Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Dong Hyeok Kang
ID:
Tax evasion in customs: Firm-level evidence from Uganda
REFNo: SS1294ES

Our research would directly to Uganda’s policy objective to raise domestic revenues through improved tax administration to finance public investments for inclusive growth, especially by monitoring import tax(i.e., customs duty and import VAT). Despite the importance of trade taxes and ample anecdotal evidence on evasion this topic has received little attention so far. The identified clients for this study are the Research, Planning and Development Department and the Customs & Excise Department of the Uganda Revenue Authority.
South Korea 2022-07-19 14:38:17 2025-07-19 Social Science and Humanities Non-Clinical Trial Non-degree Award
JOSELYN RWEBEMBERA
ID: UNCST-2021-R013915
 Case Managers and Peer Support Groups (CAMPS) for Prophylaxis Adherence in Rheumatic Heart Disease
REFNo: SS1364ES

Primary Objective
To determine the impact of support strategies including case managers and peer support groups on BPG adherence and quality of life among children newly diagnosed with latent rheumatic heart disease in Uganda .

Secondary Objectives
1. To Determine the difference in 1-year BPG adherence rates of children newly diagnosed with latent rheumatic heart disease in Uganda randomized to either: (a) case manager only strategy (Arm 2) or (b) case manager + peer group (Arm 3) when compared to (c) usual care (Arm 1).
2. To explore differences in patient reported outcomes including treatment satisfaction, patient health-related quality of life, and care giver quality of life, in relation to support strategy and adherence.

 Uganda 2022-07-19 14:36:10 2025-07-19 Social Science and Humanities Non-Clinical Trial Non-degree Award
Anthony  Fuller
ID:
Comprehensive Neurology and Neurosurgery Care Country Level Assessment in Uganda
REFNo: HS2344ES

The main objective of this study is to complete a neurological care continuum evaluation of Uganda’s public hospitals and health centers for the purposes of informing the current gaps in Uganda’s health system to manage neurological patients, elucidating the availability and distribution of neurological care throughout the country, and allowing for examination of the current infrastructure of the health system to appropriately refer and treat acute and non-acute neurological patients.
USA 2022-07-18 14:41:02 2025-07-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Michael Bermudez
ID:
Perceptions of Makerspace Learning in Uganda: A Qualitative Study
REFNo: SIR121ES

To determine what technology-based products that can potentially help students with disabilities the student participants have collaboratively created during research makerspace sessions,To determine the positive and the negative features of the use of 3D printers and circuit boards according to the student participants’ perceptions,To determine the student participants’ perceptions regarding the use of makerspace technology,To determine the student participants' perceptions regarding the learning process associated with makerspace.,
 USA 2022-07-18 14:39:37 2025-07-18 Engineering and Technology Non-Clinical Trial Non-degree Award
SIMON KIZITO
ID:
Exploring variation in infants’ preference for infant-directed speech: Ugandan Evidence from a multi-site study in Africa.
REFNo: SS1342ES

1)To find out whether infants prefer Infant-directed speech (IDS) vs. Adult-directed speech (ADS).
2)To examine the relationship between maternal socio demographics (ethnicity, gender and the caregiver’s education level, general socioeconomic status) and infant language development.
3)To examine the relationship between maternal depression and infant language development.
4)To examine the relationship between maternal psychological distress and infant language development.
5)To examine the relationship between maternal relationship discord and infant language development.
6)To examine the relationship between maternal social support and infant language development.

Uganda 2022-07-18 14:37:19 2025-07-18 Social Science and Humanities Non-Clinical Trial Non-degree Award
Xavier Giné
ID:
Monitoring the Real Cost of Domestic Payments (Transaction Cost Index) - Uganda
REFNo: SS1358ES

Assess the impact of government policies and regulations on DFS by tracking costs over time, Measure customer service quality (including availability of fraud redress, customer service response time, accuracy of customer service response, and discrepancies between customer service and listed fees),Collect provider information (including provider types, market share, regulatory authority, product age, and website language),Collect data on fees (including fee schedule, fee schedule availability, location of fee information, currency, government tariffs, and time cost),Collect official, listed pricing data,Conduct a cost effectiveness analysis in year 1 (determining which of the three methods is most cost effective in developing the TCI),Measure the true costs of DFS transactions in Uganda by creating a price comparison index. ,
 Spain 2022-07-18 14:36:22 2025-07-18 Social Science and Humanities Non-Clinical Trial Non-degree Award
Amanyire Jordan Mutambi
ID:
Depression, associated factors and psychosocial interventions among elderly individuals living with HIV/AIDS in SW Uganda accessing services in Mbarara City
REFNo: HS2331ES

