Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
Search By Approval Date:
Clear Filter Total: 6,049
Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Ellen Kayendeke Jessica
ID:
Participatory Modeling of the Linkages Between Agricultural Productivity and Wetland Management in Iganga District, Uganda
REFNo: NS341ES

Main Objective
To generate information about the causal links and feedback mechanisms between wetland management and agricultural productivity

Specific objectives
1. To generate a causal loop diagram about the causal linkages and feedback between wetland uses (drainage, vegetation harvesting, fishing) and ecosystem services (crop productivity, water quantity and quality)
2. To provide a platform for stakeholder dialogue about viable and sustainable wetland management options
3. To develop a system dynamics model that informs about the impacts of alternative wetland management scenarios on the wetland-agricultural system

Uganda 2022-05-20 18:29:12 2025-05-20 Natural Sciences Non-Clinical Trial Non-degree Award
Hellen Owasa Abbo Owasa
ID:
CARBON SEQUESTRATION AND SORGHUM PRODUCTIVITY UNDER SELECTED INTERCROPPING SYSTEMS IN FRAGILE AGRO-ECOLOGICAL ZONES OF UGANDA
REFNo: A188ES

3. To determine the most efficient sorghum/legume intercrop practice for the 2 agro ecological zones,2. To determine the quantity of Carbon sequestered by orghum under selected sorghum-legume intercrops in different agro ecological zones,1. To assess the existing practices on carbon sequestration amongst small holder farmers in selected agro ecological zones of Uganda,To evaluate the effect of existing legume/Sorghum intercrops in enhancing Carbon Sequestration in order to inform policy making.,
Uganda 2022-05-19 17:26:07 2025-05-19 Agricultural Sciences Non-Clinical Trial Degree Award
Samuel Okok
ID:
An Ethical Inquiry into the Socio-Political Drivers of the Political Integrity Challenges in Uganda: Towards a Normative Ethical Framework
REFNo: SS1295ES

GENERAL OBJECTIVE To investigate the socio-political drivers of Uganda’s political integrity challenges with a view of developing a normative ethical framework for improving political integrity in Uganda. SPECIFIC OBJECTIVE 1. To analyse the conceptual contestations on political integrity. 2. To identify and examine the typologies of political integrity challenges in Uganda. 3. To examine the historical socio-political dynamics responsible for the persistent political integrity deficit in Uganda. 4. To develop a framework for improving political integrity in Uganda.
Uganda 2022-05-19 16:22:20 2025-05-19 Social Science and Humanities Non-Clinical Trial Degree Award
Edrisa Mutebi Ibrahim
ID:
Assessing the quality of care and management practices among Diabetes Mellitus Type 1 Patients while in School: Case study- Patients Seeking Care from Diabetic Treatment Centers in Uganda
REFNo: HS2157ES

General objective

The main objective of this study is to assess the quality of care and management practices among school going Diabetes Mellitus Type 1 Patients in school and health facilities in Arua, Lira, Soroti, Mbarara and Kampala districts in order to develop strategic solutions that can inform programs and policies around management of diabetes in schools and health facilities.


Specific objectives
i.To explore the lived experiences of adherence to recommended feeding practices among diabetes mellitus type 1 patients in Uganda; Arua, Soroti, Mbarara, Lira and Kampala cities
ii.To examine the level of adherence to recommended feeding practices among diabetes mellitus type 1 patients while in school in Arua, Soroti, Lira, Mbarara and Kampala cities
iii.To assess the factors associated with the level of adherence to recommended feeding practices among diabetes mellitus type 1 patients while in school in Arua, Soroti, Mbarara, Lira and Kampala cities
iv. To describe the quality of care offered to patients with type 1 DM in the treatment centers of Arua, Soroti, Mbarara, Lira and Kampala cities
v. To assess the readiness of schools to manage patients with type 1 diabetes mellitus in Arua, Soroti, Mbarara, Lira and Kampala cities
?

Uganda 2022-05-19 16:16:36 2025-05-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
RONALD BAMPIGA
ID:
UPTAKE OF HBV VACCINATION AND HEALTH-RELATED QUALITY OF LIFE AMONG ADULT COMMUNITY MEMBERS IN SELECTED DISTRICTS WITHIN CENTRAL UGANDA
REFNo: HS2065ES

1. To analyse the effect between HBV vaccination and Health Related Quality of Life (HRQoL) among adult community members aged 18 years and above in selected central Uganda districts.
2. To examine HBV factors that influence uptake of HBV vaccination among adult community members aged 18 years and above in selected central Uganda districts.
3. To evaluate the HBV factors that affect Health Related Quality of Life (HRQoL) among adult community members aged 18 years and above in selected central Uganda districts.

