Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Munshi Sulaiman
ID:
Mobile money, privacy, security and women’s empowerment: Exploring the impact pathways of digital finance for women’s empowerment
REFNo: SS907ES

This research aims to assess the mechanisms (e.g. security and privacy) through which digital transfers may increase women’s agency and economic empowerment. The study will answer a number of research questions including:
• Are digital transfers more adequate instruments compared to cash transfers for improving women’s economic empowerment?
• Do digital transfers increase women’s privacy over financial information?
• Does privacy of information enhance the women’s enactment of choices?
• Does the secure nature of mobile money transfers significantly impact WEE outcomes?
• Which DFS pathways play a greater role in enhancing women’s agency and enactment of choices; security of money or privacy of information?
Bangladesh 2021-08-17 2024-08-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
Laura Sirabella
ID:
Translating sustainable development goals to address poor reproductive health: exploring the role of civil society organisations
REFNo: SS949ES

The objectives of this study are to:
- explore the role of CSOs in translating the SDGs in the context of reproductive health in effective policies;
- explore how CSOs implement such policies;
- investigate how CSOs advocate for the implementation of policies aimed at addressing reproductive health;
- elaborate the role of CSOs in promoting individual and community’s agency to advocate for reproductive justice.
 Italy 2021-08-17 2024-08-17 Social Science and Humanities Non-Clinical Trial Degree Award
Akulia Agnes
ID:
UNDERSTANDING ACCESS TO SCHOOL LEADERSHIP: A CASE OF WOMEN IN PUBLIC PRIMARY SCHOOLS IN KOBOKO DISTRICT, UGANDA
REFNo: SS623ES

The main objective of this study is to establish how women in school leadership been able to navigate their way into leadership positions. Specifically the study will establish factors that motivate women to pursue school leadership positions, the barriers women have to navigate to access positions of school leadership and the strategies women use to enhance them access school leadership positions.
 Uganda 2021-08-16 2024-08-16 Social Science and Humanities Degree Award
Joseph  Olobo Okao Olobo
ID:
A multicentre observational study to assess immune response status in patients before and after treatment for visceral leishmaniasis
REFNo: HS1266ES

Primary Objective To assess systemic and skin immune responses and parasite load in patients before, and at end of treatment for visceral leishmaniasis
Secondary Objectives
1. To identify systemic and local immune correlates of treatment outcome.
2. To evaluate parasite genotype in relation to immune response characteristics
3. To compare immunology and parasitological data across each site and determine possible correlates of progression to PKDL


 Uganda 2021-08-16 2024-08-16 Medical and Health Sciences Non-degree Award
Joseph  Matovu KB
ID: UNCST-2020-R014654
 Formative research to inform the design of a youth-led self-care intervention to increase uptake of voluntary family planning and reproductive health care services among adolescent girls (10-19 years) in Uganda
REFNo: HS1294ES

The overall objective of the study will be to explore adolescent girls perceptions towards provision of self-care FP services and stakeholders’ perceptions towards provision of voluntary FP and RHC information and services to adolescent girls aged 10-19 years by fellow adolescents in order to inform the design of a youth-led self-care intervention to improve uptake of voluntary FP and RHC services to adolescent girls aged 10-19 years in Uganda. Specifically, this study will aim to:
1. Determine differentials in teenage pregnancy rates and contraceptive use by socio-demographic and behavioural characteristics
2. Assess the association between modern contraceptive use and teenage pregnancy rates among adolescents (15-19 years) across the different demographic and health surveys.
3. Explore the FP and RHC information and service needs of the very young adolescent girls (10-14 years) and older adolescents (15-19 years).
4. Explore mechanisms through which adolescent girls (10-19 years) can be involved in the design and delivery of voluntary FP and RHC interventions for fellow adolescents.
5. Explore adolescent girls’ perceptions about self-care FP methods and whether or not self-care FP methods can help to reduce the barriers that adolescents face in accessing and utilizing FP services.
6. Explore key stakeholders’ perceptions towards: a) provision of self-care FP information and services to adolescents; and b) provision of voluntary FP and RHC information and services to adolescent girls aged 10-19 years by fellow adolescents.
7. Explore key stakeholders’ perceptions on the acceptability of an intervention that entails provision of FP and RHC information and services to adolescent girls (10-19 years) by fellow adolescent girls.
8. Explore the barriers to and facilitators of interventions that provide FP and RHC information and services to adolescent girls by adolescent girls in the target districts and how provision of such information and services to adolescent girls by fellow adolescent girls can be improved.
 Uganda 2021-08-16 2024-08-16 Medical and Health Sciences Non-degree Award
Elizeus Rutebemberwa
ID: UNCST-2022-R009070
 Advancing the health of rural communities in Uganda through strong community health programs
REFNo: SS872ES