1. To document evidence on psychosocial interventions those have been effective in treatment of depression among elderly people in low and middle income countries.
2. To determine the prevalence of depression among the elderly living with HIV/AIDS in SW Uganda accessing HIV/AIDS care within selected health facilities in Mbarara city.
3. To explore the factors associated with depression among elderly people living with HIV/AIDS in SW Uganda accessing services in selected health facilities in Mbarara city
4. To assess the effectiveness of Behavioral Family Therapy (BFT) in reducing depressive symptoms among elderly HIV patients accessing HIV care in selected health facilities Mbarara city, southwestern Uganda.

 Uganda 2022-07-18 14:34:09 2025-07-18 Medical and Health Sciences Non-Clinical Trial Degree Award
Joseph Baluku B
ID: UNCST-2019-R000612
 Mycobacterium tuberculosis infection and DNA damage in HIV-associated lung cancer in Uganda
REFNo: HS2328ES

STUDY AIM 1: To determine the association between Mycobacterium tuberculosis
infection and HIV-associated lung cancer in Uganda.

STUDY AIM 2: To compare the degree of DNA damage and methylation among people
with HIV-associated cancer with and without Mycobacterium tuberculosis infection.


SECONDARY AIM: To determine the effect of tuberculosis preventive therapy (TPT) on
the six-month survival of people with HIV-associated lung Cancer and LTBI in
Uganda
 Uganda 2022-07-18 14:31:31 2025-07-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Nelson Sewankambo K
ID: UNCST-2020-R014578
 Development and Evaluation of an Information Management and Communication System for Population-wide Point-of-Care Infant Sickle Cell Disease Screening (SIMCS)
REFNo: HS2333ES

1. To develop and evaluate a four module 3G or more cell phone app for a novel SCD screening information management and communication system (SIMCS) 2.To evaluate the impact of the SCD SIMCS on access to screening and care and outcomes of children with SCD.
Uganda 2022-07-18 14:29:19 2025-07-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Andrew Obuku Ekii
ID: UNCST-2024-R002288
 IMMUNOLOGICAL AND VIROLOGICAL FACTORS ASSOCIATED WITH VIROLOGICAL CONTROL IN ACUTE AND EARLY HIV-I INFECTION.
REFNo: HS2264ES

• To characterize the earliest host factors associated with plasma viral load decline from peak viremia to viral setpoint.
a) To determine the functional and molecular profile of innate immune cells at each stage of acute and early HIV infection.
b) To determine the functional and molecular profile of adaptive immune cells at each stage of acute and early HIV-I infection.
c) To determine the impact of early cART treatment on:
l) Size of translational competent viral reservoirs
Il) Development of HIV specific immune responses
d) To determine HIV evolution in acute and early HIV1 infection

Specific objectives are:
1 . To determine the association of CD8 T cell subsets with plasma viral load and CD4 trajectories following acute and early HIV-I infection.
2. To determine the association of cell death mechanism with T cells following acute and early HIV-I infection.
3. To determine the viral replicative inhibitory properties of CD8 T cell subsets following acute and early HIV-I infection.
4. To determine the TCR and BCR of the cells with the highest viral inhibition potency.
5. Predict antigen that induced the TCR and BCR specificity in the cellular subsets with the highest viral inhibition potency.
6. To associate HIV specific B cell phenotypes with viremia in acute and early HIV infection.
7. To associate complement proteins with viremia and development of broadly neutralizing antibody in acute and early HIV-I infection.


 Uganda 2022-07-18 14:27:23 2025-07-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Macdonald Isabel
ID:
Do anonymous ratings build trust in mobile money agents? Evidence from Uganda
REFNo: SS1344ES

The goal of the research is to determine if mobile money users in Uganda trust anonymous customer ratings, and if these ratings would make users more willing to trust unknown agents. Furthermore, the research will explore the extent to which social stigmas restrict information sharing about agent trustworthiness.
Specific Objectives
Establish whether anonymous reviews increase trust, both in behavioral games and in unknown mobile money agents
Investigate if social stigmas restrict info sharing about agent trustworthiness

 USA 2022-07-15 15:59:49 2025-07-15 Social Science and Humanities Non-Clinical Trial Non-degree Award
Polycarp Omara
ID: UNCST-2022-R011110
 CHILDREN’S EXPOSURE TO VIOLENCE IN REFUGEE EDUCATIONAL SETTINGS: MITIGATING THE EFFECTS ON EDUCATION AND SOCIAL WELLBEING IN WEST NILE, UGANDA
REFNo: SS1331ES

1. To analyse the various forms of VAC among the refugee children in Refugees Educational settings in West Nile.
2. To establish the common perpetrators of VAC in refugee education settings in West Nile.
3. To establish the effects of VAC in refugee education settings in West Nile.
4. To propose the strategies for preventing VACs in refugee education settings in West Nile.

