Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
MOREEN ASASIRA
ID: UNCST-2026-R023307
Climate Resilient Tea Innovations In Uganda: A Case of Nature-Based Strategies in The Tea Value Chain
REFNo: A775ES

1.To evaluate farmer awareness, perceptions, and attitudes about the use of nature-based innovations in tea production 2.Establish the probability of use of nature-based innovations in tea production 3.To map the Uganda tea value chain 4.Establish perceived actor preference of the resilient tea varieties among tea chain actors
Ugandan 2026-07-16 20:13:13 2029-07-16 Agricultural Sciences Non-Clinical Trial Degree Award
Faizo Mugerwa
ID: UNCST-2025-R021837
EVALUATION OF THE FEASIBILITY AND ACCEPTABILITY OF AN EXHALED BREATH CONDENSATE SAMPLING DEVICE TO COLLECT A RESPIRATORY SAMPLE FOR LIPOARABINOMANNAN TESTING AMONG SUSPECTED TUBERCULOSIS PATIENTS AT MBARARA REGIONAL REFERRAL HOSPITAL (EXHALE STUDY)
REFNo: HS7963ES

To determine the sensitivity, specificity, of the Alere LAM test if used to test the sample collected by the EBC device among suspected tuberculosis patients. To assess the feasibility and acceptability of the EBC sampling device by patients, and healthcare workers. To determine the positive and negative predictive values of the Alere LAM test if used to test the sample collected by the EBC device among suspected tuberculosis patients.
Uganda 2026-07-16 20:11:09 2029-07-16 Medical and Health Sciences Non-Clinical Trial Degree Award
Catriona  Waitt John
ID: UNCST-2019-R001068
PHASE IV HUMAN LACTATION STUDY TO DESCRIBE THE PHARMACOKINETICS OF SEMAGLUTIDE IN LACTATING MOTHER-INFANT PAIRS IN UGANDA
REFNo: HS7927ES

Primary Objective
To define the transfer of semaglutide from mother to
breastfed infant during the postpartum period.

Secondary Objectives
? To determine the effect of maternal semaglutide on
breastmilk composition
? To determine the effect of maternal semaglutide on
breastmilk volume and breastfeeding practice
(frequency, duration)
? To determine the effect of maternal semaglutide on
infant growth
? To determine the effect of maternal semaglutide on
maternal HbA1c
? To measure the effect of maternal semaglutide on
body composition (BMI, lipid profile, hip/waist
circ)
? To evaluate participant perceptions of semaglutide
use and the paradigm of postpartum initiation of
medication
? To calibrate semaglutide PBPK model to predict
untested clinical scenarios (infant oral bioavailability,
maternal dose, dose ranges, milk
characteristics/composition)
UK 2026-07-16 20:06:07 2029-07-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bridgious Walusimbi
ID: UNCST-2026-R026054
Genetic causes and epigenetic consequences of infection in childhood (GECo)
REFNo: HS8006ES

The project will use human genetic tools to understand why some children are at increased risk of infection and how childhood infection shapes immune cell function and long-term health. To deliver this, the project has 3 linked work packages:
1. Work Package 1: Genome-wide association studies of common infection in Ugandan children, addressing:
� What are the human genetic drivers of common childhood infections in Ugandan children?
2. Work Package 2: eQTL and epigenetic studies in immune cells across variable burdens of childhood infection, addressing:
� Whether the epigenetic and transcriptional landscape of monocytes is shaped by childhood infection.
3. Work Package 3: Define clonal haematopoeisis (CH) in genomic data from Ugandan adults, addressing:
� What is the frequency of CH in Ugandan adults?
� Is risk of CH influenced by lifetime infection burden?


Uganda 2026-07-16 20:04:22 2029-07-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Annet Kahunde
ID: UNCST-2025-R021768
Subject Inversion Constructions in Rutooro: A Morphosyntactic, Semantic and Information Structural Account
REFNo: SS5204ES

i. To describe the agreement patterns in Rutooro SICs.
ii. To examine the thematic restrictions on arguments and predicates in Rutooro SICs.
iii. To analyse the role of information structure in Rutooro SICs.

