Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
CHARLES BENSTONS IBINGIRA RUKAMBURA
ID: UNCST-2021-R008521
 : NANOBODY BASED POINT OF CARE DIAGNOSTIC KIT FOR CERVICAL CANCER
REFNo: HS1414ES

This study will to generate and characterise nanobodies for early cervical cancer diagnosis targeting non-invasive biomarkers expressed in urine. Specifically, the study will , 1. Determine the expression levels of cervical cancer discriminatory urine biomarkers at different stages among cervical cancer cases, 2. Generate nanobodies cross-reactive to target cervical cancer specific biomarkers secreted in urine/cervical mucus, and 3. Develop and validate a Nb based lateral flow based multiplex biomarker detection assay for cervical cancer.
Uganda 2021-06-24 2024-06-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Harriet Akello
ID: UNCST-2021-R013785
 Relationship between mental health and health work functioning during the covid-19 pandemic in Uganda
REFNo: HS1407ES

To identify connection between depression, anxiety and stress with health functioning during COVID-19 pandemic ,To determine prevalence of depression, anxiety and stress among healthcare workers during COVID-19 pandemic ,To determine relationship between mental health and health work functioning during covid-19 pandemic in Uganda,
 Uganda 2021-06-24 2024-06-24 Medical and Health Sciences Non-Clinical Trial Degree Award
Jackson Amone
ID:
A usability study on the knowledge and practice of a novel Medium Pressure Reservoir oxygen prototype in Uganda
REFNo: HS1497ES

Phase 2: The primary objective of the usability study is to gather clinical and BMET feedback on the use of the MPR with patients of diverse characteristics and its ability to function through power interruptions &/or in situations where there is high patient volume,Phase 1: The primary objective of the simulated use summative evaluation is to gather evidence of safe and effective use of the device to support regulatory filing.,
 Uganda 2021-06-24 2024-06-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JUDITH NASSAAZI
ID: UNCST-2023-R007664
 LONG TERM EFFECTS OF ORTHOPAEDIC INJURY ON PATIENTS IN UGANDA
REFNo: HS1047ES

General Objective
To determine long-term effects of orthopaedic injury on patients in Uganda 8years following the injury.
Specific Objectives
• To determine the long-term economic impact of tibia and femur fractures on patients and their families
• To determine the health related quality of life of the patients who sustained tibia and femur fractures 8years following their injuries.

 Uganda 2021-06-23 2024-06-23 Medical and Health Sciences Non-degree Award
Kaijuka Benson
ID:
CORPORATE SOCIAL RESPONSIBILITY AND FINANCIAL PERFORMANCE OF SAVINGS AND CREDIT COOPERATIVE SOCIETIES IN UGANDA. A CASE STUDY OF MITOOMA DISTRICT, WESTERN UGANDA
REFNo: SS668ES

The research will specifically tackle the following research objectives; to establish the level of investment made in philanthropic involvement activities on the financial performance of SACCOs in Mitooma district, Western Uganda, to examine the role of investment made in ethical involvement activities on the financial performance of SACCOs in Mitooma district, Western Uganda and to find out how of investment made in economic involvement activities on the financial performance of SACCOs in Mitooma district, Western Uganda.
Uganda 2021-06-23 2024-06-23 Social Science and Humanities Degree Award
Rosalind  Parkes-Ratanshi Parkes
ID: UNCST-2019-R000717
 Characterizing STIs and antimicrobial resistance in men with urethral discharge syndrome in Uganda
REFNo: HS1338ES

Primary:
• To assess and compare the prevalence of pharyngeal STIs (gonorrhea, chlamydia) in relation to urogenital STIs, characterize the antimicrobial resistance (AMR) profile of pharyngeal and urogenital gonorrhea, and identify demographic and behavioral risk factors associated with STIs at different anatomical sites. STIs and AMR profiles will be determined using a combination of traditional laboratory methods (cultures) and molecular approaches, including, but not limited to nucleic acid amplification tests (NAATs).

