Pontiano Kaleebu
ID: UNCST-2020-R019901
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Performance evaluation of the CheckNOW™ HIV Self-Test study
REFNo: HS2170ES
1. To evaluate the performance (Sensitivity and specificity) of the CheckNOW™ HIV SELF TEST when compared to the Genscreen ULTRA HIV1/2 Ag/Ab EIA followed by the Murex diasorin HIV1/2 Ag/Ab combination (reference testing) in the laboratory and the national testing algorithm.
2. To describe the clinical performance (sensitivity and specificity) of the CheckNOW™ HIV SELF TEST, as obtained by the professional users, when compared to the reference testing and the national testing algorithm.
3. To describe the clinical performance (sensitivity and specificity) of the CheckNOW™ HIV SELF TEST, as obtained by the lay users, when compared to the reference testing and the national testing algorithm.
4. To assess the accuracy of the lay user interpretation of the HIVST result. This will be compared with the interpretation by the RA.
5. To assess the usability of the CheckNOW™ HIV SELF TEST. The usability of the test will be evaluated by questionnaires completed by the study staff observers and by the lay users.
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Kampala, Kampala
Kalungu, Kalungu
Kayunga, Kayunga
Mukono, Mukono
|
Uganda |
2022-04-01 |
2025-04-01 |
1000 |
Adults aged 18 years and above who are willing to have an HIV test. |
- Abott Diagnostics |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Fred Ssewamala
ID: UNCST-2020-R014060
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Suubi4Stronger Families: Addressing Child Behavioral Health by Strengthening
Financial Stability and Parenting among Families in Uganda
REFNo: SS1205ES
The study examines the mechanisms by which economic empowerment (EE) and family strengthening (FS) interventions targeting social, familial and context-specific drivers affect childhood behavioral health.
Specific aims of the study are:
Aim 1: Examine the impact of EE only, MFG-based FS only, and combined EE+MFG-based FS on children’s DBD symptoms and behavioral functioning.
Aim 2: Test the influence of EE only, MFG-based FS only, and combined EE+MFG-based FS on family financial stability (e.g., food and housing stability, material assets, savings), parenting and protective family
processes (e.g., family organization, caregiver/child interaction, cohesion, support) and perceptions related to
help seeking (e.g., stigma) on CBH and functioning; and assess whether these change mechanism mediate intervention effects on DBD symptoms and behavioral functioning, and explore moderation by context specific moderators of intervention effects.
Aim 3: Qualitatively examine participants’ experiences with each intervention arm.
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Masaka, Kimaanya
Rakai, Kakuuto
Kyotera, Kyotera TC
Lwengo, Lwengo
Kalungu, Bukulula
|
Uganda |
2022-03-30 |
2025-03-30 |
900 |
A total of 900 primary-school-going children (ages 10-14 at enrollment) in upper primary (the last 3 year of
primary school: P5-P7), both male and female will be enrolled and followed for three school-academic terms(12 months). To avoid stigma that surro |
National Institute of Mental Health (NIMH) |
Social Science and Humanities |
Clinical Trial |
Non-degree Award |
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SIMON ARUNGA
ID: UNCST-2021-R013498
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Cluster randomised controlled trial of a complex intervention package to reduce blindness from severe microbial keratitis in Uganda.
REFNo: HS1814ES
To determine if a complex intervention package delivered at the Primary Health Centres (PHCs) including early recognition, prompt chlorhexidine 0.2% treatment and rapid referral can result in reduced rates of blindness from severe MK at three months
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Ntungamo, All parishes
Isingiro, All parishes
|
Uganda |
2022-03-21 |
2025-03-21 |
Participants Individuals with corneal abrasions and corneal infection (microbial keratitis) presenting at the cluster primary health centres in these two districts in South Western Uganda will be elig |
All individuals aged 18 and above, of all sexes in the two districts |
London School of Hygiene and Tropical Medicine |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Johanna Blomgren
ID: UNCST-2021-R012309
|
MIDWIZE - Strengthening midwives to implement and sustain quality improvements to optimise maternity care: A longitudinal observational study in Uganda
REFNo: HS1885ES
This PhD project aims to explore how midwives can take the lead in implementing or enhancing QI components within maternal health care in Uganda.
The overall goal of this project is to improve the health of women and newborns. The way to achieve this is through enhancing the quality of care by capacitating midwives.
Sub-study 1 - Co-creating and developing the intervention and the implementation
Specific objectives: To explore multisectoral stakeholders' perspectives and ideas on how to strengthen midwives' capacity to implement QI components.
To explore which QI components the midwives will implement or enhance.
Sub-study 2 - Implementation and evaluating the sustainability of the implementation
Specific objectives:
-To measure the uptake of evidence-based QI components when midwives lead, organise and provide enhanced intra- and postpartum care.
-To measure the long-term sustainability of the midwives' QI projects.
Sub-study 3 – Process evaluation
Specific objective: To evaluate the process of strengthening midwives' capacity to implement QIs in maternal care.
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Kampala,
|
Sweden |
2022-03-21 |
2025-03-21 |
668 |
Study 1
Midwives at Naguru hospital, women and their relatives, other professionals and managers, multisectoral stakeholders (professional association, education, policymakers)
Study 2
Pregnant women above 18 years in the uptake area. However, dependin |
Karolinska Institutet |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
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|
Pontiano Kaleebu
ID: UNCST-2021-R013577
|
A Randomized, Observer-Blind, Phase 2 Clinical Trial of COVAC-2 in Generally Healthy Adults
REFNo: HS2124ES
Primary Objective:
• To evaluate the safety and tolerability of the COVAC-2 vaccine (25 ?g dosing of S1 antigen) in generally healthy adults ages 18+.
Secondary Objectives:
• To determine spike-binding and pseudovirus neutralizing antibody responses against the Wuhan strain of SARS-CoV-2 induced by COVAC-2; and
• To determine a cellular immune response induced by COVAC-2.
Exploratory Objectives:
• To determine Receptor-Binding Domain (RBD)-binding antibody responses induced by COVAC-2; and
• To determine the neutralizing antibody response induced by COVAC-2 against one or more Variant(s) of Concern (VOC) and/or Variant(s) of Interest (VOI).
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Wakiso, NOT APPLICABLE
Mbarara, NOT APPLICABLE
Masaka, NOT APPLICABLE
|
Uganda |
2022-03-21 |
2025-03-21 |
300 |
The target population for this Phase 2 study is generally healthy adults of diverse gender ? 18 years of age. The target indication for the candidate COVAC-2 vaccine is adults because they are a population that experiences significant age-related COVID-19 |
The study is funded by the Government of Canada through the University of Saskatchewan’s Vaccine and Infectious Disease Organization (VIDO). |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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