Uganda 2022-05-19 15:52:28 2025-05-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Charles Batte
ID: UNCST-2021-R013587
Self-directed online learning on sustainable health and the agenda 2030 among public, private, civil society and academic professionals: a longitudinal study.
REFNo: HS2253ES

General objective: To evaluate the efficiency of delivering a self-directed online learning asynchronous course on sustainable health and the agenda 2030 to professionals from various sectors. Specific Objective 1. To determine the knowledge, attitudes and perception on sustainable health and the Agenda 2030 among private, civil society, public and academic professionals. 2. To determine the effectiveness of delivering a self-directed online learning (SDOL) course on sustainable health and the Agenda 2030. 3. To determine the barriers and facilitators of delivering the self-directed online learning (SDOL) course on sustainable health and the Agenda 2030.
Uganda 2022-05-18 9:57:46 2025-05-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Achilles Katamba
ID: UNCST-2019-R000540
Clinic versus Hotspot Active Case Finding and Linkage to TB Preventive Therapy (ACF/TPT) Strategy Evaluation for Tuberculosis
REFNo: HS2166ES

3. To estimate (using simulation) the impact of each intervention on diagnostic delays and TB prevalence.,2. To measure the implementation of hotspot-based and facility-based ACF + TPT, including the reach (number of individuals willing to be screened), implementation (measured via cascades of care), and maintenance (of effectiveness over time).,1. To compare the effectiveness of hotspot-focused versus facility-based ACF + linkage to TPT in terms of the number of individuals started on treatment for microbiologically confirmed TB in each community (i.e., reduction in undiagnosed TB prevalence, primary outcome) ,
Uganda 2022-05-18 9:43:01 2025-05-18 Medical and Health Sciences Clinical Trial Non-degree Award
Penlope Yaguma
ID:
Electricity access in Uganda's urban slums
REFNo: SS1036ES

Main objective: To investigate the electricity access challenges faced by households and businesses in Nankulabye slum, Kampala, Uganda
Specific Objectives
1. To identify the key socio-economic factors that influence electricity access in the slum
2. To model the daily load profile of a typical household and business in the slum
Uganda 2022-05-18 9:32:25 2025-05-18 Social Science and Humanities Non-Clinical Trial Degree Award
Ponsiano Ocama
ID: UNCST-2019-R001799
Prevention of Mother to child transmission of Hepatitis B virus in Uganda: the effect of Birth dose and antiviral therapy on neonatal transmission
REFNo: HS2201ES

Specific objectives
1. To determine prevalence of HBsAg in mothers attending antenatal care in the selected hospitals in Uganda
2. To determine the prevalence of HBsAg among 9-12month-old infants who received the HBV birth dose vaccination and the HBV 3 dose vaccinations and born to HBsAg+ve mothers who had viral load <20,000IU/ ML and never received TDF treatment.
3. To determine the HBsAg prevalence among 9-12month-old infants who received the HBV birth dose and the HBV 3 dose vaccinations and born to HBsAg+ mothers who had a viral load ?20,000 IU/ML and also received 3 months of TDF treatment.

Secondary objectives
a) Assess HBV viral load among pregnant women in different regions of Uganda.
b) Assess the predictor relationship between HBeAg and HBV viral load to transmission of the infection to unborn babies among pregnant women.

Uganda 2022-05-18 17:20:32 2025-05-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Muge Cevik
ID: UNCST-2022-R011548
Unravelling the role of host microenvironment in the development of phenotypic resistance in Mycobacterium Tuberculosis
REFNo: HS2010ES

1. To quantify the proportion of mycobacterial LBs in TB-DM patients compared to those with TB alone through a proof-of-concept clinical study.

3.2. Secondary Objectives
1. To assess total proteomic and lipidomic analysis of blood plasma from patients undergoing TB treatment to detect protein and lipid signatures/markers with the potential to predict patients’ clinical outcomes

2. To identify risk factors for poor treatment response among patients with DM and TB 1. To quantify the proportion of mycobacterial LBs in TB-DM patients compared to those with TB alone through a proof-of-concept clinical study.

