or their families that experience catastrophic or impoverishing expenditure due to cancer related expenses by cancer type and stage;
3.To characterize the socio-economic interruptions experienced by persons affected by cancer in Uganda.
4.To examine the sociodemographic characteristics associated with cancer care burden in Uganda
5.To assess patients and care givers perceptions and attitudes of cancer care expenditures and health care in Uganda


Uganda 2021-05-17 2024-05-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
Julia Dickson-Gomez
ID: UNCST-2019-R000775
 Integration of buprenorphine into a multi-component harm reduction program for people who inject drugs in Kampala, Uganda
REFNo: HS1229ES

To develop a combination HIV prevention intervention for PWID in Kampala Uganda, using the Consolidated Framework for Intervention Research. The combination intervention includes social network HIV/HCV testing, linkage to care for PWID and PrEP for HIV negative PWID. All participants will be offered safe injection equipment, condoms and HIV risk reduction education, and naloxone, buprenorphine, and CBT4CBT for heroin users.
2. To refine the intervention iteratively through implementation cycles using the CFIR framework to identify barriers and find solutions to implementation and scale-up.
3. To assess feasibility, acceptability and initial promise of the intervention with a 6-month pilot test.

 USA 2021-05-10 2024-05-10 Medical and Health Sciences Non-degree Award
Erisa Mwaka Sabakaki
ID: UNCST-2019-R001625
 Engaging Young People in the Development of Digital Mental Health Innovation in Africa
REFNo: SS795ES

To build a network of experts and stakeholders to develop a framework for responsible and relevant digital mental health interventions for young people in African countries
 Uganda 2021-05-10 2024-05-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
William Worodria Ofuti
ID: UNCST-2022-R010915
 Management of Lower Respiratory Tract Infections in Sub-Saharan Africa, a Pragmatic Approach
REFNo: HS1160ES

Primary objective: To define aetiology and resistance patterns of clinically diagnosed CAP among hospitalized individuals using a comprehensive microbiological approach.

Secondary objectives:
1.To determine the level of agreement between molecular and conventional laboratory testing for the diagnosis of CAP.
2.To determine clinical predictors of treatment outcomes (early treatment failure, mortality) in patients hospitalized with CAP.
3.To determine the role of the CURB-65 severity score and biomarkers (CRP and PCT) in predicting treatment outcomes (early treatment failure, mortality) of patients hospitalized with CAP in a high HIV burden setting.

 Uganda 2021-05-07 2024-05-07 Medical and Health Sciences Non-degree Award
Kenneth Mutesasira
ID:
Patient perspectives and reasons for interruption of TB treatment within central Uganda.
REFNo: HS1383ES

-The overall aim of the study is to understand patient reasons for treatment interruption to inform the interventions for improving TB patient retention and final treatment outcomes.
- The second objective is to explore patient's suggestions for improving their adherence throughout the course of treatment.
 Uganda 2021-05-07 2024-05-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Semitala Fred
ID: UNCST-2020-R014202
 An assessment of current hypertension care (HTN) practices, routines, barriers, and facilitators for people living with HIV at selected health facilities in Kampala and Wakiso Districts in Uganda. A Formative Study
REFNo: SS808ES

Objective 1: To assess for knowledge, attitudes and practices of hypertension management and control.
Objective 2: To document existing guidelines and recommended routines for HTN-HIV integration in HIV clinics.Objective 3: To assess the current practice, routines, barriers and facilitators of HTN-HIV integration in HIV clinics.
Objective 4: To explore key stakeholders’ perspectives on HTN-HIV integration in HIV clinics in Kampala and Wakiso Districts.


Uganda 2021-05-07 2024-05-07 Social Science and Humanities Non-degree Award
James Nyonyintono Mwangwa
ID: UNCST-2023-R005636
 Reporting neonatal demographics, clinical characteristics and outcomes using the deidentified Kiwoko Hospital newborn care unit database
REFNo: SS813ES

Aim 1- Describe demographics, clinical characteristics and outcomes of neonates Aim 2- Describe mortality by birthweight and birth location Aim 3- Evaluate the changes to growth and length of stay after introduction of cue-based feeding in 2019 Aim 4- Evaluate the short-term clinical correlates to a diagnosis of birth asphyxia Aim 5- Determine if frequency of low birthweight admissions correlates to transmission of p. falciparum and decreased use of insecticide treated nets
 Uganda 2021-05-07 2024-05-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
Robert Kalyesubula
ID:
Task Shifting Screening and Measurement of Blood Pressure and Blood Sugars by Community Health Workers for Early Detection and Referral of Hypertension and Diabetes in Rural Uganda.
REFNo: SS821ES

1. To train CHWs in detection, referral, and promotion of continuity for diabetes and
hypertension care among community members in Nakaseke district, Uganda.
2. To assess the ability of trained CHWs to detect and refer patients with diabetes and or hypertension in Nakaseke district.
3. To determine compliance to diabetes and hypertension referral care among community
members in Nakaseke district
 Uganda 2021-05-07 2024-05-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
FREDRICK MAKUMBI
ID:
VACCINATION COVERAGE AND ITS DETERMINANTS AMONG CHILDREN AGED 0 TO 59 MONTHS IN KENYA / UGANDA: A HOUSEHOLD SURVEY
REFNo: HS1391ES

STUDY OBJECTIVES

Broad Objective
The main objective of the baseline and endline surveys is to determine the current status and uptake of immunization services in Living Goods’ focus areas in Kenya and Uganda.
Specific Objectives
The specific objectives of the baseline and endline surveys in Kenya and Uganda are to:
1. Determine the percentage of children (aged 0-59 months) fully vaccinated before and after implementation of the program.
2. Determine the equity or lack thereof in immunization coverage.
3. Assess knowledge, skills (CHWs only) and attitudes of CHWs and caregivers of children aged ≤59 months before and after the intervention.
4. Determine health system factors (stock outs, outreaches, micro-plans, etc.) that facilitate or deter vaccine uptake.

 Uganda 2021-05-07 2024-05-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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