4.3 General Objective
To evaluate non-monetary incentive packages required for strengthening the community health workforce, which provides critical health services to the rural poor in Masindi District.

Specific objectives
i. To identify the priorities of the national government regarding compensation packages for the VHTs in Masindi District.
ii. To assess how the national government compensation packages align with the priorities of the VHTs in Masindi District.
iii. To identify the structure and group of incentives best suited to motivate VHTs, improve their performance in the delivery of services, and increase their retention in the health workforce in Masindi District.
iv. To identify the behavioural mechanism through which the new incentives may work or fail to work in Masindi District
v. To understand how changes in the national VHT program impact utilization of maternal and child health services, sanitary practices and perception of quality of health services at the community-level



 Uganda 2021-08-16 2024-08-16 Social Science and Humanities Non-Clinical Trial Non-degree Award
Manjari Quintanar-Solares
ID:
MICROARRAY PATCH FOR PEDIATRIC ANTIRRETROVIRAL TREATMENT STAKEHOLDER INTERVIEWS IN UGANDA
REFNo: HS1359ES

To define the target product profile (TPP) and preferred user characteristics, identify stakeholder needs, and evaluate potential acceptability of a pediatric ARV MAP
 Mexico 2021-08-16 2024-08-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eun Seok Kim
ID:
Cross-sectional prevalence study of schistosomiasis and soil-transmitted helminthiasis with nested open-label randomised controlled study of evaluating the impact of fatty meal co-administration and double-dosing on albendazole effectiveness against hookworm infection among school-aged children in Mayuge district: Implications for Mayuge NTDs Elimination (MANE) Project
REFNo: HS1411ES

Objective 1: To determine the effect of albendazole administration with a fatty meal such as avocado, versus albendazole administration without a fatty meal, on hookworm cure rate and egg reduction rate.

Objective 2: To determine the effectiveness of dual-dose (400mg/day, two consecutive days) versus single-dose (400mg) albendazole treatment regimens on hookworm cure rate and egg reduction rate.

Objective 3: To identify and evaluate environmental, social and cultural variables affecting hookworm infection, and cure rate and egg reduction rate of albendazole against hookworm.

 South Korea 2021-08-16 2024-08-16 Medical and Health Sciences Clinical Trial Degree Award
Carmen  Logie
ID: UNCST-2021-R013185
 Kuwawezesha Vijana (Empowering Youth): An HIV Self-Testing and Comic Intervention with Refugee Adolescents and Youth in a Refugee Settlement in Northern Uganda
REFNo: SS884ES

The primary study aim is to compare the effectiveness of adding HIV self-testing, education- comics, or both to the standard of care approaches of HIV testing among refugee youth in Bidi Bidi in increasing HIV status knowledge.
The primary outcome is HIV testing uptake (HIV status knowledge, verified through asking HIV serostatus and verifying with voluntary point of care testing).
The secondary outcomes include HIV knowledge, HIV-related stigma, use of SRH services (e.g., condoms, contraception), and linkage to a clinic for confirmatory testing.
 Canada 2021-08-16 2024-08-16 Social Science and Humanities Non-Clinical Trial Non-degree Award
Doris Kakuru
ID:
Representation of Young Motherhood: Performing young womanhood, subjectivities and agency in Sexual and Reproductive Health in Uganda
REFNo: SS960ES

