Kathy Burgoine
ID: UNCST-2022-R011521
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Impact of prophylactic Continuous Positive Airway Pressure in the Delivery Room (DR-CPAP) on neonates <1500g in a low-resource setting: A feasibility trial
REFNo: HS2605ES
- To determine the acceptability of DR-CPAP to healthcare workers in a low-resource setting
- To determine the post-intervention acceptability of using a two-stage consent process in neonatal emergencies in the delivery room in this setting
- To evaluate the feasibility of a third-party allocation process for randomisation by determining the time to randomization
- To evaluate feasibility of initiating DR-CPAP in a low-resource setting in infants with birthweight 800-1500g within 15 minutes of delivery
- To determine the safety of initiating DR-CPAP in a low-resource setting
- To estimate the sample size to be used for future evaluation in the full trial
- To assess the feasibility of secondary outcome measures to be used in the full trial
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Mbale,
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UK |
2023-02-02 12:18:23 |
2026-02-02 |
100 |
The study population will be inborn preterm infants with a birthweight of 800g to less than 1500g who are spontaneously breathing at 5 minutes of life. They will be recruited within 15 minutes of birth and followed up until death or 28 days. Both male and female infants will be included. |
Mbale Clinical Research Institute (MCRI) |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Yerusa Kiirya
ID:
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Acceptability, Feasibility and Effectiveness of a WhatsApp peer support group as a strategy to improve antiretroviral therapy adherence among youth in Kampala District
REFNo: SIR170ES
To determine the effectiveness of a WhatsApp peer support group combined with the standard of care in improving ART adherence among YLHIVA aged 15-24 years in Kampala district.,To determine the effect of a WhatsApp peer support group combined with the standard of care on psychosocial barriers to ART adherence and retention in care among YLHIVA aged 15-24 years in Kampala district.,To assess the feasibility of using a WhatsApp peer support group combined with the standard of care as an ART adherence and retention in care strategy among YLHIVA aged 15-24 years, To asses the acceptability of a WhatsApp peer support group combined with the standard of care as an ART adherence and retention in care strategy among YLHIVA aged 15-24 in Kampala district.,To assess the acceptability, feasibility and effectiveness of a WhatsApp peer support group combined with current standard care as a strategy to improve ART adherence among YLHIVA in Kampala.,
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Kampala, Kiswa
Kampala, Komambogo
Kampala, Kawala
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Uganda |
2023-01-20 14:23:51 |
2026-01-20 |
488 |
This study will be conducted among YLHIVA aged 15-24 years currently receiving ART services at
Kiswa, Komambogo and Kawala HCIII with an
ART adherence score of less than 95% within the past 12 months |
Strengthening behavioral and social science research capacity to address evolving challenges in HIV care and prevention in Uganda. |
Engineering and Technology |
Clinical Trial |
Degree Award |
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Winnie Muyindike R
ID: UNCST-2021-R013558
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Gabapentin to Reduce Alcohol and Improve Viral Load Suppression (GRAIL) – “Promoting Treatment as Prevention”
REFNo: HS2622ES
2. To assess the impact of gabapentin compared to placebo on: a) alcohol consumption; b) pain severity; c) ART adherence; and d) engagement in HIV care, in order to explore potential mechanisms by which gabapentin may lead to HVL suppression.,1. To test the efficacy of gabapentin versus placebo to achieve undetectable HVL (Primary Outcome at 3 months; Secondary Outcome at 6 & 12 months),
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Mbarara, Kamukuzi
Mbarara, Kakoba
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Uganda |
2023-01-18 18:33:54 |
2026-01-18 |
300 |
18 years and above, female and male, irrespective of tribe, who are on antiretroviral therapy with detectable viral load and are unhealthy alcohol consumers. |
National Institute of Health |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Isaac Ssewanyana
ID: UNCST-2020-R014336
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Evaluation of the performance of novel molecular point of care diagnostics for SARS-CoV-2
REFNo: HS2588ES
To assess the ease of use of the molecular POC devices being evaluated using a System Usability Scale (SUS) questionnaire administered to platform’s operators (minimum 3, where possible)., To evaluate the diagnostic accuracy of such platforms in detecting SARS-CoV-2 on respiratory specimens, compared with reference standard RTPCR in specific subgroups defined based on disease stage (days since symptoms onset), RTPCR Ct values (as surrogate for viral load). Participant’s vaccination status, previous COVID-19 infection(s) and SARS-CoV-2 genetic variant causing participant’s infection, determined by sequencing of the viral genome, may also be considered as subgroups. , To evaluate the diagnostic accuracy of molecular POC devices in detecting SARS-CoV-2 on respiratory specimens, compared with reference standard RT-PCR (WHO EUL or FDA EUA approved), among COVID-19 symptomatic individuals,
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Kampala, Mulago
Kampala, Kiruddu
Kampala, Kawempe
Kampala, Butabika
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Uganda |
2023-01-18 18:21:06 |
2026-01-18 |
200 |
The study will focus on adults with symptoms compatible with COVID-19 (and/or specimens collected from them) attending healthcare facilities in Uganda.
If a participant is screened and enrolled but is not able to provide the specimens required for the study, this participant will be withdrawn. |
FIND GENEVA |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Raymond Tweheyo
ID: UNCST-2020-R014507
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Evaluating the pilot of the Community Health Extension Worker (CHEW) strategy in Uganda: assessing feasibility, and effectiveness for improving Village Health Team (VHT) supervision and reporting
REFNo: HS2545ES
General Objective
To explore the acceptability, document the implementation process and evaluate the effectiveness of the Community Health Extension Worker strategy in two districts of Uganda to guide improving the community health system
Specific Objectives
1) To assess the acceptability of introducing a Community Health Extension Worker (CHEW) strategy in a district health system.
2)To document the process of setting up and implementing a Community Health Extension
Worker (CHEW) strategy within a district health system.
3) To estimate the program costs and duration for setting up a government-led Community Health Extension Worker (CHEW) strategy within a district health system.
4) To determine the effectiveness of the CHEW strategy for improving the quality of Village Health Team (VHT) member’s supervision and reporting in a district health system.
5) To assess the effect of the CHEW strategy on community-level indicators: completion of four antenatal care visits, skilled delivery attendance, fully immunized under-fives, and U5 sick children seen by VHTs and treated within 24 hours.
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Mayuge, all parishes
Lira, all parishes
Kabarole, all parishes
Kyotera, all parishes
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UK |
2023-01-03 13:08:01 |
2026-01-03 |
3,016 women of reproductive age |
1) Household members: Adult women of reproductive age 18 to 49 years.
2) Community health workers - 18 years and above
3) Health facility workers - 18 years and above
4) District technical and political leaders - 18 years and above
5) Community Health Implementing partners - adults, 18 years and above |
USAID/ Uganda Health Systems Strengthening Activity (UHSS) |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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