Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
ROSELILIAN ANDANJE KHANALI
ID:
Health seeking behaviour and management outcomes of Breast cancer patients in Uganda. A case of Mbale regional referral hospital, Eastern region
REFNo: HS1795ES

To evaluate the effects of patient factors on breast cancer management outcomes at Mbale regional referral hospital.,To determine the influence of patient factors on health seeking behavior of breast cancer patients at Mbale regional referral hospital.,To describe health seeking practices of breast cancer patients on at Mbale regional referral hospital.,To analyse the Health seeking behaviour and management outcomes of Breast cancer patients at Mbale regional referral hospital and to develop a model that will guide and improve the Health seeking behaviour of breast cancer patients.,
 Kenya 2022-06-29 14:03:08 2025-06-29 Medical and Health Sciences Non-Clinical Trial Degree Award
Basil Ajer
ID:
Small and Medium Enterprise Innovations: Precursors in the Agri-Food Value Chain in Central and Eastern Uganda
REFNo: A205ES

General Objectives: To investigate the precursors to Small and Medium
Enterprise level of innovation in Uganda’s agri-food value chain.
Specific Objectives
1. Characterize agri-food value chain SMEs in Central and Eastern
Uganda by their levels of innovation
2. Analyze factors that influence the level of agri-food SME innovation in
central and eastern Uganda
3. Determine the association among SME market orientation,
entrepreneurial orientation and SME level of innovation in the agri-food
value chain
Uganda 2022-06-29 14:00:45 2025-06-29 Agricultural Sciences Non-Clinical Trial Degree Award
Kearsley Stewart
ID: UNCST-2021-R011830
 Reducing Sickle Cell Burden in Kalangala, Uganda: A Student Research and Training Program
REFNo: HS2312ES

Aim 4: To develop educational activities for adolescent sickle cell patients (non-research) We aim to develop non-research, educational activities specifically designed for adolescent sickle cell patients who attend the monthly sickle cell clinic at Kalangala Health Center. Activities will include a “kids camp” that will train older children to share their experiences managing their sickle cell disease with younger clinic patients. Also, we will establish a “MDD Troupe”, or “Music Dance and Drama Troupe” to spread awareness about sickle cell in community settings such as schools and youth clubs. These activities are not part of the testing initiative, nor are they generalizable research. However, these activities will be conducted by Duke undergraduate students in collaboration with Ugandan students from Kalangala - this is part of the “student research training program the “twins” or matches Ugandan and US-Based students on collaborative teams.,Aim 3: Conduct a retrospective chart review of all SCD patients at KHCIV since 2015 Conduct a retrospective chart review of all sickle cell patients appearing in various KHCIV paper-based databases (Ministry of Health Outpatient Register 002, registries, laboratory forms, death records, etc) since the opening of the KHCIV sickle cell clinic in 2015. Build a standardized form to record data such as medical history, demographics, clinical data, pain episodes, routine and acute clinic visits, etc.,Aim 2: To increase community knowledge and understanding about SCD and the importance of diagnostic testing for Kalangala. We aim to increase community knowledge about SCD through a community educational component that will complement the testing initiative. Study participants will go through an education module prior to testing that will describe SCD, symptom management and treatment options, the importance of testing, and SCD-related stigma. Study participants will also be briefed on their options for counseling post SCD testing, in the event of a positive diagnosis. ,Aim 1: To improve access to sickle cell RDTs and establish a standard RDT for Kalangala, Uganda. We aim to improve access to screening and confirmatory sickle cell RDTs and establish a standard RDT that best fits the health infrastructure in Uganda, specifically Kalangala Health Center IV, which is the government referral health center for Kalangala District. Another goal is to increase the capacity of local health centers to diagnose patients efficiently, informing more of the population of their status and treatment options, and lowering SCD disease burden in the area over time.,The main objective of this study is to reduce the burden of sickle cell disease in Kalangala, Uganda through rapid testing, education, and retrospective patient chart review. This pilot study aims to identify methods and tools to mitigate the burden of SCD, increase community awareness of SCD diagnosis status, improve knowledge and understanding of SCD within the Kalangala community, and better understand retrospective trends in health indicators of sickle cell patients in Kalangala, Uganda. ,
 USA 2022-06-28 17:17:19 2025-06-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sarah Nakaziba
ID:
Role of Continuing Professional Development in the Digital Transformation of Selected University Libraries in Uganda
REFNo: SS1317ES

