Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Annet Musiimenta
ID:
SCHOOL MANAGERS COLLABORATION WITH UNIVERSITIES FOR TEACHER EDUCATION SUPPORT DURING SCHOOL PRACTICE
REFNo: SS1468ES

1. To explore the roles school managers perform during school practice supervision 2. To assess the roles university supervisors take up in collaboration with schools during School Practice supervision 3. To explore student teacher’s perceptions regarding the support of school managers and university supervisors during school practice.
Uganda 2022-11-15 3:44:24 2025-11-15 Social Science and Humanities Non-Clinical Trial Degree Award
Proscovia Nabunya
ID: UNCST-2019-R000970
Suubi-Mhealth: A mobile health intervention to address depression and improve ART adherence among Youth living with HIV (YLHIV) in Uganda
REFNo: SS1442ES

The overall goal of this proposal is to develop a mobile health intervention (hereafter “Suubi-Mhealth”) for use among Ugandan youth with comorbid HIV and depression, taking into account their unique contextual, cultural, and developmental needs. This digital therapy intervention (mobile app) will apply user-centered design methodologies and will be based on the cognitive-behavioral therapy (CBT) tenets found to improve depression among individuals with HIV.

The study will be conducted in two phases (R21 and R33) as specified below

Phase 1. R21 Aim 1: Develop and iteratively refine an intervention protocol for Suubi-Mhealth based on formative work to understand the needs of depressed YLHIV, ages 14-17. We will conduct four focus groups, each with 6-8 depressed YLHIV and two focus groups with health care providers, recruited from clinics across the greater Masaka region of Uganda for feedback on proposed intervention content and methods to increase participation and retention.

R21 Aim 2: Based on the results of Aim #1, we will explore the feasibility and acceptability of Suubi- Mhealth for use with depressed YLHIV on a small scale (N= 30) to inform subsequent refinement for the larger phase of this project (R33 phase).

Phase 2. R33 Aim 1: Pilot test the preliminary impact of Suubi-Mhealth versus a waitlist control group (to receive the intervention after the active treatment condition), on reducing depression (primary outcome) and improving ART adherence, mental health functioning, quality of life, and lowering HIV stigma (secondary outcomes).

R33 Aim 2: Qualitatively examine barriers and facilitators for integrating Suubi-Mhealth into health care settings for depressed YLHIV.

Uganda 2022-11-15 3:42:47 2025-11-15 Social Science and Humanities Clinical Trial Non-degree Award
Patience Atumanya
ID:
FEASIBILITY AND SAFETY OF SEGMENTAL THORACIC SPINAL ANESTHESIA FOR OPEN GASTROSTOMY: Experience from an Oncology Center during the COVID-19 pandemic.
REFNo: HS2215ES

1. To evaluate the feasibility of segmental thoracic spinal anesthesia for oncology patients undergoing open gastrostomy.
2. To assess incidence of spinal cord injury potentially associated with segmental thoracic spinal anesthesia.

Uganda 2022-11-15 3:38:33 2025-11-15 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Nestor Atukwatse
ID:
Capacity needs assessment on gender/youth responsive and inclusive planning, budgeting, data for decision-making and Sexual Reproductive and Health supportive supervision.
REFNo: SS1516ES

To conduct training for the District Health Management Teams and Technical Working Groups on gender/youth responsive and inclusive planning and budgeting, data for decision making and SRH supportive supervision.,To develop/adapt existing training modules on gender/youth responsive and inclusive planning and budgeting, data for decision making and Sexual, Reproductive and Health supportive supervision based on the findings from the Capacity gaps assessment.,To assess the capacity gaps among the District Health Management Teams and Technical Working Groups in managing and coordinating gender/youth responsive and inclusive planning, budgeting, data for decision-making and Sexual, Reproductive and Health supportive supervision. ,
Uganda 2022-11-11 17:26:00 2025-11-11 Social Science and Humanities Non-Clinical Trial Non-degree Award
William Buwembo
ID: UNCST-2022-R009661
Oral Papilloma Virus, Microbiota and Cancer in People Living with HIV (OHPVMC)
REFNo: HS2541ES

Aim 1: To characterize and understand oncogenic Oral Human Papilloma Virus (OHPV) infections in People Living With HIV (PLWHIV)in reference to non-clearance of OHPV. To test our hypothesis that the oncogenic OHPV type 16 infections in PLWHIV are associated with non-clearance, we will use a prospective cohort design to characterize and understand OHPV infections in PLWHIV.
Aim 2: To determine the differences in the periodontitis associated bacteria of PLWHIV with or without OHPV. To test our hypothesis that OHPV is associated with the presence of periodontitis associated oral bacteria, we will compare the patterns of periodontitis (red and orange complex) associated bacteria in PLWHIV in the presence or absence of OHPV infections.

