Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Susan Babirye
ID: UNCST-2021-R013201
 Expert Clients’ delivered Cognitive Behavioral Therapy for Reducing Self-Stigma among HIV positive Pregnant Young Women and Adolescent Girls Living in Slums Areas of Kampala, Uganda
REFNo: HS1488ES

This research broadly aims to provide evidence about expert client-delivered CBT model for reducing HIV Self-stigma in a resource limited setting.To achieve this, four interrelated questions are proposed;
1) How effective is the expert client-delivered CBT model in reducing or influencing self-stigma?
2) Can trained expert clients effectively provide CBT sessions?
3) Can expert client-delivered CBT model be accepted by clients and implementers?
4) What are the factors that contribute to acceptance of CBT delivered by expert clients?
5) What are the contextual factors that favor or hinder implementation of the expert client-delivered CBT model?

 Uganda 2021-07-30 2024-07-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Noeline Nakasujja
ID: UNCST-2019-R001428
 A collaborative research program between Michigan State University and Makerere University psychiatry departments on climate change and gender-based violence in Uganda
REFNo: HS1517ES

To conduct key-informant interviews with key personnel in the identified organizations and other stakeholders.,To identify institutions and stakeholders in based in Kampala but who work in other Ugandan regions as well related to climate change mitigation and adaptation and GBV prevention.,To establish the initial activities and steps for the development of a joint MSU-MU research program in mental health factors associated with GBV and climate change. ,
 Uganda 2021-07-30 2024-07-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Godfrey  Siu
ID: UNCST-2021-R005439
 Implementation Science and Impact evaluation of the parenting for respectability programmes: A hybrid CRCT Design”
REFNo: SS900ES

The overall objective of this study is to conduct a cRCT evaluation of PfR to test its effectiveness and cost-effectiveness for reducing violence against children and gender based violence.

1. Test the effectiveness of PfR in modifying key outcomes on parent-child relationships and relationships between partners that underlie violence against children and girls/women.
2. Examine the cost effectiveness of PfR using incremental cost-effectiveness analyses (CEA) based both on the primary outcomes of harsh parenting and partner conflict as well as on disability-adjusted life years (DALYs).
3. Examine how three implementation variables – rural vs peri-urban locality, previously established groups vs new groups, and professional vs non-professional facilitators – affect participation, programme fidelity, and quality of delivery (measured quantitatively);
4. Examine the impact of implementation variables – participant engagement and quality of delivery by facilitators – on primary outcomes of parent- and child-report of harsh parenting and partner conflict.
5. Qualitatively investigate the five elements of implementation: (i) what training facilitators need (length, follow-up, who delivers training, location, etc.); (ii) what supervision facilitators need (frequency, by whom, nature of feedback, etc.); (iii) targeting of PfR at the most vulnerable families and how this can be done; (iv) disseminating PfR’s messages beyond those participating in group sessions to operate at a community, as well as individual, level; (v) differences between Wakiso and Amuru Districts in facilitative and hindering contextual factors. We will explore how these affect participation, programme fidelity, quality of delivery, participant response and community-wide impact.

 Uganda 2021-07-30 2024-07-30 Social Science and Humanities Non-Clinical Trial Non-degree Award
Erisa Mwaka Sabakaki
ID: UNCST-2019-R001625
 DESIGN AND FABRICATION OF A LUMBAR MODIFIED SPINAL BRACE
REFNo: HS1558ES

Our main objective is to design, fabricate and test a modified fit-for-purpose lumbar orthosis through use of locally available raw materials whose design can be adopted by different orthopaedic workshops in low income countries. This will be achieved through the following sub aims;
1. Conduct a needs assessment to determine the needs and requirements of people with low back pain and derive specifications for a modified brace well suited for use by people in LICs.
2. Test and assess the functionality of the modified brace using simulations.
3. Fabricate a sturdy brace with locally sourced components that suits the specifications derived from the simulations so as to make it suitable for use in low income countries.

