Jackson Mukonzo
ID: UNCST-2021-R013916
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Ivermectin-artemisinin Combination Therapy for Eradication of Malaria
REFNo: HS2081ES
Main Objective:
1. To investigate the effect of ivermectin adjunct therapy on household transmissibility of malaria from malaria-infected patients receiving artemether /lumefantrine
Specific objectives
1. To determine the household malaria transmissibility within one month of IVN and
artemether / lumefantrine therapy.
2. To determine the structural similarity of the nanopore plasmodium sequences between
infecting plasmodium species isolated from the index patient and other household malaria
positive patients.
3. To assess the safety of ivermectin-artemether/lumefantrine in malaria-infected patients.
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Kasese, NA
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Uganda |
2022-07-13 16:29:55 |
2025-07-13 |
110 Participants |
Adults aged 18 to 65 years of age, both males and females. No specific tribe in our inclusion criteria but most of the study participants are expected to be Bakonzo given that the study site is Kasese. |
MAKERERE UNIVERSITY RESEARCH AND INNOVATION FUND |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Andrew Mujugira
ID: UNCST-2019-R000871
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CHOICE-BASED PrEP DELIVERY FOR TRANSGENDER PEOPLE IN UGANDA
REFNo: HS2316ES
Aim 1: Identify PRECEDE factors that influence PrEP implementation for transgender people in Uganda.
Guided by the PRECEDE-PROCEED model, which is widely used for public health interventions, we will analyze previously collected qualitative data from four TGP studies and also conduct two new focus groups with TGP and providers to identify predisposing, reinforcing, and enabling factors that may impact implementation of choice-based PrEP. A stakeholder workshop anchored in good participatory practice will discuss results of the qualitative research and guide design of the optimal choice-based PrEP delivery model for Aim 2.
Aim 2: Offer PrEP choice to transgender people in a DSD model and evaluate implementation and effect on PrEP use (PROCEED).
We will offer choice of CAB-LA or oral PrEP, and choice of facility or community delivery (with option to switch), to 300 HIV-negative TGP with follow-up for 24 months. Adverse events, product switching, and trajectories of choice over time will be monitored and documented. Persistence on CAB LA and oral PrEP will be compared during the choice period, and with a historical cohort without PrEP choice (ClinicalTrials.gov, NCT04491422). Primary outcomes are choice of PrEP option & delivery model, adherence, and persistence.
Aim 3: Use mixed methods to evaluate how choice influences PrEP use among TGP (PROCEED).
Inductive and deductive analyses based on in-depth interviews with purposively sampled PrEP users (n=50) and providers (n=10) will be used to explain “how” and “why” choice did or did not work and interpret implementation data from Aim 2. Choice preferences will be assessed via structured questionnaires.
Aim 4: Estimate cost implications associated with integrating CAB LA into HIV programs.
We will conduct health system versus client cost analyses to inform budgeting. Costs incurred and averted will be estimated using activity-based micro-costing, study budget, and the literature. Costs and modeled outcomes will be combined to estimate budget impact with PrEP persistence at 6 and 12 months.
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Wakiso, Kasangati
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Uganda |
2022-06-28 16:44:09 |
2025-06-28 |
420 |
Population: Trans women and men (up to 300 participants)
Eligibility Eligible TGP must be aged ≥18, weigh ≥35kg, be interested in taking PrEP, at high risk for sexually acquiring HIV (i.e., any self-report of condomless sex, multiple partners, stimulant drug use or STIs) in the prior six months, and eligible for PrEP in accordance with Uganda National PrEP Guidelines
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United States National Institute of Mental Health (R01 MH130208) |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Agnes Nyabigambo
ID:
|
Effectiveness of clinic-based patient-led HPV DNA self-sampling among HIV-infected women in Uganda.
REFNo: HS2084ES
1. To assess the difference and associated factors of uptake of clinic-based compared to home-based HPV self-sampling approach among HIV infected women in rural Uganda.
2. To identify factors associated with the prevalence of HPV among HIV-infected women in rural Uganda.
3. To determine factors influencing sample viability HPV self-collected samples in clinic arm compared with home -based arm.
4. To explore the facilitators and barriers of clinic-based compared to home-based HPV self-sampling approaches among HIV-infected women in rural Uganda.
5. To estimate the cost-effectiveness of the clinic-based approach compared to the home-based HPV-DNA self-sampling among HIV-infected women in rural Uganda.
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Luweero, Kasana
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Uganda |
2022-06-08 15:13:10 |
2025-06-08 |
382 |
Women living with HIV aged 25-49 years. |
HEARD PhD Scholarship |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
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Joshua Muhumuza
ID:
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Effect of chewing gum on duration of postoperative ileus following laparotomy for gastroduodenal perforations; a multi centre study.
REFNo: HS1665ES
i. To compare the time taken for post-operative ileus to resolve in the two groups.
ii. To compare the duration of hospital stay in the two groups.
iii. To determine other factors associated with the duration of post-operative ileus in the study population.
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Kabarole, Central Division
Bushenyi, Central Division
Hoima, Central Division
|
Uganda |
2022-05-30 17:10:09 |
2025-05-30 |
52 participants |
All adult patients 18 years and above, male and female admitted to the surgical wards of study centre hospitals irrespective of tribe with gastric or duodenal perforations during the study period at will be the study population |
self sponsored |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
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Lisa Hartwig
ID:
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The effectiveness of a behavioral science and design intervention for family savings on increased use of maternal health services and male involvement: a randomized controlled trial
REFNo: HS2194ES
To assess the effectiveness of a behavioral intervention designed to encourage financial savings for healthcare costs and birth preparedness among pregnant women and their partners in Uganda. To examine whether increased earmarked financial savings for healthcare costs leads to increased utilization of maternal health services and male involvement in maternal healthcare.
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Kyotera, All
|
USA |
2022-05-23 9:28:49 |
2025-05-23 |
700 |
To be eligible for joining the study, the participants must fulfill the following eligibility criteria: (1) 18-49 years old, (2) Between 12-32 gestational weeks (pregnant female) OR partner of someone who is (male), (3) Own a mobile phone, (4) Has a regis |
The University of Tokyo |
Medical and Health Sciences |
Clinical Trial |
Degree Award |
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