1. To assess the extent to which university libraries in Uganda promote CPD activities and the dissemination of the acquired CPD knowledge. 2. To establish the CPD training strategies for librarians working in Ugandan universities. 3. To examine the role of technology-related CPDs towards digital transformation in selected university libraries in Uganda. 4. To assess the status of digital transformation in selected university libraries in Uganda. 5. To determine the barriers hindering the implementation of the current digital trends in university libraries in Uganda. 6. To develop a model for addressing challenges affecting CPD activities and digital transformation in university libraries in Uganda.
Uganda 2022-06-28 17:12:56 2025-06-28 Social Science and Humanities Non-Clinical Trial Degree Award
Miriam Nakalembe
ID: UNCST-2021-R014040
 INTRODUCING HEAT-STABLE CARBETOCIN AND TRANEXAMIC ACID INTO HEALTH FACILITIES IN FIVE HIGH-BURDEN AFRICAN COUNTRIES: AN IMPLEMENTATION RESEARCH PROTOCOL
REFNo: HS2293ES

1. Identify a feasible and scalable model for implementation of WHO PPH guidelines
2. Identify factors (facilitators and barriers; contextual or otherwise) that influence successful introduction of and adherence to the PPH guidelines in clinical practice
3. Describe the effect of introduction of new guidelines – including added value and potential negative effect of introducing heat-stable uterotonics and additional therapeutic agents

 Uganda 2022-06-28 17:11:36 2025-06-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Resty Naiga
ID:
Drivers of Violence against Children in Rural Uganda: A Case Study of Kayunga District.
REFNo: SS1329ES

The study aims to explore the drivers of physical, sexual, and emotional violence against children at individual, society, community, and family levels in Central Uganda. Specifically, i) To explore the drivers of psycho-social (emotional) violence against children in central Uganda, ii) To find out the drivers of physical violence against children in central Uganda., iii) To establish the drivers of sexual violence against children in central Uganda,
 Uganda 2022-06-28 17:09:34 2025-06-28 Social Science and Humanities Non-Clinical Trial Non-degree Award
Bianca Zoletto
ID:
The influence of lightning on tropical forests of Equatorial Africa
REFNo: NS366ES

(1) Quantify the frequency of lightning induced canopy disturbances at Bwindi
and Rwenzori National Parks, (2) identify the characteristics of trees struck and/
or killed by lightning and (3) identify within and between species differences in
tree electrical resistance
 Italy 2022-06-28 17:06:20 2025-06-28 Natural Sciences Non-Clinical Trial Degree Award
David Musoke
ID:
Integrated malaria prevention in Wakiso district, Uganda: an implementation study
REFNo: HS2270ES

Broad objective
To conduct implementation research on integrated malaria prevention in Wakiso district using photovoice as a participatory action research methodology so as to generate information required for implementation of the RCT in future.


Specific objectives
1. To assess the extent of implementation of the various methods in integrated malaria prevention.
2. To explore facilitators and barriers to implementation of the various methods in integrated malaria prevention individually and holistically.

 Uganda 2022-06-28 17:05:03 2025-06-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Patrick Eyul
ID:
Wheels of Change? Exploring 'Bicycles for Development' for Women and Girls in the (Post-)Pandemic Contexts of Canada, Uganda and Nicaragua
REFNo: SS1274ES

1. To assess the impact and activities of BFD programming on gender inequality, development, mobility, social entrepreneurship, and the environment.

2. To investigate the efficacy of a trauma-and-violence-informed approach, and the use of participatory mapping and visual research methods within a south-south framework to improve program sustainability, impact and effectiveness.

3. To understand how BFD programs and access to bicycles contribute to lessening, augmenting, and/or exacerbating gender-based inequalities in (post-)pandemic life.

4. To explore the strategies and approaches that BFD programs for women and girls take with respect to: a) GBV prevention; b) social entrepreneurship; and c) environmental sustainability promotion.

5. To examine the contextual factors – such as COVID-19, the ‘shadow pandemic’ and the emerging impacts of ‘green recovery’ – that shape a) the work of BFD nongovernmental organizations; and b) their efforts at achieving gender equality through BFD work.

 Uganda 2022-06-28 17:04:08 2025-06-28 Social Science and Humanities Non-Clinical Trial Non-degree Award
DICKSON KALUNGI
ID:
AN ONTOLOGY-BASED MODEL FOR EFFECTIVE CAREER GUIDANCE
REFNo: SIR83ES

1. To establish the requirements for developing an Ontology model for effective Career Guidance
2. To design and develop Ontology sub-models that support 21st century career guidance Services
3. To integrate the developed sub-models into an Ontology model for effective career guidance
4. To evaluate the integrated Ontology model
 Uganda 2022-06-28 17:01:19 2025-06-28 Engineering and Technology Non-Clinical Trial Degree Award
Naome Wandera Namakula
ID:
Assessing the social and economic impact of COVID-19 on women working in the informal urban economy in Uganda (SPH2022-223)
REFNo: SS1323ES

i) To investigate how COVID-19 policies impacted pre-existing gender inequalities, including GBV/SRH among women workers in informal urban economies. ii) To understand the coping and resilience strategies of IWWs in the context of the pandemic and its effects. iii) To assess women's GBV and SRH experiences, including access to related services during the COVID-19 pandemic.
Uganda 2022-06-28 16:53:23 2025-06-28 Social Science and Humanities Non-Clinical Trial Non-degree Award
Carolyn Pelnik
ID:
Identifying and Easing Constraints on Microenterprise Location within Kampala, Uganda (Experimental Phase)
REFNo: SS1324ES