Uganda 2026-07-16 20:01:01 2029-07-16 Social Science and Humanities Non-Clinical Trial Degree Award
Grace Nalukwago Kakoola
ID: UNCST-2025-R022885
IMPLEMENTATION OF THE NON-MOTORIZED TRANSPORT PILOT CORRIDOR AND ITS EFFECTS ON ACTIVE MOBILITY IN KAMPALA UGANDA.
REFNo: HS7552ES

I. To explore the acceptability, inclusivity, and perceived barriers influencing the intended use of Kampala’s NMT pilot corridor. II. To examine the effect of the NMT pilot corridor on overall walking and cycling experiences in comparison to a motorized road. III. To compare walking-related physical activity levels between adults working along the NMT pilot corridor and those working along a motorized road in Kampala. IV. To examine the implementation of the NMT pilot corridor by examining the strategies adopted, and their outcomes over time during the post-construction phase (2021-2026).
Uganda 2026-07-16 19:58:26 2029-07-16 Medical and Health Sciences Non-Clinical Trial Degree Award
PRISCILLA NASOLO
ID: UNCST-2025-R021017
MANAGEMENT PRACTICES AND PERFORMANCE IN UGANDA REVENUE AUTHORITY AND UGANDA BROADCASTING CORPORATIONS IN UGANDA
REFNo: SS5228ES

1. To assess the effect of internal audit functions on the performance of URA and UBC in Uganda.
2. To evaluate the influence of corporate governance mechanisms on the performance of URA and UBC in Uganda.
3. To assess the extent to which strategic plan compliance affects the performance of URA and UBC in Uganda.
4. To determine the effect of capacity-building initiatives on the performance of URA and UBC in Uganda.
5. To examine the moderating effect of organizational culture on the relationship between selected management practices and the performance of URA and UBC in Uganda.

Uganda 2026-07-16 19:56:25 2029-07-16 Social Science and Humanities Non-Clinical Trial Degree Award
Peter Waitt
ID: UNCST-2023-R007926
Developing Educational Resources Using a Participatory Model for Refugee Mothers Using Maternity Services in West Nile District: CLEAR � Clear Language and Engaging Resources
REFNo: HS8007ES

To support refugee communities in Northern Uganda to develop resources to communicate effectively, in languages which their communities understand to reduce the risk of post operative sepsis. We aim to co-create materials including simple written material, infographics, flip-charts and short videos.
UK 2026-07-16 19:55:13 2029-07-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Baker Ssekitto
ID: UNCST-2026-R025418
REGENERATIVE BUSINESS MODELS AS PREDICTORS OF INCLUSIVE DIGITAL SERVICE DELIVERY OUTCOMES IN RURAL WEST NILE, UGANDA: A MIXED METHODS STUDY
REFNo: SS5272ES

i. To explore the contextual requirements of a Regenerative Business Model in rural West Nile.
ii. To design a Regenerative Business Model artifact that integrates the identified dimensional requirements through stakeholder-validated Design Science Research workshops.
iii. To evaluate the effect of Regenerative Business Model dimensions on inclusive digital service delivery outcomes in rural West Nile, Uganda.
iv. To examine the moderating role of Community Engagement and Ownership on the dimensional relationships between RBM aligned practices and inclusive digital service delivery in rural West Nile, Uganda

Uganda 2026-07-16 19:54:05 2029-07-16 Social Science and Humanities Non-Clinical Trial Degree Award
ONESMUS BYAMUKAMA
ID: UNCST-2021-R013826
Association Between Pre-eclampsia/Eclampsia and Chronic Kidney Disease at 6 Months Postpartum Among Women in Southwestern Uganda
REFNo: HS7902ES

General Objective: To determine the incidence and risk factors of chronic kidney disease among women at 6 six months postpartum in southwestern Uganda, and to explore knowledge and perceptions of long-term renal health risks among women and healthcare providers Specific Objectives Primary Objectives 1.To determine the incidence and risk factors of chronic kidney disease among women at six months postpartum in southwestern Uganda. 2.To explore the knowledge and perceptions of postpartum women and healthcare providers regarding long-term renal health risks associated with pre-eclampsia/eclampsia. Secondary Objectives 1.To determine the proportion and factors associated with multi-organ dysfunction among pregnant women in southwestern Uganda. 2.To explore genetic polymorphisms potentially associated with distinct clinical phenotypes of pre-eclampsia among women in southwestern Uganda
Uganda 2026-07-16 19:52:20 2029-07-16 Medical and Health Sciences Non-Clinical Trial Degree Award
Fred Nalugoda
ID: UNCST-2021-R013343
Adapting a Transitional HIV Treatment Support Model for Persons Leaving Incarceration in Uganda
REFNo: SS5343ES