Secondary:
• To assess acceptability of self-collected tests in men with UDS and pharyngeal testing for STIs in Uganda.
• To estimate the prevalence of 4 STIs in a population of men with UDS caused by the following pathogens: Chlamydia trachomatis (CT), Neisseria gonorrhoea (NG), Trichomonas vaginalis (TV), and Mycoplasma genitalium (MG) using NAATs.
• To estimate the proportion of STIs (CT/NG/MG) at multiple anatomical sites (penis and pharynx (throat))
• To assess the prevalence of HIV and syphilis, and compare HIV result to self-reported HIV status.
• To explore socio-demographic, behavioural and clinical factors associated with positive STI diagnosis and antimicrobial-resistant infections.
• To compare the antimicrobial susceptibility profiles of pharyngeal and urogenital NG isolates recovered the same participant(s).
• To compare the distribution of AMR markers in pharyngeal and urogenital NG.
• To determine the effectiveness of treatment for urogenital NG infections on pharyngeal infections.
• To explore the feasibility of detecting NG and AMR markers using a single-cell molecular approach directly from pharyngeal samples.
• To collect pharyngeal samples for future metagenomics analysis to explore the role of microbiome on pharyngeal NG infections and AMR.
• To explore the role of commensal Neisseria species on the development of AMR in NG.
To provide samples to be added to the Johns Hopkins International STI biorepository at Johns Hopkins School of Medicine, Baltimore, MD USA.


 UK 2021-06-23 2024-06-23 Medical and Health Sciences Non-degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
 Drug Interactions between Dolutegravir (DTG) and escalating-doses of Rifampicin (RIF) Study
REFNo: HS1376ES

The secondary objectives of the trial are to determine the safety and tolerability of the DTG/RIF combination, the PK of RIF, induction of PgP and CYP3A4 and effect of DTG on appetite,Primary Objective The primary objective of the study is to determine changes to the PK parameters of DTG when administered with standard, medium and high doses of RIF in HIV-negative, TB-monoinfected participants coming to the end of continuation TB therapy with standard doses of RIF and INH over a 10 week period,
 Nigeria 2021-06-23 2024-06-23 Medical and Health Sciences Clinical Trial Non-degree Award
Mark Okwir
ID: UNCST-2021-R013417
 Meningitis: Burden, Causes, Pathogenesis and Prevention in Rural Northern Uganda
REFNo: HS1420ES

Aim 1: To prospectively collect data on all patients with meningitis and meningitis symptoms who were admitted to LRRH to assess etiologies and pathogenesis of meningitis using modern diagnostic testing not previously available and evaluate the causes, burden of disease, and outcomes of meningitis. Aim 2: To perform CrAg screening of 10,000 HIV-positive patients to determine the prevalence of cryptococcal antigenemia and conduct a case control study to compare outcomes among CrAg-positive patients and CD4-matched CrAg-negative controls.
 Uganda 2021-06-23 2024-06-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Olivia Kituuka
ID:
HLA TYPING OF 5 MAJOR ETHNIC GROUPS IN UGANDA AND KNOWLEDGE AND ATTITUDES ABOUT ORGAN DONATION AND TRANSPLANTATION AMONG HEALTH CARE WORKERS, HEALTH POLICY MAKERS AND THE URBAN POPULATION IN UGANDA.
REFNo: HS1447ES

To determine the prevalence of Human Leucocyte Antigen (HLA) sub-types among individuals from five largest ethnic groups in Uganda. ,To assess Knowledge Attitudes and perceptions among urban populations and key stakeholders in Kampala city on organ transplantation in Uganda,
 Uganda 2021-06-23 2024-06-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bernard Kikaire
ID:
Perspectives of stakeholders in research on post-trial access to investigative products: The Post Trial Access (PTA) Study
REFNo: HS1449ES

General Objective
To explore the understanding and perspectives of key research stakeholders about the provision of post-trial access in clinical trials conducted in Uganda.
Specific Objectives
1.To explore research stakeholders’ knowledge of post-trial access in Uganda

2.To explore research stakeholders’ perspectives about post-trial access in clinical trials conducted in Uganda.

3.To describe the post-trial access practices and or experiences among key research stakeholders in Uganda

 Uganda 2021-06-23 2024-06-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Shelley Jones
ID:
Women to Women Research for Economic Empowerment in Uganda: A Participatory Action Research Project
REFNo: SS710ES

