Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Timothy  Muwonge Ronald
ID: UNCST-2020-R014680
Evaluating the implementation of assisted partner notification for HIV in refugee settlements in West Nile Uganda: An implementation Science approach
REFNo: HS1970ES

AIM 2.To explore barriers and facilitators to APN for HIV in refugee settlements in West Nile using qualitative methods to evaluate each stage of RE-AIM, guided by the Consolidated Framework for Implementation Research (CFIR) domains. ,AIM 1. To assess the reach, effectiveness, adoption, implementation, and maintenance of APN for HIV in refugee settlements in West Nile utilizing the RE-AIM framework. ,
Uganda 2022-01-24 2025-01-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Esther Nanfuka Kalule
ID:
Resilience during and After quarantine: A qualitative study of people affected by Covid-19 in Uganda
REFNo: SS1047ES

1. To examine the socio-economic constraints faced during and after quarantine
2. To examine the psychological constraints faced during and after quarantine
3. To examine the protective factors that facilitated the successful management of the socio-economic and psychological risks faced during and after quarantine.

Uganda 2022-01-21 2025-01-21 Social Science and Humanities Non-Clinical Trial Non-degree Award
Justine  Komunyena Tumusiime
ID: UNCST-2023-R008465
Assessing willingness to pay for HIV self-testing and evaluation of distribution, linkages, and referral models for HIV self-testing in Uganda
REFNo: HS1982ES

1) To assess the knowledge and attitudes of the different categories of key populations with respect to HIV self-testing in the districts with STAR III project intervention (STAR III intervention districts) and selected districts without STAR project interventions (non-intervention districts)
2) To assess access and extent of use of different HIVST kits available in Ugandan market in districts with STAR III interventions and non-intervention districts
3) To understand respondents' preferences to blood-based and oral fluid-based HIVST kits in the districts selected (see section 2.2)
4) To assess willingness to pay and estimate the specific price points HIVST kit users and non-users are willing to pay for the different HIVST kits available in Uganda
5) To identify the constraints to HIVST adoption and WTP for HIVST kits in the districts selected
6) To assess and compare the different distribution models with respect to selected indicators of effectiveness and cost-effectiveness

Uganda 2022-01-20 2025-01-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
AGATHA NSHABOHURIRA
ID:
FACTORS INFLUENCING LOW UPTAKE OF DPT3 AMONG INFANTS AGED 16 TO 52 WEEKS IN RUBIRIZI TOWN, RUBIRIZI DISTRICT
REFNo: HS1513ES

General objective for the study
To explore factors influencing uptake of DPT 3 Immunization amongst infants aged 16-52 weeks in Rubirizi Town, Rubirizi District.
Specific objectives of the study
• To find out individual level perceptions influencing uptake of DPT 3 Immunization amongst parents/caretakers of infants aged16-52 weeks in Rubirizi Town, Rubirizi District.
• To examine community influencing factors associated with uptake of DPT 3 Immunization amongst infants 16-52 weeks in Rubirizi Town, Rubirizi District.
• To explore the health service related factors influencing uptake of DPT 3 Immunization amongst infants aged 16-52 weeks in Rubirizi Town, Rubirizi District.

Uganda 2022-01-20 2025-01-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Keneth Kananura
ID:
Hematological Recovery among People Living with HIV after Cotrimoxazole prophylaxis discontinuation at Infectious Diseases Institute in Uganda
REFNo: HS1908ES

1.To determine the proportion of PLHIV with hematological complications of anemia and neutropenia who experience hematological recovery following discontinuation of CTX prophylaxis. 2. To determine the factors associated with hematological recovery among PLHIV after discontinuation of cotrimoxazole prophylaxis.
Uganda 2022-01-20 2025-01-20 Medical and Health Sciences Non-Clinical Trial Degree Award
JAMES MULEME
ID: UNCST-2021-R012263
Reservoirs, transmission and antibiotic resistance profiles of Extended Spectrum Beta Lactamase-producing Escherichia Coli at the human-animal-environment interface among farming communities in Wakiso district, Uganda
REFNo: HS1919ES

General Objective
To decipher the reservoirs and transmission pathways for ESBL-PE at the human-animal-environment interface among farming communities in Wakiso district

Specific Objectives
1. To determine the comparative distribution of ESBL-PE from humans, animals and environment among selected households in Wakiso district.

