Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Denis Muhangi
ID:
Enhancing Institutional Capacity for Ethical Conduct of Research Involving Animals
REFNo: A141ES

Program objectives
1. To enhance technical capacity of MakSVAR-IACUC to international accreditation level.
2. Establish an Institutional Biosafety committee at the College of Veterinary Medicine, Animal Resources and Biosecurity.
3. To enhance awareness of the national guidelines for the use of animals in research and teaching among researchers and training institutions.

Specific study objectives

1. To determine the status of practices for the ethical conduct for research involving animals in Uganda.
2. To evaluate the available practices for ethical conduct for intervention.

Uganda 2021-08-16 2024-08-16 Agricultural Sciences Non-Clinical Trial Non-degree Award
Kenneth Ssebambulidde Ssebambulidde
ID: UNCST-2021-R013976
 Relationship between maternal or newborn cholesterol levels and neonatal septicaemia: A Ugandan cohort of mother-new-born pairs
REFNo: HS1204ES

Primary objective: To elucidate a relationship between maternal and neonatal cholesterol levels and neonatal septicaemia

Secondary objectives:
1. To determine whether abnormal maternal cholesterol levels are associated with a risk for neonatal septicaemia.
2. To describe the correlation between maternal cholesterol levels and cord blood neonatal cholesterol levels at birth.
3. To determine the association between cord blood cholesterol levels and neonatal septicaemia

Uganda 2021-08-11 2024-08-11 Medical and Health Sciences Non-degree Award
ANTHONY KAYIIRA
ID:
Prognostic value of serum hCG-β level, 12 days after embryo transfer, on predicting live birth among Ugandan women.
REFNo: HS1569ES

4. To determine the sensitivity and specificity of serum hCG-β level cut offs, 12 days after embryo transfer, on predicting pregnancy loss,3. To determine the sensitivity and specificity of serum hCG-β level cut offs, 12 days after embryo transfer, on predicting clinical pregnancy ,2. To determine the sensitivity and specificity of serum hCG-β level cut offs, 12 days after embryo transfer, on predicting biochemical pregnancy ,1. To determine the sensitivity and specificity of serum hCG-β level cut offs, 12 days after embryo transfer, on predicting live birth,To evaluate the prognostic value of serum hCG-β level cut off, 12 days after embryo transfer, on predicting pregnancy outcome among Ugandan women following an IVF-ET cycle.,
 Uganda 2021-08-11 2024-08-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Abel Atukwase
ID:
EXPOSURE ASSESSMENT AND ANALYSIS OF HEALTH RISKS ASSOCIATED WITH CONSUMPTION OF AFLATOXIN CONTAMINATED STAPLES IN UGANDA
REFNo: A132ES

The overall objective of the project is to generate information that will guide the development of evidence-based policies and strategies for management of health risks associated with aflatoxins in Uganda. The specific objectives are to;
1. Determine the levels of aflatoxins in maize, sorghum and groundnuts produced and consumed in Uganda
2. Assess aflatoxin exposure among children (6-59 months) and women of reproductive age (15-49 years)
3. Characterise the health risks associated with consumption of maize, sorghum and groundnuts among children 6-59 months and women of reproductive age (15-49 years)
4. Develop policy briefs aimed at improving awareness amongst policy makers and stimulate formulation of policies and strategies for mitigating aflatoxin associated health risks.
 Uganda 2021-08-11 2024-08-11 Agricultural Sciences Non-Clinical Trial Non-degree Award
Maxensia owor
ID: UNCST-2021-R014003
 IMPAACT 2017: Phase I/II Study of the Safety, Acceptability, Tolerability, and Pharmacokinetics of Oral and Long-Acting Injectable Cabotegravir and Long-Acting Injectable Rilpivirine in Virologically Suppressed HIV-Infected Children and Adolescents. Version 3.0, dated 13 August 2020
REFNo: HS1356ES

