Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Michael  Ediau
ID:
Stakeholders’ perspectives on early infant male circumcision for HIV prevention in a traditionally non-circumcising community in Northeastern Uganda
REFNo: HS2109ES

To explore the stakeholders’ perspectives on the feasibility of introducing and scaling up EIMC in Katakwi and Soroti districts, traditionally non-circumcising communities – northeastern Uganda,To assess the health system-related facilitators and barriers for introduction and scale-up of EIMC for HIV prevention in Katakwi and Soroti districts, traditionally non-circumcising communities – northeastern Uganda,To explore the health workers individual-level and parents’ related perspectives regarding EIMC for HIV prevention in Katakwi and Soroti districts,To explore the knowledge, attitudes, norms, behavior control, intention and experiences on EIMC for HIV prevention among parents of male children in Katakwi and Soroti districts, traditionally non-circumcising communities – northeastern Uganda,To explore stakeholders’ perspectives on early infant male circumcision for HIV prevention in Katakwi and Soroti districts, traditionally non-circumcising communities – northeastern Uganda,
 Uganda 2022-03-07 2025-03-07 Medical and Health Sciences Non-Clinical Trial Degree Award
Florence Ndagire
ID:
Access to Maternal, sexual and reproductive health for persons with disabilities in Uganda
REFNo: SS1062ES

The aim of this study is to conduct empirical research on access to maternal, sexual and reproductive health services for persons with disabilities in Uganda to ascertain whether the services, programmes and policies are inclusive of persons with disabilities.
Specific objectives
1. To analyse the legal and policy framework on access to maternal, sexual and reproductive health services to ascertain whether they mainstream reproductive health needs of persons with disabilities in Uganda.
2. To assess the barriers faced by persons with disabilities in accessing MSRH services.
3. To examine the lived experiences of persons with disabilities in accessing MSRH services.
4. To assess the effects of COVID 19 on access to maternal, sexual and reproductive health services by persons with disabilities in Uganda.

 Uganda 2022-03-04 2025-03-04 Social Science and Humanities Non-Clinical Trial Degree Award
Justus Atwijukire
ID:
Understanding the context in which it is profitable for various vanilla agricultural market actors to invest in stronger relationships and adopt product quality standards to meet the needs of higher-value markets
REFNo: A185ES

Identify the context in which it is profitable for agricultural actors, particularly producers and processors, to comply with and invest in higher product quality standards.,Assess the types of market linkages that best enable multinationals to collaborate with emerging agricultural markets to increase efficiency and effectiveness along the value chain in a mutually beneficial manner.,Evaluate the extent to which strengthening linkages and relationships between supply chain actors increasing horizontal and vertical market linkages among agricultural actors at various levels (companies, SMEs, smallholders, and intermediaries) promote economic benefits for the different actors and market expansion. ,To understand how existing vanilla supply chains in Uganda and targeted interventions designed to strengthen relationships between market actors affect production, quality, market access, profits and investment within supply chains. ,
 Uganda 2022-03-03 2025-03-03 Agricultural Sciences Non-Clinical Trial Non-degree Award
ALEX KAYONGO
ID: UNCST-2019-R001641
 In-vitro Susceptibility of Broncho-alveolar-derived Macrophages to Mycobacterium tuberculosis among persistently IGRA-negative TB household contacts in Uganda
REFNo: HS1767ES

Study Aim:
Phenotypic characterization of persistently IGRA-negative individuals based on in-vitro killing of luciferase-expressing recombinant Mtb in broncho-alveolar lavage.

Specific Objectives
1. To demonstrate in-vitro BAL and blood monocyte derived macrophage killing of luciferase-expressing recombinant Mtb among persistently IGRA-negative individuals.

2. To validate in-vitro BAL-derived macrophage killing assays using virulent Mtb strains identified from “the Ugandan TB cohort.

3. To compare BAL-derived macrophage expression profiles for selected cytokines, phagocytic receptors, phagosome maturation and microbial killing genes between IGRA-negative and positive individuals.