Uganda 2022-11-11 17:24:02 2025-11-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joseph  Matovu KB
ID: UNCST-2020-R014654
Willingness to take COVID-19 vaccine and uptake of locally adapted COVID-19 prevention measures among high-risk populations in Malaba and Mutukula points of entry
REFNo: HS2530ES

i) To assess willingness to take the COVID-19 vaccines among high-risk populations in Malaba and Mutukula points of entry.
ii) To explore facilitators and barriers to willingness to take COVID-19 vaccines among high-risk populations in Malaba and Mutukula points of entry.
iii) To assess uptake of locally adapted COVID-19 prevention measures among high risk populations in Malaba and Mutukula points of entry.
iv) To explore facilitators and barriers of locally adapted COVID-19 prevention measures among high-risk populations in Malaba and Mutukula points of entry.

Uganda 2022-11-11 17:21:54 2025-11-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joseph Kizito BADA
ID:
FOSTERING DIGITAL LEARNING ENVIRONMENT FOR ADOLESCENT REPRODUCTIVE HEALTH EDUCATION
REFNo: SS1489ES

Specific Objectives
1) To sensitize and introduce a select sample of 14 teachers from 7 schools to multimedia teaching material and digital stories for teenage reproductive and mental health education with the goal of expanding teachers’ knowledge and skills in use of digital stories and multimedia content as pedagogical tools.
2) To provide hands on training on e-content curriculum creation, multimedia content development, digital stories development and digital game design for teenage reproductive and mental health education.
3) To implement multimedia educational content, multimedia content and digital stories in the 7 schools and train a total of 400 students in reproductive health education.
4) To evaluate effectiveness and impact of cartoon-based stories and multimedia educational materials on the higher level cognitive skills developent of the students.
5) To mentor 10 junior teaching staff in action research through participation in project implementation activities and disseminate the outcomes of the project in the form of online resources, academic and professional publications, conference presentations as well as policy briefs to the government agencies.

Uganda 2022-11-11 17:20:33 2025-11-11 Social Science and Humanities Non-Clinical Trial Non-degree Award
Jonathan Marino
ID:
How the social and material conditions of teaching influence early grades teachers’ implementation of reading pedagogies
REFNo: SS1509ES

To understand how social and material conditions shape the way teachers think about these reading pedagogies and their own teaching practice.,To understand how early primary educators in Uganda make sense of various reading pedagogies they are asked to undertake, such as mother-tongue instruction and child centered pedagogies.,To understand what are the social and material conditions of teaching experienced by early primary educators in Uganda. and how the COVID-19 pandemic has influenced these conditions.,The goal of this study is to explore how early primary teachers in Uganda make sense of and implement new pedagogical approaches to teaching reading and how the social and material constraints of their teaching environment influence their reading instruction.,
USA 2022-11-11 17:18:21 2025-11-11 Social Science and Humanities Non-Clinical Trial Degree Award
GRACE  MUSINGUZI
ID:
Relationship between family support and self efficacy on resilience among school going adolescent victims of trauma in Kampala, Uganda
REFNo: SS1475ES

Purpose of the study The purpose of this study is to examine the relationship between family support, self-efficacy and resilience among adolescents facing trauma in Kampala, Uganda. Specific objectives 1.To find out the prevalence of trauma among adolescents in Kampala District. 2.To find out the relationship between family support and resilience among adolescent trauma victims. 3.To find out the relationship between family breakdown and resilience among adolescent trauma victims. 4.To find out the relationship between self-efficacy and resilience among adolescent victims of trauma. 5.To explore strategies that can be put in place to foster resilience among traumatised adolescents in broken families in Kampala District.
Uganda 2022-11-11 17:16:15 2025-11-11 Social Science and Humanities Non-Clinical Trial Degree Award
Fred Ssewamala
ID: UNCST-2020-R014060
Suubi+Adherence4Youth: Optimizing the Suubi Intervention for Adherence to HIV Treatment for Youth Living with HIV in Uganda
REFNo: SS1449ES

The proposed Suubi+Adherence4Youth study seeks to unpack the Suubi intervention to identify the most impactful and sustainable components: economic vs. psychosocial components, for adolescents living with HIV (ALHIV) across the HIV care continuum. The Suubi intervention was tested as a package of four components: 1) Financial Literacy Training (FLT); 2) Incentivized Matched Youth Savings Accounts (YSA) with income-generating activities (IGAs); 3) a manualized and visual-based intervention for ART adherence and stigma reduction; and 4) Engagement with HIV treatment-experienced role models. We propose a factorial experiment to unpack and optimize the Suubi intervention to enhance scale up in health systems using the multi-phase optimization strategy (MOST) -an engineering-inspired intervention framework. Our ultimate goal is to build Suubi version 2.0 that meaningfully improves viral suppression while performing efficiently, affordably, and at scale for a sustained impact.

