Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Robert MPIIRA
ID: UNCST-2022-R005391
A Pilot Study on Workers’ Exposure to Air, Noise and Water Pollution, Heat, Flooding, and Waste across Homes, Workplaces and Commutes, and Its Effects on Their Health, Productivity, and Behavior in Kampala Metropolitan Area.
REFNo: SS5590ES

(i) To assess objective and perceived (self-reported) exposure to water, noise and air pollution, heat (temperature, humidity), flooding and waste at the home, at the workplace, and along the commute for prime-age workers in two contrasting parishes of the Kampala Metropolitan Area.
(ii) To characterise the socio-economic gradient of this joint exposure — the association between exposure and respondents' occupation, sector of employment, formality, earnings, and education.
(iii) To examine workers' beliefs about environmental conditions, pay, and working conditions at workplaces other than their own; compare these beliefs against the objective measurements and quantify the resulting perceived–objective exposure gaps ("information mismatches").
(iv) To analyse the association between joint environmental exposure and self-reported outcomes — including health (recent illness, respiratory and heat-related symptoms), productivity (work hours, days affected), and protective practices (actions taken at home, at the workplace, and along the commute).
(v) To validate the operational feasibility of the sampling, listing, survey, and monitoring protocol — measured by listing rates, eligibility rates, refusal rates, interview duration, item non-response, and monitor compliance — for deployment at scale in the subsequent full-scale study.

Uganda 2026-07-24 11:46:25 2029-07-24 Social Science and Humanities Non-Clinical Trial Non-degree Award
Richard Kica Ocaya
ID: UNCST-2026-R026002
Preventive health practices for Reducing Under-Five Mortality in the Refugee and the Rural Host Communities in Palabek Settlement, Uganda
REFNo: SS5566ES

i) To determine the level of knowledge of cause, symptoms and preventive measures for malaria among the refugee and host community households;

ii) To determine the attitude of the refugee and the host community households towards preventive health practices for malaria;

iii) To determine the extent of practice of preventive health behaviors and related challenges for malaria in the refugee and host community households; and

iv) To develop knowledge, attitude and practice (KAP) based primary prevention model for reduction of U5M for the refugee and the rural host communities.

Uganda 2026-07-24 11:39:56 2029-07-24 Social Science and Humanities Non-Clinical Trial Degree Award
JOYCE NAMWASE
ID: UNCST-2024-R005002
STRENGTHENING GERIATRIC SERVICES AT BUTABIKA NATIONAL REFERRAL MENTAL HOSPITAL: A SITUATIONAL ANALYSIS AND IMPLEMENTATION OF AN INTEGRATED CARE FOR OLDER PEOPLE (ICOPE)–BASED SCREENING AND CARE PATHWAY
REFNo: HS7950ES

III. To introduce and implement a routine standardized geriatric health screening and care pathway for patients aged 60 years and above at BNRMH using integrated care for older people (ICOPE).,II. To identify the potential barriers and facilitators of a geriatrics screening and care pathway at BNRMH.,I. To determine the prevalence of geriatric health conditions ands individuals screened in the past 12 months at Butabika NRMH.,
Uganda 2026-07-24 11:33:57 2029-07-24 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Lauren Hookham
ID: UNCST-2024-R016386
Characterising colonisation and transmission of Multi-Drug-Resistant Gram-negative organisms in maternal care in Uganda - GRam negative Resistance In Pregnancy (GRIP)
REFNo: HS8128ES

Overall aim: To characterise colonisation and transmission of multi-drug-resistant Gram-negative bacteria (MDR-GNB) within the maternity unit at Kawempe National Referral Hospital (KNRH), Kampala, Uganda, and evaluate interventions to reduce environmental contamination and improve infection prevention and control (IPC) practices.

Work Package 2: Characterise MDR-GNB colonisation in women undergoing elective and emergency caesarean section, their newborns, and the maternity hospital environment at KNRH; identify individual, clinical and environmental risk factors for maternal colonisation; and examine genetic similarity between environmental and patient-derived MDR-GNB strains.

Work Package 3: Explore how systemic and environmental context, resource availability, infrastructure, supervision, attitudes, perceptions, roles, responsibilities, training needs, communication and feedback influence IPC and cleaning practices among healthcare workers, cleaning staff and supervisors.