Uganda 2022-07-15 15:56:51 2025-07-15 Social Science and Humanities Non-Clinical Trial Non-degree Award
Moses Joloba Lutaakome
ID: UNCST-2022-R011558
 Performance evaluation of the Molbio Diagnostics Truenat™ MTB Plus/COVID-19 for TB and COVID-19 case detection using prospectively collected NP swabs and sputum samples from participants with symptoms suggestive of TB.
REFNo: HS2346ES

To assess the feasibility and ease of use of self-sampled tongue swab,To determine the prevalence of COVID-19 (by RT-PCR) among patients identified as having TB by MRS,To determine the prevalence of COVID-19 (by RT-PCR) among presumptive TB patients investigated for COVID-19,To determine the diagnostic accuracy of Truenat™ MTB Plus/COVID-19 multiplex for TB detection compared to GeneXpert Ultra among presumptive TB patients using a MRS,To determine the diagnostic accuracy of Truenat™ MTB Plus/COVID-19 for COVID-19 detection among presumptive TB patients using a country-approved RT-PCR COVID-19 assay,To determine the diagnostic accuracy of Truenat™ MTB Plus/COVID-19 multiplex for TB detection among presumptive TB patients using a Microbiological reference standard (MRS),
 Uganda 2022-07-14 12:36:25 2025-07-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Martin Hasselmann
ID:
The molecular mechanisms underlying local adaptation to high elevation habitats in the honey bee Apis mellifera
REFNo: NS350ES

The overall objective is to obtain a better understanding of the molecular mechanisms that have driven the local adaption of mountain honey bees.

The research plan is divided into a sequence of different complementary approaches that will
1.) Unravel the evolutionary history of chromosomal rearranged regions contributing to the genetic differentiation of mountain honeybees,
2.) Gain insight into key regulators and gene networks underlying the local adaption of honeybees,
3.) Specifically analyze the role of octopamine ? receptors and further candidate genes as key players for local adaptation to elevation (mainly temperature) in honey bees.

 Germany 2022-07-14 12:35:17 2025-07-14 Natural Sciences Non-Clinical Trial Degree Award
Katungi Ninsiima Remmy Brian
ID:
Assessment of Alternative Rites of Passage Interventions implemented by UNFPA/UNICEF Joint Programme on the Elimination of Female Genital Mutilation in Uganda
REFNo: SS1352ES

Specific objective 4: Assess the impact and sustainability of ARPs in fostering FGM abandonment and promoting egalitarian gender norms, attitudes, and behaviours among community members, by: a) assessing whether previous ARP cohorts have sustained any changes b) assessing whether communities who have undergone or are undergoing ARPs have the commitment and capacity to continue ARPs (rather than FGM) c)identifying lessons for replication/scaling up of ARP interventions (including, for example, what needs to be in place for particular ARPs to be implemented in future or in other contexts),Specific objective 3: Assess the effectiveness of ARPs in achieving positive outcomes, including: a) increasing girls’ knowledge of FGM-related issues including sexual and reproductive health, prevention of gender-based violence, and child marriage b) Promoting positive attitudes and behaviours among girls in relation to FGM and sexual and reproductive health, gender-based violence and child marriage. c) promoting social norm change within communities, including promoting egalitarian gender norms among girls, boys, parents, elders and community leaders,Specific objective 2: Assess the coherence (in terms of compatibility) of ARPs with other interventions to end FGM by implementing partners or other stakeholders in the geographical region, including by: a) identifying synergies and interlinkages between ARPs and other interventions to end FGM that are either carried out within or are expected to affect the same communities b) analysing the extent to which other interventions (including, for example, policy advocacy) support or undermine ARPs, and vice versa c )assess the consistency of the intervention with other interventions in/affecting the same contexts, including coordination with others, and the extent to which the intervention is adding value while avoiding duplication of effort,Specific objective 1: Assess the relevance of ARPs to the aim of eliminating FGM, by: a) describing the context of ARP interventions, with specific attention paid to the significance and symbolic meaning within communities of girls’ initiation rites or coming of age ceremonies b) identifying the intervention models (operating structure and procedures) of ARPs, and the roles of various community institutions and actors (such as parents, and religious and community leaders) engaged in ARPs c) analyzing if (and why/why not) specific ARPs meet community needs and are a relevant approach to include in programming to eliminate FGM d) analyzing the extent to which framing interventions as an ARP bring added value, over and above delivering the intervention under non-ARP rubric (including, for example, exploring whether framing life skills courses with graduation ceremonies as ARPs brings added value, or whether it introduces extra risk of the intervention being rejected),The primary objective of this evaluation is to provide an assessment of whether ARPs ‘work’ has been successful in promoting FGM abandonment, based on evidence of their relevance, coherence, effectiveness, impact and sustainability.,
 Uganda 2022-07-13 17:13:28 2025-07-13 Social Science and Humanities Non-Clinical Trial Non-degree Award
Moffat  Nyirenda Joha
ID: UNCST-2020-R019333
 Development and Evaluation of an Integrated Community-based Management Model for HIV, Diabetes, and Hypertension in Tanzania and Uganda (The INTE-COMM study)
REFNo: HS2278ES