Aim 1. Conduct a factorial experiment (optimization trial) to test the main effects of each of the four Suubi intervention components and combinations of components (interactions) on viral suppression (primary outcome).

Aim 2. Test mediators and explore moderators that explain and modify the relationship between each of the four Suubi intervention components and viral suppression.

Aim 3. Compare the cost and cost-effectiveness of each of the four Suubi intervention components and every combination of components.

Uganda 2022-11-11 17:11:59 2025-11-11 Social Science and Humanities Clinical Trial Non-degree Award
Moses Adriko
ID: UNCST-2019-R001787
Field testing of a portable low-cost diagnostic for the automated diagnosis of soil transmitted helminth infections from Kato-Katz thick faecal smears
REFNo: HS2431ES

Our plan of work is to travel to Uganda, where we will initially stay in Kampala, Uganda to prepare any equipment that needs to be purchased in-country (including reagents, consumables and treatment), and engage with stakeholders at the MOHU and Vector Control Division (VCD). We will then embark on a 14-day field study, travelling to an endemic area in the Tororo district. Samples will be taken from patients and analysed using gold standard diagnostic methods and the novel portable diagnostic. Clinical diagnoses will be made using gold standard microscopy by trained technician, and the efficacy of the investigational device will be compared to these diagnoses. Feedback of technicians will also be gathered during practical demonstrations, to inform a development and translation roadmap.
Uganda 2022-11-11 17:02:30 2025-11-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
OKELLO DAMOI JOSEPH
ID: UNCST-2022-R011560
The implementation of ambulatory surgery in a rural setting in Eastern Uganda
REFNo: HS2489ES

Identify factors contributing to utilization of surgical care,Develop new strategies to improve ambulatory surgery based on the results of these studies,Access the logistics and infrastructure needed to run an ambulatory surgery centre,Access surgical outcomes performed at an ambulatory surgery centre,Assess preoperative considerations for ambulatory surgery,Assess differences in outcomes of surgeries at Kyabirwa Surgical Centre,Longitudinally collect an extensive medical history, intra-operative details, clinical outcomes of the patients undergoing ambulatory procedure at KSC,Understand the prevalence of surgical diseases in the community, as compared to the prevalence of surgical diseases treated in the Centre,Analyze the data for correlative factors. The correlative factors could be the impact of demographics, medical treatment history, and/or surgical technique,Understand the needs of the patient and the community in providing better healthcare,
Uganda 2022-11-11 17:01:15 2025-11-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
RICHARD NABONGO
ID:
EXPERIMENTING WITH POTTERY DESIGNS TO PRESERVE FRUITS AND VEGETABLES IN THE RURAL COMMUNITIES OF JINJA AND IGANGA DISTRICTS IN UGANDA
REFNo: SS1084ES

The aim of this study is to explore and experiment with pottery design to preserve fruits and vegetables in the rural communities of Jinja and Iganga districts through creation of a practice based pottery product.,To establish a practice-based pottery prototype product for selected villages of Jinja and Iganga districts.,To evaluate the extent to which modern technology has influenced food production and preservation practices in the local communities of Jinja and Iganga districts.,To examine the contribution of pottery to the local communities in Jinja and Iganga districts in Uganda.,To assess the influence of pottery design in today’s contemporary world. ,
Uganda 2022-11-11 16:59:14 2025-11-11 Social Science and Humanities Non-Clinical Trial Degree Award
Namulema Edith
ID:
Feasibility of using Continuous Positive Airway Pressure via the ‘LeVe CPAP System’ among Children with Acute Hypoxemic Respiratory Failure at Mengo Hospital Kampala Uganda: A mixed methods study
REFNo: HS2478ES

1) To assess the acceptability of the LeVe CPAP system to deliver continuous positive airway pressure among children with acute hypoxemic respiratory failure at Mengo Hospital Uganda.
2) To assess the safety of LeVe CPAP system among children with acute hypoxemic respiratory failure at Mengo Hospital Uganda.