The study objectives are as follows:
1. To determine whether business relocation within Kampala can increase profits for mobile microentrepreneurs (primary objective)
2. To identify which constraints might restrict microentrepreneurs’ business locations within the city by separately relieving information and liquidity constraints (secondary objective)
 USA 2022-06-28 16:47:30 2025-06-28 Social Science and Humanities Non-Clinical Trial Non-degree Award
Khamisi Musanje
ID: UNCST-2021-R012863
 Challenges of engaging District Local Governments and Implementing Partners in the District Health Planning Process, a case study of Northern Uganda. A mixed method study
REFNo: HS2314ES

• To identify health implementing partners and their areas of intervention in the selected districts in Acholi and Lango sub-regions of Uganda.
• To determine the level of involvement of health implementing partners and the district health management teams in the development of the district health annual work plan.
• To assess factors influencing the involvement of health implementing partners and the district health management teams in the development of the district comprehensive health annual work plan in the financial year.

Uganda 2022-06-28 16:45:56 2025-06-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Andrew Mujugira
ID: UNCST-2019-R000871
 CHOICE-BASED PrEP DELIVERY FOR TRANSGENDER PEOPLE IN UGANDA
REFNo: HS2316ES

Aim 1: Identify PRECEDE factors that influence PrEP implementation for transgender people in Uganda.

Guided by the PRECEDE-PROCEED model, which is widely used for public health interventions, we will analyze previously collected qualitative data from four TGP studies and also conduct two new focus groups with TGP and providers to identify predisposing, reinforcing, and enabling factors that may impact implementation of choice-based PrEP. A stakeholder workshop anchored in good participatory practice will discuss results of the qualitative research and guide design of the optimal choice-based PrEP delivery model for Aim 2.

Aim 2: Offer PrEP choice to transgender people in a DSD model and evaluate implementation and effect on PrEP use (PROCEED).

We will offer choice of CAB-LA or oral PrEP, and choice of facility or community delivery (with option to switch), to 300 HIV-negative TGP with follow-up for 24 months. Adverse events, product switching, and trajectories of choice over time will be monitored and documented. Persistence on CAB LA and oral PrEP will be compared during the choice period, and with a historical cohort without PrEP choice (ClinicalTrials.gov, NCT04491422). Primary outcomes are choice of PrEP option & delivery model, adherence, and persistence.

Aim 3: Use mixed methods to evaluate how choice influences PrEP use among TGP (PROCEED).
Inductive and deductive analyses based on in-depth interviews with purposively sampled PrEP users (n=50) and providers (n=10) will be used to explain “how” and “why” choice did or did not work and interpret implementation data from Aim 2. Choice preferences will be assessed via structured questionnaires.

Aim 4: Estimate cost implications associated with integrating CAB LA into HIV programs.
We will conduct health system versus client cost analyses to inform budgeting. Costs incurred and averted will be estimated using activity-based micro-costing, study budget, and the literature. Costs and modeled outcomes will be combined to estimate budget impact with PrEP persistence at 6 and 12 months.


 Uganda 2022-06-28 16:44:09 2025-06-28 Medical and Health Sciences Clinical Trial Non-degree Award
Victor Musiime
ID: UNCST-2021-R013794
 Building Resources to Assess Impaired Neurocognition in Children with HIV in Low and Middle Income Countries (BRAIN Child LMICs)
REFNo: HS2271ES

(1) Adapt NeuroScreen for Luganda-speaking children 5-12 years. (a) Through expert focus groups and multiple rounds of cognitive interviewing with children, determine necessary adaptations to make the NeuroScreen tests valid, acceptable and understandable to Luganda-speaking children, (b) implement
those adaptations in the app, (c) re-evaluate the adapted app with children, (d) examine its acceptability by clinical staff most likely to administer it, and (e) make further adaptations, as needed.

(2) Examine construct validity of the child version NeuroScreen tests. (a) Compare NeuroScreen test performance to gold standard neuropsychological test battery performance among Ugandan children 5-12 years with and without HIV, and (b) explore the relationship between performance on NeuroScreen and behavioral health.


