Approved Clinical Trials This page provides a searchable list of all clinical trial research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology (UNCST).
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Name Title Study Sites Nationality Approval Date Expiry Date Sample Size Target Population Sponsors Field of Science/Classification Trial Type Research Type  
Catriona  Waitt John
ID: UNCST-2019-R001068
 Implementation of a "bundle of care" to improve anticoagulation control in patients receiving warfarin in Uganda and South Africa
REFNo: HS1422ES

Primary objective is to evaluate whether implementation of warfarin bundle improves time in therapeutic range

Secondary objectives are:
-To evaluate whether implementation of the warfarin bundle improves time to achieving a therapeutic INR
-Whether implementation of the warfarin bundle affects the occurrence of adverse events(death, bleeding and thrombotic events)
-whether staff find the interventions contained in the bundle acceptable
-To explore patients' experiences and acceptability of the package of care, and
-Whether the bundle represents good value for money
 Kampala, Salaama
Kampala, Mulago
 UK 2021-07-09 2024-07-09 444 Adult patients (18 years or older),male or female newly initiated on warfarin for the first time University of Liverpool Medical and Health Sciences Clinical Trial Non-degree Award
Deborah  Ojiambo
ID:
Efficacy of Group Activity Adherence Counselling (GAAC) for Adolescents with Unsuppressed HIV viral load at three large HIV clinics in Uganda: Randomized controlled trial
REFNo: SS805ES

1.To examine the barriers such as behavior problems and mental health problems to adherence experienced by adolescents living with HIV.
2.To evaluate the efficacy of GAAC in addressing barriers to adherence among adolescents living with HIV.

3.To assess whether GAAC is associated with viral load suppression, among adolescents living with HIV compared to Standard Service Provision (SSP)
 Kampala, Mulago 1
Wakiso, Entebbe
 Uganda 2021-07-07 2024-07-07 300 The population for this study is school-going adolescents living with HIV (12-18 years) who received ART for at least 6 or more months at Mulago ISS, TASO Mulago, TASO Entebbe HIV clinics Makerere University Research and Innovation Fund (RIF) funded by Uganda government Social Science and Humanities Clinical Trial Non-degree Award
Susan  Nabadda
ID: UNCST-2020-R014331
 Diabetes Mellitus Tuberculosis and HIV multimorbidities among adult patients attending Kiruddu National Referral Hospital, Uganda Version 2 7/26/2020.
REFNo: HS1386ES

General Objective
The overall objective of this project is to determine the prevalence of DM among patients with either TB, HIV, and TB-HIV co morbidity. This will help to assess the prevalence of silent DM in these categories of patients.
Specific objectives

1. To describe the prevalence of DM among either TB patients or HIV patients or patients with both TB and HIV co morbidity attending the Kiruddu hospital outpatient clinics
2. To determine the factors associated with DM in patients with HIV alone, TB alone and HIV – TB co-infection.

 Kampala, Buziga
 Uganda 2021-06-29 2024-06-29 1000 Adults of 18 years and above, HIV-infected patients or TB patients receiving care at Kiruddu National Referral Hospital (patients with both TB and HIV will also be included) However, patients who will be critically ill and in need of emergency clinical c Beckton Dickinson and the United States Centers for Disease Control and Prevention (CDC), Uganda. Medical and Health Sciences Clinical Trial Non-degree Award
JUSTUS BARAGEINE KAFUNJO
ID: UNCST-2020-R014150
 COMPREHENSIVE REINTEGRATION ASSISTANCE FOR WOMEN WITH FEMALE GENITAL FISTULA: INTERVENTION PILOTING
REFNo: SS890ES

Aim 1: To understand the feasibility and acceptability of a pilot reintegration program for female genital fistula. Aim 2. To assess the acceptability of the pilot reintegration intervention to patients, intervention implementors. Aim 3. To assess the preliminary effectiveness of the pilot reintegration intervention.
 Kampala, MULAGO
,
Uganda 2021-06-24 2024-06-24 40 (30 women to participate in the intervention and indepth interview plus 10 stake holders Women aged 18 years and above or considered emancipated minors under Ugandan law who are undergoing genital fistula surgery. U.S. Eunice Shriver Kennedy National Institute of Child Health and Development. Social Science and Humanities Clinical Trial Non-degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
 Drug Interactions between Dolutegravir (DTG) and escalating-doses of Rifampicin (RIF) Study
REFNo: HS1376ES

The secondary objectives of the trial are to determine the safety and tolerability of the DTG/RIF combination, the PK of RIF, induction of PgP and CYP3A4 and effect of DTG on appetite,Primary Objective The primary objective of the study is to determine changes to the PK parameters of DTG when administered with standard, medium and high doses of RIF in HIV-negative, TB-monoinfected participants coming to the end of continuation TB therapy with standard doses of RIF and INH over a 10 week period,
 Kampala, Mulago 1
 Nigeria 2021-06-23 2024-06-23 18 Inclusion Criteria • Ability to give informed consent prior to participation • Willing and able to comply with all study requirements • Receiving standard doses of RIF and INH • HIV antibody negative • Male or non-pregnant, non-breastfeedin University of Liverpool Medical and Health Sciences Clinical Trial Non-degree Award
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