4. To compare levels of selected macrophage cytokines and chemokines in BAL supernatant between IGRA-negative and positive individuals.
 Uganda 2022-03-03 2025-03-03 Medical and Health Sciences Non-Clinical Trial Degree Award
Charlotte Brown Louise
ID: UNCST-2021-R012078
 Local urban initiatives for displaced populations in Gulu and Arua cities in Uganda
REFNo: SS1167ES

To understand the role of locally situated actors in protection for refugees and asylum seekers
To understand refugees' experiences of urban life and different forms of protection in urban areas
To explore how local actors understand 'protection'
To understand how locally situated actors understand their role in relation to Uganda's national refugee response framework
To produce learning materials to inform policy responses in other cities experiencing displacement
To disseminate findings to support to local discussions of refugee integration
 UK 2022-03-03 2025-03-03 Social Science and Humanities Non-Clinical Trial Degree Award
RACHEAL ALINAITWE
ID: UNCST-2020-R014509
 Detection and referral of depression among adolescents living with HIV in Uganda
REFNo: HS2055ES

• To determine whether depression is screened for among adolescents living with HIV in care • To assess the effect of self-assessment by adolescents on the rate of detection of depression • To determine reasons for failure to access care for depression among adolescents living with HIV at the referral point
Uganda 2022-03-03 2025-03-03 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jonathan Kayondo
ID: UNCST-2021-R008325
 Target Malaria Protocol A1: Entomological Studies To Characterize Field Sites In Uganda To Support The Evaluation Of Novel Mosquito-Targeted Malaria-Control Methods
REFNo: HS1884ES

1. To characterize malaria vector species composition and abundance in selected study sites, other mosquitoes present and the ancillary fauna of larval habitats.
\r\n2. To support insectary colony (wild-type) establishment/replenishment and insecticide resistance surveys.
\r\n3. Geographical and meteorological characterization of field sites.
\r\n
 Uganda 2022-03-03 2025-03-03 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
 ‘SD Biosensor STANDARD™ M10 SARS-COV-2’ – Diagnostic sensitivity and diagnostic specificity
REFNo: HS2100ES

establish the diagnostic sensitivity and diagnostic specificity of the STANDARD™ M10 SARS-CoV-2 test according to the WHO Instructions and requirements for Emergency Use Listing (EUL) Submission: In vitro diagnostics detecting SARS-CoV-2 nucleic acid or antigen, version 5; 02 June 2021, and to provide data to demonstrate the product is safe and effective for its intended use.,
 Uganda 2022-03-02 2025-03-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Tom  Ngabirano Denis
ID: UNCST-2020-R014491
 Adapting and Validating the STARx Transition Readiness Questionnaire for Ugandan Young People Living with HIV/AIDs (YPLHIV) and their Parents
REFNo: SS1134ES

To understand the impact of COVID-19 on the health and well-being of YPLHIV,To validate the Event History Calendar (EHC) which was previously developed with Ugandan youth,To modify and validate The STARx, a transition tool for Ugandan youth,Our primary aim is to modify and validate a transition tool for Ugandan youth for use in transition from adolescent to adult HIV Care. ,
 Uganda 2022-02-28 2025-02-28 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jonathan Kayondo
ID: UNCST-2021-R008325
 Target Malaria Protocol C1: Stakeholder Engagement Protocol for Target Malaria Activities in Uganda
REFNo: HS1890ES

1. Co-developing the project pathway with stakeholders directly affected by the project and ensuring that all steps of the project receive appropriate community acceptance (in addition to regulatory approval) before they are implemented. 2. Building an enabling environment in which potential beneficiaries are at the heart of the decision-making process. 3. Position genetic approaches as a potential credible complementary tool to fight malaria and creating an enabling environment for its evaluation. 4. Ensure consent/community acceptance for field entomological and insectary activities (please refer to protocols on entomological and Insectary activities). 5. Collect stakeholder knowledge and expectations to inform and improve project activity implementation.
Uganda 2022-02-28 2025-02-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 Lung Cancer in East Africa in Relation to HIV-1 Infection: Epidemiological, Molecular Characterization and Imaging (LCH Study)
REFNo: HS1922ES