2. To describe the antibiotic susceptibility profiles of the ESBL-PE isolates obtained from humans, animals and their immediate environment among selected households in Wakiso district

3. To assess the pathways and drivers of transmission of the ESBL-PE among humans, animals and environment in selected households of Wakiso district.  

4. To explore factors influencing occurrence, transmission and management of AMR caused by ESBL-PE at the human-animal-environment interface in Wakiso district, Uganda


Uganda 2022-01-20 2025-01-20 Medical and Health Sciences Non-Clinical Trial Degree Award
Cole Harris
ID:
Pentecostalism and Development: Explaining the Variation of Church-Led Community Programs in Kampala, Uganda
REFNo: SS1151ES

Complete program observation at the community programs of the three selected case study churches.,Create three Pentecostal-Charismatic church case studies that situate the churches within the broader Pentecostal movement.,Conduct interviews with church leaders regarding the availability of community programs and their selection of those programs.,Better understand Pentecostal leaders’ decision-making process in the selection of community programs.,Take an inventory of the availability of community programs offered by Pentecostal-Charismatic churches in Kampala, Uganda.,
USA 2022-01-19 2025-01-19 Social Science and Humanities Non-Clinical Trial Non-degree Award
Susanne Guidetti Gittel Eleonora
ID: UNCST-2021-R012422
Participation in everyday life - A randomized controlled trial of mobile phone-supported and family-centred rehabilitation after stroke in Uganda
REFNo: HS1528ES

General objective (Overall aim)
To implement and evaluate the effects a mobile phone supported and family-centred rehabilitation intervention F@ce 2.0 aiming to enable performance in daily activities and participation in everyday life among persons who have had a stroke and their family members both in urban (Kampala and its surroundings) and rural (Greater Masaka) areas.

Specific objectives
• To describe the perceived impact of stroke and perceived participation in everyday life in a sample of people with stroke in rural Uganda. (Study 1)
• To evaluate the effects of F@ce in comparison with ordinary rehabilitation among persons with stroke in urban and rural Uganda regarding a) self-efficacy b) perceived performance and participation in everyday activities c) independence in ADL, d) healthcare utilization and e)their families´ perceived participation in everyday activities.(Study 2)
• To explore and describe the experiences of people with stroke and family members of participating in the F@ce (Study 3)
• To evaluate the implementation process of F@ce and to gain knowledge on the mechanisms of impact as well as the contextual factors that might influence the implementation process and its outcome. (Study 4)
• To determine the cost of delivering the F@ce intervention in comparison with the usual rehabilitation (Study 5)

Sweden 2022-01-19 2025-01-19 Medical and Health Sciences Clinical Trial Non-degree Award
Churchill Akena
ID:
; RECALL ASSESSMENT STUDY; HOW EFFECTIVE IS IT TO CARRY OUT RECALL OF PHARMACEUTICALS IN THE PRIVATE SECTOR? A CROSS SECTIONAL CASE ASSESSMENT OF GYNOZOL, EPICEPHIN AND APIDONE
REFNo: HS1916ES

1. To determine the extent of distribution of common pharmaceutical products in Uganda using examples of epicephin, gynozol and apidone.
2. To find out the percentage of distributors/customers who respond in time to class I, class II and class III recall alerts for all levels of recall.
3. To find out the percentage of wholesalers and retailers who keep adequate record of the medicines they distribute/dispense to facilitate a successful recall.

Uganda 2022-01-19 2025-01-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Doris Muhwezi Kakuru
ID:
Centering Marginal Voices: Building Research and Advocacy Skills for Young Mothers to Negotiate for their Sexual and Reproductive Health and Rights
REFNo: SS1114ES

(1)To examine existing policies, programs, and practices that shape adolescent sexual and reproductive health and (in)justice in Uganda;
(2) To assess young mothers’ everyday encounters, struggles, and resistance to the dominant gendered, generational, structural and cultural forces that frame young motherhood and how they negotiate motherhood;
(3) To analyze young mothers’ conceptualization of the gendered social norms that shape their SRH experiences and realities;
(4) To describe the process of co-creating youth-focused, contextually relevant knowledge required for young mothers’ SRH justice;
(5) To analyze public response to young people’s engagement in research, advocacy and conversations about young motherhood.