To find out the implications of representations of young motherhood on reproductive justice,To establish alternatives of young parenthood which are made available through motherhood performances by young mothers in Uganda (Including their lived experiences, identity formation and agency to adhere, comply or resist dominant subjectivities). ,To examine how dominant notions about young motherhood affect SRHR rights of young mothers in Uganda.,To ascertain how dominant assumptions of young motherhood by different SRHR actors position young mothers in urban poor locales in Uganda. ,
 Uganda 2021-08-16 2024-08-16 Social Science and Humanities Non-Clinical Trial Degree Award
Rosalind  Parkes-Ratanshi Parkes
ID: UNCST-2019-R000717
 Acceptability and feasibility of mhealth technology for sensitization and contact follow up for high-risk communities for infectious disease outbreaks; Call for Life-COVID (CFL-C) and Call for Life Ebola (CFL-E)
REFNo: SS865ES

1.To document experiences of using an IVR service to support COVID positive patients and for those in COVID quarantine.
2.To evaluate the acceptability of using an IVR service for post COVID-19 mental health screening in Uganda.
3.To assess feasibility of using an IVR service for outbreak response, through documentation of the experience and lessons learned of using CFL-C by health care workers, policy makers, developers and implementing actors
4.To explore barriers and enablers to health seeking behaviour and vaccinations, perceptions/ stigma/ fears/concerns of COVID and other epidemic outbreaks including EVD and mitigation measures (e.g. cancelling funerals – Ebola, school and business closures – COVID, including comparisons of the two) within at risk and hard to reach communities.

UK 2021-08-16 2024-08-16 Social Science and Humanities Non-Clinical Trial Non-degree Award
Stella Muyanja Zawedde
ID: UNCST-2021-R014037
 Computer aided detection of Tuberculosis using chest radiography: A clinical validation of the CAD4TB version 7 system.
REFNo: HS1575ES

The primary objective will be to:
a) To determine the sensitivity and specificity of different CAD4TB v7 scores for the detection of bacteriologically confirmed tuberculosis (using Xpert Ultra® as the reference standard) in the Ugandan population.

The secondary objectives will be to
b) To determine the optimal combination of symptoms and chest x-ray features to be used to when triaging patients at the outpatient and HIV clinics.
To determine the most cost-effective algorithm to be used while to screen for TB among patients presenting to the outpatient and HIV clinics in Gulu and Kitgum.

Uganda 2021-08-16 2024-08-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
VICTOR TUMUKUNDE SPECTOR
ID:
Assessment of the validity of the measurement of kangaroo mother care duration in a hospital in Uganda: an observational study
REFNo: HS1589ES

o To assess the accuracy of caregiver report on duration of skin-to-skin contact (SSC) in the KMC position among neonates ≤2000g before stabilization.
o To assess the accuracy of healthcare workers’ report on duration of SSC in the KMC position among neonates ≤2000g before stabilization.
o To assess the reproducibility of the two methods of measuring KMC duration.
o To assess the reliability (inter-observer agreement) of gold standard direct observation.

 Uganda 2021-08-16 2024-08-16 Medical and Health Sciences Non-Clinical Trial Degree Award
Stephen Watya
ID: UNCST-2025-R021507
 UNDERSTANDING PROSTATE CANCER IN MEN OF AFRICAN ANCESTRY.
REFNo: HS1514ES