Uganda 2022-11-09 13:49:10 2025-11-09 Medical and Health Sciences Clinical Trial Non-degree Award
Zula Namubiru
ID:
HARNESSING FISHERS' KNOWLEDGE FOR SUSTAINABLE FISHERY ON LAKE VICTORIA: A CASE OF KIGUNGU FISHING GROUND WAKISO DISTRICT
REFNo: SS1511ES

1.To assess fishers’ perceived attitude, knowledge and practice on illegal fishing on Lake Victoria
2. To engage fishers especially the youth on what they can do and how best they can be enabled to sustain the fishery resource
3. To discuss with fishers’ wives/ spouses and female fish smokers on what they can do and how best they can be enabled to sustain the fishery resource
4. To understand how different stakeholders can best support fishers for the sustainable conservation of the fishery resources
Uganda 2022-11-08 14:17:17 2025-11-08 Social Science and Humanities Non-Clinical Trial Degree Award
Francis Garuzooka John
ID:
Work and learning experiences of graduates from Technical and vocational Training Institutions in Uganda. A case Study
REFNo: SS1507ES

is to understand the work and learning experiences of graduates of TVET institutions in Uganda with a view of proposing strategies for recognizing and validating non-formal workplace learning and improving productivity,4. To Evaluate how TVET graduates balance work, training apprentices and learning at their workplaces.,3. To3. To analyse the progression of TVET graduates to higher level competences and qualifications as they work. ,2. To explain the relevance of the knowledge and skills acquired by graduates of TVET institutions to the current tasks they perform at their workplaces. ,1. To find out how TVET institutions prepare their learners for work and continuous learning,
Uganda 2022-11-08 14:14:34 2025-11-08 Social Science and Humanities Non-Clinical Trial Degree Award
Enock Matovu
ID:
COntrolling and progressively Minimizing the Burden of Animal Trypanosomiasis in Uganda [COMBAT-U]
REFNo: A237ES

i. To determine the burden, socioeconomic importance, factors driving transmission network pathways of AAT and the knowledge gaps that exist in AAT vector identification
ii. To determine the differencesin the immune responses, metabolic and genetic profiles in trypanotolerant and susceptible cattle breeds
iii. To identify molecular determinants of trypanocidal drug resistance in Trypanosoma congolense field isolates in order to develop novel molecular test(s) to detect such drug resistant strains.

Uganda 2022-11-08 14:11:16 2025-11-08 Agricultural Sciences Non-Clinical Trial Non-degree Award
Harriet Opondo
ID: UNCST-2022-R010927
Mental Health needs Assessment of Children ages 0-5 years Living with HIV in an Urban setting in Uganda.
REFNo: SS1484ES

1. To describe and assess the spectrum of mental health needs (magnitude and prevalence) among children living with HIV ages 0-5 years. 2. To establish the awareness of health care workers regarding mental health needs among CLHIV (0-5) years and establish existing resources and capacities to respond to these needs. 3. To explore parent training needs of parents/primary caregivers of CLHIV (0-5) years who are presenting with mental health needs.
Uganda 2022-11-08 14:09:12 2025-11-08 Social Science and Humanities Non-Clinical Trial Degree Award
lydia Bunalema
ID: UNCST-2020-R014729
Identification and validation of anti-plasmodial activity and artemisinin pharmacokinetic enhancement potential of medicinal plants used by Ugandan communities to treat malaria symptoms
REFNo: NS431ES

To formulate a herbal product for treatment of malaria To establish the protective effect of above herbal extracts against metabolic clearance of Dihydroartemisinin in a rabbit model To determine the susceptibility (RSA0-3h and IC50) of Plasmodium falciparum to the five most common herbal extracts used in treatment of malaria symptoms across Uganda To establish through a systematic review and ethnobotanical survey medicinal plants used in treatment of malaria symptoms in communities To investigate the anti-plasmodial activity and artemisinin pharmacokinetic enhancement potential of medicinal plants used by communities across Uganda in treatment of malaria symptoms,
Uganda 2022-11-08 14:05:34 2025-11-08 Natural Sciences Non-Clinical Trial Non-degree Award
Wilson Mugizi
ID: UNCST-2022-R009877
Resource Based View Approach in Implementation of E-Learning in Selected Ugandan Public Universities
REFNo: SS1454ES

i. To examine the relationship between universities tangible resources and e-learning implementation during and beyond Covid-19 pandemic era in Uganda
ii. To evaluate the relationship between the universities intangible resources and e-learning implementation during and beyond Covid-19 pandemic era in Uganda.
iii. To assess the relationship between universities capabilities and e-learning implementation during and beyond Covid-19 pandemic era in Uganda.
iv. To suggest the strategies for management of e-waste resulting from implementation e-learning implementation.

Uganda 2022-11-08 14:03:00 2025-11-08 Social Science and Humanities Non-Clinical Trial Non-degree Award
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