3.2. Secondary Objectives
1. To assess total proteomic and lipidomic analysis of blood plasma from patients undergoing TB treatment to detect protein and lipid signatures/markers with the potential to predict patients’ clinical outcomes

2. To identify risk factors for poor treatment response among patients with DM and TB


UK 2022-05-18 17:18:33 2025-05-18 Medical and Health Sciences Non-Clinical Trial Degree Award
Stephen Tukwasibwe
ID: UNCST-2022-R011535
Malaria drug and diagnostic resistance in refugee children in Uganda
REFNo: HS2164ES

1. Compare the prevalence of malaria parasitemia in refugee children arriving at Kyangwali and Adjumani reception centers and nearby non-refugee populations
2. Compare the prevalence of Pf mutations associated with resistance to key antimalarials between refugee and non-refugee populations
3. Compare the prevalence of Pf HRP-2 gene deletions that mediate diagnostic resistance between refugee and non-refugee populations
4. Compare Pf malaria parasites genetic relatedness between parasites isolated from newly arriving refugee children and those in refugees already in camps and in surrounding populations

Uganda 2022-05-18 17:05:19 2025-05-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
FRANCIS KIBIRIGE
ID:
National Telephone Survey to understand public opinions about governance, public services, social and economic conditions of ordinary Ugandans.
REFNo: SS1244ES

1.To gather Ugandan adults’ attitudes on issues such as economic and living conditions, access to services, and governance.

2.To compare the demographic results from this mixed mode sampling approach with census data, as a means of validating this innovative sampling and data collection approach.

Uganda 2022-05-17 9:18:06 2025-05-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
DICKSON NDOBOLI
ID:
Study of the antimicrobial resistance in bacterial faecal pathogens present in the wildlife-livestock-human interface from geographical areas close to National Parks in Uganda
REFNo: A127ES

1. To assess the risk factors associated with the presence of Campylobacter sp., Salmonella sp. and E. coli, and antimicrobial resistance from geographic areas close to National Parks in Uganda.

2. To determine the antimicrobial resistance pattern of Campylobacter sp., Salmonella sp. and E. coli isolated from faecal samples from wildlife, livestock and human from geographical areas close to National Parks in Uganda.

3. To determine the transmission model of antimicrobial resistance of Campylobacter sp., Salmonella sp. and E. coli based on the wildlife-livestock-human distribution, landscape structure, environmental and human-related factors in geographic areas close to National Parks in Uganda.

Uganda 2022-05-17 9:16:53 2025-05-17 Agricultural Sciences Non-Clinical Trial Non-degree Award
Francis Omujal
ID: UNCST-2019-R000428
INVITRO PROPAGATION, PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF Prunus africana, Warburgia ugandensis, Leonotis nepetifolia AND Aspilia africana OF UGANDA
REFNo: NS130ES

1. To develop an efficient in vitro propagation protocol for P. africana, W. ugandensis, L. nepetifolia, and A. africana.
2. To conduct genetic fidelity assessment and also use Fourier Transform Near-Infrared (FT-NIR) Spectrometer and Soil-Plant Analyses Development (SPAD) to characterize and compare the chemical and chlorophyll content parameters respectively in vitro generated plants.
3. To analyze the phytochemicals in P. africana, W. ugandensis, L. nepetifolia, and A. africana.
4. To evaluate the in vitro and/or in vivo medicinal activities of the different parts of the plants (stem bark, roots, and leaves) on targeted disease conditions i.e. P. africana (prostate cancer and related disease conditions); W. ugandensis (malaria and other conditions including its anti-inflammatory); L. nepetifolia (Malaria), A. africana (Malaria, wound healing).

Uganda 2022-05-16 13:11:09 2025-05-16 Natural Sciences Non-degree Award
Silver Bahendeka Karaireho
ID: UNCST-2019-R000876
THE UGANDA NON-COMMUNICABLE DISEASE (NCD) RISK FACTORS SURVEY 2022
REFNo: HS2184ES

6. To examine the trends of NCD and associated risk factors in the Ugandan population in relation to the 2014 NCD Risk Factors Survey and in relation to interventions against NCD that were informed by results of the 2014 NCD Risk Factors Survey.,5. To assess preventive measures for selected non-communicable conditions namely cervical cancer screening.,4. To collect data on clinical parameters important in the control and management of NCDs: weight, waist circumference, height, blood pressure, heart rate. ,3. To collect data on socio-demographic characteristics important in the control and management of NCDs: age, gender, level of education, employment, income, marital status,2. To assess the magnitude of biochemical risk factors important in the management of NCDs: raised blood glucose and total cholesterol.,1. To assess the magnitude of the following behavioural risk factors for NCDs:- physical inactivity, tobacco use and harmful use of alcohol and unhealthy diet. ,To determine the magnitude and the associated risk factors of non-communicable diseases (NCDs) among the Ugandan population.,
Uganda 2022-05-16 10:36:32 2025-05-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
LWABI PETER SOLOMON
ID:
Quality of Life in Ugandan Children and Young Adults with Repaired Congenital Heart Disease: Mixed Methods Approach Research objectives
REFNo: HS2115ES