GENERAL OBJECTIVE
The goal of this project is to understand the genetics and epidemiology of prostate cancer in men of African ancestry.
Specific Objectives (SO):
1. To study common and rare germline variation in association with prostate cancer risk in men of African ancestry, using cutting edge genotyping and sequencing techniques. (UGPCS)
2. To determine non-genetic risk factors associated with prostate cancer among men of African ancestry. (UGPCS)
3. To identify germline and tumor genomic/molecular determinants of aggressive prostate cancer and disease progression in men of African ancestry. (UGPCS)
4. To determine the acceptability and validity of a rapid screening kits for prostate cancer in the Ugandan population. (UGPCS-epi)
5. To assess population level determinants of high PSA (≥4 n/gm) in men of African ancestry (UGPCS-epi).
6. To explore whether circulating tumor cells and circulating tumor DNA can be detected in the blood of men with aggressive prostate cancer and may be used to screen for aggressive disease (UGPCS-screen).
7. To determine disease progression of prostate cancer from the time of presentation among Ugandan men. (UGPCS-screen).

 Uganda 2021-08-16 2024-08-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Violet Korutaro
ID: UNCST-2019-R000618
 IMPAACT 2017: Phase I/II Study of the Safety, Acceptability, Tolerability, and Pharmacokinetics of Oral and Long-Acting Injectable Cabotegravir and Long-Acting Injectable Rilpivirine in Virologically Suppressed HIV-Infected Children and Adolescents. Short title: ‘MOCHA’ (More Options for Children and Adolescents), DAIDS # 30070, IND # 138,754
REFNo: HS1512ES

To assess the safety of CAB LA + RPV LA through Week 24 in HIV-infected, virologically suppressed adolescents,To confirm the doses for oral CAB followed by injectable CAB LA in HIV-infected, virologically suppressed adolescents by evaluating: Safety and multiple dose PK of oral CAB through Week 4, Safety and multiple dose PK of CAB LA through Week 16, and to confirm doses for injectable RPV LA in HIV-infected, virologically suppressed adolescents by evaluating safety and multiple dose PK of RPV LA through Week 16,To confirm the dose and evaluate the safety, tolerability, acceptability, and pharmacokinetics (PK) of oral cabotegravir (CAB), long-acting injectable cabotegravir (CAB LA), and long-acting injectable rilpivirine (RPV LA) in virologically suppressed HIV‐1 infected children and adolescents aged 12 to <18 years.,
 Uganda 2021-08-16 2024-08-16 Medical and Health Sciences Clinical Trial Non-degree Award
Helen Ndagije Byomire
ID: UNCST-2021-R013939
 Skepticism on the Safety and Quality of Generic Medicines from countries with Non-stringent Regulatory Authorities in Uganda.
REFNo: HS1550ES

3. To establish knowledge, attitude and perceptions of health workers and the general population towards generic medicines from countries with the SRAs and those from the N-SRA including Uganda.,2. To compare the quality of selected registered generic medicines on the Ugandan market sourced from countries with SRAs and those from N-SRA including Uganda against the innovator product. ,1. To compare the nature and proportion of adverse drug reactions (ADRs) received by NDA in the period of June 2016 to June 2020 for selected generics from SRAs and those from the N-SRA against the innovator product.,To compare the quality and safety of selected generic medicines on the Ugandan market sourced from countries with Stringent Regulatory Authorities (SRAs) with those from non-stringent regulatory authorities N-SRAs including Uganda. ,
 Uganda 2021-08-16 2024-08-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jonathan Kayondo
ID: UNCST-2021-R008325
 Multi-Centre, Prospective, Evaluation for Matrix equivalence of capillary whole blood finger-stick and fresh and frozen venous whole blood with the NxTekâ„¢ Malaria Pf Plus Rapid Test Device and NxTekâ„¢ Malaria Pf/Pv Plus Rapid Test Device for the Detection of Plasmodium Infections in Patients with Symptoms Suggestive of Malaria within the Lab and its intended use environment for CE IVDR.
REFNo: HS1587ES

This trial is part of the R&D Verification and Validation studies, to provide clinical matrix equivalence evaluation to support the conformity assessment procedure for the use of fingerstick and venous whole blood samples with Abbott’s NxTek™ Malaria Pf Plus and NxTek™ Malaria Pf/Pv Plus Rapid Test Devices, as performed by professional users, in accordance with WHO PQ TSS-3, WHO PQ Dossier, EU 2017/7461.

