Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Catriona  Waitt John
ID: UNCST-2019-R001068
 Implementation of a "bundle of care" to improve anticoagulation control in patients receiving warfarin in Uganda and South Africa
REFNo: HS1422ES

Primary objective is to evaluate whether implementation of warfarin bundle improves time in therapeutic range

Secondary objectives are:
-To evaluate whether implementation of the warfarin bundle improves time to achieving a therapeutic INR
-Whether implementation of the warfarin bundle affects the occurrence of adverse events(death, bleeding and thrombotic events)
-whether staff find the interventions contained in the bundle acceptable
-To explore patients' experiences and acceptability of the package of care, and
-Whether the bundle represents good value for money
 UK 2021-07-09 2024-07-09 Medical and Health Sciences Clinical Trial Non-degree Award
Maureen Ayikoru
ID:
REVISED PROPOSAL IN RESPONSE TO THE OUTCOME OF ROUND 1 OF COMMITTEE REVIEW OF THE PROJECT “INDIRECT IMPACTS OF COVID-19 ON HEALTHCARE SYSTEMS: A CASE STUDY OF UGANDA’S HEALTHCARE PROFESSIONALS”
REFNo: HS1524ES

To document what lessons can be learnt from Uganda’s response to COVID-19,To analyse the impact of information and communication technologies and the media, including digital, print and broadcast media in containing the COVID-19 pandemic in Uganda.,To analyse what if any, political economy factors influence misinformation, resource reallocation and prioritisation during the ongoing pandemic and to document the perceived effects on the entire healthcare system including those most vulnerable,To identify what threats COVID-19 has had on physical, psychosocial, and overall well being of HCPs and to assess what if any formal and informal coping mechanisms have so far been available to them,To generate empirical evidence on the indirect impacts of Uganda’s response to COVID-19, focusing on the healthcare professionals.,
 Uganda 2021-07-09 2024-07-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Adoke Yeka
ID: UNCST-2021-R004300
 Efficacy and safety of artemether-lumefantrine, pyronaridine-artesunate, artesunate-amodiaquine and dihydroartemisinin – piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Uganda.
REFNo: HS1363ES

The general objective of this study is to assess the therapeutic efficacy and safety of artemether-lumefantrine (AL), pyronaridine-artesunate (PA), artesunate-amodiaquine (ASAQ) and dihydroartemisinin-piperaquine (DP) for the treatment of uncomplicated P. falciparum malaria in three sentinel sites in Uganda.
The primary objectives are:
• to measure the clinical and parasitological efficacy of 4 artemisinin-based combination therapies (ACT), artemether-lumefantrine (AL) Pyronaridine-artesunate (PA), artesunate-amodiaquine (ASAQ) and dihydroartemisinin-piperaquine (DP).
• to differentiate recrudescence from new infection of Plasmodium falciparum by molecular techniques.
The secondary objectives are:
• to evaluate the incidence of adverse events; and
• to determine the polymorphism of molecular markers mediating resistance for Artemsinin, Pyronaridine, Piperaquine and Lumefantrine resistance.
• to determine the blood concentration of Lumefantrine after treatment with Artemether- Lumefantrine .


 Uganda 2021-07-08 2024-07-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Aubryn Sidle Allyn
ID:
Emplacing Agency in Girls' Education Practice: An Evaluation of Impact
REFNo: SS651ES

1. To evaluate the impact of CDOs’ programs on girls' Agency outcomes.
2. To understand how and why programs influence agency in adolescent girls, and what aspects of program design impede or speed this development.
3. To understand the relationship between girls’ agency and educational outcomes.
4. To evaluate the relationship between girls’ agency and teenage pregnancy incidence and determine what effect, if any, increased agency has on teenage pregnancy.
 USA 2021-07-07 2024-07-07 Social Science and Humanities Degree Award
Angelique Murorunkwere
ID:
DIAGNOSTIC DELAY AND ITS CAUSES AMONG PEDIATRIC CANCER PATIENTS AT MBARARA REGIONAL REFERRAL HOSPITAL CANCER UNIT
REFNo: SS857ES

1. To determine the average time between onset
of symptoms and diagnosis among children
with cancer at MRRH
2. To outline caregiver self-reported reasons
for delayed diagnosis among children with
cancer at MRRH
3. To establish the correlates of delayed
diagnosis among children with cancer at
MRRH