 Uganda 2021-07-30 2024-07-30 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Allen Kabagenyi
ID:
Accelerating Covid-19 Vaccine Acceptance and Uptake in Uganda: Snapshot Study
REFNo: SS951ES

(3) To assess the community perceptions and barriers towards COVID-19 vaccine uptake.,The general objective of the study is to explore the factors and facilitators for COVID-19 vaccination acceptance and uptake. ,To explore the demographic and socio-economic factors associated with accelerated uptake and acceptance to receive a COVID-19 vaccination. ,(1) Examine the preparedness of the population and essential workers to receive the COVID-19 vaccine. ,
 Uganda 2021-07-30 2024-07-30 Social Science and Humanities Non-Clinical Trial Non-degree Award
Abubakar Mustafa Sadik
ID: UNCST-2021-R013642
 Willingness to use genetically modified crops: Case study of communities in Uganda
REFNo: SS738ES

General objective: To evaluate the willingness of communities in Uganda to use genetically modified (GM) crops in order to inform policies and develop targeted interventions and programs towards the introduction and scaling up of GM crops in the Ugandan market. Specific objectives: a) To assess level of knowledge of communities of GM crops in Bushenyi, Jinja and Wakiso districts b) To evaluate perceptions of communities towards GM crops in Bushenyi, Jinja and Wakiso districts c) To assess the factors that contribute towards the knowledge and perceptions of communities towards GM crops in Bushenyi, Jinja and Wakiso districts d)To link willingness to use GM crops with the knowledge and perceptions of communities in Bushenyi, Jinja and Wakiso districts
 Uganda 2021-07-29 2024-07-29 Social Science and Humanities Non-Clinical Trial Non-degree Award
Hanifah Nabbanja
ID:
Characterizing oncology-related emergencies among cancer patients attending the emergency unit of Uganda Cancer Institute, Kampala, Uganda in 2019
REFNo: HS1282ES

(1) To describe the demographics and tumor characteristics, laboratory markers, and the presenting signs and symptoms in cancer patients attending the emergency unit of the Uganda Cancer Institute (UCI), Uganda from 01 January 2019 to 31 December 2019.

(2) To determine the factors associated with the different clinical presentations of oncology-related emergencies among cancer patients attending the emergency unit of the Uganda Cancer Institute (UCI), Uganda from 01 January 2019 to 31 December 2019.
 Uganda 2021-07-29 2024-07-29 Medical and Health Sciences Non-degree Award
Peter Rukundo Milton
ID: UNCST-2020-R014799
 Nutritional Quality and Safety of Complementary Foods for Children in Landslide-prone Bududa District
REFNo: HS982ES

(i) Describe the diversity of meals and food combinations commonly used in the complementary feeding of children 6-23 months old in Bududa district. (ii) Analyse the nutrient and chemical composition of commonly used raw and cooked complementary foods. (iii) Identify the type and levels of micro-organisms in the food and water commonly used for complementary feeding.
Uganda 2021-07-28 2024-07-28 Medical and Health Sciences Non-degree Award
Suzanne  Kiwanuka N
ID: UNCST-2020-R014671
 COVID-19: Assessment of the COVID-19 Response in Eastern, Central and Western Africa
REFNo: HS1121ES

The aim of this research is to assess and curate the (i) response to the COVID-19 pandemic in Africa and the outcomes in terms of COVID-19 control and (ii) continuity of essential non-COVID-19 services within the COVID-19 period, to inform the COVID-19 response and recovery as well as health system resilience to future disease outbreaks in Africa.
 Uganda 2021-07-28 2024-07-28 Medical and Health Sciences Non-degree Award
Diane Nabikolo
ID:
DEVELOPMENT OF A SAFE READY TO EAT BHAJIA SNACK FORTIFIED WITH GRASSHOPPER (Ruspolia differens) FLOUR IN UGANDA
REFNo: A121ES

i. To establish food safety knowledge, attitudes and indigenous practices associated with safe harvesting and processing of R. differens at the household level.
ii. To determine potential allergens associated with R. differens and prevalence of allergic reactions from their consumption and handling
iii. To evaluate the effect of processing on quality and safety of bhajia snack enriched with R. differens flour
iv. To determine consumer preferences and willingness to pay for value-added ready to eat bhajia snack fortified with R. differens flour.