1. To determine the clinical epidemiology of lung cancer and its relationship to HIV-1 infection in Uganda and Tanzania. 2. To determine the molecular determinants of lung cancer in HIV infected and uninfected individuals in Uganda and Tanzania 3. To Characterize Lung Cancer in HIV infected and uninfected populations in Uganda and Tanzania using Artificial Intelligence.
 Uganda 2022-02-28 2025-02-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joseph Ngonzi
ID: UNCST-2019-R001579
 Automated visual evaluation and geospatial mapping for cervical cancer screening optimization in sub-Saharan Africa (AVE-Map)
REFNo: HS2069ES

3. To use AVE and geospatial analysis to scale up cervical cancer screening in Uganda ,2. To determine access to cervical cancer screening and referral pathways in Uganda ,1. To validate and expand use of AVE for cervical cancer screening in SSA ,We aim to leverage and develop data science expertise at our sites to first optimize and then combine AVE-based screening by health workers at peripheral health facilities with geospatial-analysis and needs-driven assessment to inform scale-up of cervical cancer screening in Uganda ,
 Uganda 2022-02-28 2025-02-28 Medical and Health Sciences Clinical Trial Non-degree Award
Richard Cartland
ID:
Techno-economic Analysis of Solar Photovoltaic Mini-grids for Enhancement of Sustainable Livelihoods of Remote Communities: Case Study Uganda
REFNo: SIR97ES

iv. To develop a tool for assessing the sustainable livelihoods of communities supplied by power from renewable energy-based mini-grids,iii. To carry out economic modelling and simulation of the operation and performance of solar photovoltaic mini-grids versus other competing options ,ii. To analyze the technical operation of solar PV mini-grids in the context of developing nations,i. To analyze the development and installations of Renewable energy-based mini-grids in Uganda,To assess how sustainable livelihood of remote communities is enhanced through the use of solar PV based mini-grids and other competing options.,
 Uganda 2022-02-28 2025-02-28 Engineering and Technology Non-Clinical Trial Degree Award
GODFREY ASIIMWE BERINDE
ID:
Public Services, Security and the Legacy of Pre-colonial States in Uganda
REFNo: SS917ES

1) examine how the legacy of pre-colonial states shapes citizens’ willingness to contribute to public services in Uganda today, focusing on crime prevention and security services
2) examine the underlying mechanisms, focusing on persistence in culture and institutions.
Uganda 2022-02-24 2025-02-24 Social Science and Humanities Non-Clinical Trial Non-degree Award
DeeAnn Reeder Marie
ID: UNCST-2021-R012240
 Tolerance and resistance responses of African bats to viral antigens: Immunological tradeoffs in zoonotic reservoir hosts.
REFNo: NS300ES

The overall goals of the proposed work are (1) to understand the role that infection tolerance plays in the ability of African bat species to serve as reservoir hosts for virulent zoonotic viruses (especially Ebola), and (2) identify the molecular and behavioral mechanisms that contribute to these tolerance phenotypes.


 USA 2022-02-24 2025-02-24 Natural Sciences Non-Clinical Trial Non-degree Award
Eliot Atekwana Anong
ID:
Dry Rifting in the Albertine-Rhino graben, Uganda (DRIAR)
REFNo: NS322ES