 Rwanda 2021-07-07 2024-07-07 Social Science and Humanities Degree Award
Roseline Katusiime
ID:
Detecting and analysing micronutrient gaps in dietary patterns in Western Uganda: A comparison of different methods
REFNo: A122ES

1. To compare the 24-hour recall method with direct observation and weighing of food portions, so as to generate knowledge on their accuracy and make expert recommendations by the end of 2021.
2. To use the CIMI to identify nutrient deficiencies in particular gaps of Vitamin A, Zinc and Iron and generate CIMI based recommendations and suggestions on improved diets for the research participants at the end of June 2021.
3. To calculate the costs of improved diets and develop recommendations on affordable nutrient adequate diets for study participants by the end of 2021
4. To assess the advantages and disadvantages of different strategies used by development organizations in western Uganda in encouraging communities to embrace affordable nutrient adequate diets and feeding practices by June 2021

Uganda 2021-07-07 2024-07-07 Agricultural Sciences Degree Award
Deborah  Ojiambo
ID:
Efficacy of Group Activity Adherence Counselling (GAAC) for Adolescents with Unsuppressed HIV viral load at three large HIV clinics in Uganda: Randomized controlled trial
REFNo: SS805ES

1.To examine the barriers such as behavior problems and mental health problems to adherence experienced by adolescents living with HIV.
2.To evaluate the efficacy of GAAC in addressing barriers to adherence among adolescents living with HIV.

3.To assess whether GAAC is associated with viral load suppression, among adolescents living with HIV compared to Standard Service Provision (SSP)
 Uganda 2021-07-07 2024-07-07 Social Science and Humanities Clinical Trial Non-degree Award
Omony Geoffrey
ID:
Safeguarding the war-affected community in Gulu district in Northern Uganda
REFNo: SS830ES

1) To explore and document the impact of research and projects on former child soldiers, both the benefits and the harms, and capture how future projects which focus on the war-affected community can benefit them and what they require for their empowerment
2) to contribute new evidence on the impacts, both direct and indirect, of COVID-19, on persons with disabilities, led by persons with disabilities, with a focus on war-related disabilities in Northern Uganda. This evidence and data will include solutions for disability-inclusive pandemic recovery informed by persons with disabilities
3) to contribute towards the evidence and literature on safeguarding war-affected and post-conflict communities, and create outputs which are accessible to various audiences, including policymakers, academics, journalists, NGOs, and general public
4) to build the esteem of ex-child soldiers, persons with disabilities, and other war-affected groups in Northern Uganda, through involving them in participatory-action research, the design of outputs, and dissemination activities to foster confidence-building, inclusion, and empowerment
Uganda 2021-07-07 2024-07-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
Georgina Pearson
ID:
Living the Everyday: Health-seeking in times of sickness and epidemics at Uganda’s borders
REFNo: SS878ES

1. To document everyday knowledge production on illness, among academics, media, public health practitioners and people living on and across border regions. 2. To identify patterns and practices of health-seeking across the border region., 3. To explore interactions between bodies of knowledge produced by various groups at the border, and detail convergences and divergences., 4. The above objectives will lead on to inform policies in response to potential and emergent threats in border regions.
 UK 2021-07-07 2024-07-07 Social Science and Humanities Non-Clinical Trial Degree Award
Gertrude Kiwanuka
ID:
ETHICAL ISSUES IN RECRUITMENT AND CONDUCTING RESEARCH DURING OUTBREAKS IN RESOURCE LIMITED SETTING
REFNo: SS883ES

1. To determine community voluntariness, understanding and preparedness to participate in research during life threatening infectious disease outbreaks.
2. To explore the perceptions of investigators and policy makers regarding the conduct of research during outbreaks of life threatening diseases in a resource limited setting. Investigators and policy makers play a critical role in setting and driving the research agenda.
3. To examine the ethical issues raised by members of research ethics committees regarding enrollment of participants in research during epidemic situations and the application of alternative designs.
4. To develop a short course on ‘‘Ethical issues in research during epidemics in a resource limited setting”. This will be based on findings from community, investigators and policy maker interactions and extensive review of the literature.