Primary Objectives:
Cohort 1
1.To confirm the doses for oral CAB followed by injectable CAB LA in HIV-infected, virologically suppressed adolescents
2.To confirm doses for injectable RPV LA in HIV-infected, virologically suppressed adolescents by evaluating safety and multiple dose PK of RPV LA through Week 16
Cohort 2:
1.To assess the safety of CAB LA + RPV LA through Week 24 in HIV-infected, virologically suppressed adolescents
Secondary Objectives: Cohort 1
• To monitor maintenance of viral suppression through Week 16 in HIV-infected, virologically suppressed adolescents
• To evaluate the tolerability and acceptability of CAB LA through Week 16 in HIV-infected,virologically suppressed adolescents
• To evaluate the tolerability and acceptability of RPV LA through Week 16 in HIV-infected,virologically suppressed adolescents
Secondary Objectives: Cohort 2
• To assess safety of oral CAB + oral RPV followed by CAB LA + RPV LA through Week 48 in HIVinfected, virologically suppressed adolescents
• To evaluate repeat-dose pharmacokinetics of CAB LA + RPV LA through Week 24, and through
Week 48 in HIV-infected, virologically suppressed adolescents.
• To assess antiviral activity of CAB LA + RPV
 Uganda 2021-08-11 2024-08-11 Medical and Health Sciences Clinical Trial Non-degree Award
John Gitta Kavuma
ID:
Corporate Governance and Christian Organisational Culture in Anglican Church Founded Universities in Uganda
REFNo: SS794ES

1-To analyse the effect of corporate governance on university policies in Ndejje and UCU.

2-To assess the relationship between governing Policies and Christian values at Ndejje and UCU

3-To evaluate the influence of Christian values on organizational culture of Ndejje and UCU.

4-To compute the contribution of Corporate Governance on promoting Christian
organizational culture.
 Uganda 2021-08-11 2024-08-11 Social Science and Humanities Non-Clinical Trial Degree Award
Jimmy, Maguru Mugisha Maguru
ID:
The ‘unexpected visitors’ and ‘good-host’ discourse: Social Accountability, Policy and Realities of Sexual and Reproductive Health of young people in two refugee settlements in Uganda
REFNo: SS828ES

1. To examine governance and accountability mechanisms of sexual and reproductive
health service delivery of the young refugees in refugee settlements in Uganda.
2. To examine the role of young refugees in the governance mechanisms of SRH and the
accountability chain and how this influences their ability to voice and to access SRH
services in refugee settings
3. To explore the challenges faced by young refugees and their coping mechanisms in
accessing and utilizing the ASRH services in refugee settlements in Uganda.

 Uganda 2021-08-11 2024-08-11 Social Science and Humanities Non-Clinical Trial Degree Award
Violet Nakibuuka
ID: UNCST-2021-R003675
 PREVALENCE AND FACTORS ASSOCIATED WITH HUMAN PAPILLOMA VIRUS VACCINATION AMONG ADOLESCENTS GIRLS AGED 9 TO 19 YEARS LIVING WITH HIV AT MULAGO ISS CLINIC, KAMPALA, UGANDA
REFNo: HS1436ES

1. To determine the prevalence of HPV vaccination among HIV positive adolescent girls aged 9-19 years at Mulago ISS Clinic, Kampala, Uganda.
2. To determine the factors associated with HPV vaccination among HIV positive adolescent girls aged 9-19 years at Mulago ISS Clinic Kampala, Uganda
3. To explore the perspectives, perceptions and experiences of healthcare providers, adolescent girls and their care takers at Mulago ISS Clinic regardingHPV vaccination among HIV positive adolescent girls.

Uganda 2021-08-11 2024-08-11 Medical and Health Sciences Non-Clinical Trial Degree Award
Derry Taylor James
ID:
Learned social knowledge in chimpanzees
REFNo: NS269ES

To understand the nature of chimpanzee social knowledge and how it is acquired
 UK 2021-08-11 2024-08-11 Natural Sciences Non-Clinical Trial Non-degree Award
MOSES EGESA
ID: UNCST-2025-R015361
 Epitope mapping of schistosome tegument and alimentary tract proteins in humans
REFNo: HS1463ES

1. To determine the change in antibody reactivity profile of individuals of an endemic area to epitopes of tegument and alimentary tract proteins before and after PZQ treatment
2. To identify antibody reactivity to epitopes putatively associated with protection against reinfection


 Uganda 2021-08-11 2024-08-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Pontiano  Kaleebu
ID: UNCST-2020-R019901
 Field Performance Evaluation of the m-PIMAâ„¢ HIV-1/2 VL plasma assay in Uganda
REFNo: HS1606ES

Main objective
To evaluate the field performance of the m-PIMATM HIV-1/2 VL plasma VL in identifying virological failure (VF) in adults on ART. The performance will be compared to standard PCR assays used at UNHLs and UVRI.
2.3.2 Primary objectives
I). To evaluate the diagnostic accuracy using the sensitivity, specificity, NPV, PPV, FPR and FNR of the m-PIMAâ„¢ HIV-1/2 VL plasma assay in comparison to a reference assay of HIV-1 RNA PCR in identifying HIV-VF at the WHO recommended threshold of 1000 copies/ml for HIV-1 infected.
II). To determine the operational characteristics of the m-PIMAâ„¢ HIV-1/2 VL plasma assay, such as ease of-use of the assay using the standardized system usability scale (SUS) by laboratory and no laboratory personnel
III). To determine changes in turn-around time and ease of clinic workflow integration.
IV).To determine acceptability of the m-PIMAâ„¢ HIV-1/2 VL plasma assay by the study participants