Primary Objective: Matrix Equivalence
To assess the matrix equivalence of:
a. Fresh CWBFS and Fresh VWB
b. Frozen VWB and Fresh VWB
when used with the NxTekâ„¢ Malaria Pf/Pv Plus and NxTekâ„¢ Malaria Pf Plus by laboratory professionals (from hereon referred to as Lab operators) in a laboratory environment to support CE IVDR certification.

The test results of the NxTekâ„¢ Malaria Pf Plus and NxTekâ„¢ Malaria Pf/Pv Plus Rapid Test using a VWB sample, will be evaluated against the NxTekâ„¢ Malaria Pf Plus and NxTekâ„¢ Malaria Pf/Pv Plus Rapid Test using CWBFS sample from the same participant. In summary: Fresh CWBFS vs. Fresh VWB*. Likewise, the test results of the NxTekâ„¢ Malaria Pf Plus and NxTekâ„¢ Malaria Pf/Pv Plus Rapid Test using VWB samples that have been exposed to 1x Freeze/Thaw cycle will be evaluated against the NxTekâ„¢ Malaria Pf Plus and NxTekâ„¢ Malaria Pf/Pv Plus Rapid Test using fresh VWB samples from the same participant. In summary: Frozen VWB vs. Fresh VWB*

*indicates: Where Fresh VWB will be the comparator sample type.

The data obtained will be used in the application for CE IVDR certification and WHO PQ. Paired CWBFS and VWB samples will be taken from the same individuals for testing on both NxTekâ„¢ Malaria Pf/Pv Plus and NxTekâ„¢ Malaria Pf Plus RDTs.

Secondary Objective: Intended Users within the Intended Use Environment
Malaria RDTs are used outside of the laboratory for near patient testing (NPT)* by non laboratory healthcare workers with limited training. Thus the secondary objective of this study is to assess the perfromance of the NxTekâ„¢ Malaria Pf/Pv Plus and NxTekâ„¢ Malaria Pf Plus results when used in its intended environment (NPT setting) by intended users (non laboratory healthcare workers with limited training) using CWBFS as the sample type.*see NPT definition Section 4.2-4.3 of protocol (or below sections on trial operator types and trial envitronment types).

 Uganda 2021-08-16 2024-08-16 Medical and Health Sciences Clinical Trial Non-degree Award
Rhoda Wanyenze
ID: UNCST-2021-R013352
 PILOT OF A NETWORK-DRIVEN, ADVOCACY INTERVENTION TO PROMOTE CERVICAL CANCER SCREENING IN UGANDA (PHASE 3)
REFNo: HS1633ES

The proposed intervention development study seeks to improve cervical cancer screening in Uganda by engaging and training local public health researchers and program implementers, and empowering women living with cervical cancer risk (WLCCR), defined as women who have ever received CC screening procedures, to advocate for CC screening and early treatment among women in their social networks.
 Uganda 2021-08-16 2024-08-16 Medical and Health Sciences Clinical Trial Non-degree Award
Vandana Sharma
ID:
Assessing StrongMinds’ Community-based Therapy Groups with a Gender Lens
REFNo: SS954ES

The overall objective of this research is to better understand gender outcomes of StrongMinds programming, including the experience of women participants of both in-person and remote IPT-G with respect to safety and GBV risks.
 Canada 2021-08-16 2024-08-16 Social Science and Humanities Non-Clinical Trial Non-degree Award
Achilles Katamba
ID: UNCST-2019-R000540
 Validating a Clinical Risk Score for early Management of Tuberculosis in Ugandan Primary Health Clinics - PredicTB study
REFNo: HS1622ES

1. To evaluate the effectiveness of the PredicTB clinical risk score on clinical outcomes. 2. To evaluate the implementation of the PredicTB clinical risk score. 3. To project the long-term impact and cost-effectiveness of PredicTB implementation.
Uganda 2021-08-16 2024-08-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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