To determine the effectiveness of community-based integrated management of HIV, diabetes, and hypertension in comparison to clinic-based integrated management of these conditions in terms of patient outcomes, acceptability, and potential cost-effectiveness.
 Malawi 2022-07-13 16:33:33 2025-07-13 Medical and Health Sciences Clinical Trial Non-degree Award
Jackson Mukonzo
ID: UNCST-2021-R013916
 Ivermectin-artemisinin Combination Therapy for Eradication of Malaria
REFNo: HS2081ES

Main Objective: 1. To investigate the effect of ivermectin adjunct therapy on household transmissibility of malaria from malaria-infected patients receiving artemether /lumefantrine Specific objectives 1. To determine the household malaria transmissibility within one month of IVN and artemether / lumefantrine therapy. 2. To determine the structural similarity of the nanopore plasmodium sequences between infecting plasmodium species isolated from the index patient and other household malaria positive patients. 3. To assess the safety of ivermectin-artemether/lumefantrine in malaria-infected patients.
 Uganda 2022-07-13 16:29:55 2025-07-13 Medical and Health Sciences Clinical Trial Non-degree Award
Eleanor  Brown Lucy
ID:
A sex and gender-based analysis of access to Vitamin A programmes in four sites in Uganda
REFNo: HS2320ES

The overall objective of the SGBA is to identify gender inequalities and inequities, as well as associated barriers and needs, which affect access and uptake of Vitamin A supplementation programmes. The SGBA will also identify strengths and opportunities and provide recommendations to make VAS programmes more gender responsive.

1. To identify the gender equality issues that influence access to preventative health and nutrition services for child survival, and the quality of services provided.
2. To assess the level of gender mainstreaming in the design of preventative health nutrition services for child survival such as VAS, their implementation and MEAL system and indicators.
3. To identify potential opportunities and enablers and provide recommendations to increase the level of gender responsiveness in preventative health and nutrition services for child survival programming models such as the VAS programme.
4. To explore how COVID-19 affected access to and use of preventative health and nutrition services for child survival programme areas, including VAS programmes, and to provide recommendations for gender-sensitive support to both programme beneficiaries and key services providers and promoters at health facility and community levels.

 UK 2022-07-13 10:48:27 2025-07-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Elizabeth Ayebare Ombeva
ID: UNCST-2020-R003666
 Translation and validation of the Perinatal Grief Intensity Scale in Kenya and Uganda
REFNo: HS2296ES

1. To perform a culturally sensitive translation and adaptation of the Perinatal Grief Intensity Scale in Kiswahili and Luganda 2. To assess validity and reliability via face, content and construct validity and internal consistency 3. To obtain statistical estimates pertaining to the use of the tool
Uganda 2022-07-13 10:47:29 2025-07-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
 Sentinel Surveillance of Acute Febrile Illness (AFI) in Regional Referral and District Hospitals in Uganda
REFNo: HS2277ES

Identify etiologies and define the epidemiology of AFI among children, adolescents and adults attending referral hospitals in Uganda.
Build and strengthen sustainable surveillance, laboratory, and information systems to improve epidemic intelligence across multiple priority outbreak-prone febrile illness in Uganda.

Nigeria 2022-07-13 10:45:57 2025-07-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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