Uganda 2021-07-07 2024-07-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
Annet Khaoya Irene
ID:
Women (in VSLA) Respond
REFNo: SS847ES

The study will be guided by the following key objectives which will also inform the key assessment questions during the survey • To assess how VSLAs (as collectives) and VSLA members are being affected by and coping with the pandemic • To assess the role VSLAs (as collectives) are playing in local response, including not only financial but also social (including health) and political roles • What action and support VSLAs need or want to see from other stakeholders including local and national authorities
Uganda 2021-07-07 2024-07-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
PaweÅ‚ SzymaÅ„ski
ID:
Trade-off between species recognition and individual discrimination in tropical Turtur doves
REFNo: NS256ES

Song is a fundamental signal associated with sexual selection in birds. The processes that allow for species
recognition as well as for individual recognition are inextricably linked and prerequisite for subsequent
decisions about strategy of territory defence and mate choice. The two mentioned functions are somewhat
contradictory, as species recognition needs the uniform feature of a song within a species, whereas
individual recognition is only possible if individuals within a species are somehow acoustically
different. This may lead to conflicting selection pressures that are dependent on the chance of mistaken
species recognition and the importance of individual recognition. The problem that we want to deal with in
this project is the evolutionary compromise between species specific uniformity and individual-specificity of
acoustic signals produced in a sexual selection context. Our model system, the dove species from the Turtur
genus inhabit forest-woodland-savanna habitats in Sub-Saharan Africa. Firstly, we want to describe the
advertisement song variation among and within all Turtur species, in order to identify species and
individually specific song features. Second, we want to experimentally test how birds respond to songs of
the same species and different species in populations occurring allopatrically and sympatrically; and if birds
can discriminate between neighbours and strangers and how similar, co-existing species affect this process.
We plan to use molecular methods to confirm phylogenetic relatedness among the five species and analyse
the genetic structure of same- and different-species populations living in sympatry and allopatry.
 Poland 2021-07-07 2024-07-07 Natural Sciences Non-Clinical Trial Degree Award
JOAN TUSABE
ID: UNCST-2021-R013942
 Understanding knowledge, perceptions and healthcare seeking practices of rural communities in the management of snake bites in Kamuli district.
REFNo: SS912ES

1.To explore and learn from the knowledge, perceptions and preffered health care seeking practices for snake bites among the adult population aged 18-65 years in Kamuli district.

2.To explore knowledge, perceptions and the preferred health care-seeking practices for snake bites among health care workers in Kamuli district

3.To explore the knowledge, perceptions and preferred health care seeking bahaviour among victims of snakebites in Kamuli district.

 Uganda 2021-07-07 2024-07-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
Francis Kalule Kizito
ID:
Molecular identification of benzimidazole resistance associated with beta-tubulin gene in adult Haemonchus contortus worms from goats slaughtered in Kalerwe abattoir in Uganda
REFNo: A133ES

1. To identify common intestinal parasites from goats slaughtered in Kalerwe abattoir in Uganda
2. To determine the prevalence of Haemonchus contortus species identified from goats slaughtered in Kalerwe abattoir in Uganda.
3. To determine the importance of ITS- 2 gene in analyzing genetic diversity among isolates of Haemonchus contortus.
4. To determine the frequency of benzimidazole resistant SNPS F200Y, F167Y and E198A in the partial β-tubulin isotype 1 gene of Haemonchus contortus identified from goats slaughtered in Kalerwe abattoir in Uganda.

 Uganda 2021-07-07 2024-07-07 Agricultural Sciences Non-Clinical Trial Degree Award
Noeline Nakasujja
ID: UNCST-2019-R001428
 ASSESSING THE IMPLEMENTATION OF THE POLICY AND REGULATIONS AGAINST SEXUAL HARASSMENT (PRASH) AT MAKERERE UNIVERSIT
REFNo: SS925ES

1. To assess the extent to which the recommendations from the 2018 committee on SM&H, and the 2018 amendments to PRASH have been implemented.
2. To conduct a dialogue among the University’s key stakeholders focused on addressing SM&H and creating a safe working and learning environment at the Makerere University.
3. To develop a set of recommendations to improve the monitoring and implementation of PRASH

 Uganda 2021-07-07 2024-07-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
Daniel Murokora Murokora
ID: UNCST-2024-R002689
 Transition To Scale: Using the FREO2 Social Enterprise model and technology to scale up access to Oxygen in Uganda
REFNo: HS1238ES

The aim of this project is to evaluate the impact of a reliable oxygen system on improving a) oxygen reliability and affordability, b) clinical outcomes for children.