 Uganda 2021-08-11 2024-08-11 Medical and Health Sciences Clinical Trial Non-degree Award
Hiroyuki Takeshima
ID:
Introducing market-oriented horticulture farming in refugee hosting areas of Uganda: An intervention that builds resilience against emergency
REFNo: SS946ES

The objective of the proposed study is to introduce training programs to farmer groups in Northern Uganda, that aim to improve the market profitability of horticulture and thus increase incomes and employment for small farmers in these refugee-hosting regions in Uganda. Such investments are urgently needed to stabilize livelihoods in this region that has suffered through the combinations of challenges posed by the influx of refugees and other challenges including desert locust invasions, and health and economic risks caused by the COVID-19 pandemic. Specifically, the training program target fostering of lead farmers who will then further train other farmers within the community, and transform farmers’ mindset to “produce strategically to sell” rather than “produce and then sell”. Disseminating knowledge through lead farmers (also sometimes known as “model farmers” “village agents”) to a wider group of farmers has been considered an important way to reach and enhance the capacity and mindset of farmers at scale. The program will contribute to stabilizing and boosting farm incomes in vulnerable, refugee-hosting communities and will build the resilience of local livelihoods to COVID-19. The study then collects data on farmers’ market interaction activities and farm production practices before and after the training programs to assess the impacts of these training programs.
 Japan 2021-08-11 2024-08-11 Social Science and Humanities Non-Clinical Trial Non-degree Award
HAPPY WALUSAGA.G. ANNET
ID:
Patients’ Perceptions and Factors Influencing Choice of differentiated service delivery (DSD) models of care in Kampala, Uganda: A Case Study of Immune Suppression Syndrome (ISS)-Clinic Mulago
REFNo: SS957ES

1.To determine the prevalence of utilization of Community clients Led ART model of care among HIV/AIDS clients at ISS clinic- Mulago
2.To determine the factors associated with patients choice of CCLAD model of care among HIV/AIDS clients at ISS clinic- Mulago
3.To explore patients’ perceptions regarding the HIV differentiated models of care

 Uganda 2021-08-11 2024-08-11 Social Science and Humanities Non-Clinical Trial Non-degree Award
Charity Okaba
ID:
Addressing barriers to HIV self-testing in the Private sector among young sexually active females and males in Uganda: A human centred design framework to developing private sector HIVST demand creation, distribution, and linkage models
REFNo: SS955ES

PSI and the Busara Center for Behavioral Economics will conduct qualitative market research that will use targeted questions to gather opinions on barriers and enablers of HIV self-testing in the private sector to uncover insights, opportunities, motivators, and unmet needs. Specifically, the research will employ in-depth interviews and focus group discussions to gather insights on both demand and supply aspects of HIVST as these relate to sexually active females and males of ages 18- 29.

Focus group discussions and in-depth interviews shall be conducted among potential beneficiaries, sexually active females and males of 18 – 29 years to better understand the perceptions and attitudes, barriers and motivators of these groups towards HIV self-testing and responding to the questions with regards to the design of interventions, including delving into the issues or experiences that exacerbate behavioral biases, thereby affecting uptake of HIVST by these populations. The focus group discussions shall consider individuals with experience of using HIV self-test kits and those without experience.
We will also conduct in-depth interviews with private pharmacists, pharmaceutical technologists, and retailers of community drug shops for an understanding of the service provider perspective in selling HIV self-test kits to the target population. In addition, we will also conduct in-depth interviews with manufacturers and distributors of HIV self-test kits to understand supply side barriers and interventions that may hinder or facilitate uptake of HIVST by the target population. Further, we will conduct in-depth interviews with Ministry of Health officials in charge of managing the national HIVST programs including regulatory mechanisms to understand policy and regulatory side barriers and interventions for rolling out HIVST in the private sector.
Uganda 2021-08-10 2024-08-10 Social Science and Humanities Non-Clinical Trial Non-degree Award
Hannah Kibuuka
ID: UNCST-2020-R014355
 A parallel-group, Phase III, multi-stage, modified double-blind, multi-armed study to assess the efficacy, safety, and immunogenicity of two SARS-CoV-2 Adjuvanted Recombinant Protein Vaccines (monovalent and bivalent) for prevention against COVID-19 in adults 18 years of age and older
REFNo: HS1638ES

1. To assess, in participants who are SARS-CoV-2 naïve, the
clinical efficacy of the CoV2 preS dTM-AS03 vaccines for
the prevention of symptomatic COVID-19 occurring ≥ 14
days after the second injection.