 Uganda 2021-07-28 2024-07-28 Agricultural Sciences Non-Clinical Trial Degree Award
Irene Andia Biraro Rebecca
ID: UNCST-2019-R001475
 Pregnancy Associated Tuberculosis: Immunological and Clinical Outcomes of Exposed Infants.
REFNo: HS1396ES

4. To determine TB treatment outcomes of mothers with pregnancy associated tuberculosis.,3. To determine the prevalence of maternal comorbidities such as hyperglycaemia, malaria, HIV, syphilis and anaemia.,2. To explore the concept of congenital TB (defined as TB acquired during the intrauterine period or during the normal birth process) among infants born to women with active TB.,Secondary objectives 1. To estimate the prevalence of active TB among pregnant and postpartum mothers seeking care from antenatal clinics and TB treatment units.,3. To describe the clinical outcomes of the women with pregnancy associated TB (defined as a diagnosis of TB during pregnancy or within six months of the postpartum period) and their exposed infants at the different time points. ,2. To explore, in a subset of infants, T cell, B cell and NK cell responses following stimulation with TB antigens.,Primary objectives 1. To compare antibody vaccine responses to BCG, measles, tetanus among children born of mothers diagnosed with TB infection or disease during pregnancy or mothers on TB treatment within a six months’ postpartum period.,To compare antibody vaccine responses in children born of mothers diagnosed with diagnosed with TB infection or disease during pregnancy or mothers on TB treatment within a six months’ postpartum period.,
 Uganda 2021-07-28 2024-07-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jonathan Izudi
ID: UNCST-2019-R000469
 Evaluating the acceptability of the Aqua Research STREAM Disinfection Generator in healthcare facilities in Uganda
REFNo: HS1467ES

The proposed acceptability study will evaluate levels of user and key stakeholder acceptability of the STREAM at the end of the initial introduction stage. Results will inform national STREAM introduction strategies
 Uganda 2021-07-28 2024-07-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joseph Baluku B
ID: UNCST-2019-R000612
 Prevalence of Soil transmitted HElminths and correlation with Cardiovascular risk factors among patients with drug resistant TuBerculosis in Uganda: a cross sectional multi-center study (SHEC-TB study)
REFNo: HS1521ES

2. To establish the correlation between soil transmitted helminths co-infection and BMI, HbA1C, blood pressure, serum lipids and the CVR score among patients with DR-TB in Uganda,1. To determine the burden of soil transmitted helminths co-infection among patients with DR-TB in Uganda,
 Uganda 2021-07-28 2024-07-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
William Worodria Ofuti
ID: UNCST-2022-R010915
 Rapid Research in Diagnostics Development for TB Network (R2D2 TB Network) Study
REFNo: HS1482ES

1. To evaluate early and late prototypes of novel TB diagnostics to provide feedback to developers on performance and usability, inform further development and identify potential strategies for use in endemic settings.
2. To conduct large-scale, multi-center assessments of the accuracy and usability of design-locked novel TB diagnostics, including in special populations, to facilitate World Health Organization (WHO) policy review.
3. To assess the potential costs and epidemiological impact of novel TB diagnostics alone or in combination with current tests and algorithms to inform their further assessment and/or the WHO policy review process.
 Uganda 2021-07-28 2024-07-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rhona Baingana Kezabu
ID: UNCST-2021-R013638
 THE 2021 DHS-8 PILOT
REFNo: HS1529ES

To compare hemoglobin concentrations between venous blood, a single drop of capillary blood, and a pooled capillary blood sample in children age 6-59 months and non-pregnant women age 15-49 in a laboratory setting and a field setting,To program and pilot collection of other types of data (for assessing/ensuring interview data quality),To improve various aspects of the CAPI data capture process,To test the computer-assisted personal interviewing (CAPI) data collection application for new sections of the questionnaire ,To understand the performance of selected new core questions and modules with respect to aspects that can be assessed through cognitive interviewing: comprehension, retrieval, judgement, and response,To test selected core questions, new modules, the Domestic Violence module, and a number of the CAPI innovations under field conditions for the eighth round of The Demographic and Health Surveys (DHS) Program. ,
 Uganda 2021-07-28 2024-07-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Gertrude Namale
ID:
Post-discharge Care for Stroke patients in Uganda: barriers and enablers of appropriate secondary preventive care, coping mechanisms and access to rehabilitation service
REFNo: HS1522ES

Overall aim
To improve the quality of life of stroke survivors in Uganda by examining the barriers and enablers of appropriate care and support following discharge from hospital.