With a strong emphasis on clinical and technical training, the project activities should:
a) Improve the availability of oxygen, the detection of hypoxaemia, and the access of a sick child to oxygen when they require it
b) Reduce patient and health system costs of oxygen
c) Understand appropriateness, acceptability, and feasibility of the system in the specific context of health facilities in Western Uganda

 Uganda 2021-07-06 2024-07-06 Medical and Health Sciences Non-degree Award
Achilles Katamba
ID: UNCST-2019-R000540
 Evaluation of Xpert® MTB/XDR test for susceptibility testing of Mycobacterium tuberculosis to first and second line drugs
REFNo: HS1395ES

Secondary: To evaluate factors for lab uptake o Training needs o Recording and Reporting Needs o Error rates o Proportion of results interpretable o TAT o Work flow,Assess sensitivity and specificity of Xpert® MTB/XDR test in previously stored sputum samples (previously stored) compared to the WHO-endorsed genotypic (MTBDRplus and MTBDRsl) method as a gold standard.,Assess sensitivity and specificity of Xpert® MTB/XDR test in previously stored sputum samples (previously stored) compared to the WHO-endorsed MGIT960 culture-based drug susceptibility method as a gold standard,The main objective is to independently validate the performance of the Xpert® MTB/XDR test for susceptibility testing of MTB among presumptive XDR-TB patients. The test performance indicators will be compared with current standard drug susceptibility test methods including the MGIT 960 liquid culture drug susceptibility (DST) systems, Line probe Assay and Whole genome sequencing. ,
 Uganda 2021-07-06 2024-07-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Frederick Mubiru Edward
ID:
Market Research on Service Delivery Implications for a 4-month Depot Medroxyprogesterone Acetate Subcutaneous (DMPA-SC) Product
REFNo: HS1520ES

1. To explore stakeholder perceptions of client-centered communication needs for a 4-month DMPA-SC product
2. To explore potential barriers and facilitators to the introduction of a 4-month DMPA-SC product
3. To assess implications for data systems, curriculums, training, supervision, logistics, and quality assurance of introducing a 4-month DMPA-SC product

 Uganda 2021-07-06 2024-07-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eugene Ruzagira
ID: UNCST-2023-R008282
 The impact of COVID-19 on primary health care service provision and utilization in Uganda, Sierra Leone and the Democratic Republic of Congo
REFNo: HS1430ES

I.To determine whether COVID-19 is having an impact on the number of people seen at a selection of healthcare facilities for antenatal care, outpatient visits, routine immunisations, family planning and HIV treatment services, using routine health registration data.
II.To document primary healthcare workers’ experiences in providing care during the outbreak and to identify barriers and facilitators to primary health care provision.
III. To estimate the level of exposure to SARS-CoV-2 among healthcare workers by conducting a repeated serosurvey over a period of 4 months.
IV. To document community members’ experiences in accessing primary healthcare during the outbreak and to identify barriers and facilitators to utilisation.
V. To formulate a set of key findings and recommendations in partnership with stakeholders.

 Uganda 2021-07-06 2024-07-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ronald Moses Galiwango
ID: UNCST-2024-R015239
 SARS-CoV-2 infection and variants surveillance in South-central Uganda (Also known as ‘SARS-CoV-2 surveillance study’)
REFNo: HS1510ES

2.1 Primary objective
To ascertain the burden and transmission patterns of SARS-CoV-2 infection within selected communities in South-central Uganda using rapid antigen tests.
2.2 Secondary objectives
A. To survey for SARS-CoV-2 infection and variants in communities at high-risk of COVID-19 transmission in South-central Uganda through sequencing of specimens positive on both rapid antigen and RT-PCR tests.
B. To determine the acceptability of SARS-CoV-2 antigen rapid diagnostic tests among residents of South-central Uganda.
C. To assess SARS-CoV-2 transmission patterns/dynamics within households and in neighborhoods among communities in South-central Uganda.
D. To assess the burden of prior SARS-CoV-2 infection in South-central Uganda using a validated IgM/IgG antibody test.

Uganda 2021-07-06 2024-07-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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