2. To assess the safety of the CoV2 preS dTM-AS03 vaccines
compared to placebo throughout the study.
 Uganda 2021-08-10 2024-08-10 Medical and Health Sciences Clinical Trial Non-degree Award
Twalib Aliku Olega
ID: UNCST-2019-R000474
 Uganda Heart Institute Cardiac Catheterization Registry: Patient profile, procedural complications and long-term outcomes
REFNo: HS1081ES

1) to determine the clinical and demographic profile of patients undergoing cardiac catheterization at the UHI
2) to describe complications associated with adult and pediatric cardiac catheterization procedures performed at the UHI and
3) to describe the immediate and intermediate outcomes of patients undergoing adult and pediatric interventional cardiac catheterization at the UHI

 Uganda 2021-08-09 2024-08-09 Medical and Health Sciences Non-degree Award
Stephen Sabiiti
ID:
CLINICAL AND HEMATOLOGICAL OUTCOMES OF CHILDREN WITH SICKLE CELL ANEMIA TREATED WITH LOW FIXED-DOSE HYDROXYUREA AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS1314ES

1. To describe the clinical and hematological
features of children with sickle cell
anemia at initiation of low fixed-dose
hydroxyurea at MRRH.
2. To describe the changes in hematological
indices after initiation of low fixed dose
hydroxyurea among children with sickle
cell disease at MRRH.
3. To describe the incidence of sickle cell
anemia related clinical events among
children with sickle cell disease treated
with low fixed-dose hydroxyurea at MRRH.
4. To identify factors associated with the
changes in hemoglobin level among children
with sickle cell anemia treated with
low fixed-dose hydroxyurea at MRRH.
 Rwanda 2021-08-06 2024-08-06 Medical and Health Sciences Non-Clinical Trial Degree Award
Elizabeth Kemigisha Kemigisha
ID:
Adolescents’ Perspectives of sexual wellbeing and consent MUST-2021-37
REFNo: HS1438ES

1) To contribute to the understanding about how local and contextual factors such as predominant religion, socially acceptable norms, cultural practices and political sentiment can influence sexual wellbeing of adolescents (10 to 24 year olds) in LMIC’s, 2) To explore adolescents’ understanding of, and perspectives on, sexual wellbeing, capturing different aspects of sexuality development during adolescence, including the evolving capacity to sexual consent,
 Uganda 2021-08-06 2024-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
ADOA DENNIS
ID:
Development and Evaluation of a Psychosocial Risk Assessment Tool for Predicting Attrition From HIV Care And Treatment Amongst Adolescents Aged 15-19 Years in Uganda
REFNo: HS1501ES

To assess the feasibility of HCWs administering the psychosocial risk assessment tool to ALHIV aged 15-19 years during routine ART visits to determine risk for attrition ,To evaluate the ability of the tool to predict risk of attrition of ALHIV aged 15-19 years at 3-months, following their enrollment date,Assessment and validation of the risk assessment tool, To develop a psychosocial risk assessment tool,To develop a psychosocial assessment tool for predicting attrition of adolescents aged 15-19 years from HIV care. ,
 Uganda 2021-08-06 2024-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Achilles Katamba
ID: UNCST-2019-R000540
 EVALUATION OF TRUENAT MTB-RIF DX AND TRUENAT MTB ASSAYS IN COMPARISON TO GENEXPERT MTB/RIF ULTRA FOR THE DIAGNOSIS OF PULMONARY TUBERCULOSIS
REFNo: HS1526ES

Primary:
• Assess sensitivity and specificity of Truenat™ MTB-RIF Dx and Truenat™ MTB assays in raw sputum compared to the WHO-endorsed GeneXpert® MTB/RIF Ultra using culture as the gold standard

Secondary:
• Assess the operational feasibility of Truenat™ MTB-RIF Dx and Truenat™ MTB assays
• Determine and compare costs between the Truenat™ MTB-RIF Dx and Truenat™ MTB assays, and Xpert MTB/RIF Ultra
 Uganda 2021-08-06 2024-08-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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