The goal of this project is to engage women in Uganda in conducting research that investigates successful community-based, women-led entrepreneurial initiatives in order to inventory, analyze, and report on best practices and lessons learned that will contribute to knowledge that can be accessed by other women who are interested in entrepreneurship. The objectives are to support the participants to 1) develop research skills that will enable them to gain information, knowledge, and insights into how to develop thriving, sustainable initiatives that provide sufficient income to attain and sustain a reasonable standard of living; 2) create and disseminate knowledge around issues directly concerned with women’s empowerment through entrepreneurship
 Canada 2021-06-21 2024-06-21 Social Science and Humanities Non-Clinical Trial Non-degree Award
Sam Ononge
ID: UNCST-2020-R000328
 A PILOT STUDY TO EVALUATE THE PRELIMINARY SAFETY OF THE WEKEBERE SYSTEM FOR THE EARLY DETECTION OF PREGNANCY COMPLICATIONS.
REFNo: HS1025ES

To determine the safety of using the wekebere system in monitoring fetal wellbeing.
To determine the acceptability of the wekebere system among the expectant mothers and clinical staff.

 Uganda 2021-06-18 2024-06-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Irene Andia Biraro Rebecca
ID: UNCST-2019-R001475
 A Randomized Double Blind Placebo Controlled Trial of Rifapentine and Isoniazid for Prevention of Tuberculosis in People with Diabetes.
REFNo: HS1112ES

Primary objective:
To assess the efficacy of preventive therapy with a 12-week course of rifapentine and isoniazid (3HP) against the development of probable or definite TB disease over 24 months in people with Diabetes Mellitus (DM) who are latent TB infection (LTBI) test positive.
Secondary objectives:
• To assess the efficacy of 3HP against the development of possible, probable or definite TB disease over 24-40 months in people with DM who are latent tuberculosis infection test positive
• To compare the proportions who complete treatment between arms
• To compare the occurrence of adverse events between arms
• To compare the rate of TB or death between arms
• To compare the overall mortality rate between arms
• To explore the efficacy of 3HP against development of probable or definite TB in those who are LTBI test positive, across the following sub-groups, separately: study site (n=3); age groups; duration of DM; level of glycaemic control (baseline HbA1C) and body mass index (BMI).
• To assess the efficacy of 3HP against development of probable or definite TB, in two restricted analyses: TST positive and IGRA positive participants.
• To carry out sub-studies including i) an economic modelling and cost effectiveness study, ii) a cohort study of those who are IGRA and TST negative a baseline, iii) a cross-sectional study of HIV and TB prevalence and DM phenotype, (iv) evaluation of point-of care (POC) testing for LTBI, and computer-assisted X-ray, (v) a public health study of patient management, and v) future genetic studies.

Uganda 2021-06-18 2024-06-18 Medical and Health Sciences Clinical Trial Non-degree Award
Elisabeth Vodicka
ID:
Evaluating the ongoing costs and operational context of national HPV vaccine delivery in Uganda
REFNo: HS1358ES

Identify the HPV vaccination program cost drivers and opportunities and challenges for improving cost efficiency.,Evaluate the quality of existing HPV vaccination program performance data.,Understand the contextual factors of the delivery approach for the HPV vaccination program.,Estimate the ongoing costs to deliver HPV vaccines for the health system and supporting platforms (e.g., department of education). ,Evaluate the annual ongoing financial and economic delivery costs for HPV vaccination in Uganda. ,
 USA 2021-06-18 2024-06-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
FRANCIS TUMWESIGYE N/A
ID:
GENDER INCLUSION AND SERVICE PROVISION BY CORE SECURITY AGENCIES IN UGANDA. A CASE OF UGANDA POLICE IN KAMPALA METROPOLITAN AREA.
REFNo: SS779ES

TO EXAMINE THE EFFECTS OF WOMEN PARTICIPATION ON PROVISION OF SERVICES BY THE UGANDA POLICE FORCE.,TO FIND OUT THE BENEFITS OF WOMEN EMPOWERMENT ON PROVISION OF SERVICES BY THE UGANDA POLICE FORCE.,TO ASSESS THE IMPACTS OF WOMEN REPRESENTATION ON EFFECTIVE PROVISION OF SERVICES IN THE UGANDA POLICE FORCE.,TO EXAMINE THE EFFECTS OF GENDER EQUALITY ON EFFECTIVE PROVISION OF SERVICES BY THE UGANDA POLICE FORCE.,THE STUDY OUGHT TO EXAMINE THE EFFECTS OF GENDER INCLUSION AND PROVISION OF SERVICES BY THE UGANDA POLICE FORCE IN THE CONTEPOLARY POLICING.,
 Uganda 2021-06-18 2024-06-18 Social Science and Humanities Non-Clinical Trial Degree Award
Thomas Baik
ID:
A Survey of Language Choice and Code Switching in Psychiatric and Neurological Practice
REFNo: HS1432ES