Work Package 4: Use Intervention Mapping to conduct a needs assessment and identify behavioural and environmental determinants; implement structured training for cleaning staff using the WHO Environmental Cleaning Toolkit; assess changes in the burden of Gram-negative and MDR Gram-negative bacteria in the maternity/postnatal environment before and after training; and explore the feasibility of a contextually appropriate supervision or audit tool.



UK 2026-07-24 11:30:42 2029-07-24 Medical and Health Sciences Non-Clinical Trial Degree Award
Eric Okwir
ID: UNCST-2025-R019992
Greening the tea? Ecolabelling, anticlimax, and the remaking of conservation people in Uganda
REFNo: SS5586ES

Objectives: Main Objective 1. This study interrogates whether and how local tea producers advance beyond the failure of ecolabelling, to adapt its elements into locally-defined environmental ideals that transform tea production and conservation in the KNP landscape. Specific Objectives 1. In what ways do conservation and political-economic processes intersect to produce conditions befitting the introduction of ecolabelling around KNP? 2. How does the nesting of ecolabel discourses with KNP’s contextual discourses produce anticlimax? 3. What rationalities do tea producers draw on to navigate the anticlimax of ecolabelling and does this remake them into new conservation people? 4. In what ways do these alternative rationalities support the transition to more transformative conservation?
Uganda 2026-07-24 10:12:52 2029-07-24 Social Science and Humanities Non-Clinical Trial Degree Award
Andrew Hughes David
ID: UNCST-2025-R021951
Hybrid Mobilities in Urban Africa: Congolese Refugees Navigating Environmental Disruption in Kampala, Uganda
REFNo: SS4686ES

Main Objective 1. - To examine how Congolese refugees in Kampala\'s informal settlements navigate environmental flooding through hybrid mobility practices—combining physical movement, digital connectivity, and transnational networks—and how spatial variations between central and peripheral settlements influence livelihood resilience and adaptive strategies. Specific Objectives 1. - To document how environmental flooding events disrupt everyday mobility practices and how refugees adapt to sustain social and economic networks during these disruptions 2. - To analyze spatial and social variations between central (Mengo-Kisenyi) and peripheral (Kawempe I) settlements that influence refugees\' adoption of hybrid mobility strategies and livelihood resilience 3. To examine how gendered, generational, and household dynamics shape refugees’ mobility constraints, risk exposure and adaptive practices during flooding.
UK 2026-07-20 12:12:29 2029-07-20 Social Science and Humanities Non-Clinical Trial Degree Award
Wilber Sabiiti
ID: UNCST-2024-R016293
Field clinical evaluation of the point of care diagnostic algorithm combining BBIOxford lateral flow device and Dragonfly molecular diagnostic device for improved Mpox diagnosis in Uganda
REFNo: HS8035ES

Overall Objective
To evaluate the diagnostic performance, operational feasibility, and cost implications of a decentralized two-step mpox point-of-care diagnostic algorithm combining the BBIOxford lateral flow antigen test with the Dragonfly molecular diagnostic platform among clinically suspected mpox patients in Uganda.

Specific Objectives

1. To validate the mpox community testing model at the study sites with key stakeholders.
2. To determine the diagnostic sensitivity, specificity, and predictive values of the BBIOxford rapid diagnostic test alone, the Dragonfly molecular platform alone, and the combined two-step diagnostic algorithm, using PCR as the reference standard.
3. To document and compare the implementation costs of the different diagnostic testing strategies at both per-test and national scale.
4. To identify circulating MPXV clades, detect recombinant strains, and map their prevalence and spatial distribution using PCR and genomic sequencing.
5. To quantify selected MPXV antigens and assess the relationship between antigen load and diagnostic test performance.
6. To assess the operational feasibility, usability, and acceptability of the Dragonfly molecular platform and the two-step diagnostic algorithm among healthcare workers and patients.