To identify key features of an evidence-based transitional HIV treatment support model requiring adaptation for implementation success in rural Uganda.
Uganda 2026-07-16 19:50:10 2029-07-16 Social Science and Humanities Non-Clinical Trial Non-degree Award
Felix Okello
ID: UNCST-2025-R021079
COMMUNITY-LED WATER, SANITATION, AND HYGIENE INTERVENTIONS TO PREVENT SCHISTOSOMIASIS: AN ANTHROPOLOGICAL PERSPECTIVE OF LAKE COMMUNITIES IN WESTERN UGANDA
REFNo: SS5342ES

The study aims to apply an anthropological lens to analyze how community-led water, sanitation, and hygiene (WASH) interventions are conceived, negotiated, implemented, and experienced in schistosomiasis-endemic lake communities in western Uganda, and how these processes shape water-contact behaviours, WASH practices, and patterns of vulnerability to schistosomiasis.

The specific objectives
The following objectives shall guide the study:
1. To analyze how socio-cultural beliefs, local knowledge systems, and structural inequalities in lake communities of Kagadi District, western Uganda, shape everyday water contact behaviors, sanitation practices, and participation in community-led WASH interventions for schistosomiasis prevention.
2. To critically examine the processes, power dynamics, and outcomes of engaging citizen scientists and local communities in co-designing WASH interventions, and how these co-created interventions reflect and negotiate local values, norms, and lived realities.
3. To interrogate the cultural logics, symbolic meanings, and gendered social relations that influence the acceptance, rejection, and everyday use of endod-based soap as a community-led strategy for schistosomiasis prevention.
4. To conduct a qualitative evaluation of how community-led WASH approaches reconfigure local power relations, social organization, and collective action, and how these transformations affect WASH coverage, utilization, and sustainability in schistosomiasis-endemic lake communities, Kagadi District, western Uganda.

Uganda 2026-07-16 19:47:07 2029-07-16 Social Science and Humanities Non-Clinical Trial Degree Award
Margaret Lubwama
ID: UNCST-2019-R000636
Comparison of bacteria isolated from the blood and gastrointestinal tract of patients with cancer and from their immediate hospital environment at the Uganda Cancer Institute (CompBac Study)
REFNo: HS7834ES

1. To determine the microbiological characteristics of the bacteria causing bacteremia, and colonizing the gastrointestinal tract of patients with at the Uganda Cancer Institute (UCI). 2. To determine the microbiological characteristics of the bacteria isolated from the immediate hospital environment of patients with cancer at the UCI. 3. To determine the phylogenetic characteristics of the bacteria causing bacteremia, colonizing the gastrointestinal tract and the immediate hospital environment of cancer patients at the UCI. 4. To determine the similarities or differences between the bacteria isolated above to previously isolated bacteria from cancer patients with bacteremia and from their immediate hospital environment at the UCI.
Uganda 2026-07-16 19:43:56 2029-07-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Nakayiki Lilian Nyanzi
ID: UNCST-2025-R019152
Validation of a region-specific Food Frequency Questionnaire for assessing habitual Dietary Intake and Indigenous Fruit and Vegetable consumption among Ugandan adults
REFNo: HS7771ES

To validate a region-specific Indigenous Fruit and Vegetable-Food Frequency Questionnaire (IFV-FFQ) as a tool for assessing habitual dietary intake, with a focus on Indigenous Fruits and Vegetables consumption, among Ugandan adults (>18 years).

Uganda 2026-07-16 19:41:34 2029-07-16 Medical and Health Sciences Non-Clinical Trial Degree Award
Ivan Segawa
ID: UNCST-2021-R012795
InstaGirls: On-Demand HIV Self?Testing, PrEP, and PEP Delivery for Online Sex Workers in Uganda
REFNo: HS7891ES

1. Assess the feasibility and acceptability of the InstaGirls on-demand, mobile-enabled courier delivery model for HIV prevention among online sex workers in Uganda. 2. Explore online sex workers’ perceptions, experiences, and perceived barriers and facilitators to using the InstaGirls model. 3. Estimate the cost of implementing the InstaGirls delivery model for HIV prevention in Uganda.
Uganda 2026-07-16 19:39:16 2029-07-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Mary Nabacwa Ssonko
ID: UNCST-2023-R007407
ASSESMENT OF MINISTRIES, DEPARTMENTS, AND AGENCIES (MDAs) PERFORMANCE ON CARE-RELATED ACTIONS IN UGANDA USING THE NATIONAL CARE POLICY SCORE CARD
REFNo: SS5483ES