Our project objectives are to (1) map the lithospheric and mantle structure below segments of the rift in the northern Western Branch, (2) map magma melt depth, thickness and spatial distribution along the rift, (3) map the rift and fault architecture and determine their relationship to rifting, (4) determine fault communication with deep magma sources via volatiles and gas chemistries, (5) provide constraints on surface motions and rift opening rates from GPS measurements, and (6) test the three hypotheses with numerical models. During this project we will:
1. Use magnetotellurics (MT), gravity and passive source seismology to determine variations in lithospheric thickness, mantle-flow or frozen lithospheric anisotropy, and to assess the presence or absence of melt at depth.
2. Use magnetics, gravity, and seismology to determine the thermal structure and thickness of the crust beneath the rift zone.
3. Constrain surface motions with new GNSS observations.
4. Collect geomorphic samples for Quaternary geochronology for landforms cut and offset by the rift-bounding faults to determine their fault slip rates.
5. Use industry seismic reflection data acquired over the Albertine-Rhino graben to investigate fault evolution and strain migration through time.
6. Conduct field observations to examine the geometry and kinematics of rift related structures for the Albertine-Rhino Graben and Precambrian structures to evaluate the possible presence of a Precambrian suture zone that was reactivated during rift evolution.
7. Use the geochemistry of hot springs and measurements of magmatic gas fluxes along the border faults to establish the presence or absence of shallow magma chambers and the presence of magmatic volatiles-assisted faulting, while also quantifying variability of tectonic CO2 flux to the atmosphere from the northern Western Branch of EARS
8. Incorporate the above observations into a geodynamic model that test hypotheses about the role of melts beneath magma-poor rifts and how variations in lithospheric thickness and asthenospheric flow or the properties of the lithosphere relate to strain localization.
The different rift basins of the northern segment of the Western Branch of EARS exhibit distinct geomorphological features from south to north that are probably controlled by processes operating in the asthenosphere and lithosphere. Thus, a field experiment designed to investigate the along axis variability of the lithosphere and upper mantle structure along this entire segment from Lake Edward in the south to the Rhino graben in the north and its termination against the Aswa Shear Zone will provide critical insights on geodynamic processes operating in the asthenosphere, lithosphere, and at the surface which drive magma poor rifting.
USA 2022-02-24 2025-02-24 Natural Sciences Non-Clinical Trial Non-degree Award
Hasifah Namatovu Kasujja
ID:
A Real-time Application for Screening Symptoms of Perinatal Depression among Expectant and Postnatal Mothers. (RAPID)
REFNo: SIR95ES

Overall Study Objective: Developing a real-time application to screen perinatal depression will be achieved through three specific aims:
i) Understanding perinatal depression issues among women and elicit requirements for model building
ii) Co-design and implement a low-cost real time application for perinatal depression (RAPID)
iii) Evaluate and deploy RAPID for usability and efficacy

 Uganda 2022-02-24 2025-02-24 Engineering and Technology Non-Clinical Trial Non-degree Award
Pooja Chitneni
ID: UNCST-2021-R012955
 The adaptation and validation of an HIV disclosure measurement tool in Uganda
REFNo: HS1872ES

Aim 1: Explore how and why heterosexual men and women disclose HIV to sexual partners. We will purposively sample up to 40 PLWH stratified approximately equally by reported prior HIV disclosure to sexual partner(s) and gender to participate in qualitative in-depth interviews. Interviews will focus on HIV disclosure beliefs, intentions, and behaviors with an emphasis on gender norms, incomplete disclosure, HIV co-morbidities (e.g., STIs), and disclosure preferences. ,
 USA 2022-02-23 2025-02-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Leonard Atuhaire K.
ID:
Development of a Life Table for Mortality Assessment in Uganda
REFNo: SS1143ES

3. Construct a pilot life table for Uganda.,2. Develop cause – of – death specific life tables.,1. Estimate age specific mortality rates for males and females in Uganda,The main objective is to generate a pilot life table for Uganda.,
 Uganda 2022-02-22 2025-02-22 Social Science and Humanities Non-Clinical Trial Non-degree Award
Geoffrey Otim
ID:
Affordability perceptions of hybrid DTM seed in Uganda: Are expectations or status-quo driving low willingness to pay?
REFNo: A183ES

The objective of this study is therefore:
To test whether behavioral reference points influence willingness to pay for hybrid maize seed and subsequent affordability perceptions about hybrid DTM seed.

The proposed study aims to provide:
1. Innovative and evidence-based insights on behavioral barriers that drive (low) willingness to pay for DTM seed.
2. Policy recommendations to address these potential behavioral barriers to purchasing hybrid seed.

Uganda 2022-02-22 2025-02-22 Agricultural Sciences Non-Clinical Trial Non-degree Award
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