Uganda 2026-07-17 19:22:15 2029-07-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Nazarius Tumwesigye Mbona
ID: UNCST-2019-R000664
KOFIH/OPM BUSOGA WASH PROJECT ON WATERBORNE DISEASE REDUCTION AND PREVENTION -AN ENDLINE SURVEY
REFNo: HS8079ES

3.1 General Objective
Assess changes in WASH indicators and waterborne disease outcomes following implementation of project interventions
3.2 Specific objectives
i. Measure project outcomes against baseline data and defined performance indicators;
ii. Evaluate the effectiveness of interventions in improving access to clean water, sanitation, and hygiene practices;
iii. Identify successes, challenges, and gaps in project implementation;
iv. Provide evidence-based recommendations for sustainability, replication, and scaling of interventions;

Uganda 2026-07-17 17:12:16 2029-07-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Mohammed Hamid Osman Ali
ID: UNCST-2026-R024137
Harnessing Borassus Fruits as a Sustainable Source of Biofuels: A Techno-Economic Feasibility Study at Soroti University
REFNo: SIR726ES

Overall Objective To evaluate and demonstrate the potential of Borassus tress as a sustainable source of renewable energy for Soroti University and its surrounding community by 2026. Smart Specific Objectives 1. To analyze the chemical composition (sugar content, metals, calorific value and moisture) of Borassus fruits and sap, and quantify their potential yield for biofuels production. 2. To conduct bench scale, high precision sap to biofuel conversion through fractional distillation and refining. 3. To conduct a techno-economic feasibility assessment comparing Borassus-derived energy with current energy sources (national electricity grid, firewood and charcoal) used in Soroti University.
Sudan 2026-07-17 17:09:06 2029-07-17 Engineering and Technology Non-Clinical Trial Non-degree Award
Sam Ononge
ID: UNCST-2020-R000328
Evaluation of a self-monitoring tool to detect early obstetric complications in the immediate postpartum period: A validation study of the ImPoWa tool
REFNo: HS7770ES

Main Objective
1. To evaluate the validity of the ImPoWA tool in facilitate self-monitoring for early warning signs of an obstetric complication during the immediate postpartum period by women and their birth companions
Specific Objectives
1. To explore the accuracy of the mothers’ and companions’ assessments when using the tool
2. To ?Explore the reliability of mothers’ and companions’ assessments when using the tool in different clinical contexts and time periods
Uganda 2026-07-17 17:05:51 2029-07-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Miriam Nakalembe
ID: UNCST-2021-R014040
A PHASE 3, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLINDED TRIAL TO EVALUATE THE SAFETY, TOLERABILITY, AND IMMUNOGENICITY OF A MULTIVALENT GROUP B STREPTOCOCCUS VACCINE IN HEALTHY PREGNANT WOMEN AND THEIR INFANTS (BEATRIX)
REFNo: HS8109ES

To describe GBS serotype-specific IgG concentrations measured from dried blood spots in a subset of infant participants at birth; To describe anti-GBS antibodies present in breast milk in a subset of maternal participants vaccinated with GBS6 To describe serum IgG responses to active immunization with diphtheria toxoid�containing vaccine and PCV in infant participants born to maternal participants vaccinated with GBS6 versus placebo. To describe PCV serotype-specific OPA titers after a toddler vaccination in infant participants born to maternal participants vaccinated with GBS6 or placebo. To additionally describe the immune responses to CPS elicited by GBS6 when administered to healthy pregnant women. To describe serum IgG responses to active immunization with diphtheria toxoid� containing vaccine and/or PCV in infant participants born to maternal participants vaccinated with GBS6 versus placebo.,To further describe the immunogenicity of GBS6 in maternal participants when administered to healthy pregnant women. To describe anti-CPS IgG antibody levels predicted to provide protection from invasive GBS EOD and LOD, separately, caused by the 6 individual vaccine serotypes (Ia, Ib, II, III, IV, and V) in infants when GBS6 is administered to healthy pregnant women,To assess the ability of GBS6 to induce opsonophagocytic activity (OPA) titers at birth in infant participants born to maternal participants vaccinated with GBS6,To describe anti-CPS IgG antibody levels in infant participants born to maternal participants vaccinated with GBS6. To describe anti-CPS IgG antibody levels predicted to provide protection from invasive GBS disease (all disease) caused by the 6 individual vaccine serotypes in infants when GBS6 is administered to healthy pregnant women,To evaluate the aggregate predicted VE combining all 6 serotypes in GBS6 to provide protection from invasive GBS EOD based on serotype-specific anti-CPS IgG concentrations measured in infants at birth,To evaluate the aggregate predicted VE combining all 6 serotypes in GBS6 to provide protection from invasive GBS LOD based on serotype-specific anti-CPS IgG concentrations measured in infants at birth. To assess the ability of GBS6 to induce anti-CPS IgG antibody levels predicted to provide protection from invasive GBS early-onset disease (EOD) caused by the 6 individual vaccine serotypes (Ia, Ib, II III, IV, and V) in infants when GBS6 is administered to healthy pregnant women,To assess the ability of GBS6 to induce anti-CPS IgG antibody levels predicted to provide protection from invasive GBS late-onset disease (LOD) caused by the 6 individual vaccine serotypes (Ia, Ib, II III, IV, and V) in infants when GBS6 is administered to healthy pregnant women,To assess the safety of maternal immunization in infant participants born to pregnant women who were vaccinated with GBS6 during pregnancy. To describe the safety and tolerability of GBS6 in maternal participants
Uganda 2026-07-17 17:00:50 2029-07-17 Medical and Health Sciences Clinical Trial Non-degree Award
Esther Nanfuka Kalule
ID:
EXPLORING ACCELERATING IMPACT FOR YOUNG WOMEN (AIM) PROGRAM COHORT # 2 AND # 3 LIVELIHOOD EXPERIENCES: A QUALITATIVE STUDY IN UGANDA
REFNo: SS5437ES

