Edwin Nuwagira
ID: UNCST-2021-R013488
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EFFICACY AND TOLERABILITY OF SHORT-COURSE INTERMITTENT INTRAVENOUS LIPOSOMAL AMPHOTERICIN B VERSUS ORAL POSACONAZOLE FOR CHRONIC PULMONARY ASPERGILLOSIS: A PHASE IIA, PROSPECTIVE, MULTI-CENTRE, RANDOMIZED, CONTROLLED, OPEN-LABEL, FEASIBILITY TRIAL
REFNo: HS6400ES
5. Assess recruitment and retention of patients with CPA on a trial to inform design and sample size for a definitive efficacy trial.,4. To assess adherence to posaconazole therapy,3. To evaluate the utility of different trial endpoints (change in Aspergillus IgG antibody titer, radiological improvement, step test and weight) across groups.,2. To compare 12-month all-cause mortality in each arm,1. To measure emergence of isolates of Aspergillus with resistance/reduced susceptibility to posaconazole in both arms. ,1. Compare the efficacy and tolerability of 1) short course, high dose of intravenous liposomal amphotericin B, 2) short course, high dose of intravenous liposomal amphotericin B followed by daily posaconazole, or 3) posaconazole alone for the treatment of CPA for 6 months.,
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Mbarara, Medical cell
Gulu, Medical cell
Kampala, Salama road
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Uganda |
2025-08-26 13:48:03 |
2028-08-26 |
120 |
Adults, age > or = to 18 years
All Ugandan tribes living in Ankole/Kigezi sub region
Both women and men |
Fungal Infection Trust |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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RACHEL LUWAGA
ID: UNCST-2024-R003040
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EFFECT OF A DISCHARGE EDUCATION INTERVENTION ON PREVENTION OF
PUERPERAL SEPSIS AMONG MOTHERS WHO HAVE DELIVERED BY CESAREAN
SECTION IN SOUTHWESTERN UGANDA
REFNo: HS5504ES
. To determine the prevalence, factors, and outcomes associated with readmission of
mothers who had undergone cesarean section delivery due to sepsis in Mbarara Regional
Referral Hospital
2. To describe the experiences and practices of mothers in the prevention of puerperal sepsis
post cesarean section in Mbarara Regional Referral Hospital
3. To explore the barriers and facilitators to the provision of discharge instructions
regarding puerperal sepsis prevention for mothers who have delivered by cesarean
section in Mbarara Regional Referral Hospital
4. To determine the effect of a discharge education intervention in the prevention of puerperal of
sepsis in post-cesarean section mothers.
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Mbarara, Kamukuzi
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Uganda |
2025-08-18 13:28:40 |
2028-08-18 |
8-10 mother with peurperal sepsis,8-10 health workers, 130 pr |
mothers diagnosed with puerperal sepsis after cesarean section delivery
Health workers working on the obstetric and gynecology ward
Primipara mothers who have delivered by cesarean section |
self sponsorship |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
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Claire Nimusiima
ID: UNCST-2025-R017994
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Assessing the association Between Disability and Mental Health among older adults: A Secondary Data Analysis of the Health and Wellbeing of Older People - Wave 5 study in Uganda.
REFNo: HS6244ES
Primary Objective
To assess the association between disability and mental health outcomes among older adults in Uganda.
Secondary Objectives
- To determine the prevalence of mental health disorders among older adults with and without disabilities.
- To explore whether any socio-demographic factors modify the association between disability and mental health outcomes.
- To assess whether HIV status confounds the association between disability and mental health outcomes.
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Not Applicable (N/A), Not Applicable
|
Uganda |
2025-08-08 13:49:11 |
2028-08-08 |
588 |
The WOPS V study population consists of older adults (aged 50 years and above), including both HIV-positive individuals on ART and HIV-negative individuals. In Wave 5, 588 participants were surveyed.
The WOPS study was conducted in 3 districts in Uganda: Masaka, Kalungu, and Wakiso. Participants are recruited from rural, peri-urban, and urban settings, including community health centers and HIV care clinics. The study was coordinated by the MRC/UVRI & LSHTM Uganda Research Unit.
It is this study population that shall be included in the "Assessing the association Between Disability and Mental Health among older adults: A Secondary Data Analysis of the Health and Wellbeing of Older People - Wave 5 study in Uganda" study |
No funding is available for this proposed research as this is going to use already existing dataset. However, the WOPSV study was sponsored by National Institutes of Ageing, USA, through World Health Organization Study on Global Ageing and Adult Health (SAGE) |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
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David Meya Bisagaya
ID: UNCST-2019-R000837
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A Phase 2 Novel Antimicrobial Combination Therapy to Treat Tuberculous Meningitis
REFNo: HS5711ES
1. Assess the safety and efficacy of a novel anti-TB combination regimen with greater bactericidal activity than current standard of care (SOC) therapy
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Kampala, all parishes
Mbarara, all parishes
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Uganda |
2025-07-18 14:05:06 |
2028-07-18 |
150 |
All adults with TBM meningitis (definite, probable) with HIV, per the uniform TBM case definition. |
Meningitis Foundation |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Felix Magala
ID: UNCST-2024-R016043
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Incidence of Post-Operative Sore Throat Among Patients Undergoing Open Abdominal Surgery: A Randomized Control Trial Comparing Video and Direct Laryngoscopy
REFNo: HS5685ES
To compare the incidence of POST, and recovery from POST following intubation using Video laryngoscopy or Direct laryngoscopy during general anaesthesia among general surgery patients undergoing laparotomy at MRRH
1. To determine the incidence of POST in the first 24 hours following intubation with either Video-laryngoscopy or Direct-laryngoscopy for patients undergoing open abdominal surgery at MRRH
2. To determine the recovery time from POST among patients intubated with Video laryngoscopy compared to Direct-laryngoscopy.
3. To describe the symptoms associated with POST amongst patients intubated for open abdominal surgery
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Mbarara, Mbarara
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Uganda |
2025-07-11 18:00:56 |
2028-07-11 |
148 |
Study population
We will recruit surgical patients scheduled for laparotomy (open abdominal surgery, requiring an incision of at least 5cm) at the surgical and emergency ward of MRRH.
Eligibility criteria
We shall include;
• General surgery patients scheduled for laparotomy under general anaesthesia.
• Aged 18 years and above.
• ASA class I to III.
• Mallampati class I to II.
We shall exclude:
• Have had an upper respiratory tract infection or have had an endoscopy or bronchoscopy procedure in the past 2 weeks.
• Have had any ENT, neck or thoracic surgery in past 3 months.
• Those who have symptoms of gastroesophageal reflux disease (GERD).
• And those with history of smoking.
• Those with anatomical abnormality in the neck, head, face.
• Edentulous patient.
• Patients with suspected difficult airway as assessed by the principal investigator.
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self sponsored |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
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