In this study we aim to explore three situations in which language choice can enhance multilingual patients’ cognitive reserve and psychological resilience. Research in psycho- and sociolinguistics suggests that languages can be used to regulate emotional and social distance. For example, one language can be associated with authority and formality, and other with compassion and solidarity (Myers-Scotton, 1995). This study aims to investigate whether such differential use of languages is also used in medicine and psychotherapy and can be applied to regulate inner emotions. This leads us to our research question: Can multilingualism benefit psychiatric and neurological patients through a mechanism of emotional distance regulation.
We will address language choice and code switching in the context of trauma and psychosis in psychotherapy as well as in the process of neurodegeneration in neurological patients. We aim to address the question of the importance of language choice in illness from all three perspectives of the biopsychosocial model, since each of the above-mentioned groups has one component of the biopsychosocial model in the foreground, meaning that in neurological patients the predominant component is biology, psychosis patients are strongly influenced by psychological factor and in trauma patients the experiences are strongly embedded in social factors.

Germany 2021-06-18 2024-06-18 Medical and Health Sciences Non-Clinical Trial Degree Award
Levicatus Mugenyi
ID: UNCST-2020-R014759
 The Impact of Child-Optimized Financial Education (COFE) Curriculum in Uganda
REFNo: SS817ES

The main study objectives are to answer the following specific research questions/objectives. Outcomes/measures are underlined below. Primary research question: • Does participation in COFE + SILC groups increase the likelihood that caregivers pay for required education expenses of all the school-age children under the caregivers’ care to stay in school vs. participation in SILC only groups? Secondary research questions include: • Does participation in COFE + SILC increase the likelihood that caregivers pay for health-related expenses of all the children under the caregivers’ care (who have a health need) vs. participation in SILC alone? • Does participation in COFE + SILC increase caregivers’ financial self-efficacy vs. participation in SILC alone?
Uganda 2021-06-17 2024-06-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
Damalie Nalwanga
ID: UNCST-2021-R013217
 Exploring understanding, attitudes and practices of frontline health workers and caretakers regarding the relationship between severe pneumonia and malnutrition in children in the context of COVID-19
REFNo: SS803ES

1.To assess the level of understanding of frontline health workers and caretakers regarding the relationship between severe pneumonia and malnutrition in the context of COVID -19
2.To assess the attitudes of frontline health workers and caretakers regarding the relationship between severe pneumonia and malnutrition in the context of COVID -19
3.To assess the practices of frontline health workers and caretakers regarding the relationship between severe pneumonia and malnutrition in the context of COVID -19

 Uganda 2021-06-16 2024-06-16 Social Science and Humanities Non-degree Award
Emmy Okello
ID: UNCST-2020-R009792
 Active Case Detection and Decentralized Dynamic Registry to Improve the Uptake of Rheumatic Heart Disease Secondary Prevention (ADD-RHD)
REFNo: HS1323ES

Primary Objective:
To develop and refine a technology-enabled approach to increase uptake of secondary prevention (ADD-RHD) that is sustainable and replicable at scale to improve outcomes for people living with RHD.

Secondary Objectives:
Aim 1: Optimize the ADD-RHD ACT Platform to maximize case retention and delivery of secondary prophylaxis.
Aim 2: Roll out and evaluate the implementation of the ACT Platform.
Aim 3: Assess the adequacy of current policy and regulatory guidance in Uganda for the adoption of new technologies for health in general, and for rheumatic heart disease diagnosis and management and to describe system and policy constructs necessary for the successful approval of new health technology.
Aim 4: Estimate costs, cost-effectiveness, and budget impact of the ACT platform intervention.

 Uganda 2021-06-16 2024-06-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Julius Okuni Boniface
ID: UNCST-2019-R000963
 A MULTI-COUNTRY, SINGLE-BLINDED, PHASE 2 STUDY TO EVALUATE RAPID DETECTION SYSTEMS OF SARS-COV-2
REFNo: HS1425ES

1. To determine the clinical sensitivity of the test assays compared to the real-time RT-PCR-based method.
2. To determine the specificity of the test assays compared to the real-time RT-PCR-based method.

 Uganda 2021-06-16 2024-06-16 Medical and Health Sciences Clinical Trial Non-degree Award
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