Main objective
This study seeks to explore the AIM financial inclusion journey for cohort #2 participants and progress thus far in the livelihoods pathway for those in cohort #3.


Specific objectives
1.To examine opportunities and challenges experienced by cohort #2 project participants and staff in transitioning participants to microfinance.
2.To identify opportunities and challenges experienced by cohort #3 project participants and staff during implementation of cost sharing and coaching elements of AIM 2.0.
3.To document cohort #2 and #3 participants’ perspectives on the impact of AIM on their lives.

Uganda 2026-07-17 16:20:28 2029-07-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
ConfiSign HCV Self-Test: Evaluation of Clinical Performance and Usability in the hands of untrained users.
REFNo: HS8059ES

The product design, instructions for use and usability of the ConfiSign HCV Self-Test for self-testing will be assessed by investigation of the following secondary objectives: - Clarity and usability of instructions and packaging � participant-reported ease of understanding and following instructions, collected via a structured questionnaire. - Occurrence of user errors � frequency and type of errors and/or deviations from the test procedure observed during the study - Invalid test results � proportion of tests yielding invalid results due to user errors.,The primary and overall objective of this study is to evaluate the performance and the usability of the ConfiSign HCV Self-Test in the hands of untrained users, recruited in a high prevalence HCV region (> 2%), who have no or limited experience in self-testing. ,
Uganda 2026-07-17 16:17:16 2029-07-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Herbert Muyinda
ID: UNCST-2019-R000373
Digital Humanitarianism: Governing Vulnerable Populations in an Age of Technological Innovation in Uganda
REFNo: SS5510ES

The general objective of this study is to provide an in-depth understanding of the role of digital innovations in (re)shaping the way humanitarian action is understood, conceived and practiced - how DTs are changing the face of Humanitarian Response in Uganda. The specific objectives are:

1. To analyze how DTs are tested on populations and how they influence conceptions of vulnerability and needs as well as solutions to address them

2. To examine how DTs are transforming humanitarian action among those displaced, the host communities, and the humanitarian workers tasked with safeguarding their rights of the refugees.

3. To identify the barriers in uptake and adaptation of DTs among refugees and the humanitarian workers

Uganda 2026-07-17 16:11:54 2029-07-17 Social Science and Humanities Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
Simplified Antenatal Integrated Testing,Partner inclusion and same day Hepatitis B prophylaxis to scale Prevention in Uganda
REFNo: HS8027ES