Interrogate drivers of change or stagnation,Identify care policy influencing opportunities,Analyse Ministries, Departments and Agencies performance using the national care policy scorecard,Assess the performance of Ministries, Departments, and Agencies (MDAs) in Uganda in implementing care-related policies, investments, and interventions using the National Care Policy Scorecard,
Uganda 2026-07-16 19:36:40 2029-07-16 Social Science and Humanities Non-Clinical Trial Non-degree Award
Milly Kwagala
ID: UNCST-2025-R020368
INNOVATIVE FINANCING MODELS AND BUSINESS FINANCIAL SUSTAINABILITY PRACTICES AMONG WOMEN-LED ENTERPRISES: A CASE STUDY OF MUKONO DISTRICT
REFNo: SS5426ES

4.3. General Objective To examine how innovative financing models and related support mechanisms influence the business financial sustainability of women-led enterprises in Mukono District, and to generate evidence-based recommendations for enhancing their long-term growth and resilience. 4.4 Specific Objectives 1) To determine how access to different financing models (traditional microfinance, blended finance, digital savings platforms, and Personality?Based Credit Screening) is associated with key indicators of business financial sustainability (profit retention, employment creation, and asset accumulation) of women-led enterprises in Mukono District. 2) To assess the extent to which participation in training and capacity-building programmes, levels of financial and digital literacy, and involvement in SACCOs/community savings groups predict business financial sustainability among women-led enterprises in Mukono District. 3) To evaluate how engagement with policy support systems (government, NGO, and donor programmes) and the roles of key stakeholders (microfinance institutions, community organizations, and business associations) contribute to business financial sustainability among women-led enterprises in Mukono District.
Uganda 2026-07-16 19:34:53 2029-07-16 Social Science and Humanities Non-Clinical Trial Non-degree Award
Isaac Ssinabulya
ID: UNCST-2021-R004352
An mHealth implementation strategy to address the syndemic of mental illness, hypertension, and HIV in Uganda. Clinical Trial: Syndemic Adapted Medly Uganda (SAMU)
REFNo: HS7936ES

To evaluate the factors impacting sustained engagement in the adapted Medly Uganda,To assess the effectiveness of the Syndemic-Adapted Medly Uganda (SAMU) to improve mental health care cascade metrics. ,
Uganda 2026-07-16 19:31:27 2029-07-16 Medical and Health Sciences Clinical Trial Non-degree Award
LYDIA NAKIGANDA
ID: UNCST-2025-R016917
FEASIBILITY AND ACCEPTABILITY OF A PEER-DELIVERED HOME-BASED PrEP MODEL (HB-PREP) FOR FEMALE SEX WORKERS IN RURAL UGANDA
REFNo: HS7906ES

1. To adapt and co-develop a peer-delivered, home-based PrEP care model for female sex workers in rural Uganda 2. Conduct a pilot RCT to evaluate the acceptability and feasibility of the HB-PrEP care model for FSW in Uganda. 3. Qualitatively examine participants’ and interventionists’ experiences with the care model and identify facilitators and barriers to its implementation
Uganda 2026-07-16 19:28:09 2029-07-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Musa Sekikubo
ID: UNCST-2021-R014010
A phase 3, randomized, placebo-controlled, double-blinded trial to evaluate the safety, tolerability, and immunogenicity of a multivalent Group B Streptococcus vaccine in healthy pregnant women and their infants.
REFNo: HS8122ES

To evaluate the aggregate predicted VE combining all 6 serotypes in GBS6 to provide protection from invasive GBS EOD based on serotype-specific anti-CPS IgG concentrations measured in infants at birth,To evaluate the aggregate predicted VE combining all 6 serotypes in GBS6 to provide protection from invasive GBS LOD based on serotype-specific anti-CPS IgG concentrations measured in infants at birth.,To assess the ability of GBS6 to induce anti-CPS IgG antibody levels predicted to provide protection from invasive GBS early-onset disease (EOD) caused by the 6 individual vaccine serotypes (Ia, Ib, II III, IV, and V) in infants when GBS6 is administered to healthy pregnant women.,To assess the ability of GBS6 to induce anti-CPS IgG antibody levels predicted to provide protection from invasive GBS late-onset disease (LOD) caused by the 6 individual vaccine serotypes (Ia, Ib, II III, IV, and V) in infants when GBS6 is administered to healthy pregnant women.,To assess the safety of maternal immunization in infant participants born to pregnant women who were vaccinated with GBS6 during pregnancy.,To describe the safety and tolerability of GBS6 in maternal participants,
Uganda 2026-07-16 19:21:43 2029-07-16 Medical and Health Sciences Clinical Trial Non-degree Award
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