Primary Objective: Assess quality of life in Ugandan children and young adults who have undergone surgery or interventional catheterization for congenital heart disease (CHD).
Secondary Objective(s): Assess clinical and demographic factors that impact quality of life in CHD
population.
Uganda 2022-05-16 10:33:45 2025-05-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Timothy  Muwonge Ronald
ID: UNCST-2020-R014680
Pharmacy Delivery of PrEP and HIVST for Adolescent Girls and Young Women seeking Emergency Contraception at Community Pharmacies in Uganda: Formative Research
REFNo: HS2037ES

Aim 1: To assess the willingness of providing HIV self-testing and PrEP to AGYW seeking emergency contraception at community pharmacies.
Approach: Using the social-ecological model, fig 2, we will conduct surveys with AGYW approximately 130 seeking EC at community pharmacies within a radius of 45km from the Infectious Diseases Institute-Kasangati (IDI-K) research center, to evaluate knowledge of HIVST and PrEP and acceptability of accessing HIVST and PrEP through a pharmacy. In addition, we will purposefully select a subsample of up to 30 to undergo in-depth interviews (IDIs) to explore potential barriers and facilitators of HIVST and PrEP delivery at community pharmacies.
Hypothesis: AGYW seeking EC at community pharmacies will be willing to use HIVST and PrEP and will highlight potential barriers and facilitators to accessing PrEP at community pharmacies
Aim 2: To identify readiness of pharmacy providers regarding AGYW sexual health and specifically HIVST, emergency contraception, and PrEP
Approach: To assess the readiness, knowledge gaps, and training needs of community pharmacists to deliver HIVST and PrEP alongside EC, we will conduct up to 20 IDIs with providers (pharmacy technicians, nurses, and pharmacists) from private pharmacies who under the pharmaceutical society of Uganda have agreed to be included in the study.
Hypothesis: Addressing knowledge gaps of pharmacy providers will inform delivery of sexual health services to AGYW.

Uganda 2022-05-13 9:02:19 2025-05-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
John Mukisa
ID:
Host genetic variation and association with HIV disease progression among pediatric cohorts in Botswana and Uganda
REFNo: HS1841ES

1) To identify common host genetic variants associated with HIV disease progression among pediatric HIV cohorts from Botswana and Uganda. 2.) To evaluate the performance of genotype imputation methods with whole genome sequences as a gold standard for determining missing genotypes among samples from Botswana and Uganda. 3.) To identify and validate KIR genotypes among children with HIV in Botswana and Uganda. 4.) To determine the KIR haplotypes associated with HIV disease progression among children with HIV from Botswana, and Uganda.
Uganda 2022-05-13 7:48:00 2025-05-13 Medical and Health Sciences Non-Clinical Trial Degree Award
Agnes Kiragga
ID:
SARS-CoV-2 international biorepository and diagnostic test performance
REFNo: HS1808ES

Primary:
• To create a biorepository to test retrospectively the performance of investigational, emerging diagnostic technologies in the intended population or setting compared to a reference comparator for diagnosing SARS-CoV-2 infection using frozen samples.
Secondary
• To test prospectively the accuracy of investigational, emerging diagnostic technologies in the intended population or setting compared to a standard comparator for diagnosing SARS-CoV-2 infection
• To determine agreement between self-collected nasal swabs, saliva and clinician-collected nasopharyngeal swab samples for the diagnosis of SARS-CoV-2 using a reference test in Uganda.
• Determine the proportion of non-reportable results (unresolved, indeterminate and incomplete) and turn-around time compared to reference test.
• To assess acceptability of self-collected nasal swab tests and saliva for testing SARS-CoV-2 in both participants and healthcare workers in Uganda.
• To explore socio-demographic, behavioural and clinical factors associated with positive SARS-CoV-2 diagnosis.


Uganda 2022-05-13 7:45:44 2025-05-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kristina Roesel
ID:
Boosting Uganda's investments in livestock development (BUILD)
REFNo: A139ES