To determine the acceptability, feasibility, and patient-level costs of the chronic care model for HBV management at intervention sites. ,To determine the optimal linkage to chronic care pathways under the expanded WHO treatment criteria at intervention sites. ,To determine the acceptability, feasibility, and patient-level costs of family-based testing.,To ascertain the yield of family- and partner-based testing of index cases (number positive / number tested) at intervention sites. ,To evaluate the acceptability, feasibility, and patient-level costs of the test-and-prophylaxis approach for both patients and healthcare providers at the intervention sites.,To assess the effectiveness of the test-and-prophylaxis approach, measured through the PMTCT cascade (prophylaxis initiation, adherence, birth dose coverage, and infant HBV status at 9 months) at the intervention sites. ,To measure the change in uptake and completion rate of antiviral prophylaxis (AVP) among HBsAg-positive women in ANC in the intervention as compared to the comparison sites.,
Uganda 2026-07-17 16:09:55 2029-07-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Benson Nasasira
ID: UNCST-2025-R023111
Evaluating the Impact of Integrating Tuberculosis Screening into Routine Community-Based Child Health Services on Childhood Tuberculosis treatment coverage in Kalangala District, Uganda � A quasi-experimental study
REFNo: HS8056ES

Primary Objective To compare monthly childhood TB treatment coverage—defined as the proportion of National TB and Leprosy Program (NTLP) paediatric TB treatment targets achieved among children aged 0–14 years, before and after integration of TB screening into routine community-based child health outreach activities in Kalangala District. Secondary Objectives • To compare the monthly absolute number of presumptive paediatric TB cases identified before and after integration. • To compare the monthly proportion of presumptive paediatric TB cases completing diagnostic evaluation before and after integration. • To compare the monthly proportion of all TB cases that are children aged 0–14 years before and after integration. • To assess the feasibility and acceptability of integrating TB screening into routine child health outreaches from the perspectives of health workers and Village Health Team (VHT) members.
Uganda 2026-07-17 15:59:12 2029-07-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Laura LaBarge Rose
ID: UNCST-2025-R017293
Next-generation animal tracking for research and conservation the Mweya ATLAS project
REFNo: NS951ES

1. To obtain proof-of-principle for reverse-GPS tracking of wild mammals, using banded mongooses as a model system. 2. To test how group ranging behaviour is influenced by ecology and intergroup interactions. 3. To test the consequences of variation in group movement patterns for reproductive success and population dynamics. 4. To use ATLAS data to anticipate and record intergroup encounters and investigate the causes of intergroup aggression.
USA 2026-07-17 15:44:11 2029-07-17 Natural Sciences Non-Clinical Trial Non-degree Award
Christine  Wiltshire Sekaggya
ID: UNCST-2019-R000578
PRIVATE HEALTH PROVIDERS POINT OF CARE TESTING FOR TUBERCULOSIS IN SELECTED URBAN PRIVATE FACILITIES IN UGANDA.
REFNo: HS7989ES

1. To evaluate whether use of near - point of care (NPOC) for tuberculosis (TB) testing using the oral and sputum-based swabs is feasible and acceptable in private health provider settings in Wakiso and Kampala districts. 2. To determine the effect of use of NPOC testing on time to TB diagnosis and time to treatment initiation following TB screening and testing at private health facilities in Wakiso and Kampala districts.
Uganda 2026-07-17 15:42:29 2029-07-17 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Abel  Kakuru
ID: UNCST-2022-R009193
Perennial Malaria Chemoprevention With Dihydroartemisinin-Piperaquine Versus Sulfadoxine-Pyrimethamine Plus Amodiaquine Versus No Chemoprevention: A Double Blind Randomised Controlled Trial
REFNo: HS7437ES

1. To compare the protective efficacy of combining R21 vaccination with PMC-DP or PMC-SPAQ vs R21 alone up to 5 years of age.
2. To compare the safety and tolerability of combining R21 vaccination with PMC-DP vs. PMC-SPAQ.
3. To determine the impact of PMC on the drug resistance landscape and R21-specific immunogenicity and durability.

Uganda 2026-07-16 20:29:47 2029-07-16 Medical and Health Sciences Clinical Trial Non-degree Award
Andrew Muhumuza
ID: UNCST-2022-R009010
CAN TOUCH HELP IDENTIFY PATIENTS WHO NEED AN IMMEDIATE FULL CLINICAL ASSESSMENT BY A PHYSICIAN?
REFNo: HS7768ES

To find out if touch can help identify patients who need an immediate full clinical assessment by a physician.,To compare the ability to predict 24-hour mortality by temperature and moisture subjectively assessed by touch in different parts of the body ,To compare the ability of temperature and moisture subjectively assessed by touch to predict 24-hour mortality with standard thermometry and the National Early Warning Score,
Uganda 2026-07-16 20:26:26 2029-07-16 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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