Specific objectives
1. To examine the barriers and enablers of stroke survivors’ participation in self-reported home-based physical activity and adherence to clinic follow-up schedules post-discharge

2. To document the experiences and opinions of facility-based health care providers on post-discharge follow-up and care for stroke patients

3. To describe the coping mechanisms among stroke survivors and their caregivers after discharge (a) adjustment to lifestyle behaviour post-stroke b) needs and concerns; c) depression symptoms

4. To document barriers and facilitators related with access to rehabilitation services among stroke patients post-discharge

Uganda 2021-07-28 2024-07-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Edgar Agaba
ID:
A framework for improving the effectiveness of integrated nutrition interventions in Uganda
REFNo: HS1549ES

1. Evaluate the program design, selected nutrition, and health outcomes among women and children under 5 years at baseline and at the end of the Community Connector interventions.
2. Explore the experiences of the implementers and the beneficiaries of the Community Connector interventions.
3. Evaluate the effectiveness of the Community Connector interventions on nutrition and health outcomes among women and children under 5 years.
4. Develop and validate a framework for improving effectiveness of integrated nutrition interventions for implementation in resource-poor settings.

Uganda 2021-07-28 2024-07-28 Medical and Health Sciences Non-Clinical Trial Degree Award
Lore Vandewalle
ID: UNCST-2021-R014028
 Small Firm Diaries with carpenters in Uganda
REFNo: SS919ES

The main objective of this research is to understand the frictions in the market for outputs that hamper the growth of small-scale carpenters in Uganda. We will write a descriptive paper that outlines the frictions we observed. Given the large number of programs targeting MSMEs to foster employment growth in low-income countries, the recommendations that will emerge from our project will be useful to policy makers operating at local, national and supra-national levels. The second objective is designing an intervention tailored to remove the most important friction we observed in the market for outputs. We will test this intervention using a randomized control trial and will estimate its causal effect on the growth of small-scale carpenters. Growth will be measured through changes in revenues, profits, productivity and employment. This should be informative to both academics and policy makers as well. The intervention is not yet defined, as we want to use the data to identify the most prominent friction in the market for outputs that limits the growth of carpenters. We will request an amendment to this IRB as soon as it has been designed. The final objective is assembling unique data on small-scale carpenters in Uganda. As detailed in the methodology subsection below, we will create two unique panels that will allow us to map a complete, real-time characterization of the performance of small enterprises, decision-making and shock responses of entrepreneurs, inputs’ usage and business relationships, including partner-specific trade interactions. These datasets are instrumental to accomplish the first two objectives: it provides the information needed to understand the frictions in the markets for outputs (main objective) and to define the intervention (objective 2). We list the datasets as a separate objective, as these will become public and can thus be used by policy makers, other researchers and students as well.
Belgium 2021-07-27 2024-07-27 Social Science and Humanities Non-Clinical Trial Non-degree Award
Ronald Twongyirwe
ID:
Analysis of past and projected future land use change and its impact on sediment fluxes in the Rwizi catchment
REFNo: NS147ES

. Firstly, the project aims at strengthening the academic research capacity at the universities of Mbarara and Gulu (Uganda) by means of the training of two PhD-researchers and several postdoctoral researchers in the field of integrated watershed management. Secondly, the project will develop fundamental research on the, hitherto largely overlooked, coupling between demographic developments on the one hand, and the degradation of soil and water resources on the other hand. Thirdly, the results from this fundamental research will be translated into landscape transformation models that will allow land managers and policymakers to evaluate alternative devel-opment pathways for the catchment.
Uganda 2021-07-26 2024-07-26 Natural Sciences Degree Award
SHANI BUDIGOLI DEODATUS
ID:
Prevalence, clinical manifestations, relationship with viral load of cutaneous disorders among children and adolescents living with HIV attending Mbarara Regional Referral Hospital.
REFNo: HS1265ES

1. To determine the prevalence of cutaneous disorders among children and adolescents living with HIV attending pediatric infectious Diseases' clinic at MRRH.
2. To describe the clinical manifestations of cutaneous disorders among children and adolescents living with HIV attending paediatric infectious Diseases’ clinic at MRRH.
3. To determine the relationship of cutaneous disorders and viral load among children and adolescents living with HIV attending pediatric infectious Diseases’ clinic at MRRH.
4. To assess the relationship between cutaneous disorders and CD4 counts among children and adolescents living with HIV attending pediatric infectious Diseases’ clinic at MRRH.



 Tanzania 2021-07-26 2024-07-26 Medical and Health Sciences Degree Award
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