 Uganda 2022-06-28 16:42:46 2025-06-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sophie Riddick
ID: UNCST-2022-R010576
 Decision-making and religious beliefs across cultures
REFNo: SS1336ES

study how children learn about religious beliefs and practices over development, gain an understanding of how children attend to normative information presented by a peer or by an adult
 UK 2022-06-28 14:39:43 2025-06-28 Social Science and Humanities Non-Clinical Trial Degree Award
ERICK SSEGUJJA
ID: UNCST-2021-R012964
 Donor transition and its effect on health coverage in Uganda
REFNo: HS2112ES

The aim of this study is to better understand how and why Uganda has (or not) been able to sustain effective coverage of health interventions after projects previously funded by donors ended and the enablers and barriers encountered in this,4. Identify health system adaptation strategies devised by (sub)national actors for sustaining coverage of the two selected interventions when donor projects ended from 2016-2017 to date.,3. Understand how the end of project funding affected the coverage of maternal health interventions and HIV services in case-study districts in 2016 and 2017 respectively.,2. Determine changes in (i) select maternal health indicators (ii) key HIV service indicators three years after the end of project funding between 2016 and 2017 in select donor- supported districts.,1. Explore the political, financing and health system factors that influenced whether coverage of maternal health interventions and HIV services were sustained once the projects funded by the donors ended between 2016 and 2017. ,
 Uganda 2022-06-27 8:45:40 2025-06-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Pontiano Kaleebu
ID: UNCST-2021-R013577
 Implementation of Point of Care HIV Viral Load Monitoring to improve Viral Load Suppression among Children and Adolescents Living with HIV in East Africa.
REFNo: HS2025ES

14. Objectives of the research project:
Purpose: The purpose of EAPOC-VL project is to examine the feasibility, acceptability, and effectiveness of using point of care viral load (PoC VL) monitoring to improve viral load suppression among children and adolescents (age ?19 years) living with HIV in Kenya, Rwanda, Tanzania and Uganda.

Main Study Aims:
i) To determine the effectiveness of PoC VL monitoring in improving viral suppression among children and youth living with HIV in East Africa. ii) To evaluate feasibility and acceptability of using PoC VL monitoring among children and adolescents living with HIV in East Africa.

Objectives of Aim 1:
Primary objective
i. To estimate the effect of PoC VL monitoring on viral load suppression among children and adolescents living with HIV in East Africa at 6 and 12 months of followup.

Secondary objectives
i. To describe the effect of PoC VL monitoring on the proportion of children and adolescents living with HIV that experiences virological rebound after initial suppression within 6 and 12 months of follow-up.
ii. To describe the effect of PoC VL monitoring on time to initiation of intensive adherence counselling following virological failure among children and adolescents living with HIV.
iii. To estimate the effect of PoC VL monitoring on the proportion of children and adolescents living with HIV that experiences change of ART regimen within 6 and 12 months of follow-up.
iv. To determine the effect of PoC VL monitoring on the proportion of children and adolescents living with HIV that is retained in care at 6 and 12 months.

Objectives of Aim 2
i. To assess the acceptability of the implementation and scale-up of PoC VL testing and monitoring from the perspective of children, adolescents and their care givers. ii. To assess the critical determinants that may affect the implementation of PoC VL testing and monitoring from the perspective of healthcare workers and policy makers.
iii. To assess potential barriers and facilitators to implementation and scale-up of PoC VL testing and monitoring among children and adolescents living with HIV.
iv. To assess the incremental cost-effectiveness of PoC VL from a modified societal perspective using established models, with data collected alongside the implementation of the intervention combined with data estimated based on existing studies.

Uganda 2022-06-27 16:03:08 2025-06-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Mercy Nwankwo Chinenye
ID:
DEVELOPING A MODEL FOR COMMUNITY RESILIENCE AND RAPID RESPONSE TO HEALTH CHALLENGES OCCASIONED BY ENVIRONMENTAL AND CLIMATE CHANGE DISASTER
REFNo: HS2267ES

i. Explore common environmental and climate change disasters and their effects in Kigezi regions and effects.
ii. Assess community and institutional level preparedness to address and mitigate the impacts of environmental disasters.
iii. Develop a community disaster response capacity to tackle any future environmental disasters in the Kigezi region.

 Nigeria 2022-06-27 15:51:51 2025-06-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Racheal Naturinda
ID:
UNDERSTANDING THE RURAL COMMUNITY BELIEFS AND BARRIERS AFFECTING IN THE MANAGEMENT OF SNAKEBITE ENVENOMING IN YUMBE DISTRICT.
REFNo: HS2243ES

The main objective of the study is to understand the community belief and barriers affecting the management of snakebite envenoming in Yumbe district. Specific objectives of the study 1. To determine the current prevalence of snake bite envenoming in Yumbe district. 2. To explore the community beliefs related to the management of snake bite envenoming in Yumbe district Northern Uganda. 3. To explore the barriers affecting management of snake bite envenoming in Yumbe Northern Uganda.
Uganda 2022-06-27 14:48:19 2025-06-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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