Uganda 2022-01-19 2025-01-19 Social Science and Humanities Non-Clinical Trial Non-degree Award
Gideon Ariong
ID:
REC.00.647.01:Household Vulnerability to Food Insecurity and Coping Strategies: The Case of Smallholder Farmers affected by Fall armyworm (Spodoptera frugiperda) Invasion in Eastern Uganda
REFNo: A173ES

To examine the status of households' food insecurity among the smallholder maize farmers affected by fall armyworm in Ngora district
To analyze the households' vulnerability to food insecurity among smallholder maize farmers affected by fall armyworm in Ngora district
To determine the household food security coping strategies among smallholder maize farmers affected by fall armyworm in Ngira district
Uganda 2022-01-19 2025-01-19 Agricultural Sciences Non-Clinical Trial Degree Award
ROSCO KASUJJA
ID: UNCST-2019-R000504
STEPPED-WEDGE CLUSTER RANDOMIZED CONTROLLED TRIAL OF THE PROACTIVE COMMUNITY CASE DETECTION TOOL FOR CHILDREN AGED 6-18 YEARS IN NEED OF MENTAL HEALTHCARE SERVICES IN NORTHERN AND WESTERN UGANDA
REFNo: HS1955ES

The primary objective is to examine whether the CCDT is effective in increasing utilization of TPO’s mental healthcare services among children and adolescents after introducing pro-active case detection using the CCDT as compared to practice-as-usual.,
Uganda 2022-01-18 2025-01-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Gregory Klazura J
ID:
Pediatric Surgery Training for Rural Ugandan Providers: An Evaluation and Quality Improvement Study
REFNo: HS1895ES

Evaluate the impact of the Pediatric Emergency Surgery Course on rural healthcare providers.
Objective 1: Measure knowledge retention for past course participants.
Objective 2: Measure provider knowledge before and after the course for new participants.
Objective 3: Evaluate course surveys to determine areas for course improvement.
Evaluate the impact of the Pediatric Emergency Surgery Course on pediatric surgical patients.
Objective 4: Measure pediatric operative volume at rural hospitals where the course was delivered before and after the course.
Objective 5: Measure complication rates (mortality, readmission, surgical site infection, reoperation) of patients treated or referred by providers at one of the designated sites before and after the course.
Objective 6: Measure the volume and time to referral of complex pediatric surgical conditions for patients who were treated at one of the designated sites before and after the course.

USA 2022-01-18 2025-01-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Catriona  Waitt John
ID: UNCST-2019-R001068
PHARMACOKINETICS OF DRUGS USED TO TREAT DRUG SENSITIVE-TUBERCULOSIS IN BREASTFEEDING MOTHER-INFANT PAIRS: AN OBSERVATIONAL PHARMACOKINETIC STUDY
REFNo: HS1948ES

To define transfer of Isoniazid, Rifampicin, Pyrazinamide and Ethambutol to the breastfed infant.
To determine the area under the concentration-time curve (AUC), clearance and volume of distribution of these drugs.

UK 2022-01-18 2025-01-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Nicholus Nanyeenya
ID:
Viral Non-Suppression, Drug Resistance, Perceptions and Effectiveness of Intensive Adherence Counselling among People Living With HIV/AIDS on Antiretroviral Therapy with Low-Level Viraemia in Uganda
REFNo: HS2008ES