The program is divided into four different components that will be aligned and integrated, especially on activities that involve national stakeholder engagement and capacity building. Component 1 on Peste de petits ruminants (PPR) combines socio-economic studies, vaccine targeting and delivery, regional Pan-African networking activities (e.g. PENAPH, PPR alliance GPRA) and capacity development at the Biosciences eastern and Central Africa (BecA)-Hub at ILRI Nairobi: Objective1: Develop a socio-economic framework to assess the impact of PPR interventions Activities: Household survey in different livestock production systems; Longitudinal study-sentinel households; System dynamic modeling; Focus group discussions Outputs: Livelihoods impacts of different PPR control options Objective 2: Update the epidemiological status of PPR to allow assessment of control options Activities: Cross-sectional survey in different livestock productions systems; Post vaccination sampling; Genetic characterization of PPRV isolates; Participatory disease search; Slaughter house surveillance; Develop PPR risk maps Outputs: Updated risk map of PPR, circulating PPR genotypes, other important SR diseases Objective 3: Capacity development Activities: Support review of National PPR control strategy; Review of animal health services; Multi-stakeholder platform for AH service delivery to discuss gaps and define new mechanisms for control and surveillance; Strengthen passive surveillance system; Awareness creation of farmers; Post vaccination sampling Outputs: Novel models of animal health service delivery, strengthened surveillance system, capacity enhanced Component 2 on Rift Valley fever (RVF) includes the characterization of animal and human samples from outbreaks in 2016 and 2018, socio-economics, development of a risk and vulnerability map for Uganda as a decision-making tool Objective 1: Improved knowledge on RVF epidemiology Activities: Genotyping (RVF and other viruses); Serology (establish Gn/Gc distribution); Outbreak response; Entomological studies; Risk mapping Objective 2: Socio-economic studies Activities: Ex-ante analyses of control options; KAP questionnaire surveys; Gender assessments – exposure and constraints on uptake of interventions Objective 3: Develop National action plans/policy work and extension Activities: Contingency plans/decision support tools; Community trainings Outputs: RVF risk map, genetic characterization of circulating strains (informs vaccine interventions), Improved RVF national action plans, Training and communication materials, capacity building, improved capacity on vector sampling/surveys and biological sampling; PhD/MSc training Component 3 on Antimicrobial resistance (AMR) will contribute to the finalization of the National AMR action plan, describe and quantify the use of antimicrobials in the peri-urban poultry value chain. Objective 1: Understand knowledge, attitude, practices, and incentives for AMU in poultry value chains in Uganda, and the role of formal and informal markets Activities: Literature review on AMR and AMU in the poultry sector in Uganda; Gender sensitive rapid appraisal with AMUSE tool; Identify possible intervention entry points to improve AMU Objective 2: Assess risks to humans from poultry-associated AMR: Research on AMR transmission risks at the human-animal-environmental interface in different poultry production systems (smallholder and commercial; rural and peri-urban) in Uganda Activities: Map possible transmission pathways within the production system; Conduct AMR and residue prevalence surveys; In-depth AMR transmission studies that include environmental samples, and farm workers, and samples from other animal species potentially housed together with poultry; Outline risk pathways for human exposure to AMR from poultry production Objective 3: Design and evaluate interventions to reduce AMU in poultry value chains in Uganda Activities: Design interventions (co-design with poultry producers), closely monitor implementation over time to understand incentives to motivate change; Establish drug use monitoring system in poultry farms to allow M&E; Qualitative and quantitative analysis of intervention impact Objective 4: Support evidence-based policy dialogue for antimicrobial surveillance and AMR strategies Activities: Organise multi-stakeholder workshops to discuss feasibility, challenges, and constraints in implementing NAP in poultry sector, involve representatives from other countries and support continued review of NAP Objective 5: Build capacity in value chain actors, implementers, researchers Activities: Conduct capacity development need assessment; Develop capacity development plan for different stakeholder groups Component 4 on Veterinary Public health (VPH) at the point of slaughter includes scaling of already piloted butcher training curricula and implementation of abattoir-based sentinel studies for animal disease surveillance Objective 1: development of curriculum for capacity building of meat handlers on good hygienic practices (slaughter house personnel, butchers, meat transporters); meat inspectors on carcass inspection and mobile reporting; Public engagement of consumers; laboratory personnel (GLP and quality assurance) Activities: Baseline assessment of meat handlers’ knowledge and practices; hygiene indicators, selected pathogens; Consolidation and adaptation of existing materials for training of butchers; assessment of suitability of consolidated training materials and delivery mode with stakeholders; delivery of the training; endline study to assess success of the intervention Objective 2: proof-of-concept slaughterhouses as sentinels for zoonotic disease Activities: Mapping slaughterhouses through key informants and GIS; grey and published literature review; prioritization of disease in slaughterhouses/ identification of critical control points – KII and FGD with vets, meat inspectors, public health staff; Ethnographic observation of slaughterhouses; biological survey in animals and humans
Germany 2022-05-13 7:44:12 2025-05-13 Agricultural Sciences Non-Clinical Trial Non-degree Award
View Sort By:

"A prosperous Science and Technology Led Ugandan Society."