d) To determine the effectiveness of intensive adherence counselling in achieving a non-detectable viral load in the management of LLV among PLHIV on ART in Uganda (Sub-study Four).,c) To explore the perceptions of low-level viraemia among PLHIV on ART and healthcare providers in Uganda (Sub-study Three).,b) To understand the prevalence of HIV drug resistance among PLHIV on ART with low-level viraemia, highlighting the significant mutations, in Uganda (Sub-study Two).,a) To determine the viral non-suppression trends among PLHIV on ART with low-level viraemia from 2016 to 2020 in Uganda (Sub-study One).,The aim of the study is to determine viral non-suppression trends, HIV drug resistance prevalence, perceptions and effectiveness of intensive adherence counselling among people living with HIV/AIDS on antiretroviral therapy with low-level viraemia in Uganda; to generate information which may guide the review of the HIV consolidated guidelines and the review of the current viral load testing algorithm in the country. ,
Uganda 2022-01-18 2025-01-18 Medical and Health Sciences Non-Clinical Trial Degree Award
Brian Turigye
ID: UNCST-2021-R012569
Determining the Prevalence and Risk Factors Associated with Hepatitis B Infection in Bugoye Sub County, of Kasese District in Western Uganda
REFNo: HS1900ES

1.Estimate the prevalence of hepatitis B infection in Bugoye sub-county. 2.Identify the risk factors associated with hepatitis B infection in Bugoye sub-county. 3.Explore the knowledge of and attitudes towards hepatitis B in Bugoye sub-county
Uganda 2022-01-17 2025-01-17 Medical and Health Sciences Non-Clinical Trial Degree Award
Esther Atukunda Cathyln
ID: UNCST-2019-R001701
SHINE - Exploring Intersectional Stigmas Among Men Living with HIV in Uganda
REFNo: HS1964ES

The primary objective in this study is to explore experiences of intersectional stigma among MWH and their partners who have unmet reproductive goals.
Uganda 2022-01-17 2025-01-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
REBECCA NANTANDA
ID: UNCST-2019-R001533
Children’s Air Pollution Profiles in Africa (CAPPA)
REFNo: HS1695ES

• To collect personal air pollution exposure data, activity profiles, and lung function measurements from a total of 420 children with asthma symptoms aged between 12 and 16 years in 7 African cities.
• To analyse personal air pollution data for exposure patterns and peak exposures, and to compare air pollution as well as activity profiles of children in relation to their socioeconomic and geographical backgrounds both within and between countries and compare with measured data from school-age children in London
• To explore potentially detrimental effects of air pollution, and feasibility of mitigation strategies in children with asthma symptoms.


Uganda 2022-01-14 2025-01-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kirsten Beyer M
ID: UNCST-2021-R013472
Exploring the impact of COVID-19 on cancer prevention and control service delivery in Uganda
REFNo: SS1098ES

The proposed study seeks to explore how COVID-19 has impacted cancer prevention and control activities and COVID-19 vaccination access and distribution in Uganda across the cancer continuum. 1. Investigate health care professionals’ perceptions regarding: a. How COVID-19 has impacted the provision and use of cancer treatment and preventive services. b. Their own personal fears about COVID-19, and fears and misconceptions they’ve encountered among their patients relating to COVID-19 impacting prognosis c. COVID-19 vaccination and its accessibility, coverage and distribution to cancer patients d. The impact of COVID-19 on data collection and analysis activities that support cancer prevention and control 2. Investigate patients’ perceptions regarding: a. How COVID-19 has impacted the provision and use of cancer treatment and preventive services b. COVID-19 vaccination access and distribution to cancer patients c. Fears about how COVID-19 impacts their cancer diagnosis and prognosis
USA 2022-01-14 2025-01-14 Social Science and Humanities Non-Clinical Trial Non-degree Award
Akampurira Paul
ID:
TOWARDS ENSEMBLE CLASSIFICATION ALGORITHMS FOR DIAGNOSIS OF BREAST CANCER IN WOMEN: A COMPARATIVE APPROACH
REFNo: SIR64ES

General objective
To design an ensemble model from heterogeneous base learners for detecting breast cancer to reduce the error rate on diagnosis, reduce the time taken to reach a diagnosis and also accurately predict a future risk of the disease.


Specific objectives
1. To establish requirements for designing machine learning model for diagnosing breast cancer in women with abnormal breast masses.
2. To design classification models for diagnosing breast cancer in women with abnormal breast masses.
3. To Evaluate the performance of the designed models and establish a better model for diagnosing breast cancer in women with abnormal breast masses.
4. To develop an ensemble model from the evaluated classification algorithms for breast cancer diagnosis in women.



Uganda 2022-01-12 2025-01-12 Engineering and Technology